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1.
Article | IMSEAR | ID: sea-210276

ABSTRACT

Background:Cartilage oligomeric matrix protein (COMP), is an extracellular matrix (ECM) non-collagenous glycoprotein that is mainly localized within the cartilage, and also be found in tendon and synovium.RecentstudiesinwestandAsiaPacificregionhasshownthatCOMP, is a prognostic marker in Rheumatoid arthritis(RA).Objective:To correlate serum COMP levels with disease severity and cartilage destruction in rheumatoid arthritis.Methods:The study was conducted in Department of Pathology and Rheumatology, Ziauddin University Hospital, Karachi from June 2018 to May 2019. Patients were recruited as per American College of Rheumatology (ACR) 2010 classification criteria. The study populationconsists of 88 healthy subjects and 88 RA patients. Sandwich ELISA technique was used to assess serum COMP level. Other inflammatory markers such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) antibodies like rheumatoid factor, and anti-cyclic citrullinated protein (anti-CCP) were also assessed. Results were analyzed using SPSS-20 and P-value ≤0.05 was considered as significant.Results: Serum COMP levels were significantly higher in RA patients 51.35ng/ml than controls 21.454ng/ml with significant p value=<0.0001. There was strong positive correlation between COMP level and disease severity in RA patients with moderate as well as high disease activity score (DAS) with significant p value. Serum COMP showed 96% sensitivity and 83% specificity at level of 27.01ng/ml for diagnosis of RA.Conclusions:COMP has significant positive correlation with severity of RA. Serum COMP can be utilized as a biomarker to quantify cartilage destruction in RA patients

2.
Article | IMSEAR | ID: sea-212476

ABSTRACT

Background: With the introduction of cytospin, the sensitivity of diagnosing malignancies has increased mainly due to the increase in cellular yield. Cell block also gives the advantage of ancillary testing and allows for retrospective studies. Immunocytochemical markers are used to differentiate and subtype various malignancies in body effusions.Aim of the study was to compare the morphological features of both technique and to assess the diagnostic utility of cell block methods in the cytodiagnosis of pleural effusions.Methods: This was a Prospective observational comparative study of two cytopreparatory techniques. All samples were examined and processed by cytospin and cell block techniques. Continuous data were expressed as Mean±SD (standard deviation) while categorical data were expressed in number, percentage and compared by chi-square (χ2) test.Results: The final diagnosis of both cytospin (147 cases) and cell block (150 cases) techniques was divided into four broad categories: Inadequate, Benign, Suspicious and Malignant. The significant diagnostic cytospin (AUC=0.857, p<0.001) in discriminating positive and negative malignant cases with 75.00% sensitivity (95% CI=53.3-90.2) and 100.00% specificity (95% CI=86.7-100.0) and with 100.0% positive predictive value and 81.2% negative predictive value. In contrast, cell block also showed significant diagnostic but with higher accuracy (AUC=1.000, p<0.001) and sensitivity 100.00% (95% CI=86.7-100.0) and specificity 100.00% (95% CI=86.7-100.0) and 100.0% positive predictive value and 100.0% negative predictive value than cytospin technique.Conclusions: Cell block as a technique should be used in routine practice as it not only increases the diagnostic yield but ancillary test can also be done.

