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1.
Article in Chinese | WPRIM | ID: wpr-867910

ABSTRACT

Objective:To report our experience in diagnosis and treatment of posterior atlantoaxial dislocation with odontoid retrolisthesis.Methods:A retrospective study was conducted of the 5 patients who had been treated from July 2012 to August 2018 at Department of Orthopaedics, General Hospital of Southern Theater Command for posterior atlantoaxial dislocation. They were 4 men and one woman, aged from 34 to 67 years (average, 47 years). All of them had a history of trauma. Of them, 4 were complicated with odontoid fracture and one with congenital free os odontoideum. Their posterior atlantoaxial dislocation ranged from 3 to 9 mm (average, 6 mm). By the American Spinal Injury Association (ASIA) grading system, their preoperative spinal injury was rated as grade B in one, as grade C in 3 cases and as grade D in one. All the 5 patients underwent skull traction at 10° flexion. Surgical trans-oralpharyngeal atlantoaxial reduction and internal fixation was performed for the one patient whose reduction had not been achieved by traction while posterior atlantoaxial screw-rod fixation or anterior odontoid screwing was conducted for the 4 patients whose reduction had been achieved by traction. The distance of posterior atlantoaxial dislocation was measured to evaluate their reduction and ASIA grade system was used to assess their spinal function after operation.Results:The postoperative distance of posterior atlantoaxial dislocation was 0 mm, showing a reduction rate of 100%. The 5 patients were followed up for 6 to 36 months (average, 15 months). By the ASIA grade system, the postoperative functional recovery of the spine was grade D in 4 cases and grade C in one. No implant loosening or breakage occurred.Conclusion:As a kind of high-energy hyperextension injury, posterior atlantoaxial dislocation is rare in clinic, but an appropriate treatment can be adopted to deal with its different clinical types to achieve good outcomes.

2.
Article in Chinese | WPRIM | ID: wpr-798183

ABSTRACT

Objective@#To explore the effect of Qutan-Tongyang decoction on cardiac function and myocardial remodeling in patients with chronic heart failure.@*Methods@#According to the random table method, 96 patients with chronic heart failure were divided into the control group (n=48) and the research group (n=48). The patients in the control group were treated with conventional treatment, and the patients in the research group were treated with Qutan-Tongyang decoction on the basis of the control group. Two groups of patients were treated for 4 weeks. The clinical total effective rate of two groups of patients after treatment was counted. The LVESD, LVEDD, LVEF, IVST, LVPWT, LVMI, BNP, Ang2 were determined respectively before and after treatment. In addition, the adverse reaction incidence of two groups of patients were observed.@*Results@#The total effective rate of research group was 89.58% (43/48), while the total effective rate of control group was 72.92% (35/48), the difference between two groups was statistically significant (χ2=4.376, P=0.036). After treatment, the LVESD (45.12 ± 3.02 mm vs. 48.05 ± 3.11 mm, t=4.683), LVEDD (52.24 ± 3.65 mm vs. 56.79 ± 4.15 mm, t=5.704), IVST (7.13 ± 0.63 mm vs. 8.02 ± 0.71 mm, t=6.496), LVPWT (8.15 ± 0.58 mm vs. 8.62 ± 0.75 mm, t=3.434), LVMI (97.65 ± 6.28 g/m2 vs. 112.26 ± 8.47 g/m2, t=9.600), BNP (120.21 ± 19.87 ng/L vs. 188.95 ± 24.18 ng/L, t=15.217), Ang2 (252.52 ± 53.74 pg/ml vs. 330.39 ± 60.85 pg/ml, t=6.645) of the research group were significantly lower than those of the control group (P<0.05), while the LVEF (46.79% ± 3.88% vs. 41.52% ± 3.04%, t=7.407) of the research group were significantly higher than the control group (P<0.05). During treatment, there was no significantly difference of adverse reaction rates of the two groups (χ2=0.545, P=0.460).@*Conclusions@#The clinical curative effect of Qutan-Tongyang decoction on the basis of conventional treatment for the treatment of chronic heart failure is significantly, which can significantly improve cardiac function and inhibit cardiac remodeling. It has the high security of the curative effect.

