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1.
Chinese Journal of Biotechnology ; (12): 2033-2041, 2022.
Article in Chinese | WPRIM | ID: wpr-927838

ABSTRACT

The study was based on the teaching effect of blended teaching of the course of Veterinary Immunology on the U-Massive Open Online Course (UMOOC) platform of Inner Mongolia Minzu University. The students of two classes majoring in veterinary medicine in Inner Mongolia Minzu University were selected to form the traditional teaching group (control group) and the blended teaching group (experimental group), respectively, and the teaching effects were further compared and analyzed. The blended teaching module improved students' active learning attitude along with their ability to grasp knowledge in class, and most students supported to use blended teaching in the future. In conclusion, the UMOOC-based blended teaching methodology stimulated students' active learning attitude toward veterinary immunology and helped to foster innovative consciousness and self-management ability.


Subject(s)
China , Curriculum , Education, Veterinary , Humans , Learning , Students , Universities
2.
Chinese Journal of Urology ; (12): 455-461, 2021.
Article in Chinese | WPRIM | ID: wpr-911049

ABSTRACT

Objective:To retrospectively analyze the urodynamics quality in Southwest China, and find out the main issues of urodynamics quality in Southwest China and try to find out the improvement ways.Methods:In this study, a two-stage sampling method was used.In the first stage, 10 medical institutions in Southwest China were selected by cluster sampling from March to June, 2020.In the second stage, according to the development of UDS in Southwest China, the sample size estimation formula was adopted, and the loss of follow-up rate in reports extraction was considered, the initial sample size was 350. As the workload of UDS in the 10 medical institutions involved in the study was equivalent, 35 urodynamics traces from each medical institution were selected. The initial samples should also meet the inclusion criteria: ①patients with clear medical history and complete clinical data; ②UDS traces were clear; ③UDS system was water filled system; ④age>18, and 150 urodynamic traces were included in the final study. We evaluated the quality of enrolled urodynamics traces, and the quality evaluation standard according to the guidelines established by the International Continence Society (ICS). The evaluation conducted by two independent urologist with more than 10 years working experience. Artifacts were divided into non-technical artifacts: abnormal abdominal pressure changes, urine volume <150 ml when did the uroflow test, and technical artifacts: non-standard zero setting, fail to record all urodynamics parameters, baseline drift, catheter displacement, misjudgment of detrusor physiological contraction and detrusor overactive in voiding phase, misjudgment between detrusor overactive and bladder low compliance in filling phase.Results:non-technical artifacts: 32 cases were found abnormal abdominal pressure changes (21.3%), 21 cases (14.0%) were found when did the uroflow test the urine volume <150 ml, and technical artifacts: Non-standard zero setting in 28 cases (18.7%), fail to record all urodynamics parameters in 8 cases, baseline drift in 16 cases, catheter displacement in 9 cases and misjudgment of detrusor physiological contraction and detrusor overactive in voiding phase in 12 cases, misjudgment between detrusor overactive and bladder low compliance in filling phase in 24 cases (16.0%).Conclusions:At present, the urodynamics quality in Southwest China need to be improved. The main issues were that the operator didn’t obey the basic operation and quality control process, and the operator did not have enough basic knowledge of urodynamics. It can be improved by strictly carry out the operation standard of UDS, identifying and correcting artifacts in time, and promoting the standardized urodynamic training courses.

