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1.
Article in English | WPRIM | ID: wpr-970293

ABSTRACT

OBJECTIVE@#To analyze the global epidemic status of the Ebola virus disease (EVD) and assess the importation risk into China.@*METHODS@#Data from World Health Organization reports were used. We described the global epidemic status of EVD from 1976-2021, and assessed and ranked the importation risk of EVD from the disease-outbreaking countries into China using the risk matrix and Borda count methods, respectively.@*RESULTS@#From 1976-2021, EVD mainly occurred in western and central Africa, with the highest cumulative number of cases (14,124 cases) in Sierra Leone, and the highest cumulative fatality rate (85%) in the Congo. Outbreaks of EVD have occurred in the Democratic Republic of the Congo and Guinea since 2018. The importation risk into China varies across countries with outbreaks of disease. The Democratic Republic of the Congo had an extremely high risk (23 Borda points), followed by Guinea and Liberia. Countries with a moderate importation risk were Nigeria, Uganda, Congo, Sierra Leone, Mali, and Gabon, while countries with a low importation risk included Sudan, Senegal, and Co


Subject(s)
Humans , Hemorrhagic Fever, Ebola/prevention & control , Epidemics , Disease Outbreaks/prevention & control , Guinea/epidemiology , Sierra Leone/epidemiology , China/epidemiology
2.
Chinese Journal of Epidemiology ; (12): 667-672, 2023.
Article in Chinese | WPRIM | ID: wpr-985544

ABSTRACT

The number of studies related to health economics evaluation is increasing. Consolidated Health Economic Evaluation Reporting Standards 2022 (CHEERS 2022) contains 28 items. Based on CHEERS 2013, CHEERS 2022 adds a health economic analysis plan, model sharing, and community, patient, public, and other relevant stakeholders' participation in the statement, taking into account the future development direction of health economics evaluation. It provides a useful review tool for peer reviewers, editors, and readers and supports health technology assessment agencies in establishing standard reporting standards for health economics evaluations. In this study, we briefly introduced and interpreted the CHEERS 2022 statement and analyzed an example of health economics evaluation in infectious disease epidemiology to provide a reference for researchers to report studies regarding health economics evaluation standardly.


Subject(s)
Humans , Cost-Benefit Analysis , Checklist , Economics, Medical , Reference Standards , Research Report
3.
Article in Chinese | WPRIM | ID: wpr-994730

ABSTRACT

Objective:To investigate the relationship between vaccination doses and the duration of positive nucleic acid or antigen tests in Corona Virus Disease 2019 (COVID-19) patients during omicron epidemic.Methods:A cross-sectional study was conducted from December 26 to December 31, 2022 among COVID-19 patients from all community health service centers in 16 districts of Beijing municipality selected by multi-stage stratified cluster quota sampling method. A questionnaire was used to collect the basic information, vaccination doses, results of nucleic acid or antigen tests of all subjects. The subjects were divided into 5 groups according to the doses of COVID-19 vaccination: the non-vaccination group, the 1, 2, 3 and 4 doses vaccination group. The relationship between vaccination doses and the duration of positive nucleic acid or antigen tests was analyzed by univariate and multivariate logistic regression models.Results:A total of 10 506 COVID-19 cases were included in the study with the age of (43.3±13.7) years. The duration of positive nucleic acid or antigen tests was longer than 7 days in 59.4%(276/465), 51.5%(67/130), 50.6%(355/701), 46.1% (3 464/7 520) and 39.2%(662/1 690) of non-vaccination, and 1, 2, 3, 4 dose vaccination groups, respectively ( P<0.001). Multivariate logistic regression analysis showed that compared with non-vaccination patients, the vaccination dose was an independent protective factor for duration of positive nucleic acid or antigen tests>7 days, and the OR values were 0.7 (95% CI 0.5-0.9, P=0.015), 0.6 (95% CI 0.5-0.8, P<0.001) and 0.5 (95% CI 0.4-0.6, P<0.001) for 2, 3 and 4 doses of vaccination, respectively. Conclusion:The vaccination doses are independently related to the duration of positive nucleic acid or antigen tests in COVID-19 patients and the risk is gradually decreases with the increasing vaccination doses.