3.
Article | IMSEAR | ID: sea-202983

ABSTRACT

Introduction: Floating knee, referred to as ipsilateralfractures of the femur and tibia, is usually associated withseveral complications and mortality. This study was designedto present our experience with treatment of this injury.Demographic parameters like age, sex, mechanism of injury,associated injuries, method and results of treatment, andcomplications of floating knee are discussedMaterial and Methods: This Prospective study wasperformed between January 2014-July 2016. All patientswith floating knee injuries who were admitted to the PMCHfulfilling the inclusion and exclusion criteria were included.The information about the 20 cases of floating knee injurieswere gathered, particularly the demographic parameters, modeof injury, bones involved, condition of skin, other associatedinjuries and their neurovascular status. The patients werefollowed for a minimum of one year duration and functionaloutcome was assessed.Result: Most of the patients were between 21-30years of age(45%). The floating knee injuries were more common in males(85%). FraserType I fracture was observed in 70% of cases.Roadtraffic accidents(RTA) was the most common cause ofsuch injuries. 18 out of 20(90%) cases were having associatedinjuries while only 10%were cases of isolated floating knee.The most common early and late complications were infectionand knee stiffness respectively. The final outcome as perKarlstrom criteria was excellent and good in 11 out of 14 casesof Fraser type I fracture and in 3 out of 6 cases of Fraser type IIfracture, and this was statistically significant (P=0.05).Conclusion: This study revealed that the complication rateassociated with floating knee injuries remain high and theprognosis mostly depends on type of injury and associatedinjuries. This study also advocates early aggressive approachfor management of these injuries.

4.
Article | IMSEAR | ID: sea-209658

ABSTRACT

Introduction:Chronic nonhealing ulcers, with varied etio-pathologies, are difficult to manage and warrant meticulous, early and prolonged directed treatment to prevent their development and complications.Methods:Patients of chronic ulcers (>3 months’ duration), having undergone surgical management at our Institute, VCSGGMS&RI-UT, between January 2018 –August 2019, numbering one hundred twenty five (N= 125), were included in this concurrent observational study, aimed at identifying implicated microrganism(s) and their antibiotic susceptibility, for promoting wound healing, along with surgical measures Results:Male patients (M:F :: 87:38; 69.6% males) in the “20-50 year” age-group (74; 59.2%), with diabetic ulcers (35;28.0%), burns etc. (21;16.8%) and traumatic ulcers (18;14.4%) etc. predominated in the chronic non-healing state. Gram positive (68; 54.4%) organisms (including Staphylococcus) were the major isolates from the ulcers; organisms showing higher sensitivity to the newer generations/groups of antibiotics. Uncontrolled Diabetes, other prolonged illnesses &/or under-nutrition were important causative factors, requiring their remediations and also debridements ± skin/flap coverage (45; 36.0%) with prolonged course of antibiotics and occasional amputations (18; 14.4%) for adequate treatment.Conclusion:Skilled intensive multidisciplinary effort is essential to achieve satisfactory healing and prevent disfigurement and to limit disability and death (11; 8.8%) among the patients.

5.
Article | IMSEAR | ID: sea-202896

ABSTRACT

Introduction Dental erosion is defined as a non-carious lesionhaving superficial tooth loss initiated by a chemical processeither intrinsic or extrinsic, without involvement of bacteria.The incentive of this study was to assess and compare dentalerosion associated with the intake of carbonated drinks amongdental students; day scholars and hostel residents of theUniversity College of dentistry, Lahore.Materials and Methods: A cross-sectional descriptive studywas carried out on 183 dental students. Dental erosion wasestimated using the index of Basic Erosive Wear Examination(BEWE).Results: 31.6% hostel residents and 11.2% day scholarsconsumed carbonated drinks multiple times daily. Highererosion index values were seen in hostel residents than dayscholars. 48.6% was the prevalence of dental erosion amongthe study participants.Conclusion: Hostel residents consume more carbonateddrinks than day scholars. Erosion of teeth by carbonated drinksis influenced by the frequency, quantity, type, carbonateddrinks temperature and persons drinking habits.

6.
Article | IMSEAR | ID: sea-203590

ABSTRACT

Background: This study was conducted to observe thehistological Effects of Radiations and Combined Effect of 2gmobile Phone Radiations with Turmeric (curcuma longa) ongerm cells of Testis in Albino Rats.Subject and Methods: The study was conducted on 32 malealbino rats. They were divided into four groups A, B, C, D.Group A was control group. Group B was exposed to radiationsfrom cell phone (2G mobile 900-1900 Mhz). Group C wasgiven curcuma longa orally and group D was exposed to bothradiations and curcuma longa given orally.Results: After given two month of mobile phone radiation theanimals were sacrificed by cervical dislocation method andtestis were used for observation of germ cells. the regularly cellphone radiation exposure on testis decrease the number ofgerm cells.Conclusion: The regularly exposure of radiation leads todecrease the number of germ cells, the harmful effect could bedecrease by cucuma longa.