3.
Article in Chinese | WPRIM | ID: wpr-910484

ABSTRACT

Objective:To investigate the application of radiotherapy and the basic situation of teaching and scientific research in Xinjiang.Methods:A unified questionnaire was adopted, distributed and collected by mail, instant messaging software and telephone. The basic situation of all radiotherapy affiliations in the whole region was counted.Results:The questionnaire coverage rate was 100% with a recovery rate of 100%. In 2020, 17 affiliations operated radiotherapy in Xinjiang, including 23 linear accelerators, 1 cobalt-60 therapeutic machine, 3 gamma knives, 6 post-installed therapeutic machines, 13 special analogue positioning machines, 46 treatment planning systems, and 103 sets of radiotherapy quality control equipment. It was estimated that the number of radiotherapy equipment for one million people in the whole region was approximately 0.84. In Xinjiang, 359 radiotherapy personnel were registered, including 220 physicians, 49 physicists and 90 technicians. A total of 1 270 beds were available, with an average daily treatment volume of approximately 1 255 person-times. From 2016 to 2021, 17 affiliations have undertaken 9 National Natural Science Foundation of China and 49 provincial and ministerial projects. Nineteen doctoral degrees and 87 master′s degrees were accredited. These affiliations participated in the publication of 25 articles in Chinese Journal of Radiation Oncology, of which 18 were published as the first authors and/or corresponding authors.Conclusions:The radiotherapy work in Xinjiang has developed rapidly in recent years, but there is still a certain gap with the national average level. At the same time, several problems still exist in the whole region, such as regional differences, unbalanced allocation of radiotherapy resources and scientific research and teaching resources, which need further improvement.

4.
Article in Chinese | WPRIM | ID: wpr-910408

ABSTRACT

Radiation-induced bystander effect (RIBE) refers to that irradiated cells release signaling factors and induce responses in nonirradiated cells.In other words, it is the communication between irradiated and nonirradiated cells by intracellular signals. RIBE could influence the efficacy of tumor radiotherapy, but also has potential risk to the normal tissues outside of radiation field. Studies have found that ionizing radiation can induce the alteration of miRNA expression not only in the irradiated cells but also in adjacent nonirradiated tissues, and miRNAs may play an important role in the regulation of signaling pathways between irradiated and nonirradiated bystander cells. This article reviewed the roles of miRNAs in RIBE.

5.
Article in Chinese | WPRIM | ID: wpr-910304

ABSTRACT

Objective:To analyze the prognostic factors of patients with locally advanced nasopharyngeal carcinoma after treatment, to develop and validate the prognostic Nomogram model.Methods:From July 2010 to June 2017, 317 patients with nasopharyngeal carcinoma who were treated with definitive intensity modulated radiation therapy were selected. The regression method of least absolute shrinkage and selection operator (LASSO) was used for univariate screening, and Cox multivariate regression analysis was performed. The prognostic Nomogram model was constructed for locally advanced nasopharyngeal carcinoma patients. C-index, calibration curve, Net Reclassification Index (NRI), integrated discrimination improvement (IDI) were used to validate and evaluate the model between Nomogram and TNM staging system. The risk evaluated through nomogram was stratified by decision tree algorithm, and the survival rate was calculated by Kaplan-Meier method and compared by Log-rank test.Results:T stage, N stage, LDH, GTVnd and pre-treated plasma EBV-DNA copy (EBV-DNA) were correlated with total survival (OS). All the above factors were included in prognostic Nomogram model, and C-index was 0.784 (95% CI: 0.736-0.831, P<0.01). The calibration curve showed that the OS probability predicted by Nomogram model was in good agreement with the actual OS, and the result were verified in the validation cohort. Furthermore, the accuracy of the Nomogram model for OS predicting was superior to AJCC 8 th version staging system judged by NRI and IDI. According to the Nomogram score, patients can be divided into four subgroups with different risk by decision tree algorithm. K-M survival curve showed that the difference of OS between different groups was statistically significant ( χ2=113.21, P<0.01), and patients in high-risk group can benefit from induction chemotherapy combined with concurrent chemoradiotherapy in survival. Conclusions:The Nomogram model established by our research group can provide information on diagnosis, treatment and prognosis evaluation for locally advanced nasopharyngeal carcinoma patients in this area.

