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1.
Article in Chinese | WPRIM | ID: wpr-880474

ABSTRACT

OBJECTIVE@#Thinking on the construction of the medical device type archives information system.@*METHODS@#This paper introduces the concept and significance of medical device variety archives, and puts forward the overall construction idea and system framework of medical device variety archives by analyzing its construction difficulties.@*RESULTS@#Considering the long-term nature and complexity of the construction of medical device variety archives, the system can be constructed in accordance with the three steps of system building, platform building and data management, and the overall technical architecture can be designed from the eight aspects of user layer, business application layer, application support layer, data resource layer, infrastructure layer, security, standards and operation and maintenance management.@*CONCLUSIONS@#Architecture design is the foundation of system construction, and its design rationality is very important for the success of system construction. The architecture design proposed in this study has a certain reference role for promoting the construction of medical device variety archives management system.


Subject(s)
Information Systems , Reference Standards
2.
Article in Chinese | WPRIM | ID: wpr-879427

ABSTRACT

Osteoporosis is one of the common clinical orthopedic diseases, which can lead to a variety of complications. There are many pathogenic factors in this disease. The latest research found that ATP6V1H is a new gene leading to the occurrence of osteoporosis, and it is likely to become a new target for the future drug treatment of osteoporosis.This paper introduces the biological structure and characteristics of H subunit, summed up the human body caused by loss of ATP6V1H and animal models such as zebrafish, mice bone loss and osteoporosis symptom such as related research reports of the loss, from osteoclast, osteoblast and marrow stromal cell level and the connection between the various subunits further expounds the H subunit regulate bone dynamic balance of mechanism, to explore ATP6V1H in bone developmentand bone related diseases has laid a solid foundation, also provide new ideas for clinical treatment of osteoporosis.


Subject(s)
Animals , Bone and Bones , Mice , Osteoblasts , Osteoclasts , Osteoporosis/genetics , Zebrafish
3.
Article in Chinese | WPRIM | ID: wpr-879038

ABSTRACT

Myocardial ischemia-reperfusion injury(MIRI) is an urgent problem in clinical treatment. As cardiomyocytes are terminal cells, MIRI-induced cardiomyocyte death will irreversibly damage the structure and function of the heart. In previous studies, apoptosis was considered to be the only way to regulate cell death, while necrosis could not be regulated. However, current studies have shown that cell necrosis could also be regulated, which was collectively called programmed cell death(PCD). Regulated cell death is actively mediated through molecular pathways, so there is the possibility of inhibiting this signaling to reduce MIRI. At present, PCD mainly includes apoptosis, autophagy, necrosis, pyroptosis and ferroptosis. As a unique treature in China, traditional Chinese medicine has the advantages of multiple pathways, multiple targets, low toxicity, less side effects and low economic costs. With the in-depth study of the efficacy of traditional Chinese medicine against MIRI, it has been confirmed that traditional Chinese medicine could regulate PCD to reduce MIRI. Therefore, this paper focuses on the relationship between PCD and MIRI, and new studies on intervention with relevant traditional Chinese medicine, with the aim to provide new MIRI prevention and treatment methods from the perspective of "intervention of PCD".


Subject(s)
Apoptosis , China , Humans , Medicine, Chinese Traditional , Myocardial Reperfusion Injury/genetics , Myocytes, Cardiac
4.
Article in Chinese | WPRIM | ID: wpr-872669

ABSTRACT

Myocardial ischemia-reperfusion injury (MIRI) was originated from the ischemic injury to myocardial cells due to some factors, and the injury will be aggravated after the blood supply recovery. MIRI will cause reperfusion arrhythmia, myocardial stagnation, microcirculation disorders or blood loss reflow, and become a key issue to be solved in the clinical treatment. Therefore, it is of important clinical significance to explore how to improve MIRI. The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway has been regarded to be an important cascade signaling pathway to prevent MIRI, which is cross-talked in such mechanisms as oxidative stress, calcium overload, autophagy, inflammation, endoplasmic reticulum stress and mitochondrial dysfunction. This pathway is at the core site and closely related to the severity of MIRI. Meanwhile, traditional Chinese medicine(TCM) has its unique advantages in the prevention and treatment of MIRI, including multiple targets, multiple pathways, fewer toxic and side effect, as well as TCM characteristics of syndrome differentiation treatment and overall concept. A great number of studies have confirmed that this pathway is a common mechanism of action for most TCM compounds, TCM monomers and extracts. In this paper, we clarify the effect of PI3K/Akt signaling pathway crosstalk on the myocardial ischemia-reperfusion injury, with the focus on the relationship between the key targets of PI3K/Akt signaling pathway and MIRI. It will give great insights to the intricate relationship between them and promote the future development of new drugs targeting the PI3K/Akt signaling pathway. Finally, we also summarized the existing findings of TCM on PI3K/Akt pathway, which provides a reference for the treatment and drug development of MIRI.