7.
Article | IMSEAR | ID: sea-211873

ABSTRACT

Background: Chronic obstructive pulmonary disease (COPD) is a common preventable and treatable disease that is characterised by persistent respiratory symptoms and airflow limitation. COPD is characterised by an intense inflammatory process in the airways, parenchyma, and pulmonary vasculature. It is possible in some cases that the inflammatory process may overflow into the systemic circulation, promoting a generalised inflammatory reaction. Patient with COPD often have concomitant chronic illness (co-morbidities). The aim of this study is to know the pattern of co-morbidities in COPD patients.Methods: This study was a cross sectional observational study conducted on 172 COPD patients (IPD and OPD) diagnosed on the basis of GOLD guideline 2017. Co morbidities were diagnosed as per standard defined criteria laid down in the respective guidelines.Results: 55.3% of the patients with COPD had co morbidities. 18/88(20.5%) patients presented with multiple co-morbidities. 49/88, 55.7% COPD patients were affected with cardiac (either only cardiac or had multiple organs affected besides cardiac), the commonest co-morbidity. Amongst cardiac, hypertension and congestive heart failure (CHF) was the commonest (n=19/49, 38.8% each) followed by CAD/CSA/IWMI/IHD/AF. Others were metabolic (n=14/88, 15.9%), GERD (n=13/88, 14.8%), Depression (n=11/88, 12.5%). Less prevalent co-morbidities were Osteoporosis (n=8/88, 9.1%), Lung cancer (n=6/88, 6.8%), Bronchiectasis (n=5/88, 5.6%) and OSA (n=3/88, 3.4%).Conclusions: Urban indwelling, advancing age and duration of illness, presentation with low mood, loss of pleasure/ interest, appetite disturbances and heart burn with relief on taking proton pump inhibitor can be predictors of co-morbidities in COPD patients. Chance of finding co-morbidities may be multifactorial. Thus, it is important to look out for co morbidities in each and every COPD patients.

8.
Article | IMSEAR | ID: sea-189119

ABSTRACT

Background: Endodontically treated teeth are widely considered to be more susceptible to fracture than vital teeth. To reinforce the instrumented teeth against fracture; sealers are used in conjugation with a core filling material. Methods: The 120 prepared teeth were randomly divided into four experimental groups and two control group of 20 teeth each. One control group of 20 teeth where access opened and left unistrumented and unobturated. Group- I: Teeth obturated with gutta percha and epoxy resin based sealer. Group- II: Teeth obturated with polymer based core and methacrylate based Sealer. Group- III: Teeth obturated with gutta percha and calcium silicate based sealer. Group IV: Teeth obturated with gutta percha and zinc oxide eugenol based sealer. Group V: Teeth instrumented and obturated with gutta percha without use of sealer (Positive control). Group VI – Teeth with no instrumentation or obturation (Negative control). Results: The mean fracture resistance values (in N) are Group I i.e. Epoxy resin root canal sealer – 286.06 N, Group II i.e. Methacrylate resin root canal sealer - 328.77N, Group III i.e. Calcium silicate based root canal sealer - 265.05N, Group IV i.e. Zinc oxide eugenol based root canal sealer - 269.85N, Group V i.e. Positive control (Obturated without root canal sealer) - 258.91N, Group VI i.e. Negative control (No instrumentation and obturation) - 285.41N. Conclusion: Among the root canal sealers; resin based root canal sealers showed higher resistance to fracture than non adhesive sealers

