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1.
Article in Chinese | WPRIM | ID: wpr-920784

ABSTRACT

Objective To investigate the resistance dynamics of Blattella germanica to commonly used insecticides in Yangpu District of Shanghai during 2014‒2020, and to provide the basis for the rational use of insecticides against cockroaches. Methods Blattella germanica was captured in two farmer’s markets in 2014, 2017 and 2020. The residual film method recommended by WHO was used to test resistance of Blattella germanica to the insecticides. Results In 2014, 2017 and 2020, the resistance ratio of Blattella germanica in Yangpu District was 6.96, 4.39, 7.26 to beta-cypermethrin, 10.41, 6.71, 5.24 to permethrin, and 2.28, 3.16, 1.01 to propoxur. Conclusion The resistance of Blattella germanica to permethrin and propoxur decreases, and the resistance to beta-cypermethrin keeps at low level. Comprehensive management and rotation of insecticides should be implemented to delay the increase of resistance.

2.
Journal of Medical Biomechanics ; (6): E004-E017, 2022.
Article in Chinese | WPRIM | ID: wpr-920662

ABSTRACT

Lumbar surgical operation is the crucial treatment against lumbar degenerative diseases (LDDs), whose development depends on persistent comprehension and innovation of vertebral biomechanics. The thorough understanding of biomechanical changes during lumbar senescence and degeneration is the important bedrock to grasp LDDs pathogenesis, renovate LDDs surgical strategy, and embrace more precise and minimally invasive treatment against LDDs. Herein, in this review, the intimate crosstalk between LDDs with degenerative biomechanics of vertebrae, intervertebral disc and paravertebral muscles was elucidated, followed by the classification of lumbar surgery history into non-vertebral implant era (before the year 1980), vertebral implant era (during the year 1980-1990), vertebral fusion era (during the year 1990-2010), precise and minimally invasive decompression era (after the year 2010) based on lumbar surgical characteristics in each era. The significance of representative biomechanical studies in each era for lumbar surgery was also concluded. From biomechanical perspectives, the history of spinal surgery is the development history of surgical strategies that has progressed as the continuously in-depth understanding of spinal biomechanics. With the deepening of spinal biomechanical researches, spinal surgeons are expected to develop treatment strategies that are more adapted to physiological and biomechanical characteristics of the spine, thereby guiding the future direction of spinal surgery advancement.

3.
Chinese Journal of Trauma ; (12): 720-725, 2021.
Article in Chinese | WPRIM | ID: wpr-909928

ABSTRACT

Objective:To explore the clinical efficacy of open-door laminoplasty in treatment of cervical spinal hyperextension injury accompanied with or without spinal cord-canal mismatch.Methods:A retrospective case-control study was performed to analyze the clinical data of 42 patients with cervical spine hyperextension in Shanghai Ninth People’s Hospital,Shanghai Jiaotong University School of Medicine from January 2016 to June 2019. There were 31 males and 11 females at age range of 40-78 years[(59.7 ± 9.9)years]. All patients underwent open-door laminoplasty.Preoperative Japanese Orthopaedic Association score(JOA)was(10.2 ± 3.8)points,and American Spinal Injury Association(ASIA)spinal cord injury score was(260.4 ± 47.5)points. Those with spinal cord occupation rate(SCOR)equal to or more than 70% were classified as spinal cord-canal mismatched group(n=21),and those with SCOR less than 70% were classified as spinal cord-canal matched group(n=21). ASIA total score,ASIA upper and lower limb motor scores,ASIA sensory score,JOA score,surgical improvement rates and complications were compared between the two groups before operation,at postoperative one week and at the latest follow-up.Results:All patients were followed up for 12-26 months[(19.1 ± 2.3)months]. Both groups had significantly improved ASIA total score at postoperative one week and at the latest follow-up,compared with that before operation( P < 0.05). The two groups showed no significant difference in ASIA total score at postoperative one week( P > 0.05). ASIA total score in unmatched group was(307.6 ± 9.9)points at the latest follow-up,significantly lower than that in matched group[(315.4 ± 8.7)points]( P < 0.01). ASIA upper limb motor score in mismatched group was(29.1 ± 7.0)points and(36.6 ± 6.5)points at postoperative one week and at the latest follow-up,significantly lower than that in matched group[(42.0 ± 5.7)points,(47.4 ± 2.5)points]( P < 0.01),while there was no significant difference in ASIA lower limb motor score and sensory score between the two groups( P > 0.05). Both groups showed significantly improved JOA score at postoperative one week and at the latest follow-up,compared with that before operation( P < 0.05). JOA score in mismatched group was(11.5 ± 3.0)points and(12.5 ± 3.0)points at postoperative one week and at the latest follow-up,significantly lower than that in matched group[(13.5 ± 2.4)points,(15.0 ± 2.0)points]( P < 0.01). Postoperative improvement rate in matched group was 95%(20/21),and was 85%(18/21)in mismatched group( P < 0.05). Cervical axial pain occurred in 3 patients in each group and C 5 nerve root palsy in 2 patients in matched group,all of which were relieved after conservative treatment. No implant loosening or breakage occurred during follow-up. Conclusions:Open-door laminoplasty can improve part of the nerve function of patients with cervical hyperextension injury. However,the overall improvement degree of nerve function especially recovery of upper limb motor function in patients with spinal cord-canal mismatch is inferior to those in spinal cord-canal matched patients.