4.
Article in Chinese | WPRIM | ID: wpr-1019789

ABSTRACT

Objective To investigate the effect and possible mechanism of Maslinic acid(MA)on apoptosis of cervical cancer HeLa cells.Methods HeLa cells were treated with different concentrations of MA,and cell survival rate was detected by MTT;Cell apoptosis was detected by Annexin V-FITC/PI flow cytometry;The changes of mitochondrial membrane potential were detected by JC-1 staining;The expression levels of OMA1,optic dystrophy protein 1(OPA1),Bax,Bcl-2,cleaved caspase-3,and cytoplasmic cytochrome C(Cyt C)were detected by Western blot.Whether MA induces HeLa cell apoptosis by regulating OMA1-mediated mitochondrial apoptosis has been verified through silencing OMA1 gene expression.Results MA inhibited the proliferation of HeLa cells in a dose-dependent manner.Different concentrations of MA could increase the apoptosis rate of HeLa cells and decrease the mitochondrial membrane potential,meanwhile,the protein expression levels of OMA1,Bax,cleaved caspase-3 and Cyt C in cytoplasm were up-regulated,and the protein expression levels of OPA1 and Bcl-2 were down-regulated.Silencing OMA1 gene expression inhibited the apoptosis of HeLa cells induced by MA.Conclusion MA can inhibit the proliferation of HeLa cells and induce cell apoptosis,and the mechanism may be related to the regulation of mitochondrial apoptosis pathway mediated by OMA1.

5.
Chinese Journal of Epidemiology ; (12): 397-402, 2022.
Article in Chinese | WPRIM | ID: wpr-935402

ABSTRACT

With the progress of globalization, the public health emergencies represented by major infectious diseases have become a major challenge for the public health management in China. The article briefly describes the emergency response capability assessment tools in China, and introduces two emergency response assessment tools with complete content structure and wide application in the world. Then the advantages and disadvantages of the tools are compared and discussed in order to provide reference for improvement of the assessment tools for public health emergency response capability in China.


Subject(s)
Humans , China , Disaster Planning , Public Health , Public Health Administration
6.
Article in Chinese | WPRIM | ID: wpr-924639

ABSTRACT

ObjectiveTo compare the functional connectivity of brain networks in stroke patients with upper limb motor dysfunction during unilateral or bilateral upper limb movement using functional near-infrared spectroscopy (fNIRS). MethodsFrom April to June, 2021, 40 stroke patients with upper limb motor dysfunction in Department of Rehabilitation Medicine, Huashan Hospital, finished unilateral (affected) and bilateral upper limb movement. Eight-minute fNIRS data were collected before and after movement, and the functional activities and connectivity of prefrontal cortex (PFC), upper limb and hand functional area (H), primary sensory cortex (S1) were analyzed based on oxygenated hemoglobin. ResultsFunctional activities increased in affected H after unilateral task (t = -3.135, P < 0.05), while the functional connectivity increased between affected H and affected S1, affected H and unaffected S1, and affected S1 and unaffected S1 (|t| > 3.218, P < 0.05). There was no significant difference in the functional activities and connectivity of all the areas after bilateral upper limb task (|t| < 2.385, P > 0.05). The improvement of affected H was more after unilateral task than after bilateral upper limb task (t = 2.026, P < 0.05). ConclusionUnilateral affected upper limb training is more effective on functional activities and connectivity for corresponding brain regions than bilateral task.