9.
Article | IMSEAR | ID: sea-203823

ABSTRACT

This review summarizes the state of the current literature relating to the associations of lung disease and adipokines (proteins produced by adipose tissue) in humans. The mechanistic basis for these associations in humans is not established, although a possible role for adipokines has been invoked. Leptin, a pro-inflammatory adipokine, and adiponectin, an anti-inflammatory adipokine, are causally associated with asthma in mice. Although human studies are currently inconclusive, high-serum leptin and low-serum adiponectin concentrations predict asthma, independent of obesity, in select population groups, such as premenopausal women in the United States. In contradistinction, low-serum leptin and high-serum adiponectin concentrations are associated with stable COPD, although these associations are likely confounded by fat mass. Interestingly, leptin may promote systemic and airway inflammation in stable COPD patients. On the other hand, COPD may upregulate systemic and lung adiponectin expression. The precise mechanism and significance of the associations between these adipokines and lung disease at the current stage are confusing and frankly paradoxical in places. It is now known that adipose tissue is not an inert organ simply for energy storage, but regulates systemic inflammation via a variety of secreted proteins (called adipokines). While the associations of obesity and adipokines with cardiovascular, endocrine, and rheumatological diseases are well described, the respiratory effects of obesity and adipokines are less well known. This review will focus on the effect of obesity and adipokines on asthma and chronic obstructive pulmonary disease (COPD) in humans. This area of research needs additional study that may open up novel therapeutic strategies for these lung diseases.

10.
Article | IMSEAR | ID: sea-203464

ABSTRACT

Background: Dimensional relationship between bodysegments and stature has been the focus of scientists for manyyears. Therefore, prediction of stature from cranial remains isvital in establishing the identity of an unknown individual. Thepresent study was conducted to predict cephalic phenotype bymeasuring cephalic index and to study the correlation betweencephalic phenotype ad cephalic index.Materials and Methods: In this prospective observationalstudy 600 patients attending in the Outpatient department ofmedical, dental and other college’s students of age group 21-25 years in various colleges at Jaipur, India were selected forthe study. Data regarding Head length and Head breadth wascollected. A complete physical examination was carried out.The data collected was compiled, tabulated, analyzed andsubjected to statistical tests. Analysis was done using SPSS.Results: In the present study total sample size was 600 inwhich 300 were male and 300 were female. Mean age offemales was found to be 22.82 and mean age of males wasfound to be 22.96. In our study age group selected was 21 to25 years where 21 were the minimum age found in our studyand 25 being the maximum. In present study result showedthat of the Dolicocephalic Male was 7.66%, Mesocephalic Malewas 82 %, Brachycephalic Male was 10.33%. DolicocephalicFemale 25 was 8.33%, Mesocephalic Female was 84 %,Brachycephalic Female was 7.66% ,Dolicocephalic (Male &female) was 8%, Mesocephalic (Male & female) was 83 %,Brachycephalic (Male & female) 54 was. 9% .Significantdifference was observed in cephalic index between males andfemales.Conclusion: Our study concluded that cephalic index showedsignificant difference.

11.
Article | IMSEAR | ID: sea-184434

ABSTRACT

BACKGROUND - Multi-drug resistant tuberculosis (MDR-TB) is an increasing health problem in India. Globally,3.5% of new TB cases and 18% of previously treated cases had MDR/RR-TB.(GLOBAL TUBERCULOSIS REPORT 2018). As per the India TB Report 2018 the estimated incidence of  MDRTB/RR in India was approximately 1,47,000.Outcome of MDR patient put on MDR regime is poor due to high cost, long duration of treatment, and various side effect of second line ATT. MATERIAL & METHOD - Study comprised patients who were diagnosed MDR by culture and DST method from RNTCP accredited lab and initiated CAT–IV treatment in D.R.TB Centre, Department of Tuberculosis & Chest Diseases, S. N. Medical College, Agra. Detailed history and pre clinical evaluation as per guideline were done and at the end of 3rd ,4th,5th  and 6th month sputum  were send for AFB staining and culture. RESULT – Out of 109 MDR patient put on CAT-IV, culture conversion at 3rd month occur in 52(47.70%)  patients, at 4th month in 58 patients (53.21%), and in 5th month 66 patients (60.55%). Out of 109 MDR TB patients 12 patients (11.01%) were found suspected XDR. CONCLUSION – MDR TB is major health problem worldwide. Due to less efficacy and more side effect of second line ATT, longer duration of treatment, MDR TB is difficult to treat even with free supply of ATT through DOTS PLUS. Close attention is needed for early diagnosis  of MDR TB , and adequate clinically monitoring of during treatment is essential.