3.
Article in Chinese | WPRIM | ID: wpr-732709

ABSTRACT

With the improvement of medical care the survival rate of preterm infants (gestational age < 37 weeks) increased dramatically,however long-term neurodevelopmental and behavioral problems are still a concern.During their stay in neonatal intensive care unit preterm patients suffer lots of repeated painful procedures while it's a period of rapid brain development.Preterm infants have the nociceptive circuitry to feel the pain,but this system is functionally immature.Because the spinal neuromodulation system is immature that repeated pain stimulation leads to increased nociceptive signaling in the central nervous system.Besides,specific cell populations in the central nervous system of preterm infants are particularly vulnerable to oxidative stress and inflammation.Therefore,it is important that pain-related stress in preterm infants is appropriately managed.

4.
Article in Chinese | WPRIM | ID: wpr-752887

ABSTRACT

Children′s esophageal stenosis is mainly benign stenosis. Esophageal foreign bodies and corrosion are common causes of esophageal stenosis in children requiring emergency management. Endoscop ̄ic treatment of esophageal stricture includes endoscopic balloon dilatation,endoscopic radial incision,medical treatement,endoscopic stenting and so on. According to the cause of the stenosis,the nature of the lesion and the morphological structure of the lesion,formulating appropriate endoscopic treatment strategy are important for therapeutic effect and reducing the incidence of complications.

5.
Article in Chinese | WPRIM | ID: wpr-751809

ABSTRACT

Objective To explore the effect of Qutan-Tongyang decoction on cardiac function and myocardial remodeling in patients with chronic heart failure. Methods According to the random table method, 96 patients with chronic heart failure were divided into the control group (n=48) and the research group (n=48). The patients in the control group were treated with conventional treatment, and the patients in the research group were treated with Qutan-Tongyang decoction on the basis of the control group. Two groups of patients were treated for 4 weeks. The clinical total effective rate of two groups of patients after treatment was counted. The LVESD, LVEDD, LVEF, IVST, LVPWT, LVMI, BNP, Ang2 were determined respectively before and after treatment. In addition, the adverse reaction incidence of two groups of patients were observed. Results The total effective rate of research group was 89.58% (43/48), while the total effective rate of control group was 72.92% (35/48), the difference between two groups was statistically significant (χ2=4.376, P=0.036). After treatment, the LVESD (45.12 ± 3.02 mm vs. 48.05 ± 3.11 mm, t=4.683), LVEDD (52.24 ± 3.65 mm vs. 56.79 ± 4.15 mm, t=5.704), IVST (7.13 ± 0.63 mm vs. 8.02 ± 0.71 mm, t=6.496), LVPWT (8.15 ± 0.58 mm vs. 8.62 ± 0.75 mm, t=3.434), LVMI (97.65 ± 6.28 g/m2 vs. 112.26 ± 8.47 g/m2, t=9.600), BNP (120.21 ± 19.87 ng/L vs. 188.95 ± 24.18 ng/L, t=15.217), Ang2 (252.52 ± 53.74 pg/ml vs. 330.39 ± 60.85 pg/ml, t=6.645) of the research group were significantly lower than those of the control group (P<0.05), while the LVEF (46.79% ± 3.88% vs. 41.52% ± 3.04%, t=7.407) of the research group were significantly higher than the control group (P<0.05). During treatment, there was no significantly difference of adverse reaction rates of the two groups (χ2=0.545, P=0.460). Conclusions The clinical curative effect of Qutan-Tongyang decoction on the basis of conventional treatment for the treatment of chronic heart failure is significantly, which can significantly improve cardiac function and inhibit cardiac remodeling. It has the high security of the curative effect.

