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1.
Journal of Korean Academic Society of Nursing Education ; : 41-50, 2023.
Article in Korean | WPRIM | ID: wpr-967259

ABSTRACT

Purpose@#The aim of this descriptive study was to identify the factors influencing depression risk among South Korean nursing students. @*Methods@#The data were collected from nursing students attending two universities through web-based questionnaires that surveyed them about depression, academic stress, social network service (SNS) addiction tendency, and upward social comparison from August 22 to September 4, 2021. The collected data from 196 nursing students were analyzed by t-test, one-way ANOVA, Pearson’s correlation coefficients, and multiple linear regression. @*Results@#The mean score of depression (using CES-D Korean version) among nursing students was 13.91, which denotes probable depression. Concerning the variance with regard to depression among nursing students, 20.2% was explained by clinical practice period, academic stress, and upward social comparison. @*Conclusion@#Programs to relieve academic stress and depression should be developed in a simple way and systematically provided at the organizational level so that nursing students secure sufficient support during the initial and continuing period of clinical practicums. Concomitantly, an attempt to reduce the upward social comparison should be highly considered.

2.
Journal of Korean Academic Society of Nursing Education ; : 240-250, 2021.
Article in Korean | WPRIM | ID: wpr-891695

ABSTRACT

Purpose@#The aim of this study is to analyze the research trends of articles on just graduated Korean nurses during the past 10 years for exploring strategies for clinical adaptation. @*Methods@#The topics of new graduate nurses were extracted from 110 articles that have been published in Korean journals between January 2010 and July 2020. Abstracts were retrieved from 4 databases (DBpia, RISS, KISS and Google scholar). Keywords were extracted from the abstracts and cleaned using semantic morphemes. Network analysis and topic modeling were performed using the NetMiner program. @*Results@#The core keywords included ‘education’, ‘training’, ‘program’, ‘skill’, ‘care’, ‘performance’, and ‘satisfaction’. In recent articles on new graduate nurses, three major topics were extracted by Latent Dirichlet Allocation (LDA) techniques: ‘turnover’, ‘adaptation’, ‘education’. @*Conclusion@#Previous articles focused on exploring the factors related to the adaptation and turnover intentions of new graduate nurses. It is necessary to conduct further research focused on various interventions at the individual, task, and organizational levels to improve the retention of new graduate nurses.

3.
Journal of Korean Academic Society of Nursing Education ; : 240-250, 2021.
Article in Korean | WPRIM | ID: wpr-899399

ABSTRACT

Purpose@#The aim of this study is to analyze the research trends of articles on just graduated Korean nurses during the past 10 years for exploring strategies for clinical adaptation. @*Methods@#The topics of new graduate nurses were extracted from 110 articles that have been published in Korean journals between January 2010 and July 2020. Abstracts were retrieved from 4 databases (DBpia, RISS, KISS and Google scholar). Keywords were extracted from the abstracts and cleaned using semantic morphemes. Network analysis and topic modeling were performed using the NetMiner program. @*Results@#The core keywords included ‘education’, ‘training’, ‘program’, ‘skill’, ‘care’, ‘performance’, and ‘satisfaction’. In recent articles on new graduate nurses, three major topics were extracted by Latent Dirichlet Allocation (LDA) techniques: ‘turnover’, ‘adaptation’, ‘education’. @*Conclusion@#Previous articles focused on exploring the factors related to the adaptation and turnover intentions of new graduate nurses. It is necessary to conduct further research focused on various interventions at the individual, task, and organizational levels to improve the retention of new graduate nurses.

4.
Asian Nursing Research ; : 144-149, 2020.
Article in English | WPRIM | ID: wpr-889440

ABSTRACT

Purpose@#This study aimed to investigate the knowledge of gestational diabetes mellitus (GDM) and thehealth beliefs about GDM management, as well as to investigate the effects of these factors on breastfeedingintention in Bangladesh. @*Methods@#This study involved a cross-sectional survey of 358 healthy pregnant women who visitedantenatal clinics in Bangladesh. @*Results@#Perceived susceptibility, perceived benefit, and self-efficacy were identified as significant factorsfor breastfeeding intention (p < .05). Participants had a poor understanding and a lack of knowledge ofGDM, which can lead to inadequate health behavior. Health beliefs were significantly associated withparticipants’ breastfeeding intention related to GDM. @*Conclusion@#Antenatal education for breastfeeding in GDM mothers should focus on providing accurateinformation on GDM and strengthening their health beliefs such as self-efficacy within the context of themothers’ culture.