12.
Article | IMSEAR | ID: sea-203386

ABSTRACT

Background: Pterion is usually marked by an H-shaped formof sutures that forms the union of the frontal, parietal, greaterwing of sphenoid, and temporal bones. The center of pterion isaround 4.0 cm higher to the zygomatic arch and 3.0-3.5 cmposterior to frontozygomatic suture. The present study wasconducted with the aim to determine the location of pterion andits clinical implications.Materials and Methods: The present study was conducted inthe Department of Anatomy, Mahatma Gandhi Medical College& Hospital, Jaipur, Rajasthan, India. The study included 40skulls of unknown gender. PT was taken as the distance fromthe center of Pterion to the superior part of thetemporozygomatic suture. For the linear measurements, onejaw of caliper pointed at the frontozygomatic suture and theother at the pterion center. All the data thus obtained wasarranged in a tabulated form and analyzed using SPSSsoftware. Mean and median values of all the results werecalculated.Results: A total of 40 skulls were studied in the present study.The mean distance on the right side was 3.5 cm and on leftside was 3.6 cm with variation between 2.1 To 4.4 cm on bothsides. The median distance on the right side was 3.46 cm andon the left side was 3.48 cm.Conclusion: The location and the type of pterion variesamongst different ethnic and racial groups. The present studymay be of use to the forensic experts and anthropologists.

13.
Article | IMSEAR | ID: sea-202402

ABSTRACT

Introduction: Type-2 diabetes mellitus is a common, chronic metabolic disorder with multiple complications if not well controlled. Depression is a very common psychiatric comorbidity in these patients. Multiple environmental and patient related factors are linked with this co-morbidity. It is important to address depression and related factors in these patients for a better outcome. This study aimed to assess depression and distribution of various socio-demographic and clinical details in patients of type-2 diabetes mellitus. Material and Methods: Using a purposive sampling technique, a total of 118 patients of type-2 diabetes mellitus who fulfilled the inclusion and exclusion criteria of this study were enrolled. They were administered Hamilton Depression Rating Scale to assess depression. Overall 66.1% of the patients had co-morbidity of depression. Results: Significantly more number of patients of type-2 diabetes mellitus with co-morbid depression were unmarried (41% vs 15%, χ2=9.029, df=2, p<.05), unemployed/unskilled workers (21.8% vs 5% / 73.1% vs 55%, χ2=24.893, df=2, p<.01), from lower socio-economic status (71.8% vs 52.5%, χ2=4.342, df=1, p<.05), joint family (33.3% vs 7.5%, χ2=9.519, df=1, p<.05) and rural background (82.1% vs 62.5%, χ2=5.453, df=1, p<.05), and had poor control of the level of HbA1c (55.1% vs 2.5%, χ2=41.022, df=2, p<.01) than those without co-morbid depression. There was a significant negative correlation of years in education with HAM-D total score (r=-.471, p<0.01). Conclusion: A co-morbidity of depression is very common in patients of type-2 diabetes mellitus and various sociodemographic and clinical factors are linked to this comorbidity. It is important to address these issues for the sake of overall better outcome in type-2 diabetes mellitus.

