Effects of aerobic exercise on body morphology in obese university students / Efeitos do exercício aeróbico na morfologia corporal de estudantes universitários obesos / Efectos del ejercicio aeróbico en la morfología corporal de estudiantes universitarios obesos

ABSTRACT Introduction The problem of obesity is relevant to the current social development model. In addition to the eminent physical health risks, obese university students also experience greater resistance to social development. Obese students participating in the national weight loss fitness program can perceive the benefits of aerobic exercise. Objective Explore the effect of aerobic exercise on body morphology in obese university students. Methods 60 obese university students were selected as study subjects and divided equally into a control and experimental group. The control group received no intervention, while the experimental group performed a battery of aerobic exercises of 60 minutes daily, four times a week for six weeks. Data before and after the experiment were compared. BMI, body fat rate, blood lipid monitoring, and blood glucose were also taken as body component monitoring indexes, and circumference measurements and proportions were taken as external body monitoring indexes. Results Aerobic exercise can effectively reduce the body weight, body mass index (BMI), body fat rate, and body circumference of college students, decrease body weight, make the body shape more symmetrical, and also improve lipid and glycemic components, thus reducing the complications caused by obesity. Conclusion University professors should perform aerobic training for university students to improve their physical fitness, regulate their physical function, and improve their physical appearance. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

RESUMO Introdução O problema da obesidade é um problema relevante no atual modelo de desenvolvimento social. Além dos riscos eminentes na saúde física, os estudantes universitários obesos também vivenciam uma maior resistência para o desenvolvimento social. Os alunos obesos que participam do programa nacional de condicionamento físico para a perda de peso podem perceber os benefícios do exercício aeróbico. Objetivo Explorar o efeito do exercício aeróbico na morfologia corporal de estudantes universitários obesos. Métodos 60 estudantes universitários obesos foram selecionados como sujeitos de estudo e divididos igualmente em grupo controle e experimental. O grupo controle não recebeu intervenção enquanto o experimental efetuou uma bateria de exercícios aeróbicos de 60 minutos diários, quatro vezes por semana, durante seis semanas. Dados antes e depois do experimento foram comparados. O IMC, a taxa de gordura corporal, monitoramento sanguíneo de lipídios e glicemia também foram tomados como índices de monitoramento dos componentes corporais, medidas de circunferências e proporções foram tomadas como índices de monitoramento corporal externo. Resultados O exercício aeróbico pode reduzir efetivamente o peso corporal, o índice de massa corporal (IMC), a taxa de gordura corporal e a circunferência corporal dos estudantes universitários, diminuir o peso corporal, deixando a forma corporal mais simétrica, além de melhorar os componentes lipídicos e glicêmicos, reduzindo assim as complicações causadas pela obesidade. Conclusão Os professores universitários devem realizar treinamento aeróbico de estudantes universitários a fim de melhorar seu condicionamento físico, regular sua função física e melhorar seu aspecto físico. Nível de evidência II; Estudos terapêuticos - investigação dos desfechos do tratamento.

RESUMEN Introducción La cuestión de la obesidad es un problema relevante en el modelo actual de desarrollo social. Además de los riesgos eminentes en la salud física, los universitarios obesos también experimentan una mayor resistencia al desarrollo social. Los estudiantes obesos que participan en el programa nacional de acondicionamiento físico para la pérdida de peso pueden obtener los beneficios del ejercicio aeróbico. Objetivo Explorar el efecto del ejercicio aeróbico sobre la morfología corporal en estudiantes universitarios obesos. Métodos Se seleccionaron 60 estudiantes universitarios obesos como sujetos de estudio y se dividieron por igual en el grupo de control y el experimental. El grupo de control no recibió ninguna intervención, mientras que el grupo experimental realizó una batería de ejercicios aeróbicos de 60 minutos diarios, cuatro veces por semana durante seis semanas. Se compararon los datos antes y después del experimento. El IMC, el índice de grasa corporal, la monitorización de lípidos y de glucosa en sangre también se tomaron como índices de monitorización de los componentes corporales, las medidas de circunferencia y las proporciones se tomaron como índices de monitorización corporal externa. Resultados El ejercicio aeróbico puede reducir eficazmente el peso corporal, el índice de masa corporal (IMC), el índice de grasa corporal y la circunferencia corporal de los estudiantes universitarios, disminuir el peso corporal, hacer que la forma del cuerpo sea más simétrica, y también mejorar los componentes lipídicos y glucémicos, reduciendo así las complicaciones causadas por la obesidad. Conclusión Los profesores universitarios deberían realizar un entrenamiento aeróbico de los estudiantes universitarios para mejorar su estado físico, regular su función física y mejorar su aspecto físico. Nivel de evidencia II; Estudios terapêuticos - investigación de los resultados del tratamiento.

