Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 87
Filter
1.
São Paulo; Sarvier;Edusp; 1982. 283 p.
Monography in Portuguese | LILACS, HANSEN, HANSENIASE, SESSP-ISACERVO, SESSP-ILSLACERVO, SES-SP | ID: biblio-1078322
2.
Rev. paul. pediatr ; 26(4): 315-320, dez. 2008. graf
Article in Portuguese | LILACS | ID: lil-507593

ABSTRACT

OBJETIVO: Determinar, em cobaias prenhes e em gestantes, a produção de antitoxina tetânica induzida pela aplicação da anatoxina tetânica e estudar a sua passagem para o recém-nascido. MÉTODOS: Na primeira fase, em estudo experimental, cobaias prenhes foram vacinadas com duas doses de toxóide tetânico em um intervalo de 15 dias, seguida da dosagem de anticorpos na cobaia imunizada, na prole ao nascer e 15 dias após o nascimento. Outro grupo de animais previamente vacinado recebeu uma dose de reforço 30 dias antes do parto, medindo-se o nível de anticorpos na cobaia e na prole. Na segunda fase, em ensaio clínico, as gestantes humanas foram vacinadas com três injeções de anatoxina tetânica, com um intervalo de 30 dias, em qualquer período da gravidez, medindo-se, a seguir, a antitoxina tetânica. Nos recém-nascidos, os anticorpos foram medidos ao nascer e aos 15 dias de vida. RESULTADOS: O título de antitoxina no sangue da prole de cobaias vacinadas com anatoxina tetânica foi elevado ao nascimento e aos 15 dias de vida. A dose de reforço provocou elevação do título basal. Nas gestantes, a aplicação de três doses de toxóide antitetânico conferiu imunidade a 95% dos recém-nascidos estudados. Os recém-nascidos de mães vacinadas apresentaram títulos elevados de antitoxina que persistiram por mais de 15 dias de vida. CONCLUSÕES: A vacinação durante a gestação foi acompanhada de títulos protetores de antitoxina contra o tétano tanto nos filhotes de cobaias quanto nos recém-nascidos humanos.


OBJECTIVE: To measure, in pregnant guinea pigs and women, the production of tetanus antitoxin, induced by vaccination with tetanus toxin, and to study the transmission of these antibodies to the offspring. METHODS: In an experimental design, pregnant guinea pigs were vaccinated with two doses of tetanus toxoid with a 15-day interval followed by determination of antibodies in the immunized guinea pig, in the offspring at birth and after 15 days of life. One group of guinea pigs received a booster dose of tetanus toxoid 30 days before delivery and the immunization status of dam and offspring was also studied. In a clinical trial, pregnant women were vaccinated in any period of gestation with three doses of tetanus toxoid with a 30-day interval; the antibody levels were measured in the mother and in the newborn infant at birth and at the 15th day of life. RESULTS: The antibody levels of guinea pigs offspring immunized with tetanus toxoid during gestation were elevated at birth and at the 15th day of life. These levels were elevated by the booster dose 30 days prior to delivery. In pregnant women, the immunization with three doses of tetanus toxoid was followed by immunity in 95% of the studied infants studied. The newborn infants of vaccinated women presented elevated levels of antibodies at birth and at 15th day of life. CONCLUSIONS: Vaccination during gestation was followed by protective levels of antibodies in guinea pigs and in newborn infants.


