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1.
Article in Chinese | WPRIM | ID: wpr-906001

ABSTRACT

Objective:To rapidly identify the chemical constituents of Chaishi Tuire granules by ultra-performance liquid chromatography-electrospray/quadrupole time-of-flight tandem mass spectrometry (UPLC-ESI-Q-TOF-MS/MS). Method:Chromatographic separation was conducted on a Phenomenex<sup>®</sup> Luna omega C<sub>18</sub> column (2.1 mm×100 mm, 1.6 μm) with 0.1% formic acid aqueous solution (A)-acetonitrile (B) as the mobile phases for gradient elution (0-20 min, 5%-40%B; 20-40 min, 40%-95%B; 40-43 min, 95%B), the flow rate was set at 0.3 mL·min<sup>-1</sup>. MS data were collected in positive and negative ion modes, the scanning range was <italic>m</italic>/<italic>z</italic> 150-1 500 and electrospray ionization (ESI) was employed. The chemical constituents of Chaishi Tuire granules were identified by comparing with the retention time and the mass data of the reference substances, as well as the accurate mass, MS/MS fragment ions, mass spectrometry databases (PubChem, MassBank, ChemicalBook and others) and related literature. Result:A total of 85 chemical constituents were identified, including 28 flavonoids, 24 phenylpropanoids, 11 terpenoids, 10 alkaloids, 4 quinones, and 8 others. Among them, 19 constituents derived from Lonicerae Japonicae Flos, 14 constituents derived from Scutellariae Radix, 10 constituents derived from Isatidis Radix, 9 constituents derived from Taraxaci Herba, 9 constituents derived from Forsythiae Fructus, 4 constituents derived from Bupleuri Radix, 4 constituents derived from Anemarrhenae Rhizoma, and 4 constituents derived from Rhei Radix et Rhizoma. Conclusion:Chaishi Tuire granules is rich in phytochemicals, which are derived from many of traditional Chinese medicines. This study can lay a foundation for the quality control, material basis and <italic>in vivo</italic> metabolic analysis of this preparation.

2.
Article in Chinese | WPRIM | ID: wpr-873033

ABSTRACT

Objective:To explore genetic relationship and population structure of Turpinia arguta in six locations of Jiangxi province by inter-simple sequence repeat (ISSR) molecular marker technique, and to provide theoretical basis for the protection and utilization of this medicinal material resource. Method:A total of 22 samples from six locations in four counties in Jiangxi province were collected, and genomic DNA was extracted by kit method. Polymerase chain reaction (PCR) amplification was performed using sixty-four universal ISSR molecular marker primers, and the products were detected with polyacrylamide gel electrophoresis (PAGE). NTsys 2.10e software was selected to calculate the genetic similarity coefficient by unweighted pair group method with arithmetic mean (UPGMA) and cluster analysis. Population genetic structure was analyzed by Structure 2.1 software. Result:A total of forty-eight ISSR primers were amplified to obtain the product, the percent of polymorphic bands ranged from 45.45% to 100%. UPGMA cluster analysis showed that these plant individuals could not be clustered according to their respective executive locations. Analysis of population genetic structure showed that 22 samples of T. arguta could be divided into three populations. Conclusion:There is gene exchange among the populations of T. arguta in Jiangxi province, and it can affect the genetic structure of germplasm resources from different geographical sources.