6.
Article in Chinese | WPRIM | ID: wpr-888317

ABSTRACT

OBJECTIVE@#To explore the clinical effect of manual reduction combined with homemade splint external fixation in the treatment of metacarpal fractures.@*METHODS@#A retrospective analysis was performed in 126 patients with metacarpal fracture treated by manual reduction and homemade splint external fixation in the emergency department of our hospital from January 2018 to December 2018, including 102 male, 24 female, ranging in age from 9 to 73 year old, with an average of (33.2±14.3)years old. During the treatment, the X-ray was re-examined regularly, and the external fixation was continued or adjusted according to the X-ray situation. The X-ray showed callus growth. After the fracture was stable, the external fixation was removed to continue functional exercise. The TAM scoring standardwas used to evaluate the hand function, and the fracture healing and complications were summarized.@*RESULTS@#Of the 126 patients, 6 patients were treated with operation because of fracture displacement during the treatment. The other 120 patients were treated with this method and all of them got bony healing. The healing time was (6.3±1.8) weeks. The follow up time ranged from 2 to 12 months, with a mean of (4.4±2.2) months. At the latest follow up, TAM score was used to evaluate the hand function:excellent in 105 cases, good in 13 cases, fair in 2 cases and poor in 0 case. Shortening deformity was found in 7 cases and angulation deformity in 3 cases.@*CONCLUSION@#Manual reduction combined with homemade splint external fixation in the treatment of metacarpal fractures can achieve good clinical results. Homemade splint is easy to obtain materials and low cost, and it is an effective method worthy of clinical promotion.


Subject(s)
Adolescent , Adult , Aged , Child , External Fixators , Female , Fracture Fixation , Fracture Fixation, Internal , Humans , Male , Metacarpal Bones , Middle Aged , Retrospective Studies , Splints , Treatment Outcome , Young Adult
7.
Article in Chinese | WPRIM | ID: wpr-888208

ABSTRACT

Vision is an important way for human beings to interact with the outside world and obtain information. In order to research human visual behavior under different conditions, this paper uses a Gaussian mixture-hidden Markov model (GMM-HMM) to model the scanpath, and proposes a new model optimization method, time-shifting segmentation (TSS). The TSS method can highlight the characteristics of the time dimension in the scanpath, improve the pattern recognition results, and enhance the stability of the model. In this paper, a linear discriminant analysis (LDA) method is used for multi-dimensional feature pattern recognition to evaluates the rationality and the accuracy of the proposed model. Four sets of comparative trials were carried out for the model evaluation. The first group applied the GMM-HMM to model the scanpath, and the average accuracy of the classification could reach 0.507, which is greater than the opportunity probability of three classification (0.333). The second set of trial applied TSS method, and the mean accuracy of classification was raised to 0.610. The third group combined GMM-HMM with TSS method, and the mean accuracy of classification reached 0.602, which was more stable than the second model. Finally, comparing the model analysis results with the saccade amplitude (SA) characteristics analysis results, the modeling analysis method is much better than the basic information analysis method. Via analyzing the characteristics of three types of tasks, the results show that the free viewing task have higher specificity value and a higher sensitivity to the cued object search task. In summary, the application of GMM-HMM model has a good performance in scanpath pattern recognition, and the introduction of TSS method can enhance the difference of scanpath characteristics. Especially for the recognition of the scanpath of search-type tasks, the model has better advantages. And it also provides a new solution for a single state eye movement sequence.


Subject(s)
Algorithms , Discriminant Analysis , Eye Movements , Humans , Markov Chains , Normal Distribution , Probability
8.
Chinese Medical Journal ; (24): 1289-1298, 2021.
Article in English | WPRIM | ID: wpr-878153