4.
Article in Chinese | WPRIM | ID: wpr-908534

ABSTRACT

Objective:To study the risk factors of hypotension after ligation of patent ductus arteriosus (PDA) in very/extremely low birth weight infants (VLBWI/ELBWI).Method:From March 2016 to January 2021, preterm infants with birth weight <1 500 g receiving bedside PDA ligation in the neonatal intensive care unit (NICU) of our hospital were enrolled in the study. According to the occurrence of hypotension within 72 hours after ligation, the infants were assigned into non-hypotension group and hypotension group. The general status and perioperative conditions of the two groups were analyzed. Multivariate Logistic regression was used to analyze the risk factors of hypotension.Result:A total of 44 cases were enrolled, including 33 in non-hypotension group and 11 in hypotension group. Univariate analysis showed that hypotension group had significantly more cases with body weight <1 100 g during surgery and receiving preoperative high frequency oscillatory ventilation (HFOV) than non-hypotension group ( P<0.05). Multivariate Logistic regression analysis showed that weight <1 100 g during surgery ( OR=12.045, 95% CI 1.351~107.394, P=0.026) and receiving preoperative HFOV ( OR=27.832, 95% CI 1.363~568.292, P=0.031)were independent risk factors of hypotension. Conclusion:Hypotension is one of the common complications of PDA ligation in VLBWI/ELBWI. The infant's body weight during ligation and receiving preoperative HFOV are independent risk factors of hypotension.

5.
Article in Chinese | WPRIM | ID: wpr-908158

ABSTRACT

Objective:To explore the experience of home dietary changes in postoperative patients with gastric cancer.Methods:From December 2019 to February 2020, purpose sampling method was used to select 13 postoperative gastric cancer patients from the Oncology Department of Taixing People's Hospital in Jiangsu Province to conduct semi-structured interviews. The Colaizzi seven-step analysis method was used to analyze the interview data and extract topics.Results:Three main themes were summarized: reconstruction of dietary habits, lack of pleasure in eating, and continuous dietary nursing needs.Conclusions:There are many dietary problems in postoperative patients with gastric cancer. Medical staff should pay attention to dietary changes of patients and take targeted intervention measures, in order to increase the positive experience of dietary.

6.
Article in Chinese | WPRIM | ID: wpr-906452

ABSTRACT

Xiehuangsan, derived from QIAN Yi's Key to Therapeutics of Children's Diseases, consists of 5 medicines, namely Gypsum Fibrosum,Gardeniae Fructus,Saposhnikoviae Radix,Pogostemonis Herba and Glycyrrhizae Radix et Rhizoma. It is used to treat children with spleen heat and tongue scratching. With the clinical use of later generations of physicians,the scope of diseases and syndromes of this prescription was gradually expanded,including aphthous bad breath,dry lips,yellow eyes,and sweet mouth. Modern doctors used this prescription to treat children with anorexia,constipation,allergic purpura,tic disorder, and other diseases. At present,more and more attention has been paid to the research of classical famous prescriptions. At the same time,the application of classical famous prescriptions of traditional Chinese medicine(TCM) must be researched and verified in ancient literature. Therefore,it has become important contents in the study of classic prescriptions that researching the source of prescriptions from the ancient books,combing and analyzing literature,and studying the evolution rules of indications,preparations,methods of administration and taboos.The author searched a variety of ancient Chinese medicine databases and collected the relevant documents related to Xiehuangsan in ancient medical books. A total of 242 pieces of relevant ancient document data were obtained,involving 131 types of ancient Chinese medicine books. Through combing the relevant records of historical documents,this paper analyzes and researches the historical evolution of Xiehuangsan,the source and composition of the prescriptions,the indications,the dosage,the textual research of Chinese herbal medicine and the determination of the basis,and the method of prescription preparation and administration,etc. The historical changes of Xiehuangsan and its internal relations are expected to provide literature references and theoretical basis for the modern development and research of Xiehuangsan.

