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1.
Chinese Journal of Rheumatology ; (12): 145-151,C3-1,C3-2, 2022.
Article in Chinese | WPRIM | ID: wpr-932458

ABSTRACT

Objective:To investigate the effect of B7-H3 gene on the biological function of fibr-oblastlike synoviocytes (FLS) in osteoarthritis (OA).Methods:Synovial tissue of five cases of OA and synovial tissue of 4 normal knee were obtained, and the primary cell lines were isolated and cultured. The expression of B7-H3 in OA synovial tissue and primary OA-FLS were studied by immunohi-stochemistry, real time-poly merase chain reaction (PCR) and FACS. According to sites 996 and 1041 of B7-H3, corresponding siRNA was designed and the expression of B7-H3 in FLS was silenced and down-regulated. The inhibition of B7-H3 and its protein in target cells was determined by Western blot and FACS. The migration and invasion ability of B7-H3 in target cells were analyzed by scratch assay and Transwell assay. CCK8 assay was used to detect cell proliferation ability, and CBA assay was used to detect cytokines and chemokines in cell culture supernatant. GraphPad Prism 8.0 software was used to analyze the experimental data. The normal distribution data was expressed as mean±standard deviation ( Mean± SD). The comparison between data was performed by T test, and P<0.05 was considered statistically significant. Results:The abnormally high expression of B7-H3 in fibro-blast-like synoviocytes of OA was detected. Compared with siNC, si996 and si1041 inhibited the expression of B7-H3 in OA-FLS. In the Transwell migration experiment, the mean cells number of random view in the siNC group, the si996 group, and the si1041 group indicating decreased migration ability of OA-FLS [siNC vs si996 (100.3±3.7) /view vs (48.7±1.2) /view, t=13.24, P<0.001; siNC vs si1041 (100.3±3.7) /view vs (59.7±1.9) /view, t=9.80, P<0.001). In the Transwell invasion experiment, the mean cells number of random view in the siNC group, in the si996 group, and in the si1041 group indicating decreased invasion ability of OA-FLS [siNC vs si996 (127.3±5.6) /view vs (39.7±3.3) /view, t=13.49, P<0.001; siNC vs si1041 (127.3±5.6) /view vs (57.3±1.9) /view, t=11.85, P<0.001]. The secretion of IL-6 [siNC vs si996 (248±21) pg/ml vs (111±12) pg/ml, t=24.08, P=0.002; siNC vs si1041 (248±21) pg/ml vs (46±5) pg/ml, t=13.21, P=0.006], IL-8 [siNC vs si996 (118.1±15.6) pg/ml vs (47.1±5.4) pg/ml, t=6.68, P=0.022; siNC vs si1041 (118.1±15.6) pg/ml vs (10.0±1.3) pg/ml, t=13.08, P=0.006], CXCL8 [siNC vs si996 (178.8±6.4) ng/ml vs (83.2±2.7) ng/ml, t=13.77, P=0.005; siNC vs si1041 (178.8±6.4) ng/ml vs (93.5±2.8) ng/ml, t=12.23, P=0.007] and CCL2 [siNC vs si996 [(184.1±5.1) ng/ml vs (109.4±5.9) ng/ml, t=9.57, P=0.011; siNC vs si1041 (184.1±5.1) ng/ml vs (97.1±1.5) ng/ml, t=16.39, P=0.004] was decreased . Conclusion:B7-H3 may regulate the migration, invasion, cytokine secretion and other biological functions of OA-FLS, providing clues for further study of B7-H3's involvement in the pathogenesis of OA.

2.
Journal of Medical Biomechanics ; (6): E105-E111, 2022.
Article in Chinese | WPRIM | ID: wpr-920676

ABSTRACT

Objective To explore the relationship between the establishment of collateral circulation caused by iliac vein compression syndrom(IVCS) and the deep venous thrombosis (DVT). Methods Different types of ideal collateral circulation models and IVCS patient-specific models were numerically simulated using computational fluid dynamics (CFD) in combination with the blood stasis model. The relationship between blood retention and collateral types and cross-sectional area was studied, and the relationship with thrombosis was explored. Results Wall shear stress (WSS) at the distal end part of each ideal model was 0.3 Pa. After four cardiac cycles, the residual blood stayed at the stenosis and the distal end part for the lumbar ascending and pelvic type models, the old blood volume fraction (OBVF) varied with collateral cross-sectional areas, ranging from 5%-90% and 70%-80%, respectively. The OBVF of the coexistence model was above 80%. The WSS at the distal end part of the patient-specific model was 0.9 Pa, and the OBVF at the distal end part was 51.5%. Conclusions The stenosis and the distal end part are most prone to blood stasis, and closely related with DVT. The larger the collateral cross-sectional area, the more serious the blood stagnation. Blood stagnation of the coexistence model is higher compared with the model with lumbar ascending type and pelvic type.