Differentially expressed genes in chronic periodontitis and the correlation with disease severity / 国际生物医学工程杂志

Objective:To study the differentially expressed genes in chronic periodontitis (CP) and to explore the correlation with disease severity.Methods:Gene expression profile data associated with CP were screened in the Gene Expression Omnibus (GEO) database and analyzed with GEO2R online software to create volcano maps. Kyoto Encyclopedia of Genes and Genomes (KEEG) and Gene Ontology (GO) analyses were performed on the screened CP-associated differentially expressed genes to predict their possible functions and signaling pathways. The protein-protein interaction database (STRING) was used to analyze the interaction relationships between the encoded proteins of the screened CP-related differentially expressed genes. Cytohubba software was used to identify key genes in the signaling pathway. One120 CP patients and 40 healthy controls were selected. The screened CP-related genes were validated by the real-time polymerase chain reaction (q-PCR) method.Results:A total of 1 151 CP differentially expressed genes that met the requirements were screened. These genes were mainly enriched in the GO pathway for positive regulation of granulocyte differentiation, helper T-cell differentiation, leukocyte aggregation, regulation of acute inflammatory response, chemokine-mediated and endoplasmic reticulum unfolded protein response, as well as in the KEGG pathway for NFB pathway, chemokine pathway, cytokine receptor interaction, leukocyte transendothelial migration pathway, B-cell receptor pathway, Toll-like receptor pathway, etc. The protein-protein interaction network was constructed using the screened CP-related differentially expressed genes, which included 78 nodes and 496 links, with a mean aggregation coefficient and mean connectivity of 0.69 and 12.7, respectively. Cytohubba analysis showed that Sell was a key gene in the signaling pathway, and its relative expression levels in the gingival fluids of the three CP groups with different degrees(1.14±0.46, 0.86±0.41, 0.52±0.46) was significantly lower than that of the control group (1.50±0.65) (all P<0.05). The area under the ROC curve (AUC) of subjects diagnosed with CP using Sell expression levels in gingival fluid was 0.79 (95% CI: 0.71 to 0.86). The AUC values were greater than 0.65 at 95% CI when Sell was used as a biological marker to evaluate the severity of CP. Conclusions:CP-related differentially expressed genes are mainly enriched in the number of pathways associated with the inflammatory response of periodontitis. The expression levels of Sell genes were significantly reduced in the gingival sulcus fluid of CP patients and correlated with the severity of the disease. The Sell genes are expected to be a biomarker for CP grading.

Pulse oximeter as a home assessment tool: Knowledge and user experience among the community in Malaysia during the COVID-19 pandemic

Objective: To determine the degree of knowledge in the usage of pulse oximeter as a home assessment tool among the community in Malaysia. Methods: A cross-sectional survey was conducted in November 2021. The questionnaire assessed the knowledge in using pulse oximeters, user experience and opinions in using pulse oximeter as a home assessment tool during the pandemic. Results: A total of 504 respondents were included in the study, and the mean score in knowledge related to application of pulse oximetry was 73.00%, while the mean score in knowledge related to factors affecting pulse oximetry readings was only 38.51%. A total of 90.5% of the respondents recognised normal pulse rate and 88.5% knew the blood oxygen saturation levels of a healthy adult, while 69.4% recognised the definition of silent hypoxia. In addition, the majority of the respondents agreed that factors such as poor blood circulation (71.2%), excessive movements (69.8%), and hand position (60.7%) affected oximetry readings. However, 61.7%, 81.7%, 77.2% and 76.8% of the respondents could not identify nail polish, skin colour, skin thickness and tattoos as factors that may affect oximetry readings respectively. Conclusions: The respondents showed a satisfactory level of knowledge related to application of pulse oximetry, but a poor level of knowledge related to factors affecting pulse oximetry readings among the community in Malaysia. Continuous efforts in educating the community on the correct use of pulse oximeters are crucial for appropriate home assessment and avoiding unnecessary stress.