7.
Article in Chinese | WPRIM | ID: wpr-906348

ABSTRACT

Objective:To explore the mechanism of resveratrol (RSV) in the treatment of lung adenocarcinoma (LUAD) based on bioinformatics and molecular biology. Method:The targets of RSV were retrieved from DrugBank and then imported into STRING for constructing a protein-protein interaction (PPI) network.TCGA database was utilized to analyze the expression of target genes in tumor and normal tissues, followed by the prediction of their impacts on tumor occurrence and development and the screening of target genes using random forest and univariate Cox regression models.With the results of bioinformatics taken into consideration, the mechanism of RSV in inhibiting LUAD was further explored by molecular biology. Result:Ten Hub genes were screened out from the PPI network of RSV targets.Among them, solute carrier family 2 member 1 (SLC2A1), arachidonate 5-lipoxygenase (ALOX5), peroxisome proliferative activated receptor gamma (PPARG), and arachidonate 15-lipoxygenase (ALOX15) differed significantly in their expression in tumor and normal tissues.As revealed by random forest and univariate COX regression analysis, SLC2A1 was of great significance to the survival and prognosis of patients with LUAD.The survival analysis through Kaplan-Meier (KM) plotter indicated that the SLC2A1 expression was closely related to the overall survival (OS), first progression (FP), and post-progression survival (PPS) of LUAD patients.The molecular biological experiments further proved that RSV inhibited the proliferation and migration of LUAD cells by reducing the expression of SLC2A1.As verified by immunohistochemical scoring, SLC2A1 protein expression in tumor tissue was significantly different from that in normal tissue. Conclusion:RSV inhibits the proliferation and migration of LUAD cells by reducing the expression of SLC2A1, which has far-reaching significance in the clinical treatment of LUAD.

8.
Article in Chinese | WPRIM | ID: wpr-906187

ABSTRACT

Objective:To investigate the effective constituents and mechanism of Tingli Dazao Xiefeitang for the treatment of heart failure through network pharmacology and high resolution mass spectrometry technique as well as molecular docking technique. Method:Chemical components and potential targets in Descurainiae Semen Lepidii Semen and Jujubae Fructus were searched by referring to literature and BATMAN-TCM database. The disease targets were searched in GeneCards database with ''heart failure'' as the key word. STRING platform was used to construct protein-protein interaction(PPI) network based on common targets of drugs and disease. The network topology was analyzed by using Cytoscape 3.7.2 software to obtain the core targets eventually. Kyoto encyclopedia of genes and genomes(KEGG) enrichment analysis of the core targets was conducted through DAVID database to draw a network of “herb-compound-target-pathway”. Based on the results of the network pharmacology research above,high resolution mass spectrometry was used to analyze the decoction and confirm the selected active components. AutoDock 4.2.6 software was used for molecular docking verification of key active components and related targets. Result:A total of 85 components were obtained in Descurainiae Semen Lepidii Semen,and 49 components were obtained in Fructus Ziziphi Jujubae. A total of 1 078 drug targets and 1 549 disease targets were identified. After PPI analysis and network topology analysis,23 core targets and 33 active components were obtained,involving 19 signaling pathways (<italic>P</italic><0.05). Mass spectrometry analysis results indicated that 18 components such as isovanillic acid,descuraininA and kaempferol-7-<italic>O-β-D</italic>-glucopyranoside were confirmed in decoction. Molecular docking analysis results indicated that 6 core components (degree value top 6),such as isovanillic acid,descurainin A and kaempferol-7-<italic>O-β-D</italic>-glucopyranoside,had good binding activity with silent information regulatory factor 1(SIRT1),interleukin(IL)1B,protein kinase B<italic>α</italic>(AKT1) and tumor necrosis factor(TNF). The compound recipe for heart failure mainly involved mitogen-activated protein kinase(MAPK),hypoxia inducible factor-1(HIF-1),Mammalian target of rapamycin(mTOR) and other signaling pathways. Conclusion:This study preliminarily investigated the effective constituents and mechanism of Tingli Dazao Xiefeitang in the treatment of heart failure. It can provide references for the precise clinical medication and screening of quality control markers,as well as the discovery of active components in the treatment of heart failure.

