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1.
Article | IMSEAR | ID: sea-208085

ABSTRACT

Background: Perinatal asphyxia may be caused by perinatal anemia. The pathophysiology and neurodevelopment effects are theoretically different from other causes of fetal asphyxia. Severe asphyxia can occur in infants around the time of birth by various reasons. The aim of this study to find the relationship between cord blood hemoglobin and perinatal asphyxia.Methods: This was a retrospective comparative study in department of OBG In tertiary care health centre. Umbilical cord blood samples were collected from 100 newborns with asphyxia at birth as study group and 100 newborns with non asphyxia as control group. Hemoglobin was measured colorimetrically.Results: This study finds that maximum number of patients in both the control and study group had hemoglobin in the range of 16.3-17.3 gm/dl. The difference was not statistically significant. P value>0.05.Conclusions: Hematological changes observed early after delivery can determine the duration of hypoxemia (acute versus chronic) Perinatal anemia causing moderate to severe perinatal asphyxia is associated with a higher risk for neonatal mortality. All survivors with perinatal anemia, however, showed no abnormalities in neurodevelopment in contrast to children who were born asphyxiated due to various another causes. The underlying pathophysiological mechanism for the favorable NDO in the perinatal anemia group needs further elucidation.

2.
Article | IMSEAR | ID: sea-212578

ABSTRACT

Background: Urinary tract infections (UTIs) are one of the most common infections. For treatment of UTIs, there are limited antibiotics due to increased resistance among uropathogens. Two older antibiotics; Nitrofurantoin and Fosfomycin have become novel oral therapeutic options against uropathogens. Aim of the study was to identify UTI causing micro-organisms and evaluate in-vitro activity of nitrofurantoin and fosfomycin against most common isolated organism (E. coli).Methods: Results of urine samples culture and susceptibility testing over a period of 1 year were analysed and included in this study.Results: Micro-organisms were isolated from 568 urine samples. Most commonly isolated organism was Escherichia coli (40.50%), followed by Klebsiella spp. (20.07%) and Staphylococcus spp. (17.07%). Susceptibility of E. coli to nitrofurantoin and fosfomycin was 91.74% and 65.65% respectively. Conclusion: Good activity of nitrofurantoin and fosfomycin against E. coli indicates that these two drugs are potential therapeutic alternatives for urinary tract infections.

3.
Article | IMSEAR | ID: sea-212567

ABSTRACT

Background: Neglected traumatic dislocation of the hip is extremely rare in children, and the preferred treatment remains unclear. In this study we studied the role of open reduction in neglected traumatic hip dislocation in children and adolescents as a modality of treatment.Methods: Eight patients with a neglected, traumatic dislocation of the hip received in the emergency department of GMC, Jammu were managed by open reduction. Types of dislocations, associated lesions, treatment methods, complications, and clinical and radiological outcomes were reviewed in the study.Results: All patients presented with limp and pain. Six patients had minimal difficulty in squatting while two had marked difficulty. Leg lengths were within 2 cm in 7 of 8 cases at follow-up, and only 1 patient had a discrepancy greater than 2 cm.Conclusions: Open reduction is a satisfactory treatment for neglected hip dislocation. It restores joint stability, range of motion and limb length.

4.
Article | IMSEAR | ID: sea-215044

ABSTRACT

Colovesical fistula (CVF) is an abnormal communication between the urinary bladder and the large intestine, usually sigmoid colon. Diverticulitis is the most common cause of CVF in most of the western studies, accounting for approximately 70% of cases. Diverticular CVF is uncommon in Asia. This case series shares the experience of six cases of diverticular CVF in Indian population. METHODSMedical records of six patients with diverticular colovesical fistulas during the period January 2016 - August 2019 were reviewed with regard to symptoms, diagnostic investigations, and management. Various aspects of the disease were analysed to determine the common features of colovesical fistula in our population. RESULTSAll patients with diverticular colovesical fistula were presented with urinary symptoms and none were aware about their existing colonic diverticulosis. Five out of the six cases presented with pneumaturia. Contrast enhanced computed tomography (CECT) abdomen detected sigmoid diverticulosis with vesical fistula in all cases. The most common site of fistula found on cystoscopy was on the left superolateral wall of bladder. All cases were operated as a single stage procedure including fistula repair, colonic resection, omental interposition with no temporary colostomy which provided an excellent surgical cure. CONCLUSIONSColovesical fistula secondary to diverticular disease has shown a rising incidence and can be effectively managed by a multidisciplinary team. It requires prompt diagnosis, adequate preoperative evaluation, perioperative care including bowel preparation, nutritional supplementation, appropriate antibiotics, and meticulous surgical skills allowing an elective one-stage approach.