PLA2G6 gene related early onset Parkinson syndrome with cerebellar atrophy: 3 cases report / 中华神经科杂志

To investigate the clinical features of patients with PLA2G6 gene related early onset Parkinson syndrome (EOP) with cerebellar atrophy, the clinical data of 3 hospitalized EOP patients with PLA2G6 gene mutation were collected in Xuanwu Hospital, Capital Medical University, and the clinical characteristics, imaging features and genetic testing results were comparatively analyzed. Related literatures were also reviewed. Cerebellar atrophy was observed on cranial magnetic resonance imaging in all 3 patients with Parkinson syndrome except for extrapyramidal symptoms. All 3 patients had heterozygous mutations of PLA2G6 gene, and the common mutation site of c.991G>T (p. D331Y) was found in 2 patients by second-generation sequencing. This report enlarges the clinical phenotypic spectrum of the disease and helps to better understand the disease.

Neuroprotection and neuroregeneration treatment strategy in non-arteritic anterior ischemic optic neuropathy / 中华实验眼科杂志

Non-arteritic anterior ischemic optic neuropathy (NAION) is a disease characterized by acute, painless visual acuity loss and visual field impairment, and there is still lack of unified and effective treatment.As new therapeutic strategies, neuroprotection and nerve regeneration have aroused wide public concern, which aim to prevent degeneration and death of neurons or establish a new neural circuit through inhibiting apoptosis pathway and inflammation, promoting axon growth and applying stem cells.Plenty of studies have applied the strategies to NAION patients or NAION animal models, which achieved certain success, but the limitations exist at the same time.For the sake of exploring practical therapies of NAION, researches on the neuroprotection and nerve regeneration strategies of NAION in recent years were reviewed in this article.

Thoughts on Construction of Information System of Medical Device Variety Archives / 中国医疗器械杂志

OBJECTIVE@#Thinking on the construction of the medical device type archives information system.@*METHODS@#This paper introduces the concept and significance of medical device variety archives, and puts forward the overall construction idea and system framework of medical device variety archives by analyzing its construction difficulties.@*RESULTS@#Considering the long-term nature and complexity of the construction of medical device variety archives, the system can be constructed in accordance with the three steps of system building, platform building and data management, and the overall technical architecture can be designed from the eight aspects of user layer, business application layer, application support layer, data resource layer, infrastructure layer, security, standards and operation and maintenance management.@*CONCLUSIONS@#Architecture design is the foundation of system construction, and its design rationality is very important for the success of system construction. The architecture design proposed in this study has a certain reference role for promoting the construction of medical device variety archives management system.

Relationship between programmed cell death and myocardial ischemia-reperfusion injury and new perspectives of traditional Chinese medicine intervention / 中国中药杂志

Myocardial ischemia-reperfusion injury(MIRI) is an urgent problem in clinical treatment. As cardiomyocytes are terminal cells, MIRI-induced cardiomyocyte death will irreversibly damage the structure and function of the heart. In previous studies, apoptosis was considered to be the only way to regulate cell death, while necrosis could not be regulated. However, current studies have shown that cell necrosis could also be regulated, which was collectively called programmed cell death(PCD). Regulated cell death is actively mediated through molecular pathways, so there is the possibility of inhibiting this signaling to reduce MIRI. At present, PCD mainly includes apoptosis, autophagy, necrosis, pyroptosis and ferroptosis. As a unique treature in China, traditional Chinese medicine has the advantages of multiple pathways, multiple targets, low toxicity, less side effects and low economic costs. With the in-depth study of the efficacy of traditional Chinese medicine against MIRI, it has been confirmed that traditional Chinese medicine could regulate PCD to reduce MIRI. Therefore, this paper focuses on the relationship between PCD and MIRI, and new studies on intervention with relevant traditional Chinese medicine, with the aim to provide new MIRI prevention and treatment methods from the perspective of "intervention of PCD".