Subject(s)
Humans , Animals , Pregnancy , Infant, Newborn , Guinea Pigs , Tetanus Antitoxin/administration & dosage , Tetanus Toxoid , Tetanus/prevention & control , Vaccination
3.
Rev. Inst. Med. Trop. Säo Paulo ; 47(3)May-June 2005. ilus
Article in English | LILACS | ID: lil-406293

ABSTRACT

La aspergilosis cerebral es una causa rara de lesión expansiva cerebral en pacientes con SIDA. Presentamos el primer reporte de un absceso cerebral causado por Aspergillus fumigatus en un paciente brasileño con SIDA. El paciente, de 26 años de edad, presentaba antecedentes de infección por el virus de la inmunodeficiencia humana (VIH), tuberculosis pulmonar y toxoplasmosis cerebral. Manifestó fiebre, tos, disnea y dos episódios de convulsiones. La tomografía computadorizada (TC) demostró una lesión hipodensa parasagital y bi-parietal con realce periférico e importante efecto de masa. Se inició tratamiento anti-Toxoplasma. Tres semanas después, el paciente evidenció confusión mental y una nueva TC de cráneo mostró aumento de la lesión. Se realizó biopsia cerebral con drenaje de 10 mL de material purulento. El examen micológico directo reveló hifas hialinas septadas. Se inició anfotericina B deoxicolato. La cultura del material demostró presencia de Aspergillus fumigatus. En los siguientes dos meses el paciente fue sometido a otras tres cirugías, insertándose un catéter de drenaje y administrándose anfotericina B intralesional. Tres meses después de la admisión hospitalaria, la condición neurológica del paciente sufrió discretos cambios. Sin embargo, falleció debido a neumonia intrahospitalaria. Aunque muy raros, los abscesos cerebrales causados por Aspergillus fumigatus deben ser considerados en el diagnóstico diferencial de las lesiones expansivas cerebrales en pacientes con SIDA.


Subject(s)
Humans , Male , Adult , AIDS-Related Opportunistic Infections/microbiology , Aspergillus fumigatus/isolation & purification , Brain Abscess/microbiology , Neuroaspergillosis/diagnosis , AIDS-Related Opportunistic Infections/diagnosis , AIDS-Related Opportunistic Infections/drug therapy , Amphotericin B/therapeutic use , Antifungal Agents/therapeutic use , Brazil , Brain Abscess/diagnosis , Brain Abscess/drug therapy , Fatal Outcome , Neuroaspergillosis/drug therapy
4.
Rev. Inst. Med. Trop. Säo Paulo ; 45(6): 315-318, Nov.-Dec. 2003. ilus, tab
Article in English | LILACS | ID: lil-353981

ABSTRACT

Chromoblastomycosis (CBM) is a chronic subcutaneous infection caused by several dematiaceous fungi. The most commonly etiological agent found in Brazil is Fonsecaea pedrosoi, which appears as thick walled, brownish colored cells with transverse and longitudinal division in the lesions, called "muriform cells". This disease is found worldwide but countries like Madagascar and Brazil have highest incidence. Diagnosis is made by clinical, direct and histopathologic examination and culture of specimens. Serological tests have been used to identify specific antibodies against Fonsecaea pedrosoi antigens, as well as immunotechniques have been used for CBM serological identification and diagnosis. In the present study double immunodiffusion (DID), counterimmunoelectrophoresis (CIE) and immunoenzymatic test (ELISA) have been used to evaluate humoral immune response in patients with CBM caused by F. pedrosoi. Metabolic antigen was used for immunoprecipitation tests (DID and CIE) while somatic antigen for ELISA. Our results demonstrated 53 percent sensitivity and 96 percent specificity for DID, while CIE presented 68 percent sensitivity and 90.5 percent specificity. ELISA demonstrated 78 percent sensibility and 83 percent specificity. Serological tests can be a useful tool to study different aspects of CBM, such as helping differential diagnosis, when culture of the pathogenic agent is impossible.


