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KMJ-Kuwait Medical Journal. 2015; 47 (2): 161-165
in English | IMEMR | ID: emr-171585


We report a case of a 3-year-old boy with dysplasia epiphysealis hemimelica [DEH] who presented with a hard painless swelling on the medial side of his left ankle joint. Plain X-rays, CT and MRI showed a bony tumor and associated soft-tissue abnormalities. At age one year, he had been diagnosed with an osteochondroma and underwent incomplete surgical excision at a local hospital. Due to joint impingement and restricted movement, we chose to completely excise the tumor. Pathologically, the specimen showed evidence of an osteochondroma. From its clinical, imaging, and pathological features and reports in the medical literature, a diagnosis of DEH was established. DEH is a rare variant of osteochondroma, resulting in many patients being incorrectly diagnosed or diagnosed with osteochondroma alone. It is important to low-grade malignant tumor or osteochondroma-like parosteal osteosarcoma from DEH of the talus, especially when accompanied by soft tissue abnormalities. Surgical treatment is mandatory in patients with symptoms such as pain, joint impingement and deformation. Incomplete excision of an articular lesion may lead to recurrence and additional surgery, making it less than complete excision

Humans , Male , Child, Preschool , Femur/abnormalities , Tibia/abnormalities , Ankle Joint/pathology , Tomography, X-Ray Computed , Magnetic Resonance Imaging , Osteochondroma , Talus , Review Literature as Topic
Article in English | WPRIM | ID: wpr-820513


OBJECTIVE@#To explore the significance of osteopontin and nuclear factor κB (NF-κB) expression in patients with knee osteoarthritis.@*METHODS@#RT-PCR and enzyme-linked immunosorbent assay were used to measure the Osteopontin (OPN) and NF-κB concentration of knee joint synovial fluid of patients with knee osteoarthritis and trauma fractures, and analyze the relationship between the expressiones of them.@*RESULTS@#OPN and NF-κB expression at the mRNA and protein levels of patients with knee osteoarthritis were significantly higher than the control group. the result showed statistical significance (P<0.05). There was a positive correlation between the OPN levels in synovial fluid of patients with knee osteoarthritis and NF-κB expression levels (P<0.05).@*CONCLUSIONS@#The high expression of OPN and NF-κB are closely related to occurrence and development of knee osteoarthritis.

Adult , Aged , Blotting, Western , Case-Control Studies , Female , Humans , Male , Middle Aged , NF-kappa B , Genetics , Metabolism , Osteoarthritis, Knee , Metabolism , Osteopontin , Genetics , Metabolism , Polymerase Chain Reaction , RNA, Messenger , Genetics , Metabolism , Statistics, Nonparametric , Synovial Fluid , Metabolism