ABSTRACT

BACKGROUND@#The significant morbidity and mortality resulted from the infection of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) call for urgent development of effective and safe vaccines. We report the immunogenicity and safety of an inactivated SARS-CoV-2 vaccine, KCONVAC, in healthy adults.@*METHODS@#Phase 1 and phase 2 randomized, double-blind, and placebo-controlled trials of KCONVAC were conducted in healthy Chinese adults aged 18 to 59 years. The participants in the phase 1 trial were randomized to receive two doses, one each on Days 0 and 14, of either KCONVAC (5 or 10 μg/dose) or placebo. The participants in the phase 2 trial were randomized to receive either KCONVAC (at 5 or 10 μg/dose) or placebo on Days 0 and 14 (0/14 regimen) or Days 0 and 28 (0/28 regimen). In the phase 1 trial, the primary safety endpoint was the proportion of participants experiencing adverse reactions/events within 28 days following the administration of each dose. In the phase 2 trial, the primary immunogenicity endpoints were neutralization antibody seroconversion and titer and anti-receptor-binding domain immunoglobulin G seroconversion at 28 days after the second dose.@*RESULTS@#In the phase 1 trial, 60 participants were enrolled and received at least one dose of 5-μg vaccine (n = 24), 10-μg vaccine (n = 24), or placebo (n = 12). In the phase 2 trial, 500 participants were enrolled and received at least one dose of 5-μg vaccine (n = 100 for 0/14 or 0/28 regimens), 10-μg vaccine (n = 100 for each regimen), or placebo (n = 50 for each regimen). In the phase 1 trial, 13 (54%), 11 (46%), and seven (7/12) participants reported at least one adverse event (AE) after receiving 5-, 10-μg vaccine, or placebo, respectively. In the phase 2 trial, 16 (16%), 19 (19%), and nine (18%) 0/14-regimen participants reported at least one AE after receiving 5-, 10-μg vaccine, or placebo, respectively. Similar AE incidences were observed in the three 0/28-regimen treatment groups. No AEs with an intensity of grade 3+ were reported, expect for one vaccine-unrelated serious AE (foot fracture) reported in the phase 1 trial. KCONVAC induced significant antibody responses; 0/28 regimen showed a higher immune responses than that did 0/14 regimen after receiving two vaccine doses.@*CONCLUSIONS@#Both doses of KCONVAC are well tolerated and able to induce robust immune responses in healthy adults. These results support testing 5-μg vaccine in the 0/28 regimen in an upcoming phase 3 efficacy trial.@*TRIAL REGISTRATION@#http://www.chictr.org.cn/index.aspx (No. ChiCTR2000038804, http://www.chictr.org.cn/showproj.aspx?proj=62350; No. ChiCTR2000039462, http://www.chictr.org.cn/showproj.aspx?proj=63353).


Subject(s)
Adult , COVID-19 , COVID-19 Vaccines , Double-Blind Method , Humans , SARS-CoV-2 , Vaccines, Inactivated/adverse effects
9.
Article in Chinese | WPRIM | ID: wpr-908235

ABSTRACT

Objective:To explore the mediating effect of perceived organizational support on the relationship between personality traits and perceived self-efficacy of male nurses.Methods:A total of 766 male nurses from 20 level-A general hospitals in Shandong province were selected by convenience sampling method in December 2020. The general status questionnaire, the simplified version of Big Five Personality Inventory, the Perceived Organizational Support Scale and the General Self-efficacy Scale were used to investigate them.Results:The total score and average item score of 766 male nurses' sense of organizational support was 44.05±9.31, 3.38±0.72, and the total score and average item score of general self-efficacy was 26.19±5.65, 2.62±0.57. In 766 male nurses, perceived organizational support had a partial mediating effect on neuroticism and openness, with effect values of 21.71% and 10.19%, respectively. In addition, perceived organizational support had a complete mediating effect on conscientiousness and self-efficacy.Conclusions:The organizational support and self-efficacy of 766 male nurses were above average, and organizational support played a mediating role in the relationship between neuroticism, openness, conscientiousness and general self-efficacy.Nursing managers should give more organizational support to male nurses to change the influence of neuroticism, responsibility, agreeableness and open personality traits on self-efficacy, so as to improve the level of self-efficacy of male nurses.