6.
Chinese Journal of Cardiology ; (12): 221-227, 2019.
Article in Chinese | WPRIM | ID: wpr-810505

ABSTRACT

Objective@#To observe the relationship between impaired myocardial untwisting and left ventricular diastolic dysfunction in patients with autoimmune diseases (AD).@*Methods@#In this retrospective study, 95 AD patients (27 males, (38.6±14.2) years old) were enrolled as AD group and 71 gender and age matched healthy subjects (24 males, (37.6±12.2) years old) were enrolled as control group, all underwent transthoracic echocardiography and two-dimensional speckle-tracking echocardiography (STE) in our hospital between January 2014 and June 2018. Left ventricular untwisting and diastolic function parameters were measured. Multiple logistic regression analysis was used to identify related factors of left ventricular diastolic dysfunction in AD patients. Receiver operating characteristic (ROC) curve was used to identify the diagnosis value of untwisting parameters for left ventricular diastolic dysfunction in AD patients.@*Results@#Compared with control group, left ventricular ejection fraction was lower (58(47, 66)% vs. 67 (62, 71) %, P<0.001), E/e′ was higher (10.78 (7.28, 13.65) vs. 6.30 (5.55, 7.25) , P<0.001), isovolumic relaxation time was longer (73.5 (56.5, 88.0) ms vs. 62.0 (58.0, 68.5) ms, P<0.001),and untwist slope during isovolumic relaxation period (USIR) was lower (31.92 (14.09, 54.92) °/s vs. 59.90 (40.09, 87.18) °/s, P<0.001) in AD group than in control group. Multiple logistic regression analysis showed heart rate (OR=0.885, 95%CI 0.840-0.931, P<0.001), E/e′ (OR=0.655, 95%CI 0.537-0.798, P<0.001) and USIR (OR=0.986, 95%CI 0.974-0.998, P=0.020) were independently related with left ventricular diastolic dysfunction in AD patients. ROC curve showed that area under the curve (AUC) was 0.919 (P<0.001), sensitivity was 87.6%, and specificity was 88.7%, when combining the heart rate, E/e′, and USIR as assessment parameters for the diagnosis of left ventricular diastolic dysfunction in AD patients at a cutoff of 0.51.@*Conclusions@#Impairment of myocardial untwisting indicates the presence of early stage left ventricular diastolic dysfunction in AD patients. USIR may be a sensitive parameter to evaluate early stage left ventricular diastolic dysfunction in AD patients.

7.
Article in Chinese | WPRIM | ID: wpr-772034

ABSTRACT

OBJECTIVE@#To explore the clinical characteristics and molecular basis for a Chinese boy affected with jaundiced skin and liver disease.@*METHODS@#The patient was subjected to clinical examination and laboratory tests. Genomic DNA of the patient and his parents was extracted and analyzed by using next generation sequencing (NGS). Suspected mutations were analyzed with bioinformatic software and verified by Sanger sequencing.@*RESULTS@#The patient had jaundice in his eyes and skin. Serum bilirubin was elevated along with hepatomegaly. Next generation sequencing showed that the patient has carried c.18C>A(p.C6X) and c.2556delA mutations in the MRP2 gene, which were respectively inherited from his father and mother.@*CONCLUSION@#The missense mutation c.18C>A and frameshift mutation c.2556delA probably account for the disease. NGS has provided a powerful tool for the diagnosis of rare genetic diseases including Dubin-Johnson syndrome.