9.
Journal of Medical Biomechanics ; (6): E184-E188, 2021.
Article in Chinese | WPRIM | ID: wpr-904384

ABSTRACT

Objective To evaluate the biomechanical properties of lumbar interbody fusion with NiTi memory alloy stent-autogenous bone granule-absorbable bone cement. Methods The normal L3-5 segment finite element model (M0), L4-5 intervertebral fusion model with box fusion cage (M1), L4-5 intervertebral fusion model with NiTi memory alloy stent (M2) and L4-5 interbody fusion model with bone granule-absorbable bone cement for casting bone graft (M3) were constructed, respectively. The models were applied with mechanical loading to analyze the mechanical stability and the peak stress of L4 interior endplate. Results The range of motion (ROM) of L4-5 segment in M1 and M2 models was significantly lower than that of M0 model under flexion, extension, lateral flexion and axial rotation. In M3 model, the stability of the surgical segment was further improved and the peak stress of L4 interior endplate was much smaller than that of M1 and M2 models. Conclusions NiTi memory alloy stent and traditional box fusion cage have biomechanical equivalence when used alone in lumbar interbody fusion, and application of bone granule-absorbable bone cement for casting bone graft can further improve the stability and reduce the stress of endplate.

10.
Article in Chinese | WPRIM | ID: wpr-921946

ABSTRACT

OBJECTIVE@#To evaluate the clinical efficacy of local infiltration anesthesia of ropivacaine combined with compound betamethasone for postoperative analgesia in patients with hallux valgus.@*METHODS@#From September 2019 to December 2020, 48 patients with hallux valgus were treated surgically. According to different postoperative analgesia methods, the patients were divided into combined local infiltration group and intravenous analgesia pump group. There were 24 cases, in the combined local infiltration group including 2 males and 22 females;the age ranged from 21 to 78 years old, with an average of (58.3±7.7) years old;soft tissue release and chevron osteotomy were performed in 15 cases and metatarsophalangeal joint fusion in 9 cases;immediately after operation, 20 ml of ropivacaine combined with compound betamethasone mixed diluent was used for local infiltration anesthesia once. There were 24 patients in intravenous analgesia pump group, including 3 males and 21 females;the age ranged from 23 to 81 years old, with an average of(56.8±8.3) years old;soft tissue release and Chevron osteotomy were performed in 17 cases and metatarsophalangeal joint fusion in 7 cases;immediately after operation, intravenous analgesia pump was used for analgesia. The basic flow was 2 ml / h;the self control dose was 0.5 ml;and the locking time was 15 min. Visual analogue scale (VAS) was recorded at 12, 24, 48 and 72 hours after operation;and the VAS was recorded at 24 hours after operation. The occurrence of adverse drug reactions at 0 to 12 hours, 12 to 24 hours and 24 to 48 hours after operation were recorded;and the healing of incision was recorded.@*RESULTS@#All patients were followed up, and the duration ranged from 14 to 17 days, with a mean of (14.60±0.92) days. There was significantdifference in VAS at 12, 24 and 48 hours between the combined local infiltration group and the intravenous analgesia pump group(@*CONCLUSION@#Compared with intravenous analgesia pump group, ropivacaine combined with compound betamethasone can significantly reduce postoperative wound pain without increasing adverse drug reactions, and does not increase wound infection.