10.
Article in Chinese | WPRIM | ID: wpr-907423

ABSTRACT

Colorectal cancer is a malignant tumor occurring in the colon or rectum, which has a high incidence rate. In order to improve the prognosis of colorectal cancer, the pathogenesis of colorectal cancer still needs to be further clarified. Epigenetics can directly affect the progression and metastasis of colorectal cancer, and histone methylation is an important means of histone modification, which can regulate the transcriptional activation and inhibition of downstream genes. A large number of studies have confirmed the effects of histone methylation on the progression of colorectal cancer, and inhibitors of related methylation and demethylation may play a role as potential therapeutic drugs for colorectal cancer. In this article, the colorectal cancer and its related methylation regulation were introduced, the types of histone methylation modifications and their regulation were summarized, and the regulation of histone methyltransferases and demethylases involved in the progression of colorectal cancer was demonstrated. In addition, the potential significance of histone methylation inhibitors for the treatment of colorectal cancer was summarized, and the possibility of related inhibitors as treatment drugs for colorectal cancer was explored.

11.
Article in Chinese | WPRIM | ID: wpr-906082

ABSTRACT

Objective:To investigate the mechanism of Duanteng Yimu decoction (DTYM) in the inhibition of pannus formation in collagen-induced arthritis (CIA) mice. Method:Twenty-four SPF-grade DBA/1 male mice were randomly divided into the following four groups: a blank group (NC group), a model group (CIA group), a methotrexate group (MTX group), and a DTYM group, with six mice in each group. The mice, except for those in the NC group, were modeled. From the second immunization, the medium, MTX (1 mg·kg<sup>-1</sup>), and DTYM (15.4 g·kg<sup>-1</sup>) were administered at an equal volume by gavage for 35 days. Mice were observed for general condition and the arthritis index. The knee and ankle joints were scanned by microcomputed tomography (micro CT). Hematoxylin-eosin (HE) and safranin O/fast green staining were performed to observe pathological changes. Immunohistochemistry was performed to detect the expression of platelet/endothelial cell adhesion molecule-1 (CD31), vascular endothelial growth factor-<italic>α</italic> (VEGF-<italic>α</italic>), vascular endothelial growth factor receptor 2 (VEGFR2), and phosphorylated(p)-VEGFR2. Result:Compared with the NC group, the CIA group showed red and swollen ankle joints, increased arthritis index scores (<italic>P</italic><0.05, <italic>P</italic><0.01), manifest injury in the knee and ankle joints, reduced cartilage thickness, elevated Micro CT bone destruction scores of knee and ankle joints (<italic>P</italic><0.01), and up-regulated absorbance values of synovial CD31, VEGF-<italic>α</italic>, VEGFR2, and p-VEGFR2 (<italic>P</italic><0.01). Compared with the CIA group, the DTYM group showed relieved ankle joint redness and swelling, reduced arthritis index scores of mice three weeks after administration (<italic>P</italic><0.05, <italic>P</italic><0.01), intact joint surfaces of the knee and ankle joints, thickened cartilage, declining Micro CT bone destruction scores in both the knee and ankle joints (<italic>P</italic><0.05, <italic>P</italic><0.01), and lowered absorbance values of CD31, VEGF-<italic>α</italic>, VEGFR2, and p-VEGFR2 in the synovium (<italic>P</italic><0.01). Conclusion:DTYM can inhibit the pannus formation in CIA mice presumedly by regulating the VEGF pathway.

12.
Article in English | WPRIM | ID: wpr-921875

ABSTRACT

Computed tomography (CT) examination is the major measure for detecting and diagnosis of foreign bodies in human body. Although CT has high sensitivity in diagnosis of foreign body, some interference factors may still lead to missed diagnosis or misdiagnosis. Here we report a rare case that a bamboo stick accidentally pierced into the left chest of a young man who was drunk and unware of this hurt. The patient experienced cough, chest pain, fever, hemoptysis, and was misdiagnosed as primary and secondary tuberculosis based on chest CT examinations at a local hospital, although no tubercular bacillus detected by sputum smear. He subsequently received anti-tuberculous treatments in the following three years, but no improvement of his symptoms was observed. Until one month before his death, the bamboo stick was detected by spiral CT examination as well as three-dimensional image reconstruction at another hospital. Postmortem examination revealed pneumonia, pulmonary infarction, and abscess as the causes of his death. We analyze the potential reasons of misdiagnosis in this case, aiming to provide reference for the diagnosis and treatment of pulmonary inflammation associated with foreign body in the future.