Subject(s)
Asians , DNA , High-Throughput Nucleotide Sequencing , Humans , Jaundice, Chronic Idiopathic , Male , Mutation
8.
Article in Chinese | WPRIM | ID: wpr-745337

ABSTRACT

With the rapid development of organ transplantation in China,the donation after cardiac death (DCD) donor organs are widely used.However,the quality of these organs is relatively poor,so the way to preserve and maintain organ still remains a severe problem.Among them,ischemic reperfusion injury (IRI) impairs the organs severely.Acetaldehyde dehydrogenase 2 (ALDH2) protects organs from stress conditions,including ischemia-reperfusion injury,and the activation and autophagy inhibition also protects the organs from stress conditions as well.Recent studies showed that ALDH2 can regulate autophagy to inhibit the organ injury during ischemia-reperfusion.Our study aims to discuss the new findings in this mechanism.

9.
Article in Chinese | WPRIM | ID: wpr-707240

ABSTRACT

Objective To evaluate the clinical outcomes and prognosis of older human immunodeficiency virus (HIV )-infected patients under antiretroviral therapy (ART ) in China .Methods This study was carried out in a retrospective cohort of HIV-infected patients initiated ART between January 2004 and December 2012 at The First Affiliated Hospital ,China Medical University .The patients were enrolled and divided into two groups ,including <50 years group (young and middle-aged group) and≥50 years group (older group) .Immunological and virological responses and mortality were analyzed . Data were analyzed by t test ,chi-square test ,two-way analysis of variance and log-rank test .Results Totally 291 subjects were included ,among whom 97 subjects were older patients and 194 subjects were young and middle-aged patients .Male was predominate in both groups ,which accounted for 91 .8% and 87 .6% ,respectively .The CD4+ T lymphocyte count in the older group before treatment was (151 .9 ±96 .2) cells /μL ,which was significantly lower than that in the young and middle-aged group (183 .4 ± 93 . 5) cells/μL (t= 2 .657 , P=0 .009) .At month 12 of treatment ,the CD4+ T lymphocyte count in the older group was significantly lower than that in the young and middle-aged groups (t= 2 .120 , P=0 .035) ,while there was no statistically significant difference between the two groups at month 24 (t=1 .025 ,P=0 .299) .The percentage of CD4+ T lymphocyte count increasing to 500 cells/μL in the older and youth groups during follow-up were 11 .3% and 16 .0% ,respectively (χ2=1 .127 ,P =0 .376) .Log-rank analysis showed that the mean times of virus inhibition in older group and young and middle-aged group were 7 .9 (95% CI:6 .8-8 .5) and 7 .6 (95% CI:6 .5 -9 .3) ,respectively ,with no statistically significant difference (χ2 =0 .002 , P=0 .961) .Virological failure was reported in 4 patients (4 .1% ) in older group and 11 patients (5 .7% ) in young and middle-aged group . Chi-square test showed no statistically significant difference between the two groups (χ2 = 0 .15 , P= 0 .78) .During follow-up , 19 .6% (19/97) in older group and 3 .6% (7/194) in young and middle-aged group died .The former was significantly higher than the latter (χ2 = 21 .113 , P< 0 .01 ) .Conclusions Older patients show a poor immunologic response ,similar viral suppression and higher risk of mortality compared with young and middle-aged patients . Future research should be aimed at the feasible and specific strategy for early diagnosis and timely treatment for older patients to improve treatment efficacy and reduce mortality .

10.
Chinese Journal of Epidemiology ; (12): 1501-1506, 2018.
Article in Chinese | WPRIM | ID: wpr-738176

ABSTRACT

Objective To analyze and reveal the distribution,research hotspots and study trend of worldwide published articles correlated with HIV/AIDS post-exposure prophylaxis (PEP),and provide information for related studies in China.Methods CiteSpace software 5.1 was used to visualize all related papers in the web of science database published during 2000-2017.Results The average growth rate of international PEP-related papers was 10.78%,and number of published papers in 2016 was highest (n=34),relevant research hotspots have shifted from the prevention of occupational HIV exposure to the prevention of non-occupational HIV exposure in group at high risk,such as MSM,in recent years.Clustering analysis classified research hotspots into three categories,including risk reduction through enhanced intervention,current status of global HIV PEP and German-Austrian Recommendation.Conclusions Non-occupational HIV PEP in groups at high-risk,especially MSM,has received increasing attention in recent years,the research of PEP mainly focus on improving the awareness and use of PEP in MSM and compliance in the course of medication.In the context of severe HIV epidemic in MSM without effective control in China,PEP should be strengthened to assess and explore the risk of HIV infection in MSM to provide reference for medical personnel and related departments to implement HIV non-occupation exposure blockade and formulate PEP medication.

