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Article in Chinese | WPRIM | ID: wpr-287349


<p><b>OBJECTIVE</b>To study the effects of Huangqi decoction (HQD) on phagocytic activity of peritoneal macrophage of mice.</p><p><b>METHOD</b>One hundred Kunming mice, whose weight varied from 18 g to 22 g, were selected and divided into 10 groups randomly in eluding contrast group, groups conducted at different doses of HQD by ig, groups conducted in various ways of taking medicine, and groups conducted with comparative treat combining Huangqi and Dexamethasone. Mice in every group were taken medicine one time daily for 6 days.</p><p><b>RESULT</b>Among the groups treated at different doses of HQD, phagocytic rate and phagocytic index of mice, which were taken HQD by ig at high, middle, and low doses, were significantly higher (P < 0.01) than that of mice in contrast group, at the same time the effect in group with high dose was the best. Among the groups treated in various ways of taking medicine, phagocytic rate of the ip group was significantly better (P < 0.01) than that of the sc group and that of the ig group respectively, but there was not significant difference (P > 0.05) of phagocytic index among them. Among the groups combining Huangqi and Dexamethasone, Huangqi could antagonize the immunosuppressive effect of Dexamethasone obviously (P < 0.01).</p><p><b>CONCLUSION</b>HQD at different doses and with various ways of taking medicine could improve phagocytic activity of peritoneal macrophage of mice at different degree, and could antagonize the immunosuppressive effect of Dexamethasone.</p>

Animals , Astragalus propinquus , Chemistry , Dexamethasone , Dose-Response Relationship, Drug , Drugs, Chinese Herbal , Pharmacology , Female , Macrophages, Peritoneal , Physiology , Male , Mice , Phagocytosis , Plant Roots , Chemistry , Plants, Medicinal , Chemistry , Random Allocation
Acta Pharmaceutica Sinica ; (12): 226-228, 2002.
Article in Chinese | WPRIM | ID: wpr-274862


<p><b>AIM</b>To prepare bioadhesive microspheres of metronidazole (Metro) with prolonging resident time in the stomach and sustaining drug release.</p><p><b>METHODS</b>The microspheres were prepared by a drying-in-liquid method. The appearance, particle size and drug release in vitro were examined. The factors influencing bioadhesive property and drug release, such as ethyl cellulose (EC)/carbopol 934P (CP) ratio, particle size and Metro content were investigated.</p><p><b>RESULTS</b>The average diameter of the Metro-EC-CP microspheres was 559.9 microns. The release profiles of metronidazole were shown to fit to first-order equations well. With the increase of CP content in the Metro-EC-CP microspheres, the microspheres showed better mucoadhesion and faster drug release. The drug release rate decreased with the increase of particle size and the decrease of Metro content.</p><p><b>CONCLUSION</b>The Metro-EC-CP microspheres have a sound mucoadhsive property and sustained drug release when the ratio of EC and CP was 17:3 and Metro content was 25%. The drug release was shown to last for 8 h in 0.1 mol.L-1 hydrochloric acid.</p>

Acrylates , Animals , Anti-Infective Agents , Pharmacology , Cell Adhesion , Delayed-Action Preparations , Female , Fluorocarbons , Chemistry , Gastric Mucosa , Physiology , Metronidazole , Pharmacology , Microspheres , Rats , Rats, Sprague-Dawley