5.
The Korean Journal of Internal Medicine ; : 185-193, 2020.
Article | WPRIM | ID: wpr-831774

ABSTRACT

Background/Aims@#For metastatic renal cell carcinoma (RCC), various prognostic scoring systems have been developed. However, owing to the low prevalence of nonclear cell RCC, the three most commonly used tools were mainly developed based on patients with clear cell histology. Accordingly, this study applied three prognostic models to Korean non-clear cell RCC patients treated with first-line temsirolimus. @*Methods@#This study analyzed data for 74 patients with non-clear cell RCC who were treated with temsirolimus as the first-line therapy at eight medical centers between 2011 and 2016. The receiver-operating characteristic (ROC) curves for the different prognostic models were analyzed. @*Results@#Twenty-seven (36.5%), 24 (32.4%), and 44 patients (59.5%) were assigned to the poor prognosis groups of the Memorial Sloan-Kettering Cancer Center (MSKCC), International Metastatic RCC Database Consortium (IMDC), and Advanced Renal Cell Carcinoma (ARCC) risk stratification models, respectively. All three prognostic models reliably discriminated the risk groups to predict progression-free survival and overall survival (p < 0.001). The area under the ROC curve (AUC) for progression and survival was highest for the ARCC model (0.777; 0.734), followed by the IMDC (0.756; 0.724) and the MSKCC (0.742; 0.712) models. Furthermore, the sensitivity and specificity for predicting progression were highest with the ARCC model (sensitivity 63.6%, specificity 85.7%), followed by the MSKCC (sensitivity 58.2%, specificity 86.5%) and the IMDC models (sensitivity 56.4%, specificity 85.7%). @*Conclusions@#All three prognostic models accurately predicted the survival of the non-clear cell RCC patients treated with temsirolimus as the first-line therapy. Furthermore, the ARCC risk model performed better than the other risk models in predicting survival.

6.
Cancer Research and Treatment ; : 277-283, 2020.
Article | WPRIM | ID: wpr-831070

ABSTRACT

Purpose@#The purpose of this study was to evaluate clinical characteristics and treatment pattern of ovarian clear cell carcinoma (OCCC) in Korea and the role of adjuvant chemotherapy in earlystage. @*Materials and Methods@#Medical records of 308 cases of from 21 institutions were reviewed and data including age, performance status, endometriosis, thromboembolism, stage, cancer antigen 125, treatment, recurrence, and death were collected. @*Results@#Regarding stage of OCCC, it was stage I in 194 (63.6%), stage II in 34 (11.1%), stage III in 66 (21.6%), and stage IV in 11 (3.6%) patients. All patients underwent surgery. Optimal surgery (residual disease ≤ 1 cm) was achieved in 89.3%. Majority of patients (80.5%) received postoperative chemotherapy. The most common regimen was taxane-platinum combination (96%). Median relapse-free survival (RFS) was 138.5 months for stage I, 33.4 for stage II, 19.3 for stage III, and 9.7 for stage IV. Median overall survival (OS) were not reached, 112.4, 48.7, and 18.3 months for stage I, II, III, and IV, respectively. Early-stage (stage I), endometriosis, and optimal debulking were identified as favorable prognostic factors for RFS. Early-stage and optimal debulking were also favorable prognostic factors for OS. Majority of patients with early-stage received adjuvant chemotherapy. However, additional survival benefit was not found in terms of recurrence. @*Conclusion@#Majority of patients had early-stage and received postoperative chemotherapy regardless of stage. Early-stage and optimal debulking were identified as favorable prognostic factors. In stage IA or IB, adding adjuvant chemotherapy did not show difference in survival. Further study focusing on OCCC is required.