7.
Chinese Journal of Epidemiology ; (12): 1774-1779, 2021.
Article in Chinese | WPRIM | ID: wpr-922728

ABSTRACT

SARS-CoV-2 Delta variant has the characteristics of stronger infectivity, higher viral load, and shorter incubation period, posing new challenges to the prevention and control of COVID-19 pandemic. SARS-CoV-2 Delta variant was first discovered in India, then quickly spread in many countries and has gradually become one of the main epidemic strains worldwide. Local epidemics caused by SARS-CoV-2 Delta variant also occurred in several provinces in China. This article summarizes the progress in research of etiological characteristics, transmission characteristics or possible mechanism and epidemiological characteristics of SARS-CoV-2 Delta variant, and the protective effects of vaccines and control measures against SARS-CoV-2 Delta variant in order to provide references for the effective prevention and control of COVID-19 epidemic caused by SARS-CoV-2 Delta variant.


Subject(s)
Humans , COVID-19/virology , China/epidemiology , Pandemics/prevention & control , SARS-CoV-2
8.
Article in Chinese | WPRIM | ID: wpr-872095

ABSTRACT

Objective:To systematically analyze the distribution of research hotspots related to the COVID, provide reference for future scientific research.Methods:Relevant literatures collected by PubMed database since December 1, 2019 were retrieved, the key information related to literatures was extracted and analyzed, and the wordcloud2 package of R software was used for word frequency analysis.Results:A total number of 194 valid papers were obtained, which published in 81 journals. Most papers was published in early February 2020, and a maximum of 24 papers were published in a single day. 167 papers (86.08%) were written in English. These papers included case reports, expert opinions, guidelines, articles, reviews, communications and other forms, and the subjects included epidemiology, prevention and control, virology, diagnosis and treatment, pathology and etiology, vaccines and drugs, epidemic prediction models, and bioinformatics analysis. The proportion of article in English literatures was higher than that in Chinese literatures ( P=0.005). Among them, 91 papers (46.9%) were independently completed by the Chinese researchers, 15 papers (7.7%) were completed by the Chinese and foreign researchers, and 88 papers (45.4%) were completed by foreign researchers. Conclusions:At present, the researches on the new coronavirus pneumonia mainly focus on virology and epidemiology, but lack of relevant research results such as treatment and prognosis.

9.
Article in Chinese | WPRIM | ID: wpr-811552

ABSTRACT

Objective@#To systematically analyze the distribution of research hotspots related to the COVID, provide reference for future scientific research.@*Methods@#Relevant literatures collected by PubMed database since December 1, 2019 were retrieved, the key information related to literatures was extracted and analyzed, and the wordcloud2 package of R software was used for word frequency analysis.@*Results@#A total number of 194 valid papers were obtained, which published in 81 journals. Most papers was published in early February 2020, and a maximum of 24 papers were published in a single day. 167 papers (86.08%) were written in English. These papers included case reports, expert opinions, guidelines, articles, reviews, communications and other forms, and the subjects included epidemiology, prevention and control, virology, diagnosis and treatment, pathology and etiology, vaccines and drugs, epidemic prediction models, and bioinformatics analysis. The proportion of article in English literatures was higher than that in Chinese literatures (P=0.005). Among them, 91 papers (46.9%) were independently completed by the Chinese researchers, 15 papers (7.7%) were completed by the Chinese and foreign researchers, and 88 papers (45.4%) were completed by foreign researchers.@*Conclusions@#At present, the researches on the new coronavirus pneumonia mainly focus on virology and epidemiology, but lack of relevant research results such as treatment and prognosis.

