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1.
Article in English | WPRIM | ID: wpr-878316

ABSTRACT

Objective@#The relationship between serum uric acid (SUA) levels and glycemic indices, including plasma glucose (FPG), 2-hour postload glucose (2h-PG), and glycated hemoglobin (HbA1c), remains inconclusive. We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.@*Methods@#The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study. A total of 105,922 community-dwelling adults aged ≥ 40 years underwent the oral glucose tolerance test and uric acid assessment. The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.@*Results@#A total of 30,941 men and 62,361 women were eligible for the current analysis. Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels, but with different inflection points in men and women. The thresholds for FPG, 2h-PG, and HbA1c for men and women were 6.5/8.0 mmol/L, 11.0/14.0 mmol/L, and 6.1/6.5, respectively (SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).@*Conclusion@#An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes, while the inflection points were reached earlier in men than in women.


Subject(s)
Aged , Asian Continental Ancestry Group , Blood Glucose/analysis , China/epidemiology , Cohort Studies , Diabetes Mellitus/blood , Female , Glucose Tolerance Test , Glycated Hemoglobin A/analysis , Glycemic Index , Humans , Male , Middle Aged , Uric Acid/blood
2.
International Eye Science ; (12): 1164-1166, 2017.
Article in Chinese | WPRIM | ID: wpr-641199

ABSTRACT

AIM: To discuss the details about the phacoemulsification and intraocular lens implantation combined with goniosynechialysis for the treatment of primary acute angle-closure glaucoma (PAACG).METHODS: Totally 21 patients (21 eyes) with PAACG from February 2013 to October 2015 were performed phacoemulsification and intraocular lens implantation combined with goniosynechialysis.The details such as incision, circular capsulorhexis, water separation, intraocular lens selection, goniosynechialysis were discussed.The vision, intraocular pressure, complications were observed.RESULTS: Postoperative intraocular pressure of all patients with were controlled under 21mmHg followed up for 1mo.Visual acuity was improved to some extent.The patients were observed with rapid recovery and fewer complications.There was 1 eye with posterior capsule rupture intraoperatively and 1 eye with decompensated corneal edema postoperatively.CONCLUSION: It makes this surgery more safe and perfect by disposing the details during operation.

3.
Pakistan Journal of Medical Sciences. 2012; 28 (3): 530-532
in English | IMEMR | ID: emr-118606

ABSTRACT

We report an unusual variant, amyloid AA, of an already unusual condition, primary localized amyloidosis of the renal pelvis. Our patient is a 68-year-old man with a space-occupying lesion in left renal pelvis found by CT. He was suspected of having malignancy before ureteroscopy. Specimens were taken from the lesion site and pathological result was amyloidosis. No treatment has been given to him for the primary pelvic amyloidosis. New lesions were found in the bladder 10 months later and in the left ureter 21 months later, respectively. It is the first case of primary renal pelvic AA type amyloidosis in which the patient has been monitored for the progress of lesions in renal pelvis, ureter and bladder

4.
National Journal of Andrology ; (12): 584-588, 2010.
Article in Chinese | WPRIM | ID: wpr-295036

ABSTRACT

<p><b>OBJECTIVE</b>To identify the differential expressions of serum cytokines between prostate cancer (PCa) and benign prostatic hyperplasia (BPH), and provide proteomic evidence for the early diagnosis of PCa.</p><p><b>METHODS</b>We used human cytokine array to determine the profiles of the serum cytokines obtained from 6 PCa and 6 BPH patients with the PSA level within the grey scale of 4 - 10 ng/ml.</p><p><b>RESULTS</b>We identified 19 differentially expressed cytokines in the PCa patients, 16 obviously up-regulated, including IL-3, IL-6 and IL-16, and 3 markedly down-regulated, which were Fas/TNFRSF6, TRALR-3 and IGFBP-6. Most of them were involved in such cellular bioprocesses as transcription, proliferation, signal transduction, and apoptosis.</p><p><b>CONCLUSION</b>The cytokine antibody assay permits simultaneous measurement of multiple markers in a small volume of serum, and can identify a panel of key cytokines related to the malignant biological behavior of cancer cells. And it helps to find the biomarkers for the early diagnosis, efficacy assessment and prognosis of prostate cancer.</p>


Subject(s)
Aged , Humans , Interleukin-16 , Blood , Interleukin-3 , Blood , Interleukin-6 , Blood , Male , Middle Aged , Prostatic Hyperplasia , Blood , Genetics , Metabolism , Prostatic Neoplasms , Blood , Genetics , Metabolism , Proteomics
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