14.
Article | IMSEAR | ID: sea-189881

ABSTRACT

Introduction: Pilonidal sinus is a cavity in the subcutaneous tissue lined by granulation tissue that contains hair and communicates with the surface by a track which is lined usually by squamous epithelium and continuous with the epidermis. It mainly affects the intergluteal furrow. Materials and Methods: It is a hospital-based descriptive study conducted in the Department of General Surgery, Sree Gokulam Medical College and Research Foundation from February 2017 to November 2018. Patients with clinically diagnosed pilonidal sinus disease admitted in the Surgery Department, Sree Gokulam Medical College and Research Foundation. Results: A total of 140 patients were evaluated postoperatively and for a mean period of 12 months (range 6–18 months), every 3 months during their review visit or over phone. Mean operative time was 54.3 min with a median hospital stay of 5 days. Postoperative pain lasted for a median duration of 2 days. Drains were removed at a median of 3 days and sutures at a median of 7 days. Three patients presented with serous wound collection and 12 patients presented with wound dehiscence. Conclusion: Karydakis flap procedure is a safe surgical treatment for sacrococcygeal pilonidal sinus disease due to the associated low complication rate, short hospital length of stay, rapid healing, and a high patient satisfaction rate.

15.
Article | IMSEAR | ID: sea-189873

ABSTRACT

Introduction: The term varicose is derived from the Latin word meaning – “dilated.” Varicose veins are defined as dilated, usually tortuous, subcutaneous veins 3 mm in diameter measured in the upright position with demonstrable reflux .Although varicose veins were identified prehistorically, only in the present century, considerable knowledge has been gained concerning the anatomy of venous system of the leg, the physiological mechanism of venous return to heart against gravity, and pathology of the disorder, which has led to many newer treatment modalities. One of the pitfalls in venous surgery lies in inadequate knowledge of the venous physiology and anatomy. In contrast to the anatomy of the arteries, the anatomy of veins is characterized by numerous variations.Hence, a thorough and precise knowledge of the anatomical variations of the great saphenous vein (GSV) and SFJ determines the successful outcome of surgery. Materials and Methods: A descriptive study was carried out on 90 patients who were operated for varicose veins in the Surgery Department, Sree Gokulam Medical College and Research Foundation, Venjarmoodu, Trivandrum, during the period of October 2012– April 2014. All patients were examined clinically after taking a detailed history. They were investigated by ultrasonography venous Doppler to confirm the diagnosis. They were subsequently posted for surgery, the intraoperative findings of which were recorded by measurement and photographs. Patients with recurrent varicose veins and perforator incompetence without saphenofemoral incompetence were not included in the study. For those patients posted for surgery, written informed consent was obtained from each patient and basic patient data were recorded in the pro forma. During surgery, documentation of the following intraoperative findings was done: • Measurement of the SFJ from the pubic tubercle. • Description of the tributaries that drain into GSV. • Presence or absence of duplex veins. All details regarding SFJ and tributaries were documented through photography and further analysis was done using standard statistic techniques. Results: During the study period, 90 cases of varicose veins were enrolled in the study, of which 35 were male and 55 were female. These patients were evaluated by clinical examination, investigations, and peroperative recording of the findings in the pro forma and the following interpretations were made and compared with other studies. Conclusions: The purpose of the present study was to assess the position of the SFJ in relation to the pubic tubercle and identify the various tributaries draining into the terminal part of GSV. During the allotted period, 90 cases of varicose veins of the lower limb were studied in detail. Analysis of the findings recorded has enabled this study to arrive at the following conclusions: • The position of SFJ junction is highly variable and should always be marked preoperatively using Doppler. The average measurement of the SFJ from the pubic tubercle was 2.1 cm below and 4.4 cm lateral to the pubic tubercle. There was considerable variation in the number and anatomical course of the tributaries draining into the terminal part of GSV. The most common tributary identified in the study was the superficial epigastric vein and the least identified tributary was the posteromedial vein. Duplication of varicose veins was observed in 9% of the cases. In conclusion, adequate knowledge of the anatomy of the tributaries at the SFJ and ligating them in combination with GSV stripping is associated with a lower rate of the recurrence of varicose veins and a better quality of life. It is always imperative to explore the first 5 cm of GSV precisely to identify all tributaries at the SFJ (about four tributaries by average) to ensure appropriate surgical technique