3.
Article in Chinese | WPRIM | ID: wpr-870187

ABSTRACT

Objectives:To study the feasibility of using ultrasound to evaluate diaphragm function in patients with invasive mechanical ventilation.Methods:From March to December 2017, 40 adult patients with acute respiratory distress syndrome who were admitted to the Department of Critical Care Medicine, Xiangya Hospital, Central South University for more than 48 hours were included. Diaphragmatic excursion and thickness of bilateral anterior, middle and posterior parts were measured by ultrasound for 5 consecutive days.Results:(1) Compared with the diaphragmatic excursion of the right [anterior: (11.05±3.04) mm; middle: (12.08±2.71) mm; posterior: (11.51±3.33) mm] and left [anterior: (13.63±7.52) mm; middle: (15.44±7.52) mm; posterior: (14.76±6.93) mm] sides on day 1, the diaphragmatic excursion of the right [anterior: (8.90±3.65) mm; middle: (10.02±4.24) mm; posterior: (10.25±4.38) mm] and left [anterior: (9.82±1.96) mm; middle: (11.60±1.13) mm; posterior: (11.52±1.98) mm] sides decreased significantly on day 3 ( P<0.05). Bilateral anterior, middle and posterior diaphragmatic excursion recovered on day 5, and was higher than the baseline levels on day 1, with the left middle and posterior diaphragmatic excursion changing most significantly. (2) Compared with day 1, 2, 3, the thickening fraction of bilateral anterior, middle and posterior diaphragm were significantly decreased on day 4, with the left middle part [day 1: (33.87±14.34)%; day 2: (37.26±13.91)%; day 3: (30.56±14.27)%; day 4: (15.53±5.68)%] and the left posterior part [day 1: (35.50±15.69)%; day 2: (39.84±15.32)%; day 3: (29.06±14.96)%; day 4: (13.30±5.79)%] changing most significantly ( P<0.05). The thickening fractions of left anterior, middle and posterior diaphragm recovered on day 5 compared with that on day 4, but still lower than those on day 1 ( P<0.05). Conclusions:It is feasible to evaluate the diaphragm function in patients with invasive mechanical ventilation by ultrasound, which can provide guidance for preventing diaphragmatic atrophy and withdrawing from mechanical ventilation.

4.
Article in Chinese | WPRIM | ID: wpr-864626

ABSTRACT

Objective:To evaluate the effect of monitoring movement index transverse section by bedside ultrasound in patients who undergoing mechanical ventilation in prone position.Methods:From June 2018 to June 2019, 78 patients with acute respiratory distress syndrome undergoing mechanical ventilation in prone position in ICU of Xiangya Hospital of Central South University were divided into observation group and control group according to random number table method with 39 cases each. The observation group was guided by movement index monitored by ultrasound to implement enteral nutrition, while the control group was guided by enteral nutrition plan according to doctor′s advice. The incidence of feeding interruption, reflux, aspiration, time to complete enteral nutrition, mechanical ventilation time and ICU length of stay were compared between the two groups.Results:The time of reaching full nutrition was (2.8 ± 0.8) d in the observation group, and (4.1 ± 1.1) d in the control group, there was significant difference between the two groups ( t value was -5.596, P < 0.01). There was no significant difference in the incidence of feeding interruption, reflux, aspiration, mechanical ventilation time and ICU length of stay between the two groups ( P > 0.05). Conclusions:The monitoring movement index transverse section by ultrasound can guide the implementation of enteral nutrition in patients with prone mechanical ventilation, and shorten the time to complete enteral nutrition.

5.
Chinese Medical Journal ; (24): 668-674, 2020.
Article in English | WPRIM | ID: wpr-878090

ABSTRACT

BACKGROUND@#Many Parkinson disease (PD) patients complain about chronic fatigue and sleep disturbances during the night. The objective of this study is to determine the relationship between fatigue and sleep disturbances by using polysomnography (PSG) in PD patients.@*METHODS@#Two hundred and thirty-two PD patients (152 with mild fatigue and 80 with severe fatigue) were recruited in this study. Demographic information and clinical symptoms were collected. Fatigue severity scale (FSS) was applied to evaluate the severity of fatigue, and PSG was conducted in all PD patients. FSS ≥4 was defined as severe fatigue, and FSS <4 was defined as mild fatigue. Multivariate logistic regression and linear regression models were used to investigate the associations between fatigue and sleep disturbances.@*RESULTS@#Patients with severe fatigue tended to have a longer duration of disease, higher Unified Parkinson Disease Rating Scale score, more advanced Hoehn and Yahr stage, higher daily levodopa equivalent dose, worse depression, anxiety, and higher daytime sleepiness score. In addition, they had lower percentage of rapid eye movement (REM) sleep (P = 0.009) and were more likely to have REM sleep behavior disorder (RBD) (P = 0.018). Multivariate logistic regression analyses found that the presence of RBD and proportion of REM sleep were the independent predictors for fatigue. After the adjustment of age, sex, duration, body mass index, severity of disease, scores of Hamilton Rating Scale for Depression, Hamilton Anxiety Rating Scale, and other sleep disorders, proportion of REM sleep and degree of REM sleep without atonia in patients with PD were still associated with FSS score.@*CONCLUSION@#Considering the association between fatigue, RBD, and the altered sleep architecture, fatigue is a special subtype in PD and more studies should be focused on this debilitating symptom.