Subject(s)
Abscess , Diagnostic Errors , Humans , Male , Pneumonia , Pulmonary Infarction , Tuberculosis, Pulmonary
13.
Article in Chinese | WPRIM | ID: wpr-921647

ABSTRACT

The present study explored the mechanism of action of Gynostemma pentaphyllum in the treatment of metabolism associa-ted fatty liver disease(MAFLD) by network pharmacology and molecular docking. The main active components and action targets of G. pentaphyllum were collected from TCMSP. Disease-related targets were obtained from GeneCards, OMIM and TTD, and the common targets of the three databases were screened out, which were converted to the genes with standard names by UniProt. The drug-disease common target genes were obtained through Venn tool and uploaded to STRING for the construction of the protein-protein interaction(PPI) network. Cytoscape was used to construct and analyze the drug-active component-common target-disease network. The gene ontology(GO) analysis and Kyoto encyclopedia of genes and genomes(KEGG) pathway enrichment analysis were performed on the common targets by DAVID. Pymol was adopted to perform molecular docking of active components and the common targets and predict their binding ability. Twenty-four active components(such as gypenosides, quercetin and sitosterol) of G. pentaphyllum were screened out. Ninety-two targets were obtained and 54 common targets were identified. Key targets included TNF, IL6, PTGS2, TP53, CCL2 and VEGFA. GO analysis on biological processes, molecular functions and cellular components and KEGG pathway analysis were performed, and the results indicated that NF-κB, PI3 K-Akt, TNF and HIF-1 signaling pathways were mainly involved. Molecular docking results showed that gypenosides and quercetin had a strong binding ability to TNF, IL6 and PTGS2. The findings of this study revealed that the therapeutic efficacy of G. pentaphyllum on MAFLD might be achieved by resisting inflammation and oxidative stress and improving insulin resistance, providing ideas and a theoretical basis for the development and application of G. pentaphyllum in the treatment of MAFLD.


Subject(s)
Drugs, Chinese Herbal , Gynostemma , Liver Diseases , Molecular Docking Simulation , Signal Transduction
14.
Article in Chinese | WPRIM | ID: wpr-912034

ABSTRACT

Objective:To evaluate the reliability and validity of the Chinese version of the Orebro musculoskeletal pain questionnaire (OMPQ-CHN) using patients with non-specific lower back pain.Methods:The OMPQ was translated into simplified Chinese according to the Beaton cross-cultural translation guidelines, and then 186 patients with acute or subacute lower back pain were asked to respond to its questions. Based on the results, the internal consistency and test-retest reliability were quantified, and its validity was assessed using content, criterion-related and predictive validity.Results:The Cronbach′s α for the instrument was 0.804. Its ICC was 0.833 (95% CI: 0.683-0.915). I-CVI ranged from 0.86 to 1, S-CVI/Ave=0.99. The correlation between the OMPQ-CHN and other questionnaires ranged from r=0.419 to r=0.646. The AUCs predicting pain, dysfunction and sick leave ranged from 0.723 to 0.810. Conclusions:The OMPQ-CHN has good reliability and validity, and suitably assesses the psychosocial risk factors of Chinese patients with low back pain.