10.
Chinese Journal of Rheumatology ; (12): 615-621,C9-2, 2020.
Article in Chinese | WPRIM | ID: wpr-868241

ABSTRACT

Objective:To estimate the diagnostic value of anti-cyclic citrullinated peptide (CCP) antibody for juvenile idiopathic arthritis (JIA) by Meta-analysis.Methods:The databases, including Wanfang Database, VIP citation databases, China National Knowledge Infrastructure (CNKI), China Biology Medicine disc, Excerpta Medica Database (EMbase), PubMed, Cochrane Library, were searched for the studies related to the diagnostic value of anti-CCP antibody for JIA. After extracting literature data and assessing the articles by Quality Assessment of Diagnostic Accuracy Studies tool. The sources of heterogeneity, sensitivity (SEN), specificity (SPE), area under the curve (AUC) were calculated by the summary receiver operator characteristic (SROC) curve by Stata 12.0 software.Results:A total of 30 literature reports were included in this Meta-analysis. The heterogeneity and the threshold effect of the included articles were tested, a mixed effects model was selected to calculate the pooled weighted SEN [0.16, 95% CI(0.11, 0.22)], SPE [0.99, 95% CI(0.98, 0.99)] and AUC [0.86, 95% CI(0.83, 0.89)]. The sensitivity estimates were highly heterogeneous, which was partially explained by the higher sensitivity in the rheumatoid factor-positive polyarthritis (RF+PA) subtypes [0.65, 95% CI (0.51, 0.76)] than in the other subtypes. The ability of diagnostic differentiation between of JIA and healthy children was better than the diagnostic differentiation between JIA and other patients ( Z=7.9, P<0.01). Conclusion:Although anti-CCP antibody cannot be used as an early diagnostic indicator of JIA, it can provide a certain guiding role in the initial screening and early treatment of the disease. CCP has clinical value in the differential diagnosis of RF+PA subtypes.

11.
Article in Chinese | WPRIM | ID: wpr-941939

ABSTRACT

OBJECTIVE@#To explore the screening value of osteoporosis self-assessment tool for Asians (OSTA) and the optimal cut-off value in Chinese healthy physical examination population.@*METHODS@#We selected a healthy physical examination population for bone mineral density screening at the Health Examination Center in Peking University Third Hospital from 2013 to 2016. Quantitative ultrasound (QUS) results were used as the gold standard, and T value ≤-2.5 was defined as osteoporosis patients. Diagnostic test methods were used to analyze the sensitivity, specificity, likelihood ratio and area under curve (AUC) of different cut points of OSTA. The screening accuracy of OSTA at different cut points was compared and the optimal cut-point value determined.@*RESULTS@#A total of 5 833 subjects were included in the study, with an average age of (48.3±17.5) years and 2 594 women (44.5%). The QUS test showed 403 patients with osteoporosis (6.9% of the total population), 343 female osteoporosis patients (13.22% of the female population). In the whole age group, AUC at the international routine cut-off value (OSTA ≤-1) screening for osteoporosis was 0.815 (95%CI: 0.804-0.825), and screening accuracy was higher in the women (AUC=0.837, 95%CI: 0.823-0.851) than that in the men (AUC=0.767, 95%CI: 0.752-0.781; P<0.05). In the whole age group, when the optimal cut-off value was 0, its AUC 0.842 (95%CI: 0.832-0.851) was significantly higher than that when the cut-off value was -1 (P<0.01), and net reclassification improvement (NRI) increased by 5.5%. In the 40 to 65-year-old group, when OSTA cut-off value ≤0, the screening accuracy was significantly higher (NRI=19.5%, P=0.003) than that when it was -1.@*CONCLUSION@#The OSTA screening tool had good osteoporosis screening value in healthy people, and the screening accuracy in women is higher than that in men. Increasing the screening cut-off value of OSTA would be helpful to improve the screening accuracy in the whole and 40 to 65-year-old population. There may be different optimal cut-off values for different age group population.


Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Absorptiometry, Photon , Asian People , Bone Density , Osteoporosis , Physical Examination , Risk Assessment , Self-Assessment , Sensitivity and Specificity
12.
Journal of Forensic Medicine ; (6): 402-405, 2019.
Article in English | WPRIM | ID: wpr-985025