7.
Journal of Korean Medical Science ; : e401-2020.
Article in English | WPRIM | ID: wpr-892011

ABSTRACT

Background@#Although international guidelines recommend palliative care approaches for many serious illnesses, the palliative needs of patients with serious illnesses other than cancer are often unmet, mainly due to insufficient prognosis-related discussion. We investigated physicians' and the general public's respective attitudes toward prognostic disclosure for several serious illnesses. @*Methods@#We conducted a cross-sectional survey of 928 physicians, sourced from 12 hospitals and the Korean Medical Association, and 1,005 members of the general public, sourced from all 17 administrative divisions in Korea. @*Results@#For most illnesses, most physicians (adjusted proportions – end-organ failure, 99.0%; incurable genetic or neurologic disease, 98.5%; acquired immune deficiency syndrome [AIDS], 98.4%; stroke or Parkinson's disease, 96.0%; and dementia, 89.6%) and members of the general public (end-organ failure, 92.0%; incurable genetic or neurologic disease, 92.5%; AIDS, 91.5%; stroke or Parkinson's disease, 92.1%; and dementia, 86.9%) wanted to be informed if they had a terminal prognosis. For physicians and the general public, the primary factor to consider when disclosing terminal status was “the patient's right to know his/her condition” (31.0%). Yet, the general public was less likely to prefer prognostic disclosure than physicians. Particularly, when their family members were patients, more than 10% of the general public did not want patients to be informed of their terminal prognosis. For the general public, the main reason for not disclosing prognosis was “psychological burden such as anxiety and depression” (35.8%), while for the physicians it was “disclosure would have no beneficial effect” (42.4%). @*Conclusion@#Most Physicians and the general public agreed that disclosure of a terminal prognosis respects patient autonomy for several serious illnesses. The low response rate of physicians might limit the generalizability of the results.

8.
Journal of Korean Medical Science ; : e401-2020.
Article in English | WPRIM | ID: wpr-899715

ABSTRACT

Background@#Although international guidelines recommend palliative care approaches for many serious illnesses, the palliative needs of patients with serious illnesses other than cancer are often unmet, mainly due to insufficient prognosis-related discussion. We investigated physicians' and the general public's respective attitudes toward prognostic disclosure for several serious illnesses. @*Methods@#We conducted a cross-sectional survey of 928 physicians, sourced from 12 hospitals and the Korean Medical Association, and 1,005 members of the general public, sourced from all 17 administrative divisions in Korea. @*Results@#For most illnesses, most physicians (adjusted proportions – end-organ failure, 99.0%; incurable genetic or neurologic disease, 98.5%; acquired immune deficiency syndrome [AIDS], 98.4%; stroke or Parkinson's disease, 96.0%; and dementia, 89.6%) and members of the general public (end-organ failure, 92.0%; incurable genetic or neurologic disease, 92.5%; AIDS, 91.5%; stroke or Parkinson's disease, 92.1%; and dementia, 86.9%) wanted to be informed if they had a terminal prognosis. For physicians and the general public, the primary factor to consider when disclosing terminal status was “the patient's right to know his/her condition” (31.0%). Yet, the general public was less likely to prefer prognostic disclosure than physicians. Particularly, when their family members were patients, more than 10% of the general public did not want patients to be informed of their terminal prognosis. For the general public, the main reason for not disclosing prognosis was “psychological burden such as anxiety and depression” (35.8%), while for the physicians it was “disclosure would have no beneficial effect” (42.4%). @*Conclusion@#Most Physicians and the general public agreed that disclosure of a terminal prognosis respects patient autonomy for several serious illnesses. The low response rate of physicians might limit the generalizability of the results.

9.
Asian Nursing Research ; : 144-149, 2020.
Article in English | WPRIM | ID: wpr-897144

ABSTRACT

Purpose@#This study aimed to investigate the knowledge of gestational diabetes mellitus (GDM) and thehealth beliefs about GDM management, as well as to investigate the effects of these factors on breastfeedingintention in Bangladesh. @*Methods@#This study involved a cross-sectional survey of 358 healthy pregnant women who visitedantenatal clinics in Bangladesh. @*Results@#Perceived susceptibility, perceived benefit, and self-efficacy were identified as significant factorsfor breastfeeding intention (p < .05). Participants had a poor understanding and a lack of knowledge ofGDM, which can lead to inadequate health behavior. Health beliefs were significantly associated withparticipants’ breastfeeding intention related to GDM. @*Conclusion@#Antenatal education for breastfeeding in GDM mothers should focus on providing accurateinformation on GDM and strengthening their health beliefs such as self-efficacy within the context of themothers’ culture.