Subject(s)
Humans , Antibodies, Fungal , Ascomycota , Chromoblastomycosis , Antigens, Fungal , Case-Control Studies , Chromoblastomycosis , Counterimmunoelectrophoresis , Enzyme-Linked Immunosorbent Assay , Evaluation Study , Immunodiffusion , Sensitivity and Specificity
5.
Rev. Inst. Med. Trop. Säo Paulo ; 45(4): 217-220, July-Aug. 2003. ilus
Article in English | LILACS | ID: lil-345386

ABSTRACT

Cerebral phaeohyphomycosis ("chromoblastomycosis") is a rare intracranial lesion. We report the first human culture-proven case of brain abscesses due to Fonsecaea pedrosoi in Brazil. The patient, a 28 year-old immunocompetent white male, had ocular manifestations and a hypertensive intracranial syndrome. Magnetic resonance imaging (MRI) of the brain revealed a main tumoral mass involving the right temporo-occipital area and another smaller apparently healed lesion at the left occipital lobe. A cerebral biopsy was performed and the pathological report was cerebral chromoblastomycosis. The main lesion was enucleated surgically and culture of the necrotic and suppurative mass grew a fungus identified as Fonsecaea pedrosoi. The patient had received a knife wound sixteen years prior to his hospitalization and, more recently, manifested a pulmonary granulomatous lesion in the right lung with a single non-pigmented form of a fungus present. It was speculated that the fungus might have gained entrance to the host through the skin lesion, although a primary respiratory lesion was not excluded. The patient was discharged from the hospital still with ocular manifestations and on antimycotic therapy and was followed for eight months without disease recurrence. Few months after he had complications of the previous neuro-surgery and died. A complete autopsy was performed and no residual fungal disease was found


Subject(s)
Humans , Male , Adult , Brain Abscess , Central Nervous System Fungal Infections , Chromoblastomycosis , Mitosporic Fungi , Brain Abscess , Central Nervous System Fungal Infections , Chromoblastomycosis , Fatal Outcome , Magnetic Resonance Imaging
6.
An. bras. dermatol ; 78(3): 279-282, maio-jun. 2003. tab
Article in Portuguese, English | LILACS | ID: lil-341617

ABSTRACT

A criocirurgia com nitrogênio líquido (C-N2L) é um método terapêutico que vem sendo usado com freqüência crescente no tratamento da cromomicose. Acreditava-se anteriormente que as temperaturas baixas poderiam destruir o agente infectante, mas foi demonstrado que as culturas fúngicas em temperaturas tão baixas como -196°C não causaria a morte do mesmo. Apesar da comprovada eficácia, ainda não se conhece o exato mecanismo de cura.Avaliar o período de persistência de fungos viáveis em lesões de cromomicose tratadas pela C-N2L.Cinco pacientes com cromomicose tiveram suas lesões tratadas pela C-N2L. Foram colhidos, em diferentes intervalos de tempo após a criocirurgia, fragmentos do tecido tratado. A coleta, realizada com punch de 4mm, foi feita em três períodos diferentes: de 0 a 48h, de cinco a sete dias e de 10 a 14 dias após a realização da criocirurgia. Os fragmentos obtidos foram inoculados em Agar Sabouraud para verificação de crescimento de colônias fúngicas. Cada paciente teve um total de três amostras colhidas, uma em cada um dos três períodos mencionados.O crescimento de colônias foi maior nas coletas mais precoces, enquanto nas amostras colhidas entre o pós-operatório imediato e o quinto dia de pós-operatório o índice de viabilidade foi de 7/8 (87,5 por cento), e naquelas colhidas a partir do sexto dia de pós-operatório foi de apenas 2/7 (28,5 por cento). O maior período de pós-operatório que demonstrou positividade foi de 12 dias.Os resultados confirmam os achados anteriores, os quais demonstraram que as baixas temperaturas alcançadas pela C-N2L não são responsáveis pela destruição dos fungos nas lesões de cromomicose. Os autores acreditam que fenômenos biológicos tardios, como necrose ou imunoestimulação sejam os verdadeiros responsáveis pela erradicação dos fungos nas lesões de cromomicose


Subject(s)
Humans , Chromoblastomycosis , Cryosurgery
7.
In. Cimerman, Sérgio; Cimerman, Benjamin. Medicina tropical. São Paulo, Atheneu, 2003. p.3-37, ilus.
Monography in Portuguese | LILACS, SES-SP | ID: lil-344584