16.
Article | IMSEAR | ID: sea-211299

ABSTRACT

Background: Femoral neck fracture in elderly continues to pose a treatment dilemma. Associated co-morbidities and high mortality (1-year mortality of 25–30% and only 25% survivorship at 10 years) often skews the surgical decision. The underlying treatment goal is minimum revision and maximum functional outcome. Lack of clear guidelines is reflected by the continued debates regarding their management namely osteosynthesis vs arthroplasty; hemiarthroplasty vs total hip arthroplasty, unipolar vs bipolar and cemented vs uncemented. A review of joint registries, uniformly suggest that cemented fixation in elderly patient results in early mobilization, less residual pain and the lowest risk of revision. We analyzed clinical outcome of cemented monoblock hemi-arthroplasty (modified design) in femoral neck fracture in elderly.Methods: Total 94 cemented hemiarthroplasty, performed since January 2009, with a minimum follow up of 3 years are included in the study. Mean modified Haris Hip score at 2 years, 3 years and in the last follow up was 88 (72-91), 84 (70-89) and 81 (65-86) respectively. Acetabular erosion was noted in three patients (3.19%) (one was symptomatic) and aseptic loosening in another two patients (2.12%). Major complications such as deep wound infection, dislocation or peri-prosthetic fracture were not noted in any patient.Results: Result of the present study is consistent to marginally superior when compared to cemented Thompson monoblock and the cemented bipolar prostheses. We attribute this to routine use of cement in the elderly osteoporotic bone along with design modification of the monoblock stem. Long term result of THA is marginally (not statistically significant) better compared to hemiarthroplasty. However, it is associated with prolonged surgery, more blood loss and higher dislocation rate. The rates of dislocation following THA, bipolar and unipolar arthroplasty were 11%, 3%, and 2% respectively.Conclusions: Cemented monoblock hemiarthroplasty is effective and viable option in displaced femoral neck fracture in elderly in terms of excellent functional outcome, low reoperation without adversely affecting morbidity and mortality. Being cost effective procedure this may be considered as first line surgical option especially in socio-economically disadvantaged section of the society.

17.
Article | IMSEAR | ID: sea-204010

ABSTRACT

Background: During pregnancy, fast growth and cell differentiation takes place in both mother and foetus. Maternal nutritional factors play an important role in the growth of the neonate. Among the micronutrient zinc is an important micronutrient whose deficiency is associated with poor pregnancy outcomes. The objective the current study was to evaluate the relationship of serum zinc concentration of the maternal blood and the neonatal cord blood with that of the infant's anthropometric measurements.Methods: A descriptive cross-sectional study was performed under the Department of Neonatology, Saveetha medical college. Duration of the study was from April 2017 to June 2018. The study included 82 singleton mother baby dyads born in Saveetha medical college. Anthropometric measurements such as birth weight, head circumference, neonate length apart from other clinical features of both the mother and neonates were recorded for statistical analysis. Serum zinc levels were estimated using 2-(5-bromo-2-pyridylazo)-5-(N-Propyl-N-sulfopropylamino)-phenol (5-Br-PAPS) protocol.Results: The mean maternal age of the study population is 25.3'2.3 years. Majority of the mother had natural mode of delivery (57%). The mean cord serum zinc level was found to be 94.0'1.6microgram /dl and the mother's serum zinc level was 93.8'30.7microgram /dl (range from 49 to 171microgram /dl) which was not found to be statistically significant. Serum zinc levels of the cord was compared with the child anthropometrics and mother's serum zinc levels to assess for the significance, but there was no correlation observed between the umbilical cord, and the birth weight (r=0.03), length of the child (r=-0.02), head circumference (r=-0.07) and mothers serum zinc levels (r=-0.002).Conclusions: According to our results authors were unable to establish a relationship between Neonates growth parameters and zinc levels in neonates cord blood and zinc levels in the mother. Further studies with a larger sample size and prospective design would establish a causal relationship between zinc and growth parameters in the neonate.