10.
Korean Journal of Rehabilitation Nursing ; : 61-70, 2018.
Article in Korean | WPRIM | ID: wpr-719148

ABSTRACT

PURPOSE: This study was aimed to identify research trends related to complementary and alternative therapy (CAT) in Korea. METHODS: Data were collected from 2000 to 2018 articles in Korean database (KISS, RISS and DBPIA). 295 semantic morphemes were extracted from 123 articles by network analysis program. Co-occurrence matrixes of the morphemes were generated by weighting Jaccard-coefficient and then we did network analysis and visualization. RESULTS: Common morphemes with high centralities were ‘Complementary and alternative medicine (CAM)’, ‘CAT’, ‘Aged’, ‘Diet therapy’, ‘Herbal medicine’, ‘Acupuncture’, and ‘Oriental medicine’. Since 2000, studies on complementary and alternative therapies have been actively involved in biological and manipulative therapies, and it has been found that the main target of CAT is the elderly. CONCLUSION: Despite much attention of complementary alternative therapies, the scientific basis is insufficient. Through this study, we could find research trends in complementary alternative therapies and set the direction of future research. It is necessary to expand research on complementary replacement therapy for various diseases and age groups.


Subject(s)
Aged , Animals , Cats , Humans , Complementary Therapies , Integrative Medicine , Korea , Musculoskeletal Manipulations , Semantics
11.
Journal of Korean Clinical Nursing Research ; (3): 73-82, 2017.
Article in Korean | WPRIM | ID: wpr-750197

ABSTRACT

PURPOSE: The aimof this study was to identify bibliographic characteristics and research trends of articles published in the Journal of Korean Clinical Nursing Research from2009 to 2015. METHODS: Descriptive statistics were used to analyze 268 articles. Bibliographic characteristics, appropriateness ofmethods for quantitative and qualitative studies, and key concepts of articles were analyzed. RESULTS: A clinical nurse was the first author for 184 (66.7%) articles. The number of collaborative works between hospital and university was 184 (68.7%). Study participants were patients (120, 38.1%), nurses (115, 36.5%) and others. IRB approval was given for 156 articles (58.2%). Written informed consent was obtained in 125 articles (46.7%). Quantitative research accounted for 98.6% of the articles but qualitative studies only 4 (1.4%). Types of interventions in the experimental studies were nursing skills (43, 42.6%) and health education (32, 31.7%). Major keywords were nurses, pain, knowledge, intensive care unit, anxiety, depression, fatigue, and stress. CONCLUSION: Articles in this journal deal with topics and concepts confronted in nursing practice so experimental studies on applicability of nursing interventions were frequently published. Findings in this study indicate that the authors published in the journal contribute to the development of nursing with characteristics distinctive from other nursing journals published in Korea.


Subject(s)
Humans , Anxiety , Clinical Nursing Research , Depression , Ethics Committees, Research , Fatigue , Health Education , Informed Consent , Intensive Care Units , Korea , Nursing , Republic of Korea
12.
Korean Journal of Medicine ; : 89-95, 2014.
Article in Korean | WPRIM | ID: wpr-224096

ABSTRACT

Patients with systemic lupus erythematosus (SLE) are at higher risk for malignant lymphomas, among which, however, primary CNS lymphoma (PCNSL) is rare. PCNSL usually occurs within the cerebral hemispheres, occasionally in the cerebellum, but rarely in the cerebellopontine angle (CPA). We report our findings in a 45-year-old man with SLE on azathioprine, who presented with sudden hearing loss and dysphagia. The brain MRI revealed a mass lesion in the right CPA. A biopsy was performed and the final diagnosis was diffuse large B cell lymphoma. This is the first report of CPA lymphoma in a SLE patient. The patient was treated with whole brain radiotherapy only because of recurrent pneumonia that was a result of dysphagia from permanent cranial nerve injury. He has been in complete remission for over 10 months.