11.
Chinese Journal of Epidemiology ; (12): 1501-1506, 2018.
Article in Chinese | WPRIM | ID: wpr-736708

ABSTRACT

Objective To analyze and reveal the distribution,research hotspots and study trend of worldwide published articles correlated with HIV/AIDS post-exposure prophylaxis (PEP),and provide information for related studies in China.Methods CiteSpace software 5.1 was used to visualize all related papers in the web of science database published during 2000-2017.Results The average growth rate of international PEP-related papers was 10.78%,and number of published papers in 2016 was highest (n=34),relevant research hotspots have shifted from the prevention of occupational HIV exposure to the prevention of non-occupational HIV exposure in group at high risk,such as MSM,in recent years.Clustering analysis classified research hotspots into three categories,including risk reduction through enhanced intervention,current status of global HIV PEP and German-Austrian Recommendation.Conclusions Non-occupational HIV PEP in groups at high-risk,especially MSM,has received increasing attention in recent years,the research of PEP mainly focus on improving the awareness and use of PEP in MSM and compliance in the course of medication.In the context of severe HIV epidemic in MSM without effective control in China,PEP should be strengthened to assess and explore the risk of HIV infection in MSM to provide reference for medical personnel and related departments to implement HIV non-occupation exposure blockade and formulate PEP medication.

12.
Article in Chinese | WPRIM | ID: wpr-775825

ABSTRACT

OBJECTIVE@#To carry out variant analysis for a Chinese boy featuring dyshormonogenesis due to congenital hypothyroidism.@*METHODS@#DNA of the patient and his parents was extracted and sequenced by high-throughput sequencing. The results were validated with Sanger sequencing and analyzed with Bioinformatics software.@*RESULTS@#Sequencing result showed that the patient has carried compound variants of c.2654G>T(p.Arg885Leu) and c.943G>T(p.Gly315X) of the DUOX2 gene, which were inherited respectively from his mother and father.@*CONCLUSION@#The missense mutation c.2654G>T and nonsense mutation c.943G>T probably underlie the disease in this child.


Subject(s)
Child , Congenital Hypothyroidism , Diagnosis , Genetics , Dual Oxidases , Genetics , High-Throughput Nucleotide Sequencing , Humans , Male , Mutation, Missense
13.
Article in Chinese | WPRIM | ID: wpr-344134

ABSTRACT

OBJECTIVE To identify potential mutations in five infants with neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD). METHODS The SLC25A13 gene was analyzed by next-generation sequencing. Suspected mutations were confirmed by PCR and Sanger sequencing in the probands and their parents. Impact of novel mutations was predicted with PolyPhen-2 software. RESULTS All neonates have harbored mutations of the SLC25A13 gene. Eight mutations were discovered, which included two novel mutations (c.1357A>G and c.1663dup23). All parents were found to be carriers of the mutations. CONCLUSION Mutations of the SLC25A13 gene probably underlie the NICCD among the five patients, among which 851del4 and 1638-1660dup were the most common ones. This has enriched the spectrum of SLC25A13 mutation in association with NICCD.

