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Article in Chinese | WPRIM | ID: wpr-252736

ABSTRACT

<p><b>AIM</b>To study the effect of angiotensin-(1-7) on the kidney of diabetic rats by observing the mRNA expression of PDGF and TGF-beta1.</p><p><b>METHODS</b>SD rats were divided into three groups: Group C (uni-nephrectomy control group), Group D (diabetic model control group), Group T (Ang-(1-7) treated group). We evaluated blood glucose,urea nitrogen, creatinine and urine albumin excretion respectively, studied the renal morphology by light microscope, and detected the gene expression of PDGF, TGF-beta1 in renal tissue by RT-PCR technique.</p><p><b>RESULTS</b>There was significant difference between the group D and T about the RW/BW, renal morphology, the total urine protein and the mRNA expression of PDGF and TGF-beta1.</p><p><b>CONCLUSION</b>Ang-(1-7) can relieve the renal process of diabetic rats.</p>


Subject(s)
Angiotensin I , Pharmacology , Animals , Diabetes Mellitus, Experimental , Metabolism , Diabetic Nephropathies , Metabolism , Kidney , Metabolism , Pathology , Male , Peptide Fragments , Pharmacology , Platelet-Derived Growth Factor , Genetics , Metabolism , RNA, Messenger , Genetics , Metabolism , Rats , Rats, Sprague-Dawley , Transforming Growth Factor beta1 , Genetics , Metabolism
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