Role of ATP6V1H gene in bone metabolism / 中国骨伤

Osteoporosis is one of the common clinical orthopedic diseases, which can lead to a variety of complications. There are many pathogenic factors in this disease. The latest research found that ATP6V1H is a new gene leading to the occurrence of osteoporosis, and it is likely to become a new target for the future drug treatment of osteoporosis.This paper introduces the biological structure and characteristics of H subunit, summed up the human body caused by loss of ATP6V1H and animal models such as zebrafish, mice bone loss and osteoporosis symptom such as related research reports of the loss, from osteoclast, osteoblast and marrow stromal cell level and the connection between the various subunits further expounds the H subunit regulate bone dynamic balance of mechanism, to explore ATP6V1H in bone developmentand bone related diseases has laid a solid foundation, also provide new ideas for clinical treatment of osteoporosis.

Expression and clinical significance of receptor-interacting protein kinase-3 levels in children with mycoplasma pneumoniae pneumonia and their relationship with inflammatory factors / 中国综合临床

Objective:To explore the level of expression, clinical significance of receptor-interacting protein kinase-3(RIPK3) in the bronchoalveolar alveolar lavage fluid (BALF) of mycoplasma pneumoniae pneumonia(MPP) in children and the relationship between RIPK3 and various cytokines.Methods:Using a case-control study, 30 refractory mycoplasma pneumoniae pneumonia children treated in Children′s Hospital of Xuzhou Medical University from February 2019 to February 2021 were selected as the MRPP group, 35 mycoplasma pneumoniae pneumonia children as the RPP group.Meanwhile, 20 sex- and age-matched hospitalized children with bronchial foreign body were selected as the case-control group.In all subjects, protein levels of RIPK3 and mixed lineage kinase domain-like protein(MLKL) were determined by Western Blot.Meanwhile, levels of IL-6, IL-1β and TNF-α were determined by enzyme linked immuno sorbent assay(ELISA). Compare levels of different parameters between the three groups and analyze the correlation between levels of RIPK3 and MLKL, L-6, IL-1β, TNF-α in the BALF of MPP children using Spearman rank correlation analysis.Results:There were statistically significant differences in the levels of RIPK3, MLKL, IL-6, IL-1β and TNF-α in BALF between RMPP group, MPP group and control group (all P<0.001). Pairwise comparisons also showed statistical differences, and the RMPP group was the highest, followed by MPP group, and the control group was the lowest.The level of RIPK3 in BALF of MPP children was positively correlated with MLKL, IL-6, IL-1β and TNF-α ( r=0.711, 0.676, 0.725, 0.651, P<0.001). Linear regression analysis shows: MLKL=0.432×RIPK3. Conclusion:RIPK3 may be involved in the occurrence and development of MPP in children, and is closely related to cytokines such as IL-6, IL-1β and TNF-α.