Subject(s)
Humans , Parkinson Disease/complications , Polysomnography , REM Sleep Behavior Disorder , Sleep , Sleep Wake Disorders/etiology
6.
Article in Chinese | WPRIM | ID: wpr-779397

ABSTRACT

Objective To understand the epidemic situation and the source of infection of the reemerge human rabies in Qinghai. Methods We collected the data on human rabies and the data on the cases of multi- victims bitten by the identical dog, and also the laboratory data of the nucleoprotein ( N) gene of rabies virus from the samples which were detected by reverse transcription-polymerase chain reaction (RT-PCR) and direct immunofluorescence assay (DFA) from 2012 to 2017, to describe the epidemiological characteristics of human rabies and the prevalence of rabies virus in host animals, and to explore the source of infection of reemerge human rabies. Results A total of 7 human cases were reported in 2012-2017 in Qinghai province, among which 1 was bitted by wolf, 2 were bitted by stray dogs, 3 were bitted by domestic dogs which injured by stray dogs or wolfs. A total of 892 canine brain tissue samples were collected, from which 46 positive samples were detected with the positive rate of 5.16% (95% CI:3.70%-6.61%). The positive samples were collected from the nomadic region, which were consistent had the location of the human rabies. The samples collected from the cases of multi-victims bitten by the identical dog/animal had the positive rate of 73.08%, and 4 out of 7 human rabies were exposed to the cases of multi-victims bitten by the identical dog/animal. Genetic sequencing of the rabies virus detected from canine brain tissue samples were belong to China IV lineage, which was closely related to the Arctic clade. Conclusions The reemerging rabies happened in nomadic region of Qinghai province could be a consequence of spillover from wildlife especially from wolfs. The better surveillance system covering the human, livestock and wildlife should be set up to mitigate the rabies virus spread from the wildlife.

7.
Article in Chinese | WPRIM | ID: wpr-777914

ABSTRACT

Objective To analyze the surveillance results of influenza-like illness ( ILI) and investigate the prevalent trend of influenza from 14th week 2017 to 13th week 2018 (April 3, 2017-April 1, 2018) in Qinghai Province so as to provide the scientific basis for the development of prevention and control measures. Methods The epidemiological and pathogenic characteristics of influenza-like cases in qinghai province from 14th week 2017 to 13th week 2018 were collected and analyzed. Results ILI mainly occurred in winter and spring from 14th week 2017 to 13th week 2018,26 086 ILI cases reported in total,accounting for 2.95% (26 086/884 529) of total number of outpatients and emergency cases; including 18 655 cases under 5 years old,accounting for 71.51%; 1 991 cases were detected with positive by real -time RT PCR with the positive rate of 17.48% (1 991/11 391), In the early stage, H3 and H1 were the predominate strains and the middle period was mixed with H3, H1 and B, and the latter was dominated by type B. Positive rates of influenza virus testing had no statistical differences in different gender ( 2=5.33, P=0.021),while with statistical differences in different age and time ( 2=108.59, P<0.001; 2= 1 629.13, P<0.001). Number of ILI cases and the percentage in the outpatients was significantly related with influenza virus positive rates (Pearson correlation coefficient was 0.896 and 0.699, respectively, P<0.001). Conclusions Influenza-like cases at sentinel hospital of Qinghai Province can accurately reflect actual activity level. The peak of positive detection of influenza samples in Qinghai province from 14 weeks 2017 to 13 weeks 2018 season was from mid-December to mid-January. The dominant strain of influenza viruses alternated, and the majority of the affected population is mainly in children under 5 years old. In the future, we should strengthen monitoring works in epidemic season, from October to March of next year and focus on the children under 5 years old and the fever clinic. The collection of samples of influenza-like cases in the 0-year-old group should be strengthened, and collective organizations should focus on influenza prevention and control.