5.
Article | IMSEAR | ID: sea-214953

ABSTRACT

Ureteric calculi are known to affect approximately 10 – 15% of the overall population. We wanted to determine as to whether silodosin can be used instead of DJ stenting in patients with uncomplicated ureteroscopic lithotripsy.METHODSWe selected 60 patients who underwent ureteroscopic lithotripsy (URSL) in the study group. They were divided into ‘stented group’ and ‘non-stented group on silodosin’. Patients with stone of 5 to 18 mm size with no intraoperative mucosal injury and no stricture were included in the study. All patients underwent surgery using an 8/9.8 Fr rigid ureteroscope, without ureteral dilation, with lithotripsy using an electro-hydraulic lithotripter, without extraction. A 4.5 Fr Double J stent was placed in the first group for three to four weeks. The patients underwent urine routine examination, plain x-ray KUB, and ultrasound abdomen before and after lithotripsy. Lower urinary tract symptoms and pain scores were recorded on 3, 7 and 15 days postoperatively. We compared mean operative time, emergency visits, rehospitalisation rates, and residual fragments between each group.RESULTSOut of 60 patients, 53.3% of patients had lower ureteric calculus, 30% had mid ureteric, and 16.7% had calculus at vesicoureteric junction. The mean calculus size on the left side was 10.23 mm, and on the right side was 10.33 mm. The mean intraoperative time was 33.23 minutes in stented and 29.9 minutes in the silodosin group (p< 0.003). Patients underwent assessment for flank pain, fever, and LUTS on postoperative days (POD) 3, 7 and 15. There was no statistically significant difference between the two groups though patients with DJ stent had more symptoms on inquiry. A total of 5 patients in the treatment groups were re-hospitalised, two patients (6.7%) in the stented group, and three patients (10%) in the silodosin group, out of which three patients (5%) required a secondary procedure which was not statistically significant. Three subjects treated with silodosin and 12 with the DJ stent in situ had residual fragments on POD 21 which was statistically significant (p 0.27).CONCLUSIONSPatients with uncomplicated URSL have similar recovery of renal function when treated with silodosin as compared to the placement of DJ stent. Treatment without stent with silodosin also has less irritative LUTS. We conclude that silodosin can be an alternative to DJ stent after uncomplicated ureteroscopic electrohydraulic lithotripsy, thereby reducing operative time and patient morbidity.

6.
Article | IMSEAR | ID: sea-212141

ABSTRACT

The background of this study is FGFR1 belongs to a family of four, high-affinity receptor tyrosine kinase and is a legitimate oncogene associated with uterine, cervical, prostate, bladder, colorectal and lung cancers. It is rarely concomitant in myeloid and lymphoid neoplasms but has an aggressive clinical course with a high mortality rate when present. Cytogenetic abnormalities involving the FGFR1 gene is most frequently observed in AML, MPN with eosinophilia, T-ALL and T-LBL with ZMYM2 gene being the most common fusion partner. Methods of this study was to authors report a series of 4 cases with FGFR1 rearrangements. Results is three patients presented as T-cell Lymphoblastic lymphoma (T-LBL) and one as mixed phenotype acute leukemia (MPAL). The T-LBL cases harboured the FGFR1/ ZMYM2 fusion and the MPAL case harbored the CNTRL/FGFR1 fusion as identified by conventional cytogenetics and confirmed by molecular studies. Conclusion is authors herewith describe the clinical, biochemical, molecular and cytogenetic features observed in these cases.

7.
Article | IMSEAR | ID: sea-207553

ABSTRACT

Obstucted hemivagina with ipsilateral renal anomaly (OHVIRA) syndrome or Herlyn-Werner-Wunderlich syndrome (HWW) is a rare congenital anomaly consist of uterus didelphys, obstructed hemivagina, and ipsilateral renal agenesis. We are reporting an adolescent girl with orofacial defect who presented with lower abdominal pain. She attained menarche 3 months earlier and had a regular menstrual cycle with cyclical abdominal pain. On abdominal examination a firm, mobile tender mass extending from left iliac fossa up to umbilicus (24 weeks size) was found.  Lower border of mass could not be approached. Further evaluation with ultrasound showed enlarged uterus with collection with internal echoes and non-visualization of the left kidney. CECT showed absent left kidney and didelphys uterus with large left hematocolpometra with left complex adenexal cyst. Patient was posted for hematocolpos drainage and vaginoplasty. An unusual presentation of regular menstruation and nonspecific abdominal pain delays the diagnosis, which can lead to severe complications such as endometriosis and infertility.