Subject(s)
Adult , Aged , Aged, 80 and over , Analgesia , Anesthesia, Local , Bunion , Feasibility Studies , Female , Hallux Valgus/surgery , Humans , Male , Middle Aged , Pain, Postoperative/drug therapy , Young Adult
11.
Cancer Research and Clinic ; (6): 877-880, 2021.
Article in Chinese | WPRIM | ID: wpr-912985

ABSTRACT

In recent years, the relationship between inflammation and the occurrence and development of cancer has attracted widespread attentions. As a pro-inflammatory factor, interleukin-6 (IL-6) plays a certain role in promoting cancer progression, and it is an important activating factor of signal transducer and activator of transcription 3 (STAT3). Many studies have shown that continuous activation of the IL-6 and STAT3 signaling pathway can induce the abnormal expression of oncogenes related to cell proliferation, apoptosis and differentiation in colorectal cancer. This article reviews the role of IL-6 and STAT3 signaling pathway in the occurrence and development of colorectal cancer, as well as the clinical value of this signaling pathway in the prognostic evaluation and treatment of colorectal cancer, in order to provide certain theoretical basis for the disease monitoring, prognostic evaluation and treatment of colorectal cancer.

12.
Article in Chinese | WPRIM | ID: wpr-911664

ABSTRACT

Objective:To explore the risk factors of paralytic ileus (PI) after simultaneous pancreas-kidney (SPK) transplantation.Methods:From January 2017 to December 2019, clinical data were reviewed retrospectively for 115 cases of SPK transplantation. The risk factors of PI after SPK were analyzed. According to the occurrence of PI, they were divided into two groups of occurrence and non-occurrence. One-way analysis of variance was utilized for analyzing such influencing factors as gender, age, body mass index (BMI), diabetic type, duration of diabetes, mode of dialysis, duration of dialysis, diabetic gastroenterology, history of open surgery, bowel preparation, operative duration, hemorrhagic volume, immunosuppressant and hypoproteinemia. Multivariate Logistic regression analysis was performed for screening the suspected risk factors.Results:Among them, 19 patients (16.5%) had PI. Univariate analysis showed that PI was associated with diabetic gastroenterology, operative duration, history of open surgery, no bowel preparation and hypoproteinemia ( P<0.05). Multivariate Logistic regression analysis revealed that the risk factors of PI after SPK included diabetic gastroenterology, operative duration time, history of open surgery and no bowel preparation ( P<0.05). Conclusions:Diabetic gastroenterology, operative duration, history of open surgery and no bowel preparation are risk factors for PI after SPK. Clinical interventions for the above factors are necessary.

13.
Article in Chinese | WPRIM | ID: wpr-911645

ABSTRACT

Objective:To explore the efficacy and safety of simultaneous pancreas-kidney (SPK) transplantation in patients aged over 60 years.Methods:A retrospective analysis was performed for 150 SPK patients from January 1, 2013 to June 30, 2019. Based upon age, they were divided into three groups of ≥60 years ( n=21), 50-60 years ( n=44) and <50 years ( n=85). Clinical data of three groups were compared, including postoperative rejection, perioperative graft thrombosis, reoperative frequency, average hospitalization time and readmission ratio. And cardiocerebrovascular complications before/after-SPK, CMV viremia within 1 year post-SPK, fasting blood glucose, fasting C-peptide, fasting insulin level, HbA1c at 1 year post-SPK, glomerular filtration rate (eGFR) at 1 year post-SPK and survival rate of patient/graft were compared. Results:There were 21 cases in ≥60 years group, accounting for 14% of the total number of cases and the maximal age was 67 years. The proportion of preoperative cardiovascular events was 14.3%(3/21) in ≥60 years group, 34.1%(15/44) in 50-60 years group and 7.1%(6/85) in <50 years group. Statistical difference existed among three groups ( P=0.001). A pairwise comparison indicated that preoperative cardiovascular event in 50-60 years group was higher than that in <50-years group ( P=0.0006). The postoperative cardiovascular events in three groups were 4.8%, 4.5% and 2.4% respectively and there was no statistical difference ( P=0.537). The incidence of graft thrombosis in three groups was 2 cases (9.5%) in ≥60 years group, 1 case (2.3%) in 50-60 years group and 7 cases (8.2%) in <50 years group ( P=0.384). The proportion of reoperation in three groups was 14.3%, 18.3% and 18.8% respectively and there was no statistical difference ( P=0.889). The causes of death were cerebral hemorrhage ( n=2), myocardial infarction ( n=2) and tumor ( n=1); ≥ 60 years group ( n=1), 50-60 years group ( n=1) and <50 years group ( n=3). No significant difference existed among three groups ( P=0.842). There was no significant difference in average postoperative hospitalization time, readmission rate, postoperative rejection, postoperative 1-year CMV viremia, postoperative cerebrovascular events, postoperative 1-year fasting blood glucose, fasting C-peptide, fasting insulin level, HbA1c, postoperative 1-year eGFR or patient/graft survival rate among three groups. Conclusions:Through strict preoperative evaluations, SPK for patients aged over 60 years increases no operative risk and achieves the same outcome.