8.
Article in Chinese | WPRIM | ID: wpr-777517

ABSTRACT

Chrysosplenium nudicaule,Tibetan name " Yajima",is recorded as an effective medicine for the treatment of liver and gallbladder diseases by Tibetan Pharmacopoeia published in the past dynasties,but its traditional efficacy has not yet been investigated by means of modern pharmacological research methods. In this paper,the protective effect of extract of C. nudicaule(ECN) on liver injury in mice was observed by using the mice model of intrahepatic cholestasis(IC) induced by α-naphthyl isothiocyanate(ANIT) and the possible mechanism by which ECN work as the therapeutic agent was discussed. The results showed that the serum levels of AST,ALT,ALP,DBIL,TBIL and TBA of the model mice were notably reduced in dose-dependent manner(P<0. 01,P<0. 05). The activity of SOD and GSH-Px in the liver homogenate of mice was increased,while the content of MDA was decreased(P<0. 01,P<0. 05).Pathological examination of liver in mice showed that ECN could improve the pathological changes of liver tissue in mice. The mRNA expression level of genes related to bile acid metabolism were detected by RT-PCR and the results suggested that ECN could significantly increase the expression of genes such as BSEP,FXR and MRP2(P<0. 01,P<0. 05),meanwhile significantly reduce the expression of CYP7 A1(P<0. 01,P<0. 05). These results confirmed the protective effect of ECN on intrahepatic cholestasis-induced liver injury in mice,and indicated that the mechanism may be related to activating FXR and its target genes,reducing bile acid synthesis and increasing bile acid excretion. This study provides a modern pharmacological basis for the clinical application of Yajima in Tibetan medicine.


Subject(s)
Animals , Cholestasis, Intrahepatic , Drug Therapy , Liver , Medicine, Tibetan Traditional , Mice , Plant Preparations , Pharmacology , Saxifragaceae , Chemistry
9.
Article in Chinese | WPRIM | ID: wpr-803506

ABSTRACT

Objective@#To investigate the impact of removing restraint on intensive care unit acquired weakness(ICU-AW), muscle strength and the incidence of extubation in patients with pancreatitis but normal cognitive function.@*Methods@#Eighty patients with pancreatitis but normal cognitive function hospitalized from February 2017 to November 2018 were divided into experimental group (40 cases) and control group (40 cases) by random digits table method. The control group received routine care and restraint, while the experimental group was removed from restraint compared with the control group. The Medical Research Council (MRC) score, incidence rate of ICU-AW, and extubation rate were compared between the two groups.@*Results@#The MRC scores of the experimental group before intervention, on 3rd, 7th and 10th day were (55.1±4.2), (54.2±4.6), (53.4±4.3), and (52.3±4.8) respectively. The MRC scores before the intervention, on the 3rd, 7th, and 10th day in the control group were (53.8±5.6), (52.0±6.2), (49.7±6.2), and (48.7±5.7) respectively. The MRC scores of the experimental group were significantly higher than those of the control group. The difference of MRC scores between the two groups was statistically significant on the 7th and 10th day(t=3.012, 3.060, P<0.05). The incidence of ICU-AW was 25.0%(10/40) in the experimental group and 37.5%(15/40) in the control group. The experimental group was lower than the control group, but the difference was not statistically significant (χ2=1.455, P>0.05). There was no unplanned extubation in both groups.@*Conclusions@#The removal of restraint in patients with pancreatitis but normal cognitive function can slow down the decline in muscle strength but has no positive impact on the incidence rate of ICU-AW.