14.
Article in Chinese | WPRIM | ID: wpr-610125

ABSTRACT

Objective:To prepare the velvet antler polypeptide-collagen/chitosan composite materials,and to investigate its promotive effect on cicatrization of mandibular defect and possible mechanism.Methods:The collagen and chitosan solution were mixed.The composite material was prepared by glutaraldehyde crosslinking method.The microstructure of the composite material was observed by transmission electron microscope (SEM).The unilateral mandibular defect models of 36 rabbits were established.The rabbits were divided into experiment and control groups,and each group was divided into 4-,8-and 12-week subgroups,and there were 6 rabbits in each sub group.The rabbits in experiment group were implanted with velvet antler polypeptide-collagen /chitosan composite materials and the rabbits in control group were treated.4,8 and 12 weeks after operation,the histology of bone defect and peripheral nerve reconstruction of the rabbit models were detected by CT;the expression of vascular endothelial growth factor (VEGF) in bone tissue of the rabbits was detected by immunohistochemistry;the ultrastructure of bone defect was observed by SEM.Results:The structure of composite materials had layered folds and the inner diameter of the stent became larger and mainly dominated by sheet structure,which was the ideal structure of biological materials.4 weeks after operation,the new bone was formatted in experiment group,most of the new bone like-tissue materials were degraded,and the VEGF expression showed an increasing trend;8 weeks after operation,the trabecular bone in the bone defect of the rabbits in experiment group was increased obviously and the expression of VEGF was decreased.12 weeks after operation,the new bone formation and the density in experiment group was consistent with the normal tissue,and the expression level of VEGF returned to normal.At each the point after operation,the degree of bone defect healing and bone formation rate in experiment group were obviously prior to control group.Conclusion:Velvet antler polypeptide-collagen /chitosan composite material has the promotive effect on the fracture healing of mandibular defect of the rabbits and its possible mechanism may be related to promoting the expression of VEGF.

15.
Chongqing Medicine ; (36): 2063-2065,2068, 2017.
Article in Chinese | WPRIM | ID: wpr-610040

ABSTRACT

Objective To study the effect of topical application of tranexamic acid(TXA)in total hip arthroplasty(THA).Methods A total of 63 patients with unilateral THA were enrolled in this study from November 2014 to March 2016.All patients were randomly divided into group A(n=37)and group B(n=26).Group A was injected with 2.0 g TXA(dissolved in 10 mL saline)in the joint cavity tube after the end of the surgical dressing.Group B injected the same amount of saline.The hemoglobin,hematocrit,postoperative blood loss,blood transfusion,blood transfusion and replacement of 24,48,72 h after the replacement,24,48 and 72 h after fibrinogen,prothrombin time and activation of part of the thromboplastin time,lower extremity deep vein ultrasound between the two groups were compared.Results The hemoglobin,hematocrit,postoperative blood loss,blood transfusion and blood transfusion were significantly better in group A than those in group B at 24,48 and 72 h after replacement(P0.05).Conclusion The local application of TXA group can significantly reduce the THA perioperative blood loss without the increase of the risk of deep vein thrombosis.

16.
Journal of China Medical University ; (12): 266-269,272, 2017.
Article in Chinese | WPRIM | ID: wpr-606321

ABSTRACT

Objective To develop a predictive model for pulmonary embolism(PE)based on the related clinical symptoms,signs,and the labo-ratory index,so as to improve the positive rate of CTPA. Methods The model was developed from a database of 119 patients with suspected PE. The risk factors of suspected PE were analyzed by logistic regression analysis ,which included significant differences in the prevalence of PE be-tween non-diseased and non-diseased groups. Receiver operating characteristic(ROC)curves was draw to determine the cut-off value of the clini-cal probability. It was validated in an independent sample of 106 patients with suspected PE. Results According to the univariate analysis ,17 of 51 variables show a significant difference between PE and non-PE patients. The model comprised 4 variables:age,dyspnea,D-dimer and unilater-al leg swelling. The area under the ROC curve is 0.776,and the cut-off value is supposed to be 0.38. In the validation sample,27% patients had PE confirmed by CTPA. The prevalence of PE was 54%when the clinical probability was above 0.38. Conclusion The proposed predictive mod-el in this study can improve the positive rate of CTPA ,simplify the diagnosis process of suspected PE patients.