Evidence for the Presence of Long-Lived Plasma Cells in Nasal Polyps

PURPOSE: Plasma cells and immunoglobulins (Igs) play a pivotal role in the induction and maintenance of chronic inflammation in nasal polyps. During secondary immune responses, plasma cell survival and Ig production are regulated by the local environment. The purpose of the present study was to investigate the presence of long-lived plasma cells (LLPCs) and specific survival niches for LLPCs in human nasal polyps.METHODS: Nasal mucosal samples were cultured with an air-liquid interface system and the Ig levels in culture supernatants were analyzed by enzyme-linked immunosorbent assay. The characteristics of LLPCs in nasal polyps were determined by immunohistochemistry and immunofluorescence. The expression of neurotrophins as well as their receptors was detected by quantitative real-time polymerase chain reaction, immunohistochemistry, immunofluorescence, and Western blotting.RESULTS: The numbers of CD138⁺ total plasma cells and BCL2⁺ plasma cells were increased in both eosinophilic and non-eosinophilic nasal polyps compared with those in normal tissues. The production of IgG, IgA, and IgE was detected in culture supernatants even after a 32-day culture of nasal polyps. Although the total numbers of plasma cells were decreased in nasal polyps after culture, the numbers of BCL2⁺ plasma cells remained stable. The expression of nerve growth factor (NGF) as well as tropomyosin receptor kinase (Trk) A, a high-affinity receptor for NGF, was upregulated in both eosinophilic and non-eosinophilic nasal polyps. In addition, BCL2⁺ plasma cell numbers were positively correlated with NGF and TrkA mRNA expression in nasal mucosal tissues. Polyp plasma cells had the expression of TrkA.CONCLUSIONS: Human nasal polyps harbor a population of LLPCs and NGF may be involved in their prolonged survival. LLPCs may be a novel therapeutic target for suppressing the local Ig production in nasal polyps.

Effect of PI3K/Akt Signal Pathway Crosstalk in Myocardial Ischemia Reperfusion Injury and Prevention and Treatment with Traditional Chinese Medicine Therapy / 中国实验方剂学杂志

Myocardial ischemia-reperfusion injury （MIRI） was originated from the ischemic injury to myocardial cells due to some factors， and the injury will be aggravated after the blood supply recovery. MIRI will cause reperfusion arrhythmia， myocardial stagnation， microcirculation disorders or blood loss reflow， and become a key issue to be solved in the clinical treatment. Therefore， it is of important clinical significance to explore how to improve MIRI. The phosphatidylinositol 3-kinase （PI3K）/protein kinase B （Akt） signaling pathway has been regarded to be an important cascade signaling pathway to prevent MIRI， which is cross-talked in such mechanisms as oxidative stress， calcium overload， autophagy， inflammation， endoplasmic reticulum stress and mitochondrial dysfunction. This pathway is at the core site and closely related to the severity of MIRI. Meanwhile， traditional Chinese medicine（TCM） has its unique advantages in the prevention and treatment of MIRI， including multiple targets， multiple pathways， fewer toxic and side effect， as well as TCM characteristics of syndrome differentiation treatment and overall concept. A great number of studies have confirmed that this pathway is a common mechanism of action for most TCM compounds， TCM monomers and extracts. In this paper， we clarify the effect of PI3K/Akt signaling pathway crosstalk on the myocardial ischemia-reperfusion injury， with the focus on the relationship between the key targets of PI3K/Akt signaling pathway and MIRI. It will give great insights to the intricate relationship between them and promote the future development of new drugs targeting the PI3K/Akt signaling pathway. Finally， we also summarized the existing findings of TCM on PI3K/Akt pathway， which provides a reference for the treatment and drug development of MIRI.

Using analytic hierarchy process to determine the weights of performance evaluation index system of autono-mous regional attached research institute of medicine in Xinjiang / 中华医学科研管理杂志

Objective To determine the weights of performance appraisal indicators of autonomous regional attached re-search institute of medicine in Xinjiang .Methods The AHP analysis method was used to establish a judgment matrix ,which determined the corresponding weights of the factors ,and calculated the total weight coefficient of the indicators that constitute the performance evaluation system of autonomous regional attached research institutes of medicine .Finally ,consistency check was performed on the judgment matrix .Results The assignment of experts to each indicator was reasonable and effective ,and the comparison with each other of the relative importance of indicators was appropriate .The weight coefficients of the criteria layer respectively were 0 .09246 ,0 .20434 ,0 .17473 ,0 .23681 ,0 .29166 ,and the total weight coefficient of the indicators were calculated .A performance evaluation model of attached research institute of medicine in Xinjiang was constructed .Conclusions The performance appraisal system of autonomous regional attached research institute of medicine in Xinjiang established by the AHP analysis method had a high degree of credibility and operability ,which can be used as a reference for further strengthe-ning the management of the institutes .