10.
Article in Chinese | WPRIM | ID: wpr-803503

ABSTRACT

Objective@#To explore the effect of nursing scheduling software combined with mobile phone APP in the nursing manpower arrangement in intensive care unit.@*Methods@#The nursing scheduling software and mobile phone APP were applied to management resources of 82 nurses in ICU, substituted for traditional manual way. The work efficiency, nursing quality and nurse satisfaction were compared before and after implementing in intensive care unit.@*Results@#After implementation of nursing scheduling software combined with mobile phone APP, the average time of scheduling was reduced from (6.49±0.62) h to (4.29±0.44) h, the difference was statistically significant (t=19.97, P<0.01). The nursing quality score was improved from (97.54±1.19) points to (95.16±1.29) points, the difference was statistically significant (t=-4.70, P<0.01). The nurses′ satisfaction about scheduling was improved from 73.2%(60/82) to 96.3%(79/82), the difference was statistically significant (χ2=17.04, P<0.01).@*Conclusions@#The mode of nursing scheduling software combined with mobile phone APP in intensive care unit has a good effect, which can improve the scheduling efficiency, the job satisfaction of nursing staff and the quality of nursing,and promote the nursing information management.

11.
Article in Chinese | WPRIM | ID: wpr-743692

ABSTRACT

Objective To study the application effect of graded nursing intervention for ICU patients combined with the Pre-Deliric prediction model. Methods A total of 288 ICU patients were elected and divided into the control group (141 cases from May 2017 to October 2017) and the intervention group (147 cases from November 2017 to April 2018) according to hospitalization time. The control group received conventional delirium prevention measures. The intervention group was assessed within 24 h following admission with Pre-Deliric prediction model to screen the risk of delirium, and then they received grading prevention care based on the assessment results of delirium risks. The data of this study were collected by Numeric Rating Scale, Critical-Care Pain Observation Tool, Richmond Agitation and Sedation Scale, Confusion Assessment Method for the ICU. The incidence and duration of delirium, 28d survival rate, ICU length of stay of the two groups were statistically analyzed. Results Compared with the control group, we detected that the incidence of delirium in the intervention group was significantly lower (χ2=5.043, P<0.05), 21.7%(32/147) vs. 35.5%(50/141). Compared with the control group, we found that the duration of delirium in the intervention group was significantly shorter,(1.68 ± 1.24) vs.( 2.82 ± 1.60)d, the ICU length of stay in the intervention group were significantly shorter than the control group(t=4.45﹐P<0.01), (3.42±3.02)d vs (6.21± 4.56)d. There was no significant difference in the 28-day ICU survival rate between the two groups (P>0.05). Conclusions the risk assessment and grading nursing care combined with Pre-Deliric prediction model could effectively prevent the occurrence and shorten the duration of delirium, and also shorten the ICU length of stay. It was significant for improve the quality of nursing.

12.
Article in Chinese | WPRIM | ID: wpr-798159

ABSTRACT

Objective@#To study the application effect of graded nursing intervention for ICU patients combined with the Pre-Deliric prediction model.@*Methods@#A total of 288 ICU patients were elected and divided into the control group (141 cases from May 2017 to October 2017) and the intervention group (147 cases from November 2017 to April 2018) according to hospitalization time. The control group received conventional delirium prevention measures. The intervention group was assessed within 24 h following admission with Pre-Deliric prediction model to screen the risk of delirium, and then they received grading prevention care based on the assessment results of delirium risks. The data of this study were collected by Numeric Rating Scale, Critical-Care Pain Observation Tool, Richmond Agitation and Sedation Scale, Confusion Assessment Method for the ICU. The incidence and duration of delirium, 28d survival rate, ICU length of stay of the two groups were statistically analyzed.@*Results@#Compared with the control group, we detected that the incidence of delirium in the intervention group was significantly lower (χ2=5.043, P<0.05), 21.7%(32/147) vs. 35.5%(50/141). Compared with the control group, we found that the duration of delirium in the intervention group was significantly shorter,(1.68±1.24) vs.(2.82±1.60)d, the ICU length of stay in the intervention group were significantly shorter than the control group(t=4.45, P<0.01), (3.42±3.02)d vs (6.21±4.56)d. There was no significant difference in the 28-day ICU survival rate between the two groups (P>0.05).@*Conclusions@#the risk assessment and grading nursing care combined with Pre-Deliric prediction model could effectively prevent the occurrence and shorten the duration of delirium, and also shorten the ICU length of stay.It was significant for improve the quality of nursing.