ABSTRACT

Objective To research the correlation between the visual acuity ratio and pattern reversal visual evoked potential (PRVEP) P100 waveform amplitude ratio of both eyes. Methods Forty-seven volunteers were selected, and the visual chart visual acuity of both eyes was measured. The visual acuity ratio of the eye with poor vision to the eye with better vision was calculated by five grade notation method. The amplitudes of P100 waveforms of both eyes were recorded respectively by using black-and-white checkerboard PRVEP and chosing 1°, 15' stimulating visual angle, and the ratio of amplitudes between the two eyes was also calculated. SPSS 20.0 software was used to analyze the correlation between the visual acuity ratio and the ratio of P100 waveform amplitudes between the two eyes. Return test and linear regression analysis with the binocular ratio of P100 waveform amplitudes as the independent variable (x) and the binocular visual acuity ratio as the dependent variable (y) were made. Results There was a positive correlation between the binocular visual acuity ratio and the ratio of P100 waveform amplitudes under 15' stimulating visual angle (Pearson correlation coefficient was 0.62, P=0.000). The fitting linear regression equation was y=0.090 x+0.846 (F=20.954, P=0.000). There was no significant correlation between the binocular ratio of visual acuity and the binocular ratio of P100 waveform amplitudes under 1° stimulating visual angle (P>0.05). Results of return test showed that there was no statistical significance in the difference between visual acuity estimated by equation and actual detected visual acuity. Conclusion In forensic appraisal of monocular injury, fitting linear regression equation of binocular visual acuity ratio and the binocular ratio of P100 waveform amplitudes under 15' stimulating visual angle, is helpful for visual acuity level estimation of the injured eye to some extent.


Subject(s)
Humans , Evoked Potentials, Visual , Eye/physiopathology , Regression Analysis , Vision, Ocular , Visual Acuity
13.
Journal of Forensic Medicine ; (6): 607-612, 2019.
Article in English | WPRIM | ID: wpr-985055

ABSTRACT

Gradation of Disability in Human Body Injuries (hereinafter referred to as Gradation) has been released and used since January 2017, and has become the most widely used standard in forensic science practice. This paper calculates and rates the visual system evaluation provisions of the current domestic disability evaluation criteria represented by the Gradation which used the methods of Guides to the Evaluation of Permanent Impairment (hereinafter referred to as GEPI) issued by American Medical Association (AMA). Through comparing, a good correlation between the provisions in Gradation and whole person impairment rating index in GEPI was shown. On the basis of this, suggestions are put forward to amend some provisions of Gradation, in order to provide reference for the revision and further improvement of domestic standards and provisions.


Subject(s)
Humans , American Medical Association , China , Disability Evaluation , Disabled Persons , Forensic Medicine/standards , Forensic Sciences , Guidelines as Topic , United States
14.
Chinese Journal of Epidemiology ; (12): 854-858, 2019.
Article in Chinese | WPRIM | ID: wpr-810740

ABSTRACT

Hepatitis B virus (HBV) infection is one of the important public health problems. In order to eliminate the threat of viral hepatitis to public health, World Health Organization has proposed to achieve the goal of reducing the HBsAg positive rate in children to 0.1% by 2030. There are regional differences in HBsAg positive rates among pregnant women worldwide, from 0.6% in areas with low prevalence to 20% in areas with high prevalence. The positive rate of HBsAg in pregnant women in China is higher than global average. In recent years, several studies have found that HBV infection in pregnancy not only increase the risk of mother-to-child transmission, but also adversely affect the health of pregnant women and their children. Therefore, this paper summarizes the progress in research both at home and abroad in terms of HBsAg positive rate in pregnant women and the influence of pregnancy complicated with HBV infection on pregnant women and perinatal infants in order to explore the effect of pregnancy complicated with HBV infection on maternal and infant safety.

15.
Chinese Journal of Epidemiology ; (12): 255-258, 2019.
Article in Chinese | WPRIM | ID: wpr-804861

ABSTRACT

Nowadays, human has entered a "risk society" . The occurrence of major public health events can seriously affect the social stability, economic development and political order, as well as the survival and future of country and people. Our country has proposed a major initiative to jointly build the "Silk Road Economic Belt" and the "21st Century Maritime Silk Road" , which is highly valued by the international community. With the progress of globalization and the continuous promotion of the Belt and Road initiative, and the frequent flows of populations and commodities, the prevention of public health risk in China is also facing new challenges. This paper summarizes the background and framework of the Belt and Road initiative, public health risks and the risks of infectious disease epidemics, analyzes the new challenges in public health risk prevention faced by China in the context of building the Belt and Road, and proposes the suggestions for risk responses to guarantee the building of the Belt and Road and national public health security.