5.
Article in English | WPRIM | ID: wpr-785341

ABSTRACT

PURPOSE: Plasma cells and immunoglobulins (Igs) play a pivotal role in the induction and maintenance of chronic inflammation in nasal polyps. During secondary immune responses, plasma cell survival and Ig production are regulated by the local environment. The purpose of the present study was to investigate the presence of long-lived plasma cells (LLPCs) and specific survival niches for LLPCs in human nasal polyps.METHODS: Nasal mucosal samples were cultured with an air-liquid interface system and the Ig levels in culture supernatants were analyzed by enzyme-linked immunosorbent assay. The characteristics of LLPCs in nasal polyps were determined by immunohistochemistry and immunofluorescence. The expression of neurotrophins as well as their receptors was detected by quantitative real-time polymerase chain reaction, immunohistochemistry, immunofluorescence, and Western blotting.RESULTS: The numbers of CD138⁺ total plasma cells and BCL2⁺ plasma cells were increased in both eosinophilic and non-eosinophilic nasal polyps compared with those in normal tissues. The production of IgG, IgA, and IgE was detected in culture supernatants even after a 32-day culture of nasal polyps. Although the total numbers of plasma cells were decreased in nasal polyps after culture, the numbers of BCL2⁺ plasma cells remained stable. The expression of nerve growth factor (NGF) as well as tropomyosin receptor kinase (Trk) A, a high-affinity receptor for NGF, was upregulated in both eosinophilic and non-eosinophilic nasal polyps. In addition, BCL2⁺ plasma cell numbers were positively correlated with NGF and TrkA mRNA expression in nasal mucosal tissues. Polyp plasma cells had the expression of TrkA.CONCLUSIONS: Human nasal polyps harbor a population of LLPCs and NGF may be involved in their prolonged survival. LLPCs may be a novel therapeutic target for suppressing the local Ig production in nasal polyps.


Subject(s)
Blotting, Western , Enzyme-Linked Immunosorbent Assay , Eosinophils , Fluorescent Antibody Technique , Humans , Immunoglobulin A , Immunoglobulin E , Immunoglobulin G , Immunoglobulins , Immunohistochemistry , Inflammation , Mucous Membrane , Nasal Polyps , Nerve Growth Factor , Nerve Growth Factors , Phosphotransferases , Plasma Cells , Plasma , Polyps , Real-Time Polymerase Chain Reaction , RNA, Messenger , Tropomyosin
6.
Article in Chinese | WPRIM | ID: wpr-756531

ABSTRACT

Objective To determine the weights of performance appraisal indicators of autonomous regional attached re-search institute of medicine in Xinjiang .Methods The AHP analysis method was used to establish a judgment matrix ,which determined the corresponding weights of the factors ,and calculated the total weight coefficient of the indicators that constitute the performance evaluation system of autonomous regional attached research institutes of medicine .Finally ,consistency check was performed on the judgment matrix .Results The assignment of experts to each indicator was reasonable and effective ,and the comparison with each other of the relative importance of indicators was appropriate .The weight coefficients of the criteria layer respectively were 0 .09246 ,0 .20434 ,0 .17473 ,0 .23681 ,0 .29166 ,and the total weight coefficient of the indicators were calculated .A performance evaluation model of attached research institute of medicine in Xinjiang was constructed .Conclusions The performance appraisal system of autonomous regional attached research institute of medicine in Xinjiang established by the AHP analysis method had a high degree of credibility and operability ,which can be used as a reference for further strengthe-ning the management of the institutes .