8.
Article | IMSEAR | ID: sea-202844

ABSTRACT

Introduction: Malnutrition is common in patients withEnd Stage Renal Disease (ESRD) on Hemodialysis (HD).Depending on the parameter measured, the prevalence ofmalnutrition in the chronic dialysis population ranges from 10to 54%. It is related with the secretion of a number of proteins(adipokines), including leptin and adiponectin and alsocytokines such as IL-6. This study was planned with the aimof reviewing the association of nutritional status with serumleptin and CRP levels in hemodialysis patients.Material and methods: The present study was conducted inthe department of Medicine at Chattrapati Shivaji SubhartiHospital from August 2017 to March 2019; consisted of50 patients of End stage Renal Disease on maintenancehemodialysis admitted in Chattrapati Shivaji Subharti Hospitalduring the time period.Results: Out of the 50 subjects, 35 (70%) were male and15 (30%) were females. The Lean Body Mass (%) in thestudy subjects was 59.76±5.92. The overall mean leptinlevel distribution among the subjects was 1.51±0.36. Theoverall mean CRP level distribution among the subjects. was3.75±0.47. A positive correlation was found between CRPand BMI with statistical significance as p<0.05 (table 11).Similarly a highly positive correlation was found betweenLeptin and BMI as p<0.01.Conclusion: Our study point to possible use of serum leptinand CRP concentration as an indicator of nutritional status inHD patients based on observed significant positive correlationbetween serum leptin and CRP concentrations with BMIvalues.

9.
Article | IMSEAR | ID: sea-201942

ABSTRACT

Background: Smoking is practiced by a third of world’s population. Tobacco is leading cause of deaths world over. Six million people (1/8 second) die from tobacco each year. Objective of this study was to study demographic profile and awareness regarding tobacco smoking among people of Rohilkhand, Bareilly.Methods: Randomly selected individuals of Rohilkhand region. Questionnaire method involved.Results: Among 1040 sample size, 70% were males with mean age of 37.68 years. 73.94% population belonged to upper lower socio-economic class. 52% (62.9% male and 26.6% females) were current smokers of which 60.6% were exclusive beedi smokers. 50% were unaware of oral and lung cancer due to smoking. 34% were unaware about effects of passive smoking. 48.48% smokers report cough with expectoration as commonest symptom. 60% finds peer group influential for the behavior. 76.9% smokers are willing to quit smoking. 63.4% are open for counseling. 26% were unaware of ban/law related to smoking in public places. 68% believe there is increasing trend in prevalence of its use, among minors, educational institutes and hospitals.Conclusions: Despite high awareness of ill effects of smoking, there is an increasing trend in prevalence of smoking with an increased involvement of minors attributed to peer pressure. People are unaware of passive smoking and its harmful effect on body. Moreover, advertisements, visuals and captions have failed in making an impact. There occurs a need of awareness programmes, intervention sessions, medical therapy and strict anti-smoking laws by the government, social welfare and healthcare volunteers to help people quit and control the menace in society.

10.
J Genet ; 2020 Feb; 99: 1-10
Article | IMSEAR | ID: sea-215549

ABSTRACT

The aim of this study was to identify the single-nucleotide polymorphisms (SNPs) in bovine candidate genes CLEC7A, CD209 and TLR4, and explore the association between these SNPs with the occurrence of bovine paratuberculosis (PTB) disease. For this purpose, 549 animals were screened by a panel of four diagnostic tests, namely Johnin PPD test, ELISA test, faecal microscopy and IS900 blood PCR against Mycobacterium avium ssp. paratuberculosis (MAP) to develop case–control populations. SNPs were genotyped by polymerase chain reaction-restriction fragment length polymorphism method. Genotypic–phenotypic associations were assessed by the PROCLOGISTIC procedure of SAS 9.3. Of the seven SNPs; rs110353594 in CLEC7A gene and rs8193046 in TLR4 gene were found to be associated with PTB. For SNP rs110353594, odds of CC and CT genotypes vs TT genotype was 1.543 (0.420–5.667; 95% CI) and 0.284 (0.104–0.774; 95% CI), respectively which means that CT genotype was more resistant than TT and CC genotypes against bovine PTB. For SNP rs8193046, odds of AA and AG genotypes versus GG genotype was 0.947 (0.296–3.034; 95% CI) and 3.947 (1.555–10.022; 95% CI), respectively, i.e. probability for getting an infection in animals with AG genotype was 3.94 times more as compared to GG genotype. Hence, a selection programme favouring CT genotype for rs110353594 and against AG genotype for rs8193046 may be beneficial for conferring resistance against bovine PTB