15.
Journal of Medical Postgraduates ; (12): 117-121, 2020.
Article in Chinese | WPRIM | ID: wpr-818386

ABSTRACT

ObjectiveAnimal model is an important means to study the pathogenesis and drug therapy of diabetic nephropathy. In this paper, the techniques of bioinformatics were used to analyze the common susceptibility genes and pathways in the kidneys of three diabetic nephropathy animal models of BKS db/db, BKS eNOS-/db/db and DBA-STZ3, so as to discover new and important genes and pathways, thus providing new ideas for the study of the pathogenesis of diabetic nephropathy.MethodsThe GSE33744 dataset was downloaded from the GEO database, and the differential genes of three animal models of diabetic nephropathy were analyzed by Limma package in R language. The genes differentially expressed in all models were obtained by intersection, and were then analyzed by GO, KEGG and PPI networks and screened for key genes and pathways.Results144 genes were differentially expressed in three animal models of diabetic nephropathy. GO analysis showed that these genes were enriched in the cell membrane and extracellular regions; in biological processes such as innate immune response, oxidation-reduction process and immune system process; and in molecular functions such as oxidoreductase activity, carbohydrate binding and heme binding. KEGG analysis indicated that the differential genes were enriched in signaling pathways such as PPAR signaling pathway, arachidonic acid metabolism, butyric acid metabolism and circadian rhythm. PPI network analysis suggested that Cd68, Ccl6, Fcer1g, Tyrobp, Clec4n, Lyz2, Ms4a6d, Ly86, Ctss, Cfp and Mpeg1 may be the key genes in the development of diabetic nephropathy.ConclusionSome genes and signaling pathways are altered in multiple kidneys of the diabetic animal models, suggesting that these genes and pathways play an important role in the pathogenesis of diabetic nephropathy.

16.
Article in Chinese | WPRIM | ID: wpr-873252

ABSTRACT

Objective::To observe the efficacy of modified Qiju Dihuang pills in protecting renal function of patients with early renal impairment with syndrome of Yin deficiency and Yang hyperactivity caused by hypertension and its effect in resisting inflammation and oxidative stress, and improving endothelial function. Method::Randomly divided into control group (59 cases) and observation group (60 cases) by random number table. Patients in control got valsartan capsules, 80 mg/time, 1 time/day. And patients whose blood pressure can't be controlled were added with nifedipine tablets, 10 mg/time, 1 time/day. In addition to the therapy of control group, patients in observation group were added with modified Qiju Dihuang pills, 1 dose/day. The control group took Qiju Dihuang pills.The courses of treatment were 16 weeks. And levels of cystatin C (CysC), urinary N-acetyl-β-glucosaminidase (NAG), β2 microglobulin (β2-MG), urinary microalbumin to creatinine ratio (UACR) and emodynamics of kidney were detected. Blood pressure, systolic pressure (SBP), diastolic pressure (DBP) and blood pressure renal artery resistance index (RI) and pulsatility index (PI) were recorded, and Yin deficiency and Yang hyperactivity were scored. Levels of nitric oxide (NO), endothelin-1 (ET-1), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), adiponectin (ADPN) and nuclear factor-kappa B (NF-κB) were detected. Result::The total effective rate in observation group was 91.67%(55/60), which was higher than 76.27%(45/59) in control group (χ2=5.255, P<0.05). Levels of SBP and DBP were lower than those in control group (P<0.05). At the 16th week during the treatment, the compliance rate of blood pressure was 90.66%, which was higher than 84.13% in control group (χ2=127.65, P<0.01). And levels of CysC, β2-MG, NAG, UACR, RI, PI, ET-1, SOD, GSH-Px, IL-6, NF-κB and TNF-α were lower than those in control group (P<0.01), while levels of NO, SOD and GSH-Px were higher than those in control group (P<0.01). Conclusion::In addition to the therapy for controlling blood pressure with routine western medicine, modified Qiju Dihuang pills can reduce level of the blood pressure, and control blood pressure with the standard, with anti-inflammatory and anti-oxidative stress effects. It can also improve the vasomotor function and the flow of kidney, protect the kidney function, and reduce the degree of injury, so as to delay the process of kidney damage and improve the prognosis.