7.
Article in Chinese | WPRIM | ID: wpr-746225

ABSTRACT

Objective To investigate the neuroprotective effect of Benztropine on retinal ganglion cells (RGCs) death and optic nerve injury in rats model of non-arteritis anterior ischemic optic neuropathy (rNAION).Methods A total of 25 Sprague-Dawley rats were randomly divided into Benztropine treatment group (n=13)and PBS control group (n=12).The right eye was set as the experimental eye.rNAION model was established by using rose Bengal combined with laser photodynamic method.The rats in the Benztropine treatment group were received intraperitoneal injection with Benztropine 10 mg/kg (0.2 ml) daily for 3 weeks,while the rats in the PBS control group were received intraperitoneal injection with an equal volume of PBS.At 1,3 and 7 days after modeling,the retinal and optic disc conditions of the rats were observed by direct ophthalmoscopy.Retrograde labeling,fluorescence microscopy and transmission electron microscopy were used to observe the survival of RGCs and the damage of the optic nerve myelin and axon at 4 weeks after modeling.The RGCs density and survival rate of the two groups were compared by One-Way Anova.Results At 1 and 3 days after modeling,the optic disc edema was observed in the rats of rNAION model group.At 7 days after modeling,the optic disc edema decreased and the boundary was blurred compared with 3 days after modeling.After 4 weeks,the RGCs density in the PBS group was 308± 194/mm2 and the survival rate was 13.7%.The density of RGCs in the Benztropine group was 1173+868/mm2 and the survival rate was 47.6%.The differences of RGCs density and survival rate were significant between the two groups (F=7.552,8.184;P=0.015,0.012).Myelin disintegration,axon degeneration,onion-like body and gliosis were observed in the optic nerve sections of rNIAON in the PBS group,while the damage ofaxon and myelin structure in the Benztropine group was significantly less than that in the PBS group.Conclusions Benztropine group showed higher RGC survival rate,less damage ofaxon and myelin structure on rNAION model.This study explored the potential neuroprotective effect of Benztropine.

8.
Article in Chinese | WPRIM | ID: wpr-824920

ABSTRACT

Objective This paper discussed the implementation effect of medical research integrity and related code of conduct in a general hospital in xinjiang,to provide theoretical basis for the construction of medical research integrity.Methods According to the gap analysis theory,a questionnaire was designed for satisfaction with the implementation effect of medical research integrity and related code of conduct in the hospital.101 researchers in the hospital were surveyed to understand their evaluation on various aspects of the hospital's scientific research integrity construction policies and the space for improvement.Results The gap analysis showed that the hospital has a large gap in the construction of "institutional construction of scientific research integrity management " and "methods and regulations for dealing with academic misconduct",which were urgently need to be improved in the scientific research integrity construction.Conclusions The hospital should further improve the system of scientific research integrity construction,combine the characteristics of medical development and the corresponding national policy development,strengthen the innovation of scientific research management,create a healthy and positive environment for scientific research activities,and promote the comprehensive construction and long-term development of scientific research integrity construction.

9.
Journal of Preventive Medicine ; (12): 886-890, 2019.
Article in Chinese | WPRIM | ID: wpr-815793

ABSTRACT

Objective@#To investigate the prevalence and related factors of obesity and central obesity among 35-75 year-old population in Jiangsu Province. @*Methods@#During 2015-2017,83 530 eligible subjects aged 35-75 years from six study sites of Jiangsu Province were interviewed and examined. The data of demography,lifestyles,disease history,height,weight and waistline were collected. Logistic regression analysis was conducted for the influencing factors for obesity and central obesity.@*Results@#A total of 83 393 residents completed the study,with a response rate of 99.84%. The prevalence of overweight,obesity and central obesity was 43.35%(standardized rate:35.90%),20.02%(19.48%)and 59.93%(57.03%). The results of multivariate logistic regression analysis showed that females(OR=0.822,95%CI:0.786-0.859;OR=0.900,95%CI:0.851-0.952;OR=1.130,95%CI:1.083-1.179),45-75 years old(OR:1.120-1.731,95%CI:1.102-1.881),graduating from high school or above(OR:0.767-0.902,95%CI:0.721-0.943),living in urban areas(OR:1.530-2.077,95%CI:1.284-3.007),smoking(OR:0.724-0.855,95%CI:0.678-0.898),drinking (OR:1.125-1.179,95%CI:1.076-1.235),hypertension(OR:1.884-3.461,95%CI:1.821-3.613),diabetes(OR:1.363-1.758,95%CI:1.305-1.851), dyslipidemia(OR:1.478-1.870,95%CI:1.429-1.851)were associated with overweight,obesity and central obesity. @*Conclusion@#The standardized prevalence rates of overweight,obesity and central obesity among 35-75 year-old population in Jiangsu Province are 35.90%,19.48% and 57.03%,respectively. Gender,age,education,residence,smoking,drinking,hypertension,diabetes and dyslipidemia are related factors.