Neuroprotective effects of benzatropine on rat model of nonarteritic anterior ischemic optic neuropathy / 中华眼底病杂志

Objective To investigate the neuroprotective effect of Benztropine on retinal ganglion cells (RGCs) death and optic nerve injury in rats model of non-arteritis anterior ischemic optic neuropathy (rNAION).Methods A total of 25 Sprague-Dawley rats were randomly divided into Benztropine treatment group (n=13)and PBS control group (n=12).The right eye was set as the experimental eye.rNAION model was established by using rose Bengal combined with laser photodynamic method.The rats in the Benztropine treatment group were received intraperitoneal injection with Benztropine 10 mg/kg (0.2 ml) daily for 3 weeks,while the rats in the PBS control group were received intraperitoneal injection with an equal volume of PBS.At 1,3 and 7 days after modeling,the retinal and optic disc conditions of the rats were observed by direct ophthalmoscopy.Retrograde labeling,fluorescence microscopy and transmission electron microscopy were used to observe the survival of RGCs and the damage of the optic nerve myelin and axon at 4 weeks after modeling.The RGCs density and survival rate of the two groups were compared by One-Way Anova.Results At 1 and 3 days after modeling,the optic disc edema was observed in the rats of rNAION model group.At 7 days after modeling,the optic disc edema decreased and the boundary was blurred compared with 3 days after modeling.After 4 weeks,the RGCs density in the PBS group was 308± 194/mm2 and the survival rate was 13.7％.The density of RGCs in the Benztropine group was 1173+868/mm2 and the survival rate was 47.6％.The differences of RGCs density and survival rate were significant between the two groups (F=7.552,8.184;P=0.015,0.012).Myelin disintegration,axon degeneration,onion-like body and gliosis were observed in the optic nerve sections of rNIAON in the PBS group,while the damage ofaxon and myelin structure in the Benztropine group was significantly less than that in the PBS group.Conclusions Benztropine group showed higher RGC survival rate,less damage ofaxon and myelin structure on rNAION model.This study explored the potential neuroprotective effect of Benztropine.

Empirical study on the implementation effect of Xinjiang General Hospital "Medical Scientific Research Integrity and related Code of Conduct" based on gap analysis / 中华医学科研管理杂志

Objective This paper discussed the implementation effect of medical research integrity and related code of conduct in a general hospital in xinjiang,to provide theoretical basis for the construction of medical research integrity.Methods According to the gap analysis theory,a questionnaire was designed for satisfaction with the implementation effect of medical research integrity and related code of conduct in the hospital.101 researchers in the hospital were surveyed to understand their evaluation on various aspects of the hospital's scientific research integrity construction policies and the space for improvement.Results The gap analysis showed that the hospital has a large gap in the construction of "institutional construction of scientific research integrity management " and "methods and regulations for dealing with academic misconduct",which were urgently need to be improved in the scientific research integrity construction.Conclusions The hospital should further improve the system of scientific research integrity construction,combine the characteristics of medical development and the corresponding national policy development,strengthen the innovation of scientific research management,create a healthy and positive environment for scientific research activities,and promote the comprehensive construction and long-term development of scientific research integrity construction.

Cross-sectional study on obesity and central obesity among 35-75 year-old people in Jiangsu Province / 预防医学

Objective@#To investigate the prevalence and related factors of obesity and central obesity among 35-75 year-old population in Jiangsu Province. @*Methods@#During 2015-2017,83 530 eligible subjects aged 35-75 years from six study sites of Jiangsu Province were interviewed and examined. The data of demography,lifestyles,disease history,height,weight and waistline were collected. Logistic regression analysis was conducted for the influencing factors for obesity and central obesity.@*Results@#A total of 83 393 residents completed the study,with a response rate of 99.84%. The prevalence of overweight,obesity and central obesity was 43.35%（standardized rate：35.90%）,20.02%（19.48%）and 59.93%（57.03%）. The results of multivariate logistic regression analysis showed that females（OR=0.822,95%CI：0.786-0.859;OR=0.900,95%CI：0.851-0.952;OR=1.130,95%CI：1.083-1.179）,45-75 years old（OR：1.120-1.731,95%CI：1.102-1.881）,graduating from high school or above（OR：0.767-0.902,95%CI：0.721-0.943）,living in urban areas（OR：1.530-2.077,95%CI：1.284-3.007）,smoking（OR：0.724-0.855,95%CI：0.678-0.898）,drinking （OR：1.125-1.179,95%CI：1.076-1.235）,hypertension（OR：1.884-3.461,95%CI：1.821-3.613）,diabetes（OR：1.363-1.758,95%CI：1.305-1.851）, dyslipidemia（OR：1.478-1.870,95%CI：1.429-1.851）were associated with overweight,obesity and central obesity. @*Conclusion@#The standardized prevalence rates of overweight,obesity and central obesity among 35-75 year-old population in Jiangsu Province are 35.90%,19.48% and 57.03%,respectively. Gender,age,education,residence,smoking,drinking,hypertension,diabetes and dyslipidemia are related factors.