14.
Article in English | WPRIM | ID: wpr-888245

ABSTRACT

ObjectiveTo describe the epidemiologic, clinical, laboratory, and radiological characteristics and prognoses of COVID-19 confirmed patients in a single center in Beijing, China. Methods The study retrospectively included 19 patients with nucleic acid-confirmed SARS-CoV-2 infection at our hospital from January 20 to March 5, 2020. The final follow-up date was March 14, 2020. The epidemiologic and clinical information was obtained through direct communication with the patients or their family members. Laboratory results retrieved from medical records and radiological images were analyzed both qualitatively by two senior chest radiologists as well as quantitatively via an artificial intelligence software. Results We identified 5 family clusters (13/19, 68.4%) from the study cohort. All cases had good clinical prognoses and were either mild (3/19) or moderate (16/19) clinical types. Fever (15/19, 78.9%) and dry cough (11/19, 57.9%) were common symptoms. Two patients received negative results for more than three consecutive viral nucleic acid tests. The longest interval between an initial CT abnormal finding and a confirmed diagnosis was 30 days. One patient's nucleic acid test turned positive on the follow-up examination after discharge. The presence of radiological abnormalities was non-specific for the diagnosis of COVID-19. Conclusions COVID-19 patients with mild or no clinical symptoms are common in Beijing, China. Radiological abnormalities are mostly non-specific and massive CT examinations for COVID-19 screening should be avoided. Analyses of the contact histories of diagnosed cases in combination with clinical, radiological and laboratory findings are crucial for the early detection of COVID-19. Close monitoring after discharge is also recommended.


Subject(s)
Adult , COVID-19/diagnostic imaging , COVID-19 Nucleic Acid Testing , Child , China , Female , Humans , Lung/diagnostic imaging , Male , Middle Aged , Retrospective Studies , SARS-CoV-2 , Tomography, X-Ray Computed
15.
Article in Chinese | WPRIM | ID: wpr-888225

ABSTRACT

Extraction and analysis of electroencephalogram (EEG) signal characteristics of patients with autism spectrum disorder (ASD) is of great significance for the diagnosis and treatment of the disease. Based on recurrence quantitative analysis (RQA)method, this study explored the differences in the nonlinear characteristics of EEG signals between ASD children and children with typical development (TD). In the experiment, RQA method was used to extract nonlinear features such as recurrence rate (RR), determinism (DET) and length of average diagonal line (LADL) of EEG signals in different brain regions of subjects, and support vector machine was combined to classify children with ASD and TD. The research results show that for the whole brain area (including parietal lobe, frontal lobe, occipital lobe and temporal lobe), when the three feature combinations of RR, DET and LADL are selected, the maximum classification accuracy rate is 84%, the sensitivity is 76%, the specificity is 92%, and the corresponding area under the curve (AUC) value is 0.875. For parietal lobe and frontal lobe (including parietal lobe, frontal lobe), when the three features of RR, DET and LADL are combined, the maximum classification accuracy rate is 82%, the sensitivity is 72%, and the specificity is 92%, which corresponds to an AUC value of 0.781. The research in this paper shows that the nonlinear characteristics of EEG signals extracted based on RQA method can become an objective indicator to distinguish children with ASD and TD, and combined with machine learning methods, the method can provide auxiliary evaluation indicators for clinical diagnosis. At the same time, the difference in the nonlinear characteristics of EEG signals between ASD children and TD children is statistically significant in the parietal-frontal lobe. This study analyzes the clinical characteristics of children with ASD based on the functions of the brain regions, and provides help for future diagnosis and treatment.