10.
Article in Chinese | WPRIM | ID: wpr-695642

ABSTRACT

Objective·To explore the influencing factors and pathways of clinicians' tumor marker prescription behavior in lung diseases,so as to find out the methods and measures to promote clinicians to optimize the tumor marker prescription.Methods · From July 24,2017 to August 10,2017,clinicians with willingness and the right of prescription mainly from hospitals in Shanghai and Beijing were invited to participate in survey on influencing factors of tumor marker prescription behavior in lung diseases.Based on the classical theoretical framework of IMB model,an IMB theoretical model of clinicians' tumor marker detection behavior was proposed.Statistical description and correlation analysis were performed by SPSS 24.0,and the IMB theoretical model was validated and corrected by AMOS 24.0.Results· The personal intention (r=0.251,P=0.000) and personal interest protection (r=0.178,P=0.007) had a significant positive correlation with information.Meanwhile,the personal intention (P=0.000) and personal interest protection (P=0.013) had a significant positive effect on behavioral skills,and the behavioral skills had a significant positive effect on tumor marker prescription behavior (P=0.000).There was no direct effect of information on behavioral skills,and motivation had no direct effect on tumor marker prescription behavior.Behavioral skills played a mediating role in the process of motivation influencing the tumor marker prescription behavior.Conclusion· The large percentage of irrational tumor marker prescription in lung diseases suggests the universality of inappropriate testing,which needs the joint efforts of governments,hospitals,clinicians and patients on improvement.

11.
Article in Chinese | WPRIM | ID: wpr-712313

ABSTRACT

Objective This study uses the KANO model to evaluate the satisfaction of the growth environment of medical science and technology innovation talents in Xinjiang,comprehensively understand the needs of talents for the growth environment,and propose specific countermeasures for the improvement and related direction of Xinjiang's science and technology innovation talent growth environment.Methods Science and technology innovation talents from three tertiary hospitals in Xinjiang were selected as research subject,questionnaire survey was conducted to understand their basic information,and to confirm the talents growth environment for the current attitude according to the structural KANO model questionnaire includes rules.Results The KANO model was used to determine five key indicators that have high sensitivity to the satisfaction of Xinjiang medical science and technology innovation talents.They are research funding,scientific research facilities,scientific research reward mechanism,scientific research team cooperation,and academic exchanges domestically and internationally.Conclusions According to the key influencing factors of Xinjiang medical science and technology innovation talent satisfaction,improving and optimizing the corresponding indicators can effectively improve the overall quality of the technological innovation talent growth environment and improve the satisfaction of scientific and technological talents.

12.
Article in Chinese | WPRIM | ID: wpr-712260

ABSTRACT

Objective Though the research on the satisfaction of environment and factors influ encing the growth of the talented in medical science in Xinjiang,the author focuses on the shortcomings and reasons of current development of the talented,and provides specific suggestions and improvement for the cultivation of the talented.Methods Using Xinjiang Medical University First Affiliated Hospital as the research object,author investigates the influential factors of growth,and the satisfaction of environment though the questionnaires.Results According to the principal components analysis,the factors which influence the growth the talented in medical science are put in flowing order:political factor>environmental factor>education factor>family factor.According to the data envelop ment analysis,in the satisfaction of environment of hospital technological innovation,the talented in hospital technological innovation consider that the cultivation plan,research expenses,support for scientific research,recruitment,and social welfare are at a better satisfaction rate;but the duration of academic research,income policies,selection of the talented,and the outcome of the research are at a low satisfaction rate.Conclusions Based on the current development and cultivation of the talented in the innovation of medical science,there are still many shortcomings.Hospital must continue interna tional cooperation,insist to do the cultivation of the talented and the innovation team,and complete the selection mechanisms,in order to give enough time for the scientific research,and create a good atmosphere of medical science innovation at the same time.Only when the services for the talented are well-prepared,Xinjiang medical science innovation can achieve enough support and motivation for the development of the talented.