Survey of tumor marker prescription behavior in lung diseases based on IMB model / 上海交通大学学报（医学版）

Objective·To explore the influencing factors and pathways of clinicians' tumor marker prescription behavior in lung diseases,so as to find out the methods and measures to promote clinicians to optimize the tumor marker prescription.Methods · From July 24,2017 to August 10,2017,clinicians with willingness and the right of prescription mainly from hospitals in Shanghai and Beijing were invited to participate in survey on influencing factors of tumor marker prescription behavior in lung diseases.Based on the classical theoretical framework of IMB model,an IMB theoretical model of clinicians' tumor marker detection behavior was proposed.Statistical description and correlation analysis were performed by SPSS 24.0,and the IMB theoretical model was validated and corrected by AMOS 24.0.Results· The personal intention (r=0.251,P=0.000) and personal interest protection (r=0.178,P=0.007) had a significant positive correlation with information.Meanwhile,the personal intention (P=0.000) and personal interest protection (P=0.013) had a significant positive effect on behavioral skills,and the behavioral skills had a significant positive effect on tumor marker prescription behavior (P=0.000).There was no direct effect of information on behavioral skills,and motivation had no direct effect on tumor marker prescription behavior.Behavioral skills played a mediating role in the process of motivation influencing the tumor marker prescription behavior.Conclusion· The large percentage of irrational tumor marker prescription in lung diseases suggests the universality of inappropriate testing,which needs the joint efforts of governments,hospitals,clinicians and patients on improvement.

Effects of Rhizoma Ligustici Chuanxiong and Radix Paeoniae Rubra on Level of Nogo-A/NgR/RhoA/ROCK mRNA in Acute Cerebral Infarction Rats / 世界科学技术-中医药现代化

Objective: To investigate effects of Rhizoma Ligustici Chuanxiong and Radix Paeoniae Rubra on the relative expression of Nogo-A/NgR/RhoA/ ROCK mRNA in acute cerebral infarction rats. Methods: Healthy male SD rats were randomly divided into sham operation group, blank group, low dose, medium dose and high dose Rhizoma Ligustici Chuanxiong and Radix Paeoniae Rubra group, Ginkgo biloba group, Nimodipine group, and each group was divided into 3 days, 7 days, 14 days three time points. Real-Time quantitative polymerase chain reaction (PCR) was used to detect Nogo-A/NgR/RhoA/ROCK mRNA relative expression changes of acute cerebral infarction rats. Results: Compared with the blank group and the sham operation group, the relative expression level of Nogo-A/NgR/RhoA/ROCK mRNA was increased in the model group both at 3 days, 7 days and 14 days (P ＜ 0.05). After the treatment of Rhizoma Ligustici Chuanxiong and Radix Paeoniae Rubra, other than there was no significant difference between the low-dose group and the model group except for 7 days, the relative expression level of Nogo-A/NgR/RhoA/ROCK mRNA in Rhizoma Ligustici Chuanxiong and Radix Paeoniae Rubra groups was lower than that in the model group (P ＜ 0. 05). Conclusion: The relative expression level of Nogo-A/NgR/RhoA/ROCK mRNA in acute cerebral infarction rats can be reduced by Rhizoma Ligustici Chuanxiong and Radix Paeoniae Rubra.