3.
Chinese Journal of School Health ; (12): 1506-1510, 2020.
Article in Chinese | WPRIM | ID: wpr-829311

ABSTRACT

Objective@#To explore the interrelationships among fathers’ parenting effectiveness, urban children’s sociality and the acceptance of “second-born children” by children (including only children and “first-born children”), and to provide a reference for interventional measured for improving children’s acceptance rate of "second-bron children".@*Methods@#Stratified cluster sampling method was used to select 3 to 9-year-old 778 only children and “first-born children” in two kindergartens and grades 1-3 of two primary schools in a city, and the children and their fathers were investigated with questionnaires survey regarding general information of both fathers and children, the acceptance degree of “second-born children”, the sociality of children and the parenting effectiveness of fathers.@*Results@#Children in different grades had different acceptance levels of “second-born children” and the difference was statistically significant (F=2.89,P<0.05). Correlation analysis showed that the acceptance of “second-born children” was negatively correlated with the interaction between the only children and “first-born children”, and positively correlated with the prosocial behavior of the only children and “first-born children”, both of which are statistically significant (r=-0.10,0.10,P<0.01). Father’s role efficacy was negatively correlated with onlychildren and “first-born-children” peer interaction problems(r=-0.15), and positively correlated with prosocial behavior(r=0.32), both of which were statistically significant (P<0.01). The structural equation model of father’s parenting effectiveness, children’s sociality and acceptance of “second-born children” showed that low father’s parenting effectiveness could positively predict children’s peer communication problems and negatively predict children’s prosocial behavior, and thus children’s peer communication problems could negatively predict the acceptance degree of only children and “first-born children” to “second-born children”, and prosocial behaviors could positively predict the acceptance degree of “second-born children”.@*Conclusion@#Promoting father’s parenting efficiency can facilitate the social development of children and the acceptance of siblings.It’s recommended that fathers actively participate in specific parenting matters for the only child and "one child",and consciously improve parenting effectiveness.

4.
Article in Chinese | WPRIM | ID: wpr-803510

ABSTRACT

Objective@#To investigate the effect of an information module for delirium assessment in ICU.@*Methods@#The information module for delirium assessment was designed according to the route chart of the Confusion Assessment Method for the Intensive Care Unit(CAM-ICU) information assessment. Totally 70 nurses Sir Run Run Shaw Hospital, Zhejiang University School of Medicine were included in the application of the information module. The compliance and accuracy of the delirium assessment and acceptance of nurses' assessment of information module were compared.@*Results@#The information module for delirium assessment was implanted into the clinical critical information system. The rate of compliance and accuracy of delirium assessed was 55.9%(2 728/4 877), 64.2%(231/360) before the application of information module, and 92.0%(4 360/4 740), 92.5%(333/360) after the application of information module. The difference between two groups were statistically significant (χ2=1 611.531, 85.139, P<0.01). The score of nurses′ acceptance of the input method before and after the application of information module were 69.00±4.00, 100.56±3.50, and the difference were statistically significant (t=-49.70, P<0.01).@*Conclusions@#The information module for delirium assessment can simplify the assessment process, improve nurses′ compliance and accuracy to assess delirium, optimize critical care management and worth spreading.