13.
Article in Chinese | WPRIM | ID: wpr-711876

ABSTRACT

Objective To establish and evaluate a rat model of nonarteritic anterior ischemic optic neuropathy (NAION).Methods The rats were randomly divided into control group (n=13), sham laser group (n=11) and NAION group (n=23). The right eye was set as the experimental eye. NAION model was induced by directly illuminating the optic nerve (ON) of the right eye with 532 nm green laser, after intravenous infusion with the photosensitizing agent Rose Bengal. Sham laser treatment consisted of illuminating the ON region with 532 nm laser without Rose Bengal injection. Rats in control group underwent no intervention. The appearance of optic disc was observed with funduscope at 12 hours, 1, 3, 7, 28 days post-illumination. The histologic changes in the retina and ON of the NAION model were evaluated qualitatively with hematoxylin and eosin (HE) staining and transmission electron microscopy. The retrograde-labeled retinal ganglion cells (RGC) were counted on photographs taken from retinal flat mounts in a masked fashion.Results The optic disc in NAION eyes were swollen 3 days after photodynamic treatment. HE-stained longitudinal ON sections of NAION revealed vacuolar degeneration on day 3 after induction. Besides, ultrastructural study showed axonal edema and collapsed sheaths in the ischemic optic nerve at the same time point after modeling. ON edema resolved 7 days after induction. The final results revealed optic disc atrophy, extensive axonal loss, severe glial scar, and RGC death in large numbers 4 weeks after modeling. There were no aforementioned manifestations in control and sham laser group. The RGC density of the right eyes was statistically significantly lower in NAION group than that in control group and in sham laser group (t=?14.142, ?14.088;P=0.000, 0.000). The survival rate of RGC was statistically significantly lower in NAION group than in control group and in sham laser group (t=?17.048, ?16.667;P=0.000, 0.000). There was no difference of RGC density and survival rate of RGC between control and sham laser group (t=0.050, 0.348;P=0.961, 0.731).Conclusion A rat model of NAION was established successfully by photodynamic treatments with Rose Bengal, which induce optic nerve damage and RGC death.

14.
Article in Chinese | WPRIM | ID: wpr-752125

ABSTRACT

Objective: To investigate effects of Rhizoma Ligustici Chuanxiong and Radix Paeoniae Rubra on the relative expression of Nogo-A/NgR/RhoA/ ROCK mRNA in acute cerebral infarction rats. Methods: Healthy male SD rats were randomly divided into sham operation group, blank group, low dose, medium dose and high dose Rhizoma Ligustici Chuanxiong and Radix Paeoniae Rubra group, Ginkgo biloba group, Nimodipine group, and each group was divided into 3 days, 7 days, 14 days three time points. Real-Time quantitative polymerase chain reaction (PCR) was used to detect Nogo-A/NgR/RhoA/ROCK mRNA relative expression changes of acute cerebral infarction rats. Results: Compared with the blank group and the sham operation group, the relative expression level of Nogo-A/NgR/RhoA/ROCK mRNA was increased in the model group both at 3 days, 7 days and 14 days (P < 0.05). After the treatment of Rhizoma Ligustici Chuanxiong and Radix Paeoniae Rubra, other than there was no significant difference between the low-dose group and the model group except for 7 days, the relative expression level of Nogo-A/NgR/RhoA/ROCK mRNA in Rhizoma Ligustici Chuanxiong and Radix Paeoniae Rubra groups was lower than that in the model group (P < 0. 05). Conclusion: The relative expression level of Nogo-A/NgR/RhoA/ROCK mRNA in acute cerebral infarction rats can be reduced by Rhizoma Ligustici Chuanxiong and Radix Paeoniae Rubra.