Subject(s)
Autism Spectrum Disorder/diagnosis , Autistic Disorder , Brain , Child , Electroencephalography , Humans , Recurrence
16.
Article in Chinese | WPRIM | ID: wpr-888097

ABSTRACT

The purpose of the present study was to investigate the relationship of the classification of traditional Chinese medicine(TCM) materials with the suitable binder concentration and dosage in the preparation of personalized water-paste pills and establish a model for predicting the binder concentration and dosage. Five representative TCM materials were selected, followed by mixture uniform design. The water-paste pills were prepared by extrusion and spheronization with hypromellose E5(HPMC E5) as the binder. The quality of intermediates and final products was evaluated, and the resulting data were subjected to multivariate statistical analysis. The prediction models for binder concentration and dosage were established as follows: binder concentration: Y_1=0.378 6 + 0.570 1X_A + 2.271 2X_B-0.894 5X_C-0.458 2X_D-1.145 4X_E(when Y_1 < 0, 10% HPMC E5 was required; when Y_1 > 0, 20% HPMC E5 was required), with the accuracy reaching up to 100%; binder dosage: Y_2=32.38 + 0.25X_A + 1.85X_B-0.013X_B~2-0.002 5X_C~2(R~2=0.932 6, P < 0.001). The results showed that the binder concentration and dosage were correlated positively with the proportion of fiber material but negatively with the proportions of sugar material and brittle material. Then the validation experiments were conducted with the prediction models and all the prescriptions could be successfully prepared at one time. These demonstrated that following the classification of TCM materials and the calculation of their proportions in the prescription, the established mathematical model could be adopted for predicting the binder concentration and dosage required in the preparation of personalized water-paste pills, which contributed to reducing the pre-formulation research and guiding the actual production of personalized water-paste pills.


Subject(s)
Drugs, Chinese Herbal , Excipients , Hypromellose Derivatives , Medicine, Chinese Traditional , Water
17.
Article in Chinese | WPRIM | ID: wpr-888096

ABSTRACT

Chinese medicinals feature different medicinal parts and enriched components, which makes their powders show obvious microscopic identification characteristics and specific physical properties. On this basis, the commonly used Chinese medicinals can be divided into several categories, such as powdery, fibrous, sugar, oil, and brittle materials, which is of great importance to the research and development of personalized Chinese medicinal preparation technology. However, the existing classification methods are highly subjective and thus difficult to meet the requirements for the development of personalized Chinese medicinal preparations with high quality. In this study, 55 representative Chinese medicinals, such as Dioscoreae Rhizoma and Leonuri Herba, were selected, and the physical properties of their powders were systematically characterized by comprehensive powder tester, torque rheometer, texture analyzer, etc., based on which a data set encompassing physical properties of these powders was built. The typical physical fingerprints of powders from the above 5 categories were established by multivariate statistical analysis. Then, the Chinese medicinals were classified according to the Euclidean distance between each of them and the typical value in the PCA score plot. For those with multiple material properties, whose classification boundary was fuzzy, the proportions of different types of materials were calculated with the combination of Euclidean distance, powder properties, microscopic identification characteristics, and chemical composition, so as to achieve the multivariate quantitative classification of Chinese medicinals. This lays the foundation for the further creation of intelligent personalized Chinese medicinal preparation technology.


Subject(s)
Drugs, Chinese Herbal , Medicine, Chinese Traditional , Powders , Rhizome
18.
Article in Chinese | WPRIM | ID: wpr-887985