18.
Article | IMSEAR | ID: sea-194246

ABSTRACT

Background: Esophageal cancer is associated with multiple risk factors and associated with poor prognosis. Incidence of Esophageal cancer is increases now a days and it became a sixth leading cause of cancer related death in world. The purpose of this study was to know the clinical profile of patients of esophageal cancer in a tertiary care teaching hospital of Gujrat, India.Methods: This is a retrospective hospital record based study for a period of 2015 to 2018 in which 103 patients with endoscopic biopsy confirmed cases of esophageal cancer were analyzed for clinical profile.Results: Esophageal cancer was most common in low socioeconomic men (66%) of 5th decades (26.21%) associated with tobacco chewing (64.07%) as a major risk factor and dysphagia (86.76%) as most common presenting feature. Most common type and involvement were sqamous type (72.81%) and distal third (50.48%) part of the esophagus respectively.Conclusions: Primordial prevention and screening of patients may decrease mortality related to esophageal carcinoma.

19.
J Genet ; 2019 Feb; 98: 1-4
Article | IMSEAR | ID: sea-215478

ABSTRACT

This study evaluates a family with two siblings having severe growth retardation and facial dysmorphism, born to consanguineous normal healthy parents. Affymetrix CytoScan 750K microarray showed a 34-Mb pericentric homozygous region on chromosome 6 for both siblings. CUL7 was one of the 141 genes present in this region. Sanger sequencing of CUL7 gene detected a 2-bp novel deletion in the 15th exon (c.2943_2944delCT of the cDNA). This deletion leads to a frameshift and a premature termination signal much upstream of the wild-type termination signal, leading to a nonsense mediated decay of the mRNA. CUL7 protein plays an important role in formation of 3M complex, ubiquitination, microtubule dynamics and cell cycle regulation. Mutations in CUL7 gene is known to cause a rare 3M syndrome. Information about the novel mutation has been accepted in the ClinVar database with rs1064792895.

20.
Article | IMSEAR | ID: sea-199876

ABSTRACT

Background: Utilization pattern of antipsychotics has undergone a major shift as the newly introduced atypical antipsychotics have heralded the market. Hence continuous studies on current prescribing trends are needed to provide most updated, effective and rational treatment of psychoses.Methods: This cross-sectional prospective study was conducted at Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India. OPD tickets of the department of psychiatry for the year 2016-2017 were evaluated for a total of 310 cases. These prescriptions were used to determine the drug utilization of antipsychotics and for their appropriateness against the WHO recommended core prescribing indicators.Results: A total of 310 patients satisfied the inclusion criteria and a male predominance was seen (male:female= 1.3:1). The most common psychotic disorder diagnosed was schizophrenia (44%). Majority of the patients (76%) received monotherapy and the prescribing trend showed a higher use of atypical antipsychotics (89%) over typical ones (11%). The most commonly prescribed anti-psychotic drugs were olanzapine (31%), followed by risperidone (26%). On analysing prescriptions according to the WHO core prescribing indicators it was observed that average number of antipsychotics prescribed per prescription was 1.32. 24% of drugs were prescribed by generic name and 5.2% were administered via injectable route. Drugs prescribed from National list of Essential Medicine, 2015 constituted 46%.Conclusions: The high inclination towards the use of atypical antipsychotics observed in our study correlates with the global changing trends in the treatment of schizophrenia. WHO prescribing indicators should be adhered to, to impart rational prescribing.

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