5.
Article in Chinese | WPRIM | ID: wpr-798135

ABSTRACT

Objective@#To investigate the characteristics of body surface electrocardiogram (ECG) of different segments of circumflex artey (LCX) occlusion.@*Methods@#The ECG characteristics of 85 patients with acute myocardial infarction caused by LCX occlusion in the People's Hospital of Rugao, Jiangsu, from February 2015 to February 2018 were analyzed.The results of coronary angiography were taken as the criteria.The efficacy of the body surface ECG for the diagnosis of LXC occlusion of acute myocardial infarction was analyzed by receiver operating characteristic curve (ROC).@*Results@#The ECG of right dominant LCX occlusion was dominated by STⅡ, Ⅲ, AVF elevation (76.47%), and the balance type was dominated by STV1-V3 (68%), and the dominant left dominant type was STⅡ, Ⅲ, AVF elevation (88.89%) and STV7-V9 elevation (66.67%). STV1-V3 moved down, STⅡ, Ⅲ, AVF elevation, STV7-V9 elevated in different coronary points.The differences between the two groups was statistically significant (χ2=4.028, 4.061, all P<0.05). The ECG changes of LCX occluded in the distal and middle segments were dominated by STⅡ, Ⅲ, AVF (100%, 78.95%), and the proximal and blunt branches were dominated by STV1-V3 (88.24%). STV1-V3 moved down, STⅡ, Ⅲ, AVF elevation, STⅠ, aVL elevation and STV7-V9 elevation had statistically significant differences(χ2=6.024, 5.318, 4.971, all P<0.05). The sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and area under the curve of STV1-V3, STⅡ, Ⅲ, AVF elevation were 82.06%, 92.63%, 89.91%, 86.34%, 88.06%, 0.830 (95%CI: 0.853-0.991), respectively, and 86.83%, 95.37%, 92.38%, 88.61%, 90.64%, 0.922 (95%CI: 0.729-0.931), respectively, the efficiency is better than STⅠ, aVL and STV7-V9.@*Conclusion@#The body surface ECG of LCX occlusive acute myocardial infarction is varied with various factors.STV1-V3 shift, STⅡ, Ⅲ, AVF elevation are of high diagnostic value for LCX occlusion of acute myocardial infarction, and the clinical history and other methods should be used for accurate diagnosis.

6.
Article in Chinese | WPRIM | ID: wpr-790891

ABSTRACT

Objective To establish a high-throughput in-vitro screening cell model for anti-atherosclerosis leading compounds.Methods Hypoxia response element (HRE) was cloned into a luciferase reporter vector, pGL3-Enhancer, to construct pGL3-HIF-1α-HRE.The THP-1human monocyte cell line was infected with the pGL3-HIF-1α-HRE and a stable cell line, THP-1-HIF-1α-HRE, was screened.Results Real-time PCR assay showed that HIF-1αexpression and luciferase activity in THP-1-HIF-1α-HRE cells was effectively upregulated by hypoxia.The increase of HIF-1αexpression and luciferase activity induced by hypoxia was significantly inhibited by lovastatin or curcumin.Conclusion THP1-HIF-1α-HRE, an in-vitro cell model for high-throughput screening lead compounds for anti-atherosclerosis (AS) was successfully established.

7.
Article in Chinese | WPRIM | ID: wpr-756593

ABSTRACT

This paper reviewed the present nursing manager succession planning at home and abroad, covering the succession standard of nursing managers, the content and form of pre-job training, and the evaluation tool of management ability. These efforts aim to provide references for the construction of nursing management talents teams in China.

8.
Article in Chinese | WPRIM | ID: wpr-755636

ABSTRACT

Objective To investigate the effect of genetic factors on the occurrence of chronic post-thoracotomy pain syndrome ( PTPS) from the perspective of genetic polymorphisms. Methods Two hun-dred patients of both sexes, of American Society of Anesthesiologists physical statusⅠ or Ⅱ, aged 18-80 yr, scheduled for elective video-assisted thoracoscopic radical lung cancer surgery, were enrolled in this study. Blood samples were taken before operation for genotype analysis of 20 SNP loci, such as rs4073 and rs3774932, after DNA extraction. Postoperative multimodal analgesia was applied to maintain the visual an-alogue scale score <3. All the patients were followed up for 2-4 months after operation to record the occur-rence of PTPS. The patients were divided into 2 groups according to whether PTPS occurred: non-PTPS group (group N) and PTPS group (group P). Results The incidence of PTPS was 38. 7% after surgery, and there were 114 patients in group N and 72 cases in group P . There was significant difference in A/T al-lele and genotype frequency at interleukin-8 rs4073 site and NF-κB1 rs3774932 site between the two groups (P<0. 05). Conclusion Interleukin-8 and NF-kappa B1 genetic polymorphisms are associated with the occurrence of PTPS.