11.
Article | IMSEAR | ID: sea-212027

ABSTRACT

Background: Interstitial Lung Diseases is a group of disorders where the pulmonary interstitium, alveolar structures and the small airways are affected. Identification of a specific pattern on HRCT, with a thorough clinical evaluation can help a physician in narrowing down the differential diagnosis for the underlying cause. Usual Interstitial Pneumonia (UIP) is a frequently identified pattern. Differentiating patients with definite UIP pattern, into IPF and non-IPF spectrums is important. Aim of this study is to compare UIP patients with a secondary cause vs Idiopathic Pulmonary Fibrosis.Methods: Statistically 33 patients having UIP pattern on HRCT were evaluated based on the history of extrapulmonary symptoms, environmental exposure, drugs and subsequent serology testing. Patients were divided into two groups - IPF and UIP with a secondary cause. Both groups were compared on various clinical parameters. Inferences were drawn from the same.Results: Total 66.6% patients were identified to have Idiopathic Pulmonary Fibrosis, 33.3% had UIP with a secondary cause. Majority of patients with a secondary cause had Connective Tissue Disorder (90.9%) and one patient of Chronic Hypersensitivity Pneumonitis (HP).Conclusions: Absence of extrapulmonary symptoms in UIP patients need no further investigations and can be diagnosed as a case of IPF. However, presence of extrapulmonary symptoms needs further evaluation to diagnose the underlying disease and start treatment for the same.

12.
Article | IMSEAR | ID: sea-202782

ABSTRACT

Introduction: TB is an infectious disease caused by thebacillus Mycobacterium tuberculosis which typically affectsthe lungs. The disease is spread by the people who are sick withactive pulmonary TB. Up to half of TB survivors have someform of persistent pulmonary symptom despite microbiologiccure. The aim of the study was to assess the symptomatic posttuberculosis patients by using spirometry and chest x ray.Material and methods: The study was conducted in theDepartment of Respiratory Medicine, Rohilkhand MedicalCollege and Hospital after seeking clearance from theInstitutional Ethical Committee. The aim of the study was toassess the symptomatic post tuberculosis patients by usingspirometry and chest x ray. The study duration was from 1stNovember 2018 to 31st October 2019 and 100 patients wereenrolled in the study. Data was collected from patients whopresented with symptoms within 6 months of completing theirtreatment for tuberculosis.Results: All the patients (post tubercular) enrolled in thestudy had symptoms (in some form) even after full courseof antitubercular treatment and bacteriological cure andamong these breathlessness was the most common presentingsymptom (96%) followed by cough (58%). Maximum patientshad abnormal findings on chest examination (80%). Fibrosisfollowed by cavitary lesions were the most common findingson chest x ray in post tuberculosis patients. Maximum patientshad restriction (56%) in their spirometry followed by mixedpattern (23%).Conclusion: In patients with restriction on spirometry andhaving symptom of breathlessness and cough, reassurance andpulmonary rehabilitation may play a major role in relievingtheir symptoms whereas in patients with mixed or obstructivepattern on spirometry, bronchodilator therapy along withpulmonary rehabilitation may be helpful in relieving theirsymptoms post tuberculosis treatment.

13.
Article | IMSEAR | ID: sea-202780

ABSTRACT

Introduction: Upper and lower respiratory diseases are closelyrelated which has been well documented in literature. Eventhough a relationship between upper and lower airway diseasehas been described, altered pulmonary function in patientswith upper airway diseases is still not fully understood. Thepresent study was conducted to assess the effect of chronicnasal obstruction on pulmonary function and to compare thepulmonary function in same patients after surgical relief ofnasal obstruction.Material and methods: The present study was carried outin the Department of ENT and Head and Neck Surgery andDepartment of Respiratory Medicine, Rohilkhand MedicalCollege and Hospital, Bareilly between November 2017to October 2018. 56 patients with chronic nasal obstructiondue to either deviated nasal septum or chronic rhinosinusitiswith or without nasal polyp underwent pulmonary functiontesting pre and post-operatively at 6 weeks and results werecompared.Results: The most common age group affected was less thanthirty years accounting for more than 50%. Mean age of totalsample size was 24.2 ± 6.98 years. Thirty three (58.9%) patientswere males while 23(41.07%) patients were females. Out of56 subjects, 34(60.71%) patients underwent septoplasty, while22(39.28%) patients underwent functional endoscopic sinussurgery. Clinically and statistically significant improvement inFEV1 and FVC was observed irrespective of age, gender orduration of obstruction.Conclusion: Patients with bilateral nasal obstruction hadworse pulmonary function initially and more significantimprovement after surgery, suggesting an association ofbilateral obstruction with bad prognosis.