17.
Article in Chinese | WPRIM | ID: wpr-616991

ABSTRACT

BACKGROUND: With the rapid development of digital orthopaedics, navigational template has been widely used in the field of orthopaedics, but the research status of the technique in China based on bibliometric analysis is never reported. OBJECTIVE: To investigate the application status of navigational template in the orthopaedic field and to explore its tendency and hot spot based on bibliometric analysis, thereby providing reference for the development of digital orthopaedics in China.METHODS: A computer-based retrieval of CBMdisc, CNKI, CSPD, CMCI databases was conducted for articles published before December 1, 2016 using the keywords of navigational template and subject heading orthopaedics and the core orthopaedic journals published in 2016 were searched by manual. The articles were screened according to inclusion and exclusion criteria, and finally were analyzed by bibilometric study.RESULTS AND CONCLUSION: (1) In China, the first paper reporting navigational template was issued in 2008. A total of 199 articles were published in the past 9 years, with more than 10 papers yearly from 2009 to 2014, while there was a rapid increase tendency during 2015 and 2016. (2) The articles were mainly published in the orthopaedic journals and some professional journals closely related to digital orthopaedics, such as biomedical engineering, basic medicine and digital medicine. About 86.9% papers belong to Chinese core journals, including Chinese Journal of Orthopaedic Trauma,Chinese Journal of Orthopaedics, and Chinese Journal of Tissue Engineering Research. (3) There is a 99.5% cooperation rate and 6.15 degree of cooperation. Zhang Yuan-zhi, Ding Huan-wen, Lu Sheng, Chen Yu-bing, Hu Yong,Huang Xuan and Zheng Peng-fei are most productive authors, and core authors contribute to 53.8%, indicating that the group of core authors is being formed. First authors are all from hospitals and universities, mostly from Kunming General Hospital of Chengdu Military Command of PLA, General Hospital of Guangzhou Military Command of PLA, the Affiliated Hospital of Inner Mongolia Medical University and South China University of Technology. The cooperation rate of more than two institutes occupies 54.8%, indicating that the study holds a promising future with the strong support of research institutes in universities. About 59.3% articles are sponsored by funding, the national and provincial foundations accounting for 64.0% in 239 projects, and 57.6% articles were supported by more than two foundations, revealing the high research levels and academic values of this technique. (4) The articles are cited by 763 times; Lu Sheng,Chen Yu-bing, and Zhang Yuan-zhi are the highly cited authors; Kunming General Hospital of Chengdu Military Command of PLA, General Hospital of Guangzhou Military Command of PLA and Nanfang Hospital of Southern Medical University are the highly cited institutes, and Chinese Journal of Orthopaedic Trauma is the highly cited journal. (5) To conclude, based on product design, manufacture and cadaver studies of the navigational template, it has been extensively applied in the spine surgery (especially cervical surgery), orthopaedic traumatology, bone and joint surgery,bone tumor and pediatric orthopaedics, and has obtained satisfactory clinical outcomes in assisting screw placement,osteotomy and precise resection and functional reconstruction. However, there is still a lack of a large-sample,multicenter, and long-term randomized trial.