16.
Chinese Journal of Epidemiology ; (12): 605-609, 2019.
Article in Chinese | WPRIM | ID: wpr-805439

ABSTRACT

In 2016, the WHO proposed the goal for elimination of hepatitis B as public health threat, by 2030. China has the heaviest burden caused by hepatitis B virus (HBV) infection in the world, and serves as the major contributor to the goal of eliminating hepatitis B by 2030, globally. During the past 30 years, great progress has been made towards the implementation on prevention and control programs of HBV infection, in China, that enabling the WHO 2030 target to be fulfilled. However, due to the size of population, the large number of HBV infections and the low coverage of diagnosis and treatment programs, China is still facing the challenge in reaching the 2030 target, on time. This paper elaborates the achievements and gaps regarding the on-going prevention and control programs, including vaccination, prevention of maternal-to-child transmission, blood and injection safety, diagnosis and treatment on HBV infection and putting forward several suggestions on relevant policies for achieving the goal of hepatitis B elimination by 2030, in China.

17.
Article in Chinese | WPRIM | ID: wpr-777937

ABSTRACT

@# Objective The study aims to investigate the prevalence of gestational diabetes mellitus (GDM) among pregnant women in Tongzhou district of Beijing and its related risk factors. Methods Information of 34 637 singleton pregnancies delivered in a maternal and child health care hospital in Tongzhou district of Beijing were collected from January 1, 2013 to December 31, 2017. GDM prevalence of pregnant women were calculated. Multivariable logistic regression analysis was used to analyze the association between GDM and its related factors. Results The prevalence of GDM in 34 637 singleton pregnant women in Tongzhou district of Beijing was 23.2% (8 034/34 637). Multivariate analysis showed that advanced maternal age(aOR=1.87, 95% CI: 1.71-2.05), high level of education(aOR=1.19-1.23), delivering during 2016-2017(aOR=1.46, 95% CI: 1.38-1.55), macrosomia(aOR=1.27, 95% CI: 1.02-1.59), history of cesarean section(aOR=1.18, 95% CI: 1.08-1.30), history of spontaneous abortion(aOR=1.23, 95% CI:1.10-1.37), history of induced abortion(aOR=1.08, 95% CI:1.01-1.14), family history of diabetes(aOR=1.51, 95% CI:1.26-1.83), multipara(aOR=1.24, 95% CI:1.15-1.34), pre-pregnancy overweight(aOR=2.02, 95% CI:1.89-2.15), pre-pregnancy obesity(aOR=3.11, 95% CI:2.81-3.43)and conceived by assisted reproductive technology(aOR=1.47, 95% CI:1.03-2.10)were the independent risk factors for GDM. Conclusions Prevalence of GDM is high in pregnant women in Tongzhou district of Beijing. Health education before and during pregnancy should be carried out to monitor and prevent the occurrence of GDM in time to ensure maternal and child health.