13.
Article in Chinese | WPRIM | ID: wpr-697167

ABSTRACT

Objective To assess and compare the predicted abilities of PRE- DELIRIC and E-PRE-DELIRIC two delirium prediction models in ICU patients. Methods From January 2017 to April 2017, 265 critically ill patients who met the inclusion criteria were included in this study. The clinical data of all the included patients, respectively calculated the scores with both PRE-DELIRIC and E-PRE-DELIRIC rating software were collected. Forecasting performance of two different models of discrimination and calibration were assessed. 2 medical staff assessed 20 patients with the Chinese version PRE-DELIRIC and E-PRE-DELIRIC,while the intraclass correlation coefficients were accumulated to evaluate the inter-rater reliability. Results The average scores of PRE-DELIRIC were46.41 ± 14.05in delirium group and20.08 ± 9.96 in patients without delirium, the difference between scores was statistically significant (t=14.34, P<0.05). The average scores of E-PRE-DELIRIC were36.23±13.34in delirium group and14.45±9.56 in patients without delirium, the difference between scores was statistically significant (t=14.59, P<0.05). The AUROCC and its 95%CI of the PRE-DELIRIC and E-PRE-DELIRIC for prediction of delirium were 0.928(0.891-0.965) and 0.904(0.861-0.947) respectively in all patients. Discrimination was generally good for two models. The PRE-DELIRIC and E-PRE-DELIRIC sensitivity were 0.841, 0.812, specificity was 0.939, 0.913, the threshold values of PRE-DELIRIC model was 36.5%and E-PRE-DELIRIC model was 30.5%. The Youden′s index of PRE–DELIRIC model was 0.779, which better than 0.725 of E-PRE-PREDIRIC model. Conclusions The PRE-DELIRIC and E-PRE-DELIRIC models both have high accuracy in predicting delirium of patients in intensive care unit. PRE-DELIRIC does better performance than E-PRE-DELIRIC, but has imitation in terms of time. E-PRE-DELIRIC model can be used in ICU patients who develop delirium within 24 h following admission.

14.
Article in Chinese | WPRIM | ID: wpr-697159

ABSTRACT

Objective To explore the value of the application of albumen powder during the early standardized nutritional support in ICU. Methods Totally 80 patients treated in ICU were enrolled. Randomized digital tables were used to divide patients into experimental and control groups. Nutritive medium was used for enteral nutrition in the control group, and intermixture of nutritive medium and albumen powder was used in experimental group. Results After the intervention, the value of index was significantly better than the control group. The sebum thickness, muscle thickness and plasma total protein and serum album in experimental group before intervention were (0.99±0.72) cm, (2.19±1.14) cm, (62.14±6.87) g/L,(35.32±2.98) g/L, and were (1.01±0.72) cm, ( 2.18±1.13) cm,(64.31±6.97) g/L, ( 36.13± 3.02)g/L in control group, the difference between the two groups was not statistically significant .After intervention, the value were (1.06±0.53)cm,(2.25±0.69) cm,(69.87±7.16)g/L,(40.32±3.17) g/L in control group, (1.39±0.63)cm,(2.62±0.81)cm,(44.21±3.22)g/L,(75.24±7.32)g/L in experimental group, there were significant difference between two groups (t=2.182- 5.445, P<0.01 or 0.05). The incidence of gastrointestinal reaction in experimental group was 20% (8/40) which was lower than 35%(14/40) of control group significantly(χ2=19.57,P=0.000). Conclusion Application of albumen powder could improve the index including sebum thickness, muscle thickness, plasma total protein and serum album and reduce the incidence of gastrointestinal reaction of patients in ICU.

15.
Article in Chinese | WPRIM | ID: wpr-697066

ABSTRACT

Objective To explore the correlation of stage early upright mobilization in critical patients and enteral nutrition- related tolerance. Methods A total of 50 critically patients with continuous enteral nutrition who admitted in ICU from October 2016 to July 2017 were randomized into two groups;the control group (receiving routine functional exercise in bed) and the observation group (stage early upright mobilization)25 cases in each group,the correlation of nutrition-related tolerance,the length of target feeding time and incidence of catheter related adverse events were compared. Results There was no statistically significant difference in the incidence of reflux of stomach,aspiration,diarrhea and catheter related adverse events in this two group patients during enteral nutrition(P>0.05),while the times of interrupting enteral nutrition in the observation group(0)was lower than that of the control group (20.83%,5/24),with a statistically significant difference(χ2=4.922,P=0.035).The length of target feeding time was shortened, (3.04 ± 0.66) d in the control group, (3.57 ± 0.83) d in the observation group,with a statistically significant difference(t=2.409,P=0.025). Conclusions Stage early upright mobilization in critical patients is safe and feasible,it can improve the feeding tolerance and shorten the length of target feeding time to promote the early recovery of the patient's disease.

