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Article in English | WPRIM | ID: wpr-296551


Rats were exposed to 1 or 10 μg/mL bisphenol A (BPA) in water during pregnancy and lactation. Offspring rats were given normal water and a standard diet from weaning to postnatal day (PND) 50. Perinatal exposure to BPA resulted in significantly increased body weight, visceral adipose tissue, abnormal serum lipids, and lower adiponectin (ADP) levels in both female and male offspring rats. Liver adipose triglyceride lipase (Atgl) mRNA levels and ADP protein in visceral adipose tissue were significantly decreased in BPA-exposed offspring rats. In both female or male offspring rats, obesity and dyslipidemia induced by perinatal exposure to BPA were associated with down regulation of Atgl mRNA in liver and ADP protein in visceral adipose tissue.

Adiponectin , Metabolism , Adipose Tissue , Metabolism , Animals , Benzhydryl Compounds , Metabolism , Body Weight , Dyslipidemias , Metabolism , Female , Humans , Lipase , Genetics , Metabolism , Lipids , Blood , Male , Obesity , Metabolism , Phenols , Metabolism , Pregnancy , Prenatal Exposure Delayed Effects , Metabolism , Rats , Rats, Sprague-Dawley
Article in Chinese | WPRIM | ID: wpr-340029


<p><b>OBJECTIVE</b>To study the effects of fluoride on the proliferation and differentiation of osteoblasts in sucking rats and the antagonism of vitamin Cin vitro.</p><p><b>METHODS</b>The enzyme digesting method was used to isolate the rat osteoblasts; the proliferative response was determined by the percents of reduced alamarBlue; the activity of alkaline phosphatase (ALP) was measured by ELISA method.</p><p><b>RESULTS</b>The proliferation of sucking rat osteoblasts was increased at 0.10 - 1.00 mmol/L of NaF, whereas inhibited at >or= 2.00 mmol/L. ALP activity was increased at 0.01 - 0.05 mmol/L of NaF, and decreased at >or= 0.10 mmol/L. The inhibition on proliferation and differentiation at 2 mmol/L NaF was antagonized by vitamin C.</p><p><b>CONCLUSION</b>Fluoride had a two-phase effect on osteoblasts, vitamin C could antagonize the inhibitory effect of higher concentration of fluoride on proliferation and differentiation of osteoblasts.</p>

Alkaline Phosphatase , Animals , Animals, Newborn , Ascorbic Acid , Pharmacology , Cell Differentiation , Cell Proliferation , Enzyme-Linked Immunosorbent Assay , Fluorides , Pharmacology , Osteoblasts , Cell Biology , Rats , Rats, Wistar