18.
Article in Chinese | WPRIM | ID: wpr-778306

ABSTRACT

Objective To understand the disease spectrum of prehospital emergency patients in Beijing, so as to provide basis for rational allocation of prehospital emergency care resources and for improvement of prehospital emergency care. Methods Emergency dispatch database from 120 dispatching command system of Beijing Emergency Medical Center to was used study the disease spectrum of 120 prehospital emergency patients from 2013 to 2017 in Beijing, and were analyzed the differences of disease spectrum among patients of different years, genders and ages, and the time distribution of different diseases. Results From 2013 to 2017 in Beijing, 1 643 375 patients used 120 prehospital emergency care. The top 3 diseases of the disease spectrum were: injury and poisoning (29.63%), diseases of the circulatory system (18.37%), and diseases of the nervous system (15.80%). The sorting of diseases remained unchanged during the 5 years. The disease spectrums were different among different age groups and gender groups. The calls in spring, summer, autumn and winter accounted for 25.23%, 24.97%, 25.05% and 24.75% respectively. Most calls were made from 08 ∶〗00 to 09 ∶〗59 (12.41%), 12 ∶〗00 to 13 ∶〗59 (10.05%), and 14 ∶〗00 to 15 ∶〗59 (9.91%) during a day. The peak months and hours of different diseases were different. Conclusions The demand for prehospital emergency care has been increasing in Beijing in recent years. It is important to strengthen the prevention of injuries among all ages, especially male, and to improve the prevention and response capacity for acute attack of chronic diseases among older people. Prehospital emergency care resources should be rationally allocated according to the peak months and hours of calls.

19.
Article in Chinese | WPRIM | ID: wpr-779519

ABSTRACT

Objective To understand the relationship between the number of prenatal examination during pregnancy in Tibetan mothers and low birth weight infants, and to provide reference for improving the quality of antenatal care and reducing the incidence of low birth weight infants. Methods Tibetan women and newborns who gave birth in a hospital in Lhasa, Tibet from January 2012 to December 2018 were selected as research objects. The basic data, delivery materials and newborn data of all single births were collected. Logistic regression models were used to analyze the relationship between the number of maternal prenatal examinations and the birth weight of the newborn. Results In 5 563 pregnant women, the prenatal check-up rate was 10.48%. Among the newborns, low birth weight accounted for 11.32%. With the increase in the number of maternal births, the neonatal low birth weight rate showed a downward trend ( 2=14.57, P=0.002). Multivariate Logistic regression model showed that after controlling for maternal age, fetal gender, mode of delivery, fetal asphyxia and other confounding factors, the number of low prenatal examinations was still related to the occurrence of low birth weight infants. The incidence of low birth weight infants who gave birth to antenatal check-ups and 1-2 prenatal visits was 1.41 times (95% CI: 1.00-1.98) and 2.34 times (95% CI: 1.09-5.02) higher than those who received standardized prenatal checkups. Conclusions Tibetan pregnant women receive a lower proportion of standardized prenatal examination and there is a higher risk of low birth weight infants. It is recommended to strengthen the quality of maternal and child health care work in minority areas to ensure maternal and child safety.

20.
China Pharmacist ; (12): 783-786,791, 2018.
Article in Chinese | WPRIM | ID: wpr-705592

ABSTRACT

Objective:To explore the effects and possible mechanism of liraglutide on hypoxia and high glucose-induced oxidative stress injury in cardiomyocytes. Methods:The neonatal rat cardiomyocytes were separated and cultured in vitro. The hypoxia and high glucose-induced injury model was established in neonatal rat cardiomyocytes. The cells were divided into six groups:the normal control group, liraglutide control group, hypoxia and high glucose model group, liraglutide treatment group, GLP-1R antagonist group and hyperosmotic control group. The metabolic ability of the cells was detected by MTT assay, the activities of LDH and CK-MB were detected by colorimetric method,SOD activity and MDA content were determined by xanthine oxidase method and thiobarbituric acid method,ROS level was measured by chemiluminescence method. The mRNA and protein expression of adaptor protein p66Shc was detected by reverse transcription-polymerase chain reaction (RT-PCR) and Western blot. Results:Compared with those in the normal control group, the cells in hypoxia and high glucose model group had poorly metabolic ability,the content of LDH, CK-MB, MDA and ROS increased (P < 0.01), the activity of SOD decreased (P <0.01), and the expression of adaptor protein p66Shc greatly increased(P <0.01). After the treatment with liraglutide,the above mentioned parameters were all improved(P < 0.01). Exendin(9-39),an antagonist of GLP-1R,attenuated the protective effect of liraglutide. Conclusion:Liraglutide has a protective effect on cardiomyocytes by down-regulating adaptor protein p66Shc expression and reducing ROS formation.

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