9.
Article in Chinese | WPRIM | ID: wpr-744772

ABSTRACT

Objective To analyze the clinical manifestation,imaging data and genetics mutation variants of late onset familial Alzheimer's disease concomitant with a novel mutation of presenilin 1.Methods The clinical manifestations and auxiliary examination recordings of the pedigree were analyzed.DNA was extracted from peripheral blood samples of the proband and her sons.Mutational analysis was performed by the next-generation sequencing technology and the mutation event was confirmed by Sanger sequencing technology.Results Two patients of the family presenting as Alzheimer's dementia were late onset.MRI of the proband showed extensive cerebral microbleeds.The gene detection showed p.S289P mutation in the exon 8 of presenilin 1 of the proband.Conclusion Mutation of p.S289P in the presenilin 1 gene may contribute to late onset Alzheimer's disease accompanied by amyloid angiopathy.

10.
Article in Chinese | WPRIM | ID: wpr-744503

ABSTRACT

Objective To investigate the characteristics of body surface electrocardiogram (ECG) of different segments of circumflex artey (LCX) occlusion.Methods The ECG characteristics of 85 patients with acute myocardial infarction caused by LCX occlusion in the People's Hospital of Rugao,Jiangsu,from February 2015 to February 2018 were analyzed.The results of coronary angiography were taken as the criteria.The efficacy of the body surface ECG for the diagnosis of LXC occlusion of acute myocardial infarction was analyzed by receiver operating characteristic curve (ROC).Results The ECG of right dominant LCX occlusion was dominated by STⅡ,Ⅲ,AVF elevation (76.47%),and the balance type was dominated by STv1-v3 (68%),and the dominant left dominant type was ST Ⅱ,Ⅲ,AVF elevation (88.89%) and STV7-v9 elevation (66.67%).STV1-V3 moved down,ST Ⅱ,Ⅲ,AVF elevation,STV7-V9 elevated in different coronary points.The differences between the two groups was statistically significant (x2 =4.028,4.061,all P < 0.05).The ECG changes of LCX occluded in the distal and middle segments were dominated by STⅡ,Ⅲ,AVF(100%,78.95%),and the proximal and blunt branches were dominated by STvi-v3 (88.24%).STv1-V3 moved down,STⅡ,Ⅲ,AVF elevation,ST I,aVL elevation and STv7-v9 elevation had statistically significant differences (x2 =6.024,5.318,4.971,all P < 0.05).The sensitivity,specificity,positive predictive value,negative predictive value,accuracy,and area under the curve of STv1-v3,STⅡ,Ⅲ,AVF elevation were 82.06%,92.63%,89.91%,86.34%,88.06%,0.830 (95% CI:0.853-0.991),respectively,and 86.83%,95.37%,92.38%,88.61%,90.64%,0.922 (95% CI:0.729-0.931),respectively,the efficiency is better than STi,aVL and STv7-v9.Conclusion The body surface ECG of LCX occlusive acute myocardial infarction is varied with various factors.STV1 ~V3 shift,STⅡ,Ⅲ,AVF elevation are of high diagnostic value for LCX occlusion of acute myocardial infarction,and the clinical history and other methods should be used for accurate diagnosis.

11.
China Pharmacy ; (12): 1807-1811, 2019.
Article in Chinese | WPRIM | ID: wpr-817236

ABSTRACT

OBJECTIVE: To study the effects of different processing technologies on the quality of Salvia miltiorrhiza decoction pieces, and to provide reference for original processing of S. miltiorrhiza to decoction pieces. METHODS: Fresh S. miltiorrhiza from two areas of Shandong province (Pingyin and Pingyi) were processed into decoction pieces by 24 kinds of processing technology, such as fresh cutting, dry cutting after dried 30%, dry cutting after dried 50%, full dry cutting, traditional cutting [from 2015 edition of Chinese Pharmacopoeia (part Ⅰ), shorted as pharmacopecia], cutting after full dry steamed, cutting after fresh steamed, cutting after dry 30% steamed, cutting after fresh boiled (then divided into air-drying and baking). The qualities of decoction pieces were evaluated for original processing comprehensively through appearance character and the contents of moisture, water soluble extract, ethanol soluble extract, and effective components (tanshinones and salvianolic acid B). RESULTS: From the appearance characteristics, the traditional cutting, cutting after fresh steamed and cutting after dry 30% steamed, decoction pieces had better surface color and high yield, which were more in line with the relevant description of the pharmacopecia. From the contents of moisture and effective components, the contents of moisture of S. miltiorrhiza decoction pieces were 3.60%-10.40%; the contents of water soluble extract were 51.07%-70.18%; the contents of ethanol soluble extract were 15.08%-20.36%, all above were all in line with the standard of pharmacopecia. The contents of tanshinones were 0.16%-0.79%. Only fresh-cut and fresh-boiled-cut baked samples from Pingyin were not up to the standard of pharmacopecia (tanshinones content was not less than 0.25%), while those from Pingyi were up to the standard. The contents of salvianolic acid B were 4.51%-8.68%, which were all in line with the standard of pharmacopecia (salvianolic acid B content was not less than 3.0%). In all processing technologies, the indexes of decoctions made by steaming, cutting and air-drying were higher. CONCLUSIONS: Comprehensive considering from the aspects of appearance character and effective components content, suitable processing method of S. miltiorrhiza raw medicinal materials is cutting after steamed and air-drying.