16.
Article in Chinese | WPRIM | ID: wpr-693837

ABSTRACT

Objective:To explore the clinicaleffect of radial arterial puncture cannulationunder ultrasonic guidance in patients with critical diseases.Methods:From December 2016 to May 2017,120 patients under critical conditions in Department of Intensive Care Unit,Xiangya Hospital,Central South University,who received arterial cannulation,were randomly divided into 2 groups:a control group (traditional blind puncture method) and an observation group (ultrasound-guided radial arterial cannulation) (60 cases in each group).The success ratio of radial arterial puncture cannulation by one time,total success ratio of radial arterial puncture cannulation,numbers of puncture,the rate of complications and the time of consumption were compared between the 2 groups.Results:There was no statistically significant difference in the total success ratio of radial arterial puncture cannulationin the 2 groups (P>0.05).The success ratio radial arterial puncture cannulation by one time was significantly greater in the observation group than that in the control group (P<0.05);the numbers of puncture,the rate of complications and the time of consumption in the observation group were lower than those in the control group,with statistically significant (all P<0.05).Conclusion:The application of ultrasound-guided radial arterial puncturecannulation can improve the success ratio of radial arterial puncturecannulation by one time,decrease the numbers of puncture,reduce the incidence of complications and save operation time.

17.
Parenteral & Enteral Nutrition ; (6): 176-179, 2018.
Article in Chinese | WPRIM | ID: wpr-692135

ABSTRACT

Objective: To explore the application value of bedside nasojejunal feeding tube placement using four steps of ultrasonic-assisted method in critical ill patients. Method: Thirty-three critical ill patients receiving enteral nutrition were enrolled. We adopt four steps of ultrasonic guidance to conduct nasojejunal feeding tube placement. The details were as followed: nasojejunal feeding tube placement within the esophagus, within Gastric body, within After the pylorus, at last the location of nasojejunal feeding tube. Results: The placement of nasojejunal feeding tube was successful in 28 patients, failed in 2 patients. The failure reason include that the false appearance of pylorus through and the lost gastrointestinal motility led to the sticking of nasojejunal feeding tube on arcus major ventriculi and it couldn't enter into gastric antrum and pylorus. Conclusion: The application of nasojejunal feeding tube placement by four steps of ultrasonic-assisted is a novel feeding technique, and it's simple, effective, noninvasive and repeatability procedure with a high success rate and low complications.

18.
Chinese Medical Journal ; (24): 899-906, 2018.
Article in English | WPRIM | ID: wpr-687011

ABSTRACT

<p><b>Background</b>Rapid eye movement (REM) sleep behavior disorder (RBD) and obstructive sleep apnea (OSA) are the most common sleep disorders in Parkinson's disease (PD). The aim of this study was to identify whether RBD could alleviate OSA severity in PD patients and its effect on cognitive impairment.</p><p><b>Methods</b>From February 2014 to May 2017, we recruited 174 PD patients from the Second Affiliated Hospital of Soochow University, all of whom underwent polysomnography (PSG). We collected clinical data, PSG results, and compared information between patients with and without RBD or OSA by analysis of covariance. We also investigated the effect of these sleep disorders on cognitive impairment using linear regression.</p><p><b>Results</b>We grouped participants as follows: PD only (n = 53), PD + OSA (n = 29), PD + RBD (n = 61), and PD + RBD + OSA (n = 31). Minimum oxygen saturation (SaO) during whole sleep and in REM sleep was higher in PD + RBD + OSA patients than that in PD + OSA patients. PD + RBD patients had worse Mini-Mental Status Examination and Montreal Cognitive Assessment (MoCA) scores than those in the PD group (P < 0.001), especially in visuospatial/executive, attention, and memory functions. The PD + OSA group performed worse than the PD group in the delayed recall domain. After adjusting for age, sex, body mass index, education, disease severity, and other sleep disorders, MoCA was negatively associated with OSA (β = -0.736, P = 0.043) and RBD (β = -2.575,P < 0.001). The severity of RBD (tonic/phasic electromyography activity) and OSA (apnea-hypopnea index/oxygen desaturation index/minimum SaO) were also associated with MoCA. The adjusted β values of RBD-related parameters were higher than that for OSA.</p><p><b>Conclusions</b>We found that RBD alleviated OSA severity; however, RBD and OSA together exacerbated PD cognitive impairment. Further studies are needed to evaluate whether OSA treatment can improve cognition in PD.</p>