17.
Article in Chinese | WPRIM | ID: wpr-872138

ABSTRACT

Objective:To explore the effectiveness of autologous fat grafting in the treatment of undesirable skin expansion.Methods:Patients' data were reviewed from 2011 to 2016, including the expanded regions with early signs of skin complications in face and neck. The effects of fat grafting group and control group were evaluated by follow-up records of expansion volume, skin thickness, skin texture and local capillary reaction.Results:Fat grafting could increase the thickness of expanded skin. It also improved the texture of expanded skin, with 0.83± 0.71 points before treatment and 1.30±0.66 points after treatment ( P=0.04). The local capillary reaction was also improved from 1.06±0.54 points before treatment and 1.45±0.51 points after treatment ( P=0.03). The expansion in the fat grafting group was 2.21±0.57 times before treatment and 2.94±0.83 times after treatment. In the control group, the expansion was 2.19 times when it showed early signs, and no obvious changes were observed during the follow-up period. Conclusions:Autologous fat grafting can effectively treat complications of skin expansion, prolong expansion process and promote tissue regeneration.

18.
Article in Chinese | WPRIM | ID: wpr-871168

ABSTRACT

Objective:To investigate any changes in proprioception or grey matter volume (GMV) after anterior cruciate ligament (ACL) rupture.Methods:Eighteen male patients with right-side ACL rupture (diagnosed through clinical examination and MRI) and healthy right hand function constituted the case group, while another 18 right-handed healthy counterparts were enrolled as the control group. Proprioception, balance and functional performance were assessed for both groups using the anteroposterior shift of the tibia (APST), an active angle reproduction test (AART), a modified star excursion balance test (mSEBT) and single-leg hop distance (SHD). MRI (at 3.0T) was used to collect the brain structure images and SPM8 software was used to perform voxel-based morphometry. Any correlation between changes in function and GMV were analyzed.Results:Significant differences were observed between the two groups in their average APST, AART, SEBT and SHD scores. Compared with the healthy controls, the average volume of grey matter in the cerebelum-crus1-L was significantly larger in the case group, while their Supp_Motor_Area_R, Parietal_Sup_R, Parietal_Inf_R, Caudate_R and ParaHippocampal_R grey matter volumes were significantly smaller. Among the case group, the average volumes of their Supp_Motor_Area_Rs, Parietal_Sup_Rs, Parietal_Inf_Rs, and Caudate_Rs were negatively correlated with their mSEBT scores.Conclusions:The brain′s structure changes after ACL rupture and neuromuscular control becomes impaired. The cortical motor control strategy shifts to subcortical motor control after ACL rupture. The mSEBT can reflect indirectly the changes in brain structure plasticity after ACL rupture.

19.
Chinese Journal of Urology ; (12): 225-226, 2020.
Article in Chinese | WPRIM | ID: wpr-869623

ABSTRACT

Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm. Although this desease may occur in any site of body, the ureter is occasionally involved. Its clinical manifestations and imaging lack specificity. The diagnosis depends on pathological results. The main treatment is surgical resection. Recurrence and metastasis seem to be rare. A rare case of ureteral IMT managed with segmental ureterectomy and ureterostomy under general anesthesia was reported.

20.
Article in Chinese | WPRIM | ID: wpr-865893

ABSTRACT

Objective:To explore the practice of inquiry-group teaching mode based on common cases in cardiology to improve the comprehensive capability of medical students.Method:A total of 85 medical students in clinical probation from September 2016 to June 2018 were selected as subjects. According to different teaching modes, they were divided into the control group ( n=40) and the observation group ( n=45). The control group were educated by traditional teaching on related knowledge of cardiology, while the observation group were given inquiry-group teaching based on cases of coronary heart disease, angina pectoris, hypertension and heart failure. The teaching effect of the two groups were analyzed by t test and chi-square test through SPSS 18.0. Results:The comprehensive application ability marks and total scores in the observation group were significantly higher than those in the control group ( P<0.05). Moreover, in the aspect of teaching mode quantitative score (teaching satisfaction, expanding knowledge, innovation, memory, learning efficiency, access to literature and self-learning skills, communication and presentation skills, etc.), the observation group was significantly better than the control group ( P<0.05). Conclusion:The case-based inquiry-group teaching mode is conducive to improve and cultivate the comprehensive application ability of medical students. It can be used as a good additive in traditional teaching mode.

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