14.
Autops. Case Rep ; 10(4): e2020189, 2020. graf
Article in English | LILACS | ID: biblio-1131847

ABSTRACT

Soft tissue tumors are not uncommon in childhood and comprise entities that range from common to very rare malignancies. Infantile fibrosarcoma (IFS) is a rare pediatric malignancy mainly seen in the first two years of life. The data about the incidence of infantile fibrosarcoma occurring in the neck in the Indian subcontinent is scarce. To the best of our knowledge, only one case of infant cervical IFS has been reported previously in the Indian subcontinent. We present another case of an eight-year-old male patient with a rapidly growing mass on the left side of the neck. He was successfully treated with a combined modality of surgery and chemotherapy with a good outcome. Among the soft tissue tumors of childhood, IFS is a rare entity. It has a good prognosis and lesser chance of distant metastasis as compared to adult fibrosarcoma. Though surgical excision is the mainstay of treatment, chemotherapy also has a significant role in the treatment of primary tumor and metastasis. We discuss the stated case to bring to the notice this uncommon cause, which can be considered as a differential diagnosis of upper cervical swellings. A better understanding of this entity would help in early diagnosis and aggressive treatment, reducing the overall morbidity and mortality.


Subject(s)
Humans , Male , Child , Rhabdomyosarcoma , Fibrosarcoma/pathology , Head and Neck Neoplasms , Soft Tissue Neoplasms/pathology , Diagnosis, Differential
15.
Article | IMSEAR | ID: sea-202692

ABSTRACT

Introduction: Iron and vitamin D are two essential nutrientswhich constitute an important worldwide health issue dueto their significant roles in biochemistry. The present studywas conducted to assess the prevalence and risk of anemiain a population of subjects with documented D25 deficiencycompared with those with normal D25 levels.Material and Methods: The present case control study wasconducted among 100 subjects (50 were cases and 50 werecontrols) in the department of Medicine at Chattrapati ShivajiSubharti Hospital. Total serum 25(OH)D concentrationwas analyzed using commercially available ELISA kits.According to the manufacturer’s instructions, concentrationsof 25(OH)D below 25 nmol/L were classified as a deficiency,and values of 25–75 nmol/L were considered a vitamin Dinsufficiency. Difference between two groups was determinedusing chi square test and student T test for categorical data andcontinuous data respectively. P-value of <0.05 was consideredas significant.Results: Hb<13 was found in 75% of the case group (male)and 25% of the control group (male). Hb<12 was found in64.29% of the case group (female) and 45.45% of the controlgroup (female). Mean iron (μg/dl) among the male and femalecase group was less as compared to the control group withstatistically significant difference as p<0.05.Conclusions: The results of the present study showed thatVitamin D metabolism is dependent on iron and its deficiencymight disturb Vitamin D activation

16.
Article | IMSEAR | ID: sea-202680

ABSTRACT

Introduction: Multiple integrated steps are required fornormal development of the female genital tract. A wide varietyof malformations can occur when this system is disruptedeither in form of non- development or defective fusion orfailure of resorption. The purpose of this study was to reviewthe spectrum of symptoms with which mullerian anomaliespresent so that timely intervention could be done to savesexual and reproductive life.Material and methods: The study was done in the departmentof Obstetrics and Gynaecology of a tertiary care teachinghospital in Bihar. Only the admitted cases i.e,those whorequired surgical correction were taken into study.Results: Majority of patients presented with severeabdominal pain(71.4%) followed by menstrual problems(46.4%), and urinary symptoms (35.7%) including vvf. 25%patients reported subfertility, 14.2% abdominal lump and14.2% dyspareunia, 10.7%PID and 10.7% rectal pressuresymptoms.Majority had transverse vaginal septum (28.5%),followed byMRKHS and OHVIRA syndrome (14.2% each),Conclusion: The variety of ways with which mullerian ductanomalies present hints that clinical suspicion should be thereif early diagnosis is not to be missed.