15.
Article in English | WPRIM | ID: wpr-772817

ABSTRACT

Objective To assess the in vivo dynamic blood flow features of posterior optic nerve head (ONH) in rat model of nonarteritic anterior ischemic optic neuropathy (rNAION). Methods rNAION was established with Rose Bengal and argon green laser in Sprague-Dawley rats. Fundus photography and fundus fluorescein angiography (FFA) were performed to assess the dynamic changes of optic disc in morphology in 90 days and in blood perfusion in 3 hours after the induction of disease. Histological examinations were performed to evaluate the success of modeling. The dynamic blood flow kinetics of posterior ONH in rNAION were measured by Laser Doppler Flowmetry (LDF) on the day 3, 7, 14, 21, and 40 after the disease induction. One-way ANOVA, Student's t-test and Bonferroni adjustment were used for multiple comparisons of kinetic measurements of blood flow. Results Optic disc edema and subsequent resolution associated with the development of optic disc pallor were observed in rNAION. FFA showed that the optic disc was hypofluorescence in the early phase and hyperfluorescence in the late phase. Histological studies suggested edema and loosened tissues of ONH, loss of retinal ganglion cells (RGCs), optic nerve substance and gliosis. Compared to the naive rats, the blood flow kinetics of posterior ONH in rNAION significant reduced at each time point after modeling (F=175.06, PConclusions Continuous blood perfusion reduction was found in rNAION, with significant alteration in 14 days after disease induction. Our results provided important information for understanding the hemodynamic changes in rNAION.


Subject(s)
Animals , Disease Models, Animal , Fluorescein Angiography , Hemodynamics , Physiology , Humans , Male , Optic Disk , Pathology , Optic Neuropathy, Ischemic , Pathology , Rats , Rats, Sprague-Dawley , Retinal Ganglion Cells , Physiology
16.
Mood and Emotion ; (2): 158-162, 2018.
Article in Korean | WPRIM | ID: wpr-786887

ABSTRACT

OBJECTIVES: he purpose of this study was to examine psychosocial factors related to burnout of social welfare officers working in Jeonnam Province.METHODS: A total of 395 social welfare officers (male 99, female 296) working in 22 areas of Jeollanam-do province, were subjects of this study. We examined socio-demographic factors, using a self-reporting questionnaire. Subjects were asked to complete the Maslach Burnout Inventory-General Survey (MBI-GS), Center for Epidemiological Studies Depression Scale (CES-D), Perceived Stress Scale (PSS), and the Generalized Self-Efficacy Scale (GSS), to assess psychosocial factors affecting to burnout of social welfare officers.RESULTS: Among 395 subjects, 221 (55.9%) reported recent experiences of burnout. There was no significant difference in age between two groups, divided by burnout. Sex (p < 0.001), rank (p=0.003), working period (p=0.034), depression (p < 0.001) revealed differences between the burnout group and control group. Scores of PSS (p < 0.001) were higher, while the scores of GSS (p < 0.001) were lower in the burnout group, than control group. Multivariate logistic regression analysis revealed that female (OR 2.840, 95%CI 1.466–5.504, p=0.002), depressive high-risk group (OR 6.824, 95%CI 2.893–16.096, p < 0.001) PSS (OR 1.247, 95%CI 1.153–1.349, p < 0.001) and GSS (OR 0.950, 95%CI 0.930–0.971, p < 0.001), were significantly associated with burnout.CONCLUSION: We found that some factors, were associated with experienced burnout in social welfare officers. Depressive symptoms were the strongest associative factor, for burnout in public servants in charge of social welfare. Sex, stress and self-efficacy also correlated with burnout, and especially self-efficacy was a protecting factor.