18.
Chinese Journal of Epidemiology ; (12): 1083-1087, 2017.
Article in Chinese | WPRIM | ID: wpr-737779

ABSTRACT

Objective To investigate the acceptability and related factors of an "on-demand"pre-exposure prophylaxis (PrEP) to prevent HIV transmission among MSM in Shenyang.Methods MSM recruited by non-probability sampling method and questionnaire survey conducted by investigators to collect information on social and behavioral characteristics,awareness of PrEP,Truvada and the acceptability of two different PrEP-based trials.Multivariate logistic regression was employed for statistical analysis.Results Among the 292 respondents,34.2% had heard of PrEP and 58.2% (170/292) reported were interested in participating a PrEP trial-"on-demand" use or 48.3% (141/292) interested on "daily" use (x2=5.785,P=0.02).Factors independently associated with those "on-demand" would include:having more than 2 male sexual partners during the past 6 month (aOR=1.7,95%CI:1.1-2.7),concerning on the positive effect of PrEP (vs.side effects) (aOR=6.4,95%CI:2.2-18.9),having an HIV-infected sexual partners (aOR=8.1,95% CI:1.0-63.3) and self-reported high risk for HIV (aOR=2.6,95%CI:1.2-6.0).The last two factors were only associated with the "on-demand" group.Conclusions "On-demand" PrEP (as opposed to daily) seemed a more feasible prevention strategy on HIV and particularly in those having high risk behavior of HIV.For those who could not follow the daily medication or having HIV risk perception,"On-demand" basis PrEP trial should be recommended for them to follow.

19.
Chinese Journal of Epidemiology ; (12): 1078-1082, 2017.
Article in Chinese | WPRIM | ID: wpr-737778

ABSTRACT

Objective To investigate the risk factors on antiretroviral therapy (ART) among HIV/AIDS positive students in Shenyang.Methods A cross-sectional study was conducted among HIV/AIDS positive students aged between 15 and 30,in an HIV-treatment-designated hospital in Shenyang city,during 2007-2015.Data were analyzed by multivariate logistic regression mode to identify the risk factors related to ART.Results A total of 2 379 HIV/AIDS patients attended the hospital and 6.1% (146/2 379) of them were students,during 2007-2015.All of the HIV/AIDS positive students were males,with homosexual transmission accounted for 93.2% (136/146).The overall rate on delayed diagnosis was 52.7% (77/146),when at diagnosis of CD4 + T lymphocyte counts ≤350 cells/μl.The proportion of ART was 67.1% (98/146).Factors as:year that the HIV diagnosis was made (aOR=1.21,95%CI:1.02-1.44),age between 24-30 (compared with age below 18-year-old,aOR=8.15,95%CI:1.46-45.52),and delayed diagnosis (aOR=2.22,95%CI:1.05-4.71),appeared independently related to ART among HIV/AIDS positive students.Conclusions Factors as the year that HIV diagnosis was made,age and delayed diagnosis of the patients seemed to be at higher risk for ART among HIV/AIDS positive students.

20.
Chinese Journal of Epidemiology ; (12): 1083-1087, 2017.
Article in Chinese | WPRIM | ID: wpr-736311

ABSTRACT

Objective To investigate the acceptability and related factors of an "on-demand"pre-exposure prophylaxis (PrEP) to prevent HIV transmission among MSM in Shenyang.Methods MSM recruited by non-probability sampling method and questionnaire survey conducted by investigators to collect information on social and behavioral characteristics,awareness of PrEP,Truvada and the acceptability of two different PrEP-based trials.Multivariate logistic regression was employed for statistical analysis.Results Among the 292 respondents,34.2% had heard of PrEP and 58.2% (170/292) reported were interested in participating a PrEP trial-"on-demand" use or 48.3% (141/292) interested on "daily" use (x2=5.785,P=0.02).Factors independently associated with those "on-demand" would include:having more than 2 male sexual partners during the past 6 month (aOR=1.7,95%CI:1.1-2.7),concerning on the positive effect of PrEP (vs.side effects) (aOR=6.4,95%CI:2.2-18.9),having an HIV-infected sexual partners (aOR=8.1,95% CI:1.0-63.3) and self-reported high risk for HIV (aOR=2.6,95%CI:1.2-6.0).The last two factors were only associated with the "on-demand" group.Conclusions "On-demand" PrEP (as opposed to daily) seemed a more feasible prevention strategy on HIV and particularly in those having high risk behavior of HIV.For those who could not follow the daily medication or having HIV risk perception,"On-demand" basis PrEP trial should be recommended for them to follow.

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