ABSTRACT
Radiation-induced intestinal injury(RIII), a common complication of radiotherapy for pelvic malignancies, affects the quality of life and the radiotherapy efficacy for cancer. Currently, the main clinical approaches for the prevention and treatment of RIII include drug therapy, hyperbaric oxygen therapy, and surgical treatment. Among these methods, drug therapy is cost-effective. Traditional Chinese medicine(TCM) containing a variety of active components demonstrates mild side effects and good efficacy in preventing and treating RIII. Studies have proven that TCM active components, such as flavonoids, terpenoids, phenylpropanoids, and alkaloids, can protect the intestine against RIII by inhibiting oxidative stress, regulating the expression of inflammatory cytokines, modulating the mitochondrial apoptosis pathway, adjusting intestinal flora, and suppressing cell apoptosis. These mechanisms can help alleviate the symptoms of RIII. The paper aims to provide a theoretical reference for the discovery of new drugs for the prevention and treatment of RIII by reviewing the literature on TCM active components in the last 10 years.
Subject(s)
Medicine, Chinese Traditional , Drugs, Chinese Herbal/pharmacology , Quality of Life , Intestines , AlkaloidsABSTRACT
OBJECTIVE: To understand the quality status and problems of human albumin. METHODS: A total of 153 batchs human albumin samples from 33 manufacturers were analyzed according to the legal quality standard. Three exploratory researches on human parvovirus B19 screening, protein impurity and influencing factors of alum inumion content were conducted. RESULTS: The qualified rate of the 153 batches of samples was 100.0%. The positive rate of B19 DNA in 60 batches from 33 manufacturers was zero. Twenty-three types of other plasma protein were identified in 28 batches of samples from 27 manufacturers. The increase in aluminum contents was related with glass bottle and citrate ion content.CONCLUSION: The overall quality of human albumin is good. However, the content of aluminium ion increases significantly during storage. It is suggested to conduct further study on the influencing factors of aluminium ion content.
ABSTRACT
Objective To investigate the protective mechanism of spironolactone pretreatment on myocardium during perioperation period of percataneous coronary interventional (PCI). Methods A total of 237 patients who under went PCI during Jun. 2007 to Dec. 2010 in People's Hospital of Rugao County were included in the present study. The patients were randomly divided into two groups: treatment group (n=116) and control group (n=121). Patients in the treatment group were given spironolactone (20-40 mg/d) and those in the control group were given placebo. The mean arterial pressure in root of aorta (MAPA), concentrations of aldosterone, troponin I(cTn-I), brain natriuretic peptide (BNP) and c-reaction protein (CRP) were determined before and after PCI. All the data were analyzed by SPSS 11. 5 software system. Results There were no significant differences in the age, sex, operation time, times of balloon and number of stents between the two groups. The concentrations of Aldo, cTn-I, BNP and CRP were greatly increased in the two groups after operation. The concentrations of the Aldo were similar between the two groups before and after PCI; the concentrations of cTn-I, CRP and BNP in treatment group were significantly lower than those in the control group (P<0.05) and the MAPA was higher than that in the control group. We also found that ΔMAPA (postoperative MAPA-preoperative MAPA)was negatively correlated with ΔcTn-I(postoperative cTn-I/preoperativec Tn-I), ΔCRP(postoperative CRP/preoperative CRP), and ΔBNP(postoperative BNP/preoperative BNP), with the coefficients being-0.69, -0.51 and- 0.56 (P<0.05 or P<0.01). Conclusion Pretreatment with spironolactone can alleviate myocardial injury, inhibit inflammatory reaction and relieve heart failure in perioperative period of PCI, which might be related to spironolactone-Induced myocardial perfusion.