ABSTRACT

With Sangtang Yin granule as model drug,and based on the strategy of " unification of medicines and excipients",the feasibility of preparing high drug loading granules with traditional Chinese medicine( TCM) raw powder as carrier was explored. The powder yield,particle size and particle size distribution,fillibility,flowability,hygroscopicity,reconstituability and other key physical properties relating to preparations of 8 herbs( Dioscoreae Rhizoma,Euryales Semen,Atractylodis Macrocephalae Rhizoma,Coicis semen,Poria,Puerariae Lobatae Radix,Puerariae Thomsonii Radix and Coicis Semen by stir-frying with bran) were studied after being smashed,and the feasibility of taking them as excipients of TCM granules was evaluated by co-spray drying,dry granulation and other preparation techniques. According to the results of the physical properties of raw powders,raw powders of Dioscoreae Rhizoma,Euryales Semen and Puerariae Thomsonii Radix had a high powder yield,uniform particle size distribution,good fillibility,poor hygroscopicity and good reconstitutability,with the feature of assisting granule forming. Compared with the prescription of spray dry powder Sangtang Yin without any excipient,the co-sprayed powder had a high yield,good fillibility and compressibility. The yield of dry granules prepared by co-spraying dry powder was increased by more than 10%,and the particles had a uniform color,good fluidity and dissolubility with the drug-loading rate up to 100%. Based on the physical characteristics of TCM raw powder combined with the analysis of the preparation process,Dioscoreae Rhizoma and Puerariae Thomsonii Radix raw powder were selected as the carriers of granule preparations,and Sangtang Yin granule without any excipient was successfully prepared. The findings provide a feasible idea for the preparation of TCM granules with a high drug loading capacity.


Subject(s)
Excipients , Medicine, Chinese Traditional , Particle Size , Powders , Pueraria , Rhizome
19.
Acta Pharmaceutica Sinica ; (12): 2127-2135, 2021.
Article in Chinese | WPRIM | ID: wpr-887052

ABSTRACT

To improve the fluidity and compactibility properties of raw powders of traditional Chinese medicine by particle modification technology, Lonicera Japonica Flos was used as a model drug, fluidized bed bottom spray technology was used, and Plasdone S-630 was used as a modifier to prepare modified particles. The powder properties, tablet compactibility parameters, disintegration time and dissolution were measured. The surface morphology of the powder particles before and after modification and compressed tablets were characterized by combining with scanning electron microscopy technology. The results showed that the particle size of Lonicera Japonica powder has been increased after particle modification, the fluidity, compressibility and compactibility of the powder have been improved to some extent, the disintegration time has also been reduced, and the dissolution in vitro is not affected. Therefore, this study can provide reference and ideas for the common problem that raw powder of traditional Chinese medicine that cannot meet the needs of preparation production due to poor powder properties such as fluidity and compressibility.

20.
China Pharmacy ; (12): 2410-2414, 2021.
Article in Chinese | WPRIM | ID: wpr-886926

ABSTRACT

OBJECTIVE:To evaluate the implementation of national drug centralized volume-based procurement (called “VBP”for short)in a public hospital,so as to provide reference for promoting VBP policy guided by value-based healthcare. METHODS:A total of 6 varieties and 12 specifications of antibiotics included in VBP in a public hospital in Chongqing were analyzed. The drug use data of the hospital one year before the implementation of VBP(i.e. April 20,2019- April 19,2020)and one year after the implementation(i.e. April 20,2020-April 19,2021)were collected and analyzed in respects of price change, generic drug substitution rate,average daily cost(DDDc),actual cost savings and other indicators. The problems and suggestions were put forward,and the effects of VBP policy implementation whether reflects the core connotation of value-based healthcare were evaluated. RESULTS:After the implementation of VBP,drug prices fell by an average of 63.44%,the average price drop of original drugs was 27.38% ,and substitution rate of generic drugs was 25.59% . DDDc of selected antibiotics in the hospital decreased in varying degrees,of which the decline of four drugs was 10%-40%,and that of Moxifloxacin hydrochloride tablets was 80.14%. Compared with bef VBP,6 kinds of antibiotics saved about 521 300 yuan,of which the imported Moxifloxacin hydrochloride tablets and Moxifloxacin hydrochloride sodium chloride injection saved 495 300 yuan(accounting for 94.97% of the total cost savings of antibiotics). CONCLUSIONS:The value of VBP based on the perspective of value-based healthcare is mainly reflected in the dual channel management mechanism of drugs,which improves the availability of drugs,effectively controls the unreasonable growth of medical expenses,reduces the expenditure of medical insurance fund,and helps to further reduce the drug burden of patients. At present,the implementation of VBP still faces difficulties,including the need for drug prices to return to a reasonable range,the need for foreign enterprises to change strategies to seek a breakthrough,and different therapeutic efficacy due to the difference in quality between the selected generic drugs and the original drugs. Therefore,the author believes that the pharmaceutical market structure should be transformed positively,value-based healthcare should help the regulation of medical insurance,and the consistency evaluation system should be optimized,so as to further improve the health level of patients.

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