Subject(s)
Tropical Medicine
8.
Rev. Inst. Med. Trop. Säo Paulo ; 44(4): 225-228, July-Aug. 2002. ilus
Article in English | LILACS | ID: lil-321225

ABSTRACT

The authors report a male patient, a seller with no detected immunosuppression, with an extensive ulcerated skin lesion localized on the left forearm, caused by Cryptococcus neoformans var. gattii serotype B. Oral treatment with fluconazole was successful. A review of the literature showed the rarity of this localization in HIV-negative patients. In contrast, skin lesions frequently occurs in HIV-positive patients, with Cryptococcus neoformans var. neoformans serotype A predominating as the etiological agent. In this paper, the pathogenicity of C. neoformans to skin lesions in patients immunocompromised or not, is discussed, showing the efficacy of fluconazole for the treatment of these processes


Subject(s)
Humans , Male , Aged , Cryptococcosis , Dermatomycoses , Cryptococcus neoformans , Immunocompromised Host
9.
São Paulo; s.n; 2002. 2 p. ilus.
Non-conventional in Portuguese | LILACS, SES-SP, HANSEN, HANSENIASE, SESSP-ILSLACERVO, SES-SP | ID: biblio-1238527
10.
São Paulo; Fundação Maria Cecília Souto Vidigal; 2002. 208 p.
Monography in Portuguese | LILACS, SES-SP | ID: lil-431393

ABSTRACT

A partir de uma revisão histórica da medicina brasileira, enfoca a história da hematologia no mundo e no Brasil, dando destaque à hematologia no século XX e na atualidade. Apresenta, ainda, uma bibliografia hematológica brasileira


Subject(s)
Hematology/history , History of Medicine , Brazil , Schools, Medical/history , Hematology/education
12.
Säo Paulo; s.n; 2001. 63 p. ilus.
Monography in Portuguese | LILACS | ID: lil-320474

ABSTRACT

Retrata a vida plena de sucessos de um médico que nasceu na Roda da Santa Casa de Misericórdia de Säo Paulo, criado por um casal de Guaxupé e cujo sucesso profissional se baseou fundamentalmente no caráter, vocaçäo, talento, esforço e disciplina, somando ao grande amor que sempre dedicou a seus pacientes


Subject(s)
Humans , Female , Child , Physicians , Biography , Brazil , Child, Abandoned , Hospitals, Voluntary , Public Health/history
13.
Rev. med. (Säo Paulo) ; 79(1): 32-5, jan.-fev. 2000. ilus
Article in Portuguese | LILACS | ID: lil-279186

ABSTRACT

Na historia das vacinacoes, protegendo ativamente a populacao contra diversas doencas infecciosas, duas grandes figuras aparecem, ao lado de Louis Pasteur, Albert Sabin, Wright, Calmette e tantos outros pesquisadores do passado e do presente. Refiro-me a Edward Jenner e a Gustavo Ramon. A primeira vacinacao praticada em seres humanos foi realizada pelo medico escoces Edward Jenner, utilizando material de pustulas do cow-pox, vaccinia ou variola do gado bovino. Dai o nome VACINA (do latim vacca) para designar todo imunogeno que, aplicado por via oral ou parenteral garante a...


Subject(s)
Vaccination/history , Communicable Diseases/immunology
14.
An. bras. dermatol ; 74(6): 591-5, nov.-dez. 1999. ilus
Article in Portuguese | LILACS | ID: lil-254937

ABSTRACT

Os autores registram um caso de eumicetoma de gräos branco-amarelados, em paciente do sexo masculino, procedente da Bahia, com lesöes no pé esquerdo, provocadas por Acremonium kiliense (Grütz, 1925). O exame histopatológico näo demonstrou a presença de gräos, revelados, todavia, ao exame "a fresco", todos eles com estrutura de eumicetos. Discreta regressäo do quadro inflamatório com o uso de itraconazol, após tratamento prolongado