17.
Article | IMSEAR | ID: sea-202673

ABSTRACT

Introduction: Surgical removal of the impacted mandibularthird molar is one of the most frequently performed surgicalprocedures in oral and maxillofacial surgery. The purpose ofthis study was to compare the primary and secondary woundclosure after surgical removal of impacted mandibular thirdmolars by evaluating the extent of facial swelling, the severityof pain and degree of trismus.Material and Methods: A prospective, randomized,clinical trial was conducted in 80 patients. The patients wererandomly divided into two groups of 40 each. In Group 1:patients underwent primary closure of the wound and inGroup 2: patients underwent secondary closure of the wound.Postoperative pain, swelling, and trismus were evaluated onthe 2nd and 7th day postoperatively.Results: Statistically significant difference was observed forfacial swelling and trismus on 2nd postoperative days betweenboth groups. Postoperative pain was less in the secondaryclosure group.Conclusion: From the outcome of the above study we canconclude that the secondary wound closure technique has asignificant advantage over primary wound closure concerningswelling and trismus.

18.
Article | IMSEAR | ID: sea-194433

ABSTRACT

Celiac disease is a common malabsorptive disorder in the Indian subcontinent and autoimmune dysfunction of thyroid and pancreas is frequently encountered along with. Chronic Calcific pancreatitis is a unique entity commonly seen in alcoholics but very rare in a patient of celiac disease. This case report includes the interesting constellation of calcific pancreatitis with celiac disease in a young adult male patient known case of insulin dependent diabetes and hypothyroidism. We believe it to be the only case report from north India. A 32 year old Indian male patient known case of Diabetes and hypothyroidism presented with features of malabsorption and was diagnosed with Celiac disease and calcific pancreatitis on imaging. The symptoms and insulin requirement also improved with the treatment of Celiac disease. Although a common involvement of pancreas in celiac disease, calcific pancreatitis is a rare finding and improvement of both the insulin requirement and malabsorptive symptoms with the treatment of celiac disease and pancreatitis vice-a-versa.

19.
Article | IMSEAR | ID: sea-190066

ABSTRACT

Acetohydroxamic acid is a pharmaceutically active metal chelating agent which has various applications in the field of medicine. Current study focuses on the enzymatic synthesis of acetohydroxamic acid catalysed by thermophilic amidase from Bacillus smithii IIIMB2907. Bacterial cells were grown in 7 L fermenter for amidase production and effect of pH, temperature and substrate concentration for the biotransformation of acetamide to acetohydroxamic acid was studied. Batch reaction was also successfully optimized at bench scale with the recovery of ≈ 81% acetohydroxamic acid (purified).

20.
Article | IMSEAR | ID: sea-211663

ABSTRACT

Background: Infantile hemangiomas are the most common benign soft tissue tumor of infancy and childhood occurring 4-10% of all infants. It is more frequent in premature children (23% of infants <1200g) and females (3:1 to 5:1). For many hemangiomas treatment is not required, however hemangioma in some locations need treatment to prevent complication. The Present study was done with an Aim to assess the efficacy and safety of oral Propranolol in management of infantile heamangioma in our set-up.Methods: This study was conducted from May 2016 to Nov 2017 at Department of Surgery and Pediatrics, M.L.B. Medical College, Jhansi after obtaining Ethical permission. Patients having confirmed were recruited & admitted for initiation of Oral Propranolol therapy for 5 days under the observation of Paediatrician. Oral Propranolol treatment was continued till the age of 11/2 years. A clinical assessment was made at each visit to the Outpatients Clinic every four weeks.Results: The incidences of infantile hemangioma were more in age group (0-7 months) i.e 55% (22 patients) followed by age group of (8-15 days) i.e. 30% (12 patients). As age advances presentation gradually decreases as after 30 days incidence is only 5%. Infantile hemangioma were more common in females’ patients (55% patients) & mostly 90% (36 patients) present as single lesion and only 10% (4 patients) present as multiple lesions. Most of hemangiomas presented as reddish in color 80% (32 patients) which reflected lesions are mostly superficial & only 10% were brownish red and 10% skin color indicated incidence of deeper penetration.Conclusion: Authors found that drug (Propranolol) to be effective even at low dose of 1mg/kg/day. In our study group it was effective and safe in almost all patients.

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