Subject(s)
Depression , Epidemiologic Studies , Female , Humans , Logistic Models , Psychology , Social Welfare
17.
Article in Chinese | WPRIM | ID: wpr-666753

ABSTRACT

Objective To observe the effect of treadmill running on skeletal muscle lipid deposition,and the expression of vascular endothelial growth factor-B(VEGFB)and its receptor in soleus muscles of high-fat diet mice.Methods Thirty-two 5-week-old C57BL/6 male mice were randomly divided into a control group(n=8)and a high-fat diet group(n=24),and fed with normal and high-fat diet respectively.Eight weeks later,16 obesity mice were selected from the latter group and randomly divided into a sedentary group(n=8)and a treadmill running group(n=8).The running group underwent treadmill running at 25 m/min for an hour every day,five days a week for 8 weeks,while the other two groups did not do any exercises.The weight was measured before the mice were killed.The soleus lipid deposition level was determined using oil red O staining,The expression of VEGFR1 and Neuropilin-1(NRP1)was determined using the immunohistochemical staining,while the mRNA expression of VEGFB,VEG-FR1,NRP1 and peroxisome proliferator-activated receptor-γcoactivator-1α (PGC-1α) was detected using the real-time PCR.Results Compared with the control group,a significant increase was observed in the weight and the soleus lipid deposition of the high-fat diet group,while there were no significant differences in the expression of VEGFB,NRP1,VEGFR1 and PGC-1α.mRNA between the two groups.Compared with the sedentary obese mice,significant decrease in the body weight and soleus lipid deposition,significant increase in VEGFR1 mRNA expression,but no significant changes in the expression of VEGFB,NRP1 and PGC-1α mRNA were observed in the treadmill-running obese mice.Conclusion The treadmill running has no effect on the VEGFR1 expression in soleus of obese mice,but significantly up-regulates the expression of its receptors.It indicates that the treadmill running can lower the intramyocellular lipid deposition as it can strengthen the VEGFB/VEGFR1 in soleus muscles.

18.
Chinese Journal of Immunology ; (12): 1832-1837, 2017.
Article in Chinese | WPRIM | ID: wpr-663754

ABSTRACT

Objective:To evaluate the association with serum Interleukin-17 ( IL-17 ) and multiple sclerosis ( MS ) systematically evaluated .Methods:The retrieval words of "multiple sclerosis or MS"and "interleukin-17 or IL-17"were searched in PubMed,SpringerLink,Embases,OVID,China National Knowledge infrastructure (CNKI),Chinese VIP database,Chinese Biomedical Literature Database (CBM),Wan Fang Database through computer.Review Manager 5.3.was selected as the software edition.The time frame was ranged from January 1,2000 to March 10,2017.The language was not restricted .Results: Eventually 8 case-control studies were included with 544 cases.We found that the serum IL-17 level was associated with MS according to the weighted mean difference and 95%confidence interval ( WMD =38.65;95%CI:18.66 ,58.63 ) ,which had significant difference in statistics .Conclusion:The serum IL-17 level increases the risk of MS , suggesting that the serum IL-17 level can be used as a predictive biomarker for MS development and a target for MS effective prevention and treatment .

19.
Article in Chinese | WPRIM | ID: wpr-610847

ABSTRACT

Secondary hyperparathyroidism (SHPT) is a common complication in patients with chronic renal failure (CRF).Medical treatment may be the first choice for most SHPT patients,but parathyroidectomy (PTX) is neededwhen medical treatment doesn't work in patients with refractory SHPT.However,there is no strong evidence to support which surgical procedure is the most effective one for patients with SHPT.An interdisciplinary discussion between nephrologists and surgeons is needed when choosing a preferred surgical method for refractory SHPT patients.The factors must be discussed including:the patient's age,the underlying kidney disease,clinical symptoms,the level of intact parathyroid hormones (iPTH) and blood calcium,the patient's ability to obtain and comply with medication treatment and the estimated duration of dialysis before kidney transplantation.Refractory SHPT patients will benefit from the surgical operation treatment and reoperation of recurrent SHPT is still an ideal treatment method.

20.
Basic & Clinical Medicine ; (12): 1336-1339, 2017.
Article in Chinese | WPRIM | ID: wpr-609272

ABSTRACT

Aerospace physiology is an important part of aerospace medicine.There are some problems existing in the current practice classes.Microlecture is a new kind of teaching methods.With its advantages, microlecture improved the teaching efficiency, and played a good role in the practice classes for undergraduate students, successfully solving part of the problems and promoting the teaching reform.The microlecture, as an auxiliary means, provides a new way for practice class of aerospace physiology.It`s suggested to be popularized in undergraduate teaching of aerospace medicine.

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