Subject(s)
Humans , Middle Aged , Azathioprine , Biopsy , Brain , Cerebellopontine Angle , Cerebellum , Cerebrum , Cranial Nerve Injuries , Deglutition Disorders , Diagnosis , Hearing Loss , Hearing Loss, Sudden , Lupus Erythematosus, Systemic , Lymphoma , Lymphoma, B-Cell , Magnetic Resonance Imaging , Pneumonia , Radiotherapy
13.
Korean Journal of Medicine ; : 130-134, 2013.
Article in Korean | WPRIM | ID: wpr-108754

ABSTRACT

Hyperphosphatemia develops when there is impaired renal phosphate excretion or massive extracellular fluid phosphate load. For example, renal insufficiency, hypoparathyroidism, exogenous phosphate administration, and extensive cellular injury induce a hyperphosphatemic state. In patients with multiple myeloma, renal insufficiency occurs as a result of hypercalcemia, light chain tubulopathy, urate nephropathy or infection, and hyperphosphatemia usually results from renal failure. We report here a case of a patient with multiple myeloma who had an elevated serum phosphate level measured by the phosphomolybdate UV method without significant renal insufficiency and was finally diagnosed with pseudohyperphosphatemia.


Subject(s)
Humans , Extracellular Fluid , Hypercalcemia , Hyperphosphatemia , Hypoparathyroidism , Light , Molybdenum , Multiple Myeloma , Phosphoric Acids , Renal Insufficiency , Uric Acid
14.
Korean Journal of Medicine ; : 674-678, 2012.
Article in Korean | WPRIM | ID: wpr-224695

ABSTRACT

Primary malignant lymphoma of the stomach comprises 1 to 7% of all gastric malignancies and is mostly B-cell type. Anaplastic large cell lymphoma (ALCL) of the stomach is very rare and regarded to have a poor prognosis. A 66-year-old man complained of dyspepsia for 3 days. A esophagogastroduodenoscopic examination revealed a flat, depressed ulcer at the distal antrum. Biopsy of the lesion showed diffuse infiltration of large pleomorphic lymphoid cells that were positive for CD3 and CD30 and negative for cytokeratin and anaplastic lymphoma kinase (ALK). We diagnosed the patient with ALK-negative primary gastric ALCL with multiple lymphadenopathies, and he received systemic chemotherapy. CHOP-like regimens followed by consolidation therapy have been widely used for ALK-negative ALCL. However, the patient maintained complete remission for 36 months with only induction chemotherapy. This case suggests that heavy treatment for ALK-negative ALCL is not required for all patients.


Subject(s)
Aged , Humans , B-Lymphocytes , Biopsy , Dyspepsia , Induction Chemotherapy , Keratins , Lymphocytes , Lymphoma , Lymphoma, Large-Cell, Anaplastic , Phosphotransferases , Prognosis , Receptor Protein-Tyrosine Kinases , Stomach , Ulcer
15.
The Korean Journal of Internal Medicine ; : 403-409, 2011.
Article in English | WPRIM | ID: wpr-46543

ABSTRACT

BACKGROUND/AIMS: The clinical efficacy and safety of a three-drug combination of melphalan, prednisone, and thalidomide were assessed in patients with multiple myeloma who were not candidates for high-dose therapy as a first-line treatment. Because the side effects of thalidomide at a dose of > or = 100 mg daily can be a barrier to effective treatment for these patients, we evaluated the efficacy and safety of a reduced dose of thalidomide, 50 mg, for non-transplant candidates. METHODS: Twenty-one patients were treated in 4-week cycles, receiving 4 mg/m2 melphalan and 40 mg/m2 prednisone on days 1-7 and 50 mg thalidomide daily. The primary efficacy outcome was the overall response rate. Aspirin (100 mg daily) was also provided as prophylactic treatment for thromboembolism. RESULTS: The overall response rate was 57.1%; a complete response was seen in 23.8% of patients, a partial response in 33.3%, and stable disease in 9.5%. After a median follow-up time of 16.1 months, the median time to progression was 11.4 months (95% confidence interval, 2.1 to 20.6); the median overall survival was not reached. Grades 3 and 4 adverse events included infection (10%), peripheral neuropathy (5%), diarrhea (5%), thrombosis (10%), and loss of consciousness (10%). Two patients discontinued treatment due to loss of consciousness and neuropathy. CONCLUSIONS: Low-dose thalidomide (50 mg) plus melphalan and prednisone is an effective combination drug therapy option for newly diagnosed myeloma patients who are ineligible for high-dose chemotherapy.