Subject(s)
Humans , Male , Middle Aged , Acremonium , Foot Dermatoses , Itraconazole/therapeutic use , Mycetoma
15.
Rev. Inst. Med. Trop. Säo Paulo ; 41(5): 313-7, Sept.-Oct. 1999. ilus
Article in English | LILACS | ID: lil-250205

ABSTRACT

The authors report the first case of dermatophytosis caused by Trichophyton raubitschekii in a patient from the State of São Paulo with Tinea corporis lesions localized on the buttocks. Culture on Sabouraud-agar with cycloheximide permitted the isolation and identification of the fungus, and the diagnosis was confirmed by Dr. Lynne Sigler, University of Alberta, Canada. Systemic treatment with fluconazole, 150 mg/week for 4 weeks, in combination with topical treatment with isoconazole initially yielded favorable results, with recurrence of the lesions after the medication was discontinued. This is the fifth case of this dermatophytosis published in the Brazilian medical literature


Subject(s)
Humans , Female , Tinea/microbiology , Trichophyton/isolation & purification , Antifungal Agents/therapeutic use , Fluconazole/therapeutic use , Tinea/diagnosis , Tinea/drug therapy
16.
Rev. Inst. Med. Trop. Säo Paulo ; 41(5): 319-23, Sept.-Oct. 1999. ilus
Article in English | LILACS | ID: lil-250206

ABSTRACT

The authors report two cases of onychomycosis in the dystrophic form, one of them involving an HIV-positive patient, provoked by Scytalidium dimidiatum, previously called Scytalidium lignicola. The subject is reviewed from the taxonomic viewpoint, considering the anamorph Hendersonula toruloidea as a synonym of Nattrassia mangiferae, and having Scytalidium dimidiatum as the major synanamorph. According to many mycologists, Scytalidium hyalinum may be a separate species or a hyaline mutant of Scytalidium dimidiatum. Scytalidium lignicola Pesante 1957 was considered to be the type-species of the genus by ELLIS (1971)13 and later to be a "conidial state" of Hendersonula toruloidea by the same author, today known as Nattrassia mangiferae. The microorganism lives only on the roots of certain plants (mainly Platanus and Pinus). It produces pycnidia and is not considered to be a pathogen, although it is considered as a possible emerging agent capable of provoking opportunistic fungal lesions. The importance of this topic as one of the most outstanding in fungal taxonomy, so likely to be modified over time, as well as its interest in the field of dermatologic mycology, are emphasized


Subject(s)
Humans , Male , Adult , Female , Mitosporic Fungi/classification , Onychomycosis/microbiology , Antifungal Agents/therapeutic use , Foot Dermatoses/drug therapy , Foot Dermatoses/microbiology , Hand Dermatoses/drug therapy , Hand Dermatoses/microbiology , Itraconazole/therapeutic use , Ketoconazole/therapeutic use , Mitosporic Fungi/isolation & purification , Onychomycosis/drug therapy
17.
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo ; 54(5): 169-71, Sept.-Oct. 1999. ilus
Article in English | LILACS | ID: lil-255574

ABSTRACT

Although oportunistic fungal infections occur commonly in immunocompromised hosts, mycetoma has never been reported in association with HIV infection. The authors present a case that to their knowledge is the first reported case of mycetoma associated with HIV infection. Diagnosis was confirmed by direct examination of grains and histologic examination. Precise identification of the agent, an actinomycete, was not possible. The unusual site of infection may probably be related to the use of contaminated needless and sirynges for HIV drug injection


Subject(s)
Humans , Male , Adult , AIDS-Related Opportunistic Infections/microbiology , HIV Infections/complications , Mycetoma/microbiology , Mycetoma/pathology
18.
Rev. Inst. Med. Trop. Säo Paulo ; 41(3): 195-202, May-Jun. 1999. ilus
Article in English | LILACS | ID: lil-240790