Subject(s)
Aged , Female , Humans , Linear Models , Male , Middle Aged , Parkinson Disease , Pathology , Polysomnography , REM Sleep Behavior Disorder , Pathology , Sleep Apnea, Obstructive , Pathology , Sleep, REM , Physiology
19.
Chinese Journal of Epidemiology ; (12): 799-804, 2018.
Article in Chinese | WPRIM | ID: wpr-738049

ABSTRACT

Objective To investigate the infection pattern and etiological characteristics of a case of human infection with highly pathogenic avian influenza A (H7N9) virus and provide evidence for the prevention and control of human infection with highly pathogenic avian influenza virus.Methods Epidemiological investigation was conducted to explore the case's exposure history,infection route and disease progression.Samples collected from the patient,environments and poultry were tested by using real time reverse transcriptase-polymerase chain reaction (RT-PCR).Virus isolation,genome sequencing and phylogenetic analysis were conducted for positive samples.Results The case had no live poultry contact history,but had a history of pulled chicken processing without taking protection measure in an unventilated kitchen before the onset.Samples collected from the patient's lower respiratory tract,the remaining frozen chicken meat and the live poultry market were all influenza A (H7N9) virus positive.The isolated viruses from these positive samples were highly homogenous.An insertion which lead to the addition of multiple basic amino acid residues (PEVPKRKRTAR/GL) was found at the HA cleavage site,suggesting that this virus might be highly pathogenic.Conclusions Live poultry processing without protection measure is an important infection mode of "poultry to human" transmission of avian influenza viruses.Due to the limitation of protection measures in live poultry markets in Guangzhou,it is necessary to promote the standardized large scale poultry farming,the complete restriction of live poultry sales and centralized poultry slaughtering as well as ice fresh sale.

20.
Chinese Journal of Epidemiology ; (12): 799-804, 2018.
Article in Chinese | WPRIM | ID: wpr-736581

ABSTRACT

Objective To investigate the infection pattern and etiological characteristics of a case of human infection with highly pathogenic avian influenza A (H7N9) virus and provide evidence for the prevention and control of human infection with highly pathogenic avian influenza virus.Methods Epidemiological investigation was conducted to explore the case's exposure history,infection route and disease progression.Samples collected from the patient,environments and poultry were tested by using real time reverse transcriptase-polymerase chain reaction (RT-PCR).Virus isolation,genome sequencing and phylogenetic analysis were conducted for positive samples.Results The case had no live poultry contact history,but had a history of pulled chicken processing without taking protection measure in an unventilated kitchen before the onset.Samples collected from the patient's lower respiratory tract,the remaining frozen chicken meat and the live poultry market were all influenza A (H7N9) virus positive.The isolated viruses from these positive samples were highly homogenous.An insertion which lead to the addition of multiple basic amino acid residues (PEVPKRKRTAR/GL) was found at the HA cleavage site,suggesting that this virus might be highly pathogenic.Conclusions Live poultry processing without protection measure is an important infection mode of "poultry to human" transmission of avian influenza viruses.Due to the limitation of protection measures in live poultry markets in Guangzhou,it is necessary to promote the standardized large scale poultry farming,the complete restriction of live poultry sales and centralized poultry slaughtering as well as ice fresh sale.

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