Subject(s)
Aged , Female , Humans , Male , Middle Aged , Angiogenesis Inhibitors/therapeutic use , Antineoplastic Agents, Alkylating/therapeutic use , Antineoplastic Agents, Hormonal/therapeutic use , Confidence Intervals , Disease Progression , Drug Therapy, Combination , Kaplan-Meier Estimate , Korea , Melphalan/therapeutic use , Multiple Myeloma/drug therapy , Prednisone/therapeutic use , Risk , Thalidomide/therapeutic use , Time Factors , Treatment Outcome
16.
Journal of Korean Oncology Nursing ; : 237-246, 2011.
Article in Korean | WPRIM | ID: wpr-196089

ABSTRACT

PURPOSE: The aim of this study was to investigate the relationships between stigma, distress, and quality of life (QOL) in patients with lung cancer. METHODS: The subjects of the study were 123 lung cancer patients who visited the outpatient department of S hospital in Seoul from July 21st to August 29th, 2011. To measure stigma, distress, and QOL, Cataldo Lung Cancer Stigma Scale, Hospital Anxiety and Depression Scale (HADS), and EORTC QLQ-C30 (Quality of Life Questionnaire, Core 30) were used in this study. The collected data were analyzed using frequency, average, t-test, ANOVA, and Pearson correlation with SPSS WIN 19.0. RESULTS: Stigma showed positive correlations with anxiety, depression, and symptom (r=.37, p<.001; r=.44, p<.001; r=.23 p=.012), while it showed negative correlations with global QOL and function (r=-.26, p=.003; r=-.40, p<.001). Anxiety and depression also positively correlated with symptoms (r=.43, p<.001; r=.58, p<.001) while anxiety and depression negatively correlated with global QOL (r=-.40, p<.001; r=-.56, p<.001) and function (r=-.64, p<.001; r=-.66, p<.001). CONCLUSION: The findings of the study demonstrated that lung cancer patients experienced stigma and distress that had a negative influence on the subjects' QOL. Thus the study's findings can be useful in developing psychosocial nursing strategies to improve QOL of lung cancer patients in the future.


Subject(s)
Humans , Anxiety , Depression , Lung , Lung Neoplasms , Outpatients , Quality of Life , Surveys and Questionnaires
17.
Korean Journal of Medicine ; : 327-330, 2010.
Article in Korean | WPRIM | ID: wpr-86083

ABSTRACT

Breast cancer is one of the most common cancers in women. Even if appropriate treatments are applied, metastasis can occur in any organ of the body. Uterine metastasis from an extrapelvic tumor such as breast cancer is very rare. A 62-year-old woman with breast cancer was treated with modified radical mastectomy after neoadjuvant chemotherapy and adjuvant chemoradiotherapy. A single lung metastasis developed at 2 years after surgery, and the patient underwent wedge resection followed by capecitabine chemotherapy. Afterwards, the patient was treated with gemcitabine/vinorelbine chemotherapy for skin metastasis. Recently, she complained of vaginal spotting for 3 weeks. MRI of the uterus revealed a 1.1 cm endometrial tumor with myometrial invasion. Biopsy confirmed papillary carcinoma that originated from previous breast cancer. Although she was treated by palliative radiotherapy to the uterus, docetaxel/cyclophosphamide and trastuzumab, disease progression was observed.


Subject(s)
Female , Humans , Middle Aged , Antibodies, Monoclonal, Humanized , Biopsy , Breast , Breast Neoplasms , Carcinoma, Papillary , Chemoradiotherapy, Adjuvant , Deoxycytidine , Disease Progression , Fluorouracil , Lung , Mastectomy, Modified Radical , Metrorrhagia , Neoplasm Metastasis , Skin , Uterus , Capecitabine , Trastuzumab
18.
Korean Journal of Medicine ; : 506-509, 2009.
Article in Korean | WPRIM | ID: wpr-183142