ABSTRACT

O presente trabalho registra caso de histoplasmose em paciente de 5 anos, HIV negativo, natural e procedente da cidade da Sao Paulo, com lesoes cutaneas nao diagnosticadas clinicamente. Exame histopatologico negativo para infeccao fungica. Cultivos em duas ocasioes, positivos para Histoplasma capsulatum var. capsulatum (amostras 361 e 387). Sorologia negativa para anticorpos anti-Histoplasma capsulatum e Paracoccidioides brasiliensis pelas provas de Imunodifusao dupla e ...


Subject(s)
Humans , Child , Erythema Infectiosum/etiology , Histoplasma/isolation & purification , Histoplasmosis/diagnosis , Atypical Bacterial Forms , Blotting, Western , Culture Media , Fever , Fever/etiology , Histoplasmosis/immunology , Histoplasmosis/therapy , Immunocompromised Host/immunology , Immunohistochemistry , Itraconazole/therapeutic use , Polysaccharides, Bacterial/analysis
19.
Rev. Inst. Med. Trop. Säo Paulo ; 41(2): 79-86, mar.-abr. 1999. ilus
Article in English | LILACS | ID: lil-236048

ABSTRACT

Os autores estudaram do ponto de vista micologico, imunoquimico e de sua biologia molecular, duas amostras de Paracoccidioides brasiliensis, uma isolada do solo, no municipio de IBIA (MG) por Silva-Vergara et al (1996,1998) denominada IBIA e outra, BAT, cultivada de um caso humano de paracoccidioidomicose em Ribeirao Preto (SP) por Freitas da Silva (1996). Tais amostras apresentam colonias cotonosa (M) e leveduriforme (L ou Y), sendo patogenicas para cobaios inoculados por via testicular, produzindo orquite granulomatosa e/ou supurativa. Do ponto de vista imunoquimico, atraves de provas de Imunodifusao dupla, Imunoeletroforese e Western Blotting, foi demostrada a presenca da gp43


Subject(s)
Humans , Animals , Immunochemistry/methods , Mycology , Paracoccidioidomycosis/immunology , Base Sequence , Blotting, Western , Immunodiffusion , Immunoelectrophoresis , Orchitis/pathology , Paracoccidioides/isolation & purification
20.
Rev. Inst. Med. Trop. Säo Paulo ; 40(5): 321-3, Sept.-Oct. 1998. ilus
Article in English | LILACS | ID: lil-225854

ABSTRACT

Paciente portador de leucemia mieloide cronica, com irma HLA-compativel foi submetido a transplante alogenico de medula ossea. No dia +90 pos-TMO foi diagnosticado doenca do enxerto contra o hospedeiro (DECH) extensa e iniciado protocolo alternado de imunossupressao com altas doses de ciclosporina A e prednisona. O seguimento ambulatorial foi complicado, com granulocitopenia intermitente e quadros frequentes de sinusite e pneumonia. Um ano apos o transplante, o paciente apresentou rouquidao e voz anasalada. Foi realizada uma biopsia de corda vocal mas nenhum agente infeccioso pode ser identificado. Na diminuicao das doses das drogas imunossupressoras, houve piora da DECH cronica e foi reiniciado esquema de doses altas no dia +550. Tres meses apos, permanecendo o quadro de DECH fora do controle, foi tentado imunossupressao com azatioprina sem sucesso...


Subject(s)
Humans , Male , Adult , Fungi/isolation & purification , Sinusitis/complications , Bone Marrow Transplantation/adverse effects , Cyclosporine/therapeutic use , Graft vs Host Disease/complications , Graft vs Host Disease/therapy , Follow-Up Studies , Fungi/classification , Immunosuppression Therapy/methods , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/etiology , Maxillary Sinus/surgery , Respiratory Insufficiency/complications
SELECTION OF CITATIONS
SEARCH DETAIL