Longitudinal Measurement of Hemodynamic Changes within the Posterior Optic Nerve Head in Rodent Nonarteritic Anterior Ischemic Optic Neuropathy / 中国医学科学杂志(英文版)

Objective To assess the in vivo dynamic blood flow features of posterior optic nerve head (ONH) in rat model of nonarteritic anterior ischemic optic neuropathy (rNAION). Methods rNAION was established with Rose Bengal and argon green laser in Sprague-Dawley rats. Fundus photography and fundus fluorescein angiography (FFA) were performed to assess the dynamic changes of optic disc in morphology in 90 days and in blood perfusion in 3 hours after the induction of disease. Histological examinations were performed to evaluate the success of modeling. The dynamic blood flow kinetics of posterior ONH in rNAION were measured by Laser Doppler Flowmetry (LDF) on the day 3, 7, 14, 21, and 40 after the disease induction. One-way ANOVA, Student's t-test and Bonferroni adjustment were used for multiple comparisons of kinetic measurements of blood flow. Results Optic disc edema and subsequent resolution associated with the development of optic disc pallor were observed in rNAION. FFA showed that the optic disc was hypofluorescence in the early phase and hyperfluorescence in the late phase. Histological studies suggested edema and loosened tissues of ONH, loss of retinal ganglion cells (RGCs), optic nerve substance and gliosis. Compared to the naive rats, the blood flow kinetics of posterior ONH in rNAION significant reduced at each time point after modeling (F=175.06, PConclusions Continuous blood perfusion reduction was found in rNAION, with significant alteration in 14 days after disease induction. Our results provided important information for understanding the hemodynamic changes in rNAION.

Analysis of satisfaction degree of medical science and technology innovation talents growth environment in Xinjiang based on KANO model / 中华医学科研管理杂志

Objective This study uses the KANO model to evaluate the satisfaction of the growth environment of medical science and technology innovation talents in Xinjiang,comprehensively understand the needs of talents for the growth environment,and propose specific countermeasures for the improvement and related direction of Xinjiang's science and technology innovation talent growth environment.Methods Science and technology innovation talents from three tertiary hospitals in Xinjiang were selected as research subject,questionnaire survey was conducted to understand their basic information,and to confirm the talents growth environment for the current attitude according to the structural KANO model questionnaire includes rules.Results The KANO model was used to determine five key indicators that have high sensitivity to the satisfaction of Xinjiang medical science and technology innovation talents.They are research funding,scientific research facilities,scientific research reward mechanism,scientific research team cooperation,and academic exchanges domestically and internationally.Conclusions According to the key influencing factors of Xinjiang medical science and technology innovation talent satisfaction,improving and optimizing the corresponding indicators can effectively improve the overall quality of the technological innovation talent growth environment and improve the satisfaction of scientific and technological talents.

An empirical study on the growth factors and environmental satisfaction of medical innovative talents in Xinjiang / 中华医学科研管理杂志

Objective Though the research on the satisfaction of environment and factors influ encing the growth of the talented in medical science in Xinjiang,the author focuses on the shortcomings and reasons of current development of the talented,and provides specific suggestions and improvement for the cultivation of the talented.Methods Using Xinjiang Medical University First Affiliated Hospital as the research object,author investigates the influential factors of growth,and the satisfaction of environment though the questionnaires.Results According to the principal components analysis,the factors which influence the growth the talented in medical science are put in flowing order:political factor＞environmental factor＞education factor＞family factor.According to the data envelop ment analysis,in the satisfaction of environment of hospital technological innovation,the talented in hospital technological innovation consider that the cultivation plan,research expenses,support for scientific research,recruitment,and social welfare are at a better satisfaction rate;but the duration of academic research,income policies,selection of the talented,and the outcome of the research are at a low satisfaction rate.Conclusions Based on the current development and cultivation of the talented in the innovation of medical science,there are still many shortcomings.Hospital must continue interna tional cooperation,insist to do the cultivation of the talented and the innovation team,and complete the selection mechanisms,in order to give enough time for the scientific research,and create a good atmosphere of medical science innovation at the same time.Only when the services for the talented are well-prepared,Xinjiang medical science innovation can achieve enough support and motivation for the development of the talented.