ABSTRACT

Acinar cell carcinoma of the pancreas is a rare tumor that constitutes 1~2% of all pancreatic cancers. The clinical and radiologic findings are inconclusive when diagnosing this disease. Acinar cell carcinoma progresses rapidly and metastasizes early, resulting in a poor prognosis. A 41-year-old man was admitted for abdominal pain. Abdominal computed tomography (CT) and positron emission tomography (PET)-CT showed a splenic mass involving the pancreatic tail with increased 18F-fluorodeoxyglucose (18F-FDG) uptake. A primary radical distal pancreatectomy and splenectomy were carried out. The pathology revealed acinar cell carcinoma of the pancreas. Three months later, a gastric recurrence was detected and a total gastrectomy was performed. Four months later, multiple hepatic metastases were found and a left hepatectomy was carried out. During treatment with capecitabine, no evidence of tumor progression was observed for 14 months. We report a case of metastatic pancreatic acinar cell carcinoma that did not progress for 14 months with capecitabine treatment.


Subject(s)
Adult , Humans , Abdominal Pain , Acinar Cells , Carcinoma, Acinar Cell , Deoxycytidine , Fluorouracil , Gastrectomy , Hepatectomy , Neoplasm Metastasis , Pancreas , Pancreatectomy , Pancreatic Neoplasms , Positron-Emission Tomography , Prognosis , Recurrence , Splenectomy , Capecitabine
19.
Yeungnam University Journal of Medicine ; : 143-147, 2009.
Article in Korean | WPRIM | ID: wpr-216577

ABSTRACT

Hemorrhagic cystitis (HC) is a common complication after allogeneic transplantation. Early posttransplant HC occurs in association with cyclophosphamide, while later on HC results from viral infections such as polyomavirus BK (BKV) and adenovirus. We report here the case of a 57-year-old woman who received an instillation of cidofovir into the bladder for the treatment of hemorrhagic cystitis after allogeneic peripheral stem cell transplantation for her acute myeloid leukemia. Cyclophosphamide and busulfan were used as conditioning treatments. Cyclosporin was administered daily. On the 71st day after transplantation, the patient developed acute severe hemorrhagic cystitis, and BK virus was demonstrated in the urine samples using polymerase chain reaction. Her urinary symptoms did not improve in spite of palliative treatment, but a response was evident after intravesical cidofovir treatment.


Subject(s)
Female , Humans , Middle Aged , Adenoviridae , BK Virus , Busulfan , Cyclophosphamide , Cyclosporine , Cystitis , Cytosine , Leukemia, Myeloid, Acute , Organophosphonates , Palliative Care , Peripheral Blood Stem Cell Transplantation , Polymerase Chain Reaction , Polyomavirus , Stem Cell Transplantation , Stem Cells , Transplantation, Homologous , Transplants , Urinary Bladder
20.
Yeungnam University Journal of Medicine ; : 128-133, 2008.
Article in Korean | WPRIM | ID: wpr-11324

ABSTRACT

Acinar cell carcinoma is a rare tumor that represents 1~2% of all pancreatic cancers. Clinical and radiologic findings are inconclusive in this disease. Acinar cell carcinoma is characterized by rapid progression and early metastasis, which lead to its poor prognosis. A 41-year-old man was admitted to our hospital for abdominal pain. Abdominal computed tomography (CT) and positron emission tomography-computed tomography (PET-CT) showed a splenic mass, which was being invaded by a pancreatic tail mass and which had increased 18F-fluorodeoxyglucose (FDG) uptake. Primary radical distal pancreatectomy and splenectomy were performed. Pathologic findings revealed an acinar cell carcinoma of the pancreas. The patient underwent a total gastrectomy three months later because of gastric recurrence. Four months later, multiple hepatic metastases were discovered, and the patient underwent a left hepatectomy. During treatment with capecitabine, there was no evidence of tumor progression for 14 months. We report a case of metastatic pancreatic acinar cell carcinoma, which did not progress for an extended period while the patient was being treated with capecitabine.


Subject(s)
Adult , Humans , Abdominal Pain , Acinar Cells , Carcinoma, Acinar Cell , Deoxycytidine , Electrons , Fluorouracil , Gastrectomy , Hepatectomy , Neoplasm Metastasis , Pancreas , Pancreatectomy , Pancreatic Neoplasms , Recurrence , Splenectomy , Capecitabine
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