12.
Article in Chinese | WPRIM | ID: wpr-790848

ABSTRACT

Objective To study the extraction technology and optimize the extraction process of Fuyuan Xingnao gran-ule.Methods The preliminary extraction process was designed by routine extraction method combined with the results of pharmacological activity experiment.The extraction process was optimized with orthogonal test.Results The extract was ob-tained by ethanol reflux extraction,water decoction extraction or ethanol precipitation followed by filtration and concentration. The optimal process for ethanol reflux extraction was extracting twice with 50% ethanol.The ratio of liquor to dry material was 8∶1 for the first time and 6∶1 for the second time.The extraction time was 120 minutes for the first time and 80 minutes for the second time.The optimal process for water decoction extraction was extracting twice with 120 minutes and 80 minutes each time.The ratio of liquor to dry material was 10∶1 for the first time and 8∶1 for the second time.The extraction temper-ature was100 ℃.The best ethanol precipitation process was 16 hour extraction with 80% ethanol.The ratio of ethanol to dry material was 2∶1.Conclusion The quality of Fuyuan Xingnao granule extract with this optimized extraction process was in line with requirements of Pharmacopoeiaof the People's Republic of China 2015,4 Volumes(0104 granule).

13.
Article in Chinese | WPRIM | ID: wpr-697497

ABSTRACT

Objective: To evaluate the anti-gingivitis efficacy of a novel stabilized stannous-containing sodium fluoride dentifrice. Methods: A randomized, controlled and double blind clinical study was conducted. 156 adults with gingivitis were enrolled and randomly assigned to experimental group(group of novel stabilized stannous-containing sodium fluoride dentifrice, n = 51), positive control group (group of Yunnan Baiyao dentifrice, n = 54) and negative control group (group of Crest dentifrice, n = 51). Gingival health was assessed using Mazza Modification of the Papillary Bleeding Index(Mazza GI) at Baseline, day 3 and week 4 and pocket depth was evaluated at baseline and week 4, respectively. Results: At day 3 and week 4, the experimental and positive control groups exhibited lower clinical parameters than the negative control group(P< 0. 000 1). At week 4, the mean Mazza GI scores and PD of the experimental group were significantly lower than those of the positive control group(P< 0. 05). Conclusion: The novel stannous-containing sodium fluoride dentifrice has anti-gingivitis efficacy.

14.
Article in Chinese | WPRIM | ID: wpr-790749

ABSTRACT

Objective To evaluate the efficacy of Scrophularia ningpoensis granules combined with fosinopril in treatment of congestive heart failure.Methods 60 congestive heart failure patients were randomly divided into 2 groups, 30 patients in the treatment group and 30 patients in the control group.Besides the conventional therapy, the control group was treated with fosinopril and the treatment group received Scrophularia ningpoensis granules plus fosinopril for 90 days.Left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular ejection fraction (LVEF) and serum B-type brain natriuretic peptide (BNP) were measured before and after treatment.Results The total effective rate in the treatment group and the control group were 90%, but significantly effective number in the treatment group was higher than the control group.The levels of BNP, LVEDD and LVESD in both groups were decreased, while LVEF was increased after the treatment.The difference was statistically significant (P<0.01).The degree of improvement of heart function in the treatment group was better than that in the control group (P<0.05).Conclusion The combination therapy of Scrophularia ningpoensis granules and fosinopril is efficacious in treating CHF.

