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Article | IMSEAR | ID: sea-196277


Context: In India, lung carcinoma is the fifth-most common tumor and second-most common tumor in the males as per the Indian Council of Medical Research registry of 2002. It has been seen that ALDH1 expression in non-small cell lung cancer (NSCLC) and the presence of marker was linked to a more tumorigenic potential in the in vivo assessment and shorter disease-free survival in NSCLC patients with platinum treatment. Aims: Hence, our objective was to detect association of cancer stem cell (CSC) marker aldehyde dehydrogenase 1 (ALDH1) with clinicopathological profile in lung carcinoma patients. Settings and Design: This is a Pilot study. Subjects and Methods: It was a Pilot study where biopsies from 55 fresh previously untreated lung cancer patients visiting the Pulmonary Medicine Department of Era's Lucknow Medical College and Hospital Lucknow and King George's Medical University were taken for 18 months November 2014–April 2016, after taking proper informed consent from them. Paraffin blocks were taken and stained by hematoxylin and eosin (Sigma) to make the histopathological diagnosis and immunohistochemistry was done for detection of CSC marker ALDH1 (Daco). Statistical Analysis Used: The statistical analysis was done using Statistical Package for Social Sciences Version 15.0 Statistical Analysis Software. The values were represented in number (%) and mean ± standard deviation. Results: Expression of stem cell marker ALDH1 with the staging of the tumor was observed in 62.5% of Stage I, 80% of Stage II, 94.1% of Stage III, and 100% of Stage IV cases. Statistically, there was a significant association between ALDH1expression and stage of disease (P < 0.001). Diagnostic efficacy of ALDH1 expression in the detection of any positive clinical stage, it was found to be 88.6% sensitive and 90.9% specific. Conclusions: Strong ALDH1 expression correlates with higher stage of lung carcinoma making it a prognostic marker needing in-depth study.

Article in English | IMSEAR | ID: sea-167657


Approximately 95% of intussusception occurs in children, However it is a rare entity in adults accounting for 0.003% to 0.02 % of all the hospital admissions. Various causes of intussusception are well known, However intussusception caused by heterotropic pancreas is extremely rare and the rarity increases manifolds if it is in the duodenum of an adult and the cause being heterotropic pancreas. We report this rare case of intussusception due to pancreatic heterotropia in 43 year old male who presented with acute pain abdomen.

Article in English | IMSEAR | ID: sea-63873


We report a 17 year old girl with prepancreatic and preduodenal portal vein. She presented with recurrent vomiting. Barium study revealed malrotation of the gut. Laparotomy confirmed malrotation of the gut with a prepancreatic and preduodenal portal vein. The patient is asymptomatic after gastrojejunostomy and vagotomy.

Adolescent , Congenital Abnormalities/diagnosis , Female , Humans , Intestinal Obstruction/complications , Intestines/abnormalities , Portal Vein/abnormalities
J Indian Soc Pedod Prev Dent ; 1991 Mar; 9(1): 41-6
Article in English | IMSEAR | ID: sea-115049


Fifty repaired complete cleft lip and palate cases (38 UCLP and 12 BCLP) in the age range of 6 to 14 years were evaluated for transverse and vertical asymmetry using postero-anterior cephalograms. A total of nine bilateral landmarks, representing upper face, mid face and lower face were used. Results showed that asymmetry was not confined to any single plane of reference but manifested in both dimensions--transverse and vertical. The UCLP group had greater asymmetry of mid face than the BCLP group. Asymmetry was found to be extending to distant areas besides the contiguous structures.

Adolescent , Child , Cleft Lip/complications , Cleft Palate/complications , Facial Asymmetry/etiology , Female , Humans , Male , Maxillofacial Development
Indian J Pathol Microbiol ; 1989 Jul; 32(3): 179-85
Article in English | IMSEAR | ID: sea-73690


A twenty five year retrospective study of malignant tumours was carried out. Malignant digestive tract tumours were about 10% of the total. Segment distribution of the lesion showed highest incidence in large intestine (43.3 percent), oroparynx (34.5 percent), stomach (11.3 percent), oesophagus (6.5 percent) and small intestine (4.4 percent). The maximum cases (74.2 percent) were between 31-60 years, the youngest being a two month old female with rhabdomyosarcoma orpharynx and the oldest a 82 year old male with squamous cell carcinoma anal canal.

Adolescent , Adult , Aged , Aged, 80 and over , Child , Child, Preschool , Digestive System Neoplasms/epidemiology , Female , Humans , India , Infant , Infant, Newborn , Male , Middle Aged , Retrospective Studies
Article in English | IMSEAR | ID: sea-20532


The relationship of serum and CSF immunoglobulins with the number and duration of schizophrenic episodes was assessed in 40 schizophrenics. The mean IgA was increased in patients having 3 or more episodes as compared with those having the first episode (P less than 0.001). IgM showed a moderate increase in patients with the second episode and those having 3 or more episodes. IgG/TP per cent (IgG/total protein %) was found to be significantly increased in CSF of patients having the first episode, as compared with those having 3 or more episodes (P less than 0.001). IgG was increased (although insignificantly) in the CSF of patients with illness of five years duration as compared to patients having illness of one year duration or for illness between 1-5 yr. IgG/TP per cent was found to be significantly increased in patients having illness for 5 or more years when compared to patients having illness for less than 1 yr (P less than 0.001) and for 1-5 yr (P less than 0.01).

Adolescent , Adult , Humans , Immunoglobulin A/analysis , Immunoglobulin G/analysis , Immunoglobulin M/analysis , Immunoglobulins/analysis , Middle Aged , Schizophrenia/etiology , Schizophrenic Psychology , Time Factors