15.
Article in Chinese | WPRIM | ID: wpr-695951

ABSTRACT

Processing technology of Chinese herbal medicine is the unique pharmaceutical technology in China.Chinese herbal pieces production enterprises are the main carrier of processing technology.Reasonable and normative master and use of the processing technology by production enterprises can directly affect the quality of Chinese herbal pieces and the clinical efficacy.Therefore,it is necessary to carry out investigation on the processing technology of Chinese herbal pieces production enterprises.In order to better inherit and develop processing technology,to promote the development of Chinese herbal pieces production enterprises and to ensure the quality of pieces,the general situation and existing problems of Chinese herbal pieces production enterprises were identified,concluded,summarized.Relevant countermeasures were put forward by carrying out investigation in Chinese herbal pieces production enterprises.

16.
China Pharmacy ; (12): 3040-3043, 2017.
Article in Chinese | WPRIM | ID: wpr-618180

ABSTRACT

OBJECTIVE:To study the common characteristic component peaks in water decoction of crude curcumae radix and the vinegar roasted products from 4 different sources,compare the contents of its water decoction,and provide reference for resolv-ing the multi-source of curcumae radix piece in clinical application,complementing and improving the quality standard of curcumae radix. METHODS:HPLC was used to determine the characteristic spectrums of crude curcumae radix and the vinegar roasted prod-ucts from different sources (Curcuma wenyujin,Curcuma kwangsiensis,Curcuma longa,Curcuma phaeocaulis),and component analysis was conducted by using fingerprint software and mirror comparison. And the changes of water decoction content before and after vinegar roasted were compared. RESULTS:Both crude curcumae radix and the vinegar roasted products from 4 different sourc-es had 7 common characteristic component peaks. Vinegar roasted had effect on peaks in different degree,some peaks areas were in-creased,some peaks areas were reduced,some peaks were generated,and some peaks were disappeared. However,the common components of curcumae radix from different sources showed no qualitative changes after vinegar roasted,except the increase or de-crease in peak areas. Areas of 5 common component peaks were increased in the 7 common components of C. wenyujin,C. kwang-siensis and C. longa after vinegar roasted,and only 3 in C. phaeocaulis after vinegar roasted. Contents of 4 water decoctions were increased after vinegar roasted. CONCLUSIONS:There are 7 common components in curcumae radix from 4 different sources. Vin-egar roasted has no qualitative effect on common components,while it can increase the chromatographic peak areas and contents of water decoction.

17.
Progress in Modern Biomedicine ; (24): 5290-5293, 2017.
Article in Chinese | WPRIM | ID: wpr-615223

ABSTRACT

Objective:To investigate the relationship between FA,ET-1,Hcy and VEGF in patients with pregnancy induced hypertension.Methods:Selected 80 cases of patients with pregnancy induced hypertension who were treated in our hospital from January 2013 to September 2016,divided into A group (40 cases),and preeclampsia and preeclampsia B group (40 cases),60 cases of normal late pregnant women as C group,60 cases of normal non pregnant women as D group.The plasma levels of FA,ET-1,Hcy and VEGF in each group were detected,and the correlation analysis was performed.Results:The plasma levels of FA and VEGF of group B were lowest in the four groups (P<0.05),the plasma ET-1 and Hcy levels of group B were highest (P<0.05).The plasma FA and VEGF levels of women with pregnancy induce hypertension were lower than those of the healthy late pregnant women.The plasma ET-1 and Hcy levels were higher (P<0.05).The multivariate logistic regression analysis showed that FA,ET-1,Hcy and VEGF levels were risk factors for pregnancy induce hypertension.Conclusion:The elevation of plasma Hcy level caused by FA deficiency in pregnancy might be related to the development of the disease and the incidence of pregnancy induced hypertension syndrome,VEGF might be an important factor in the occurrence and development of pregnancy induced hypertension syndrome.

18.
Article in Chinese | WPRIM | ID: wpr-815128

ABSTRACT

To explore the status of two-week illness in primary and secondary students and to provide the basis for rationally distributing heath resources in primary and secondary schools.
 Methods: Stratified cluster sampling method was used to select 6 744 primary and secondary students aged from 9.0-16.9 years, and the name or symptoms of two-week illness, frequencies, medical expenses and days of sick leave were surveyed by using the self-made questionnaires.
 Results: Respiratory system disease (73.6%) and digestive system diseases (13.2%) were the major two-week illness. When they were ill, 58.9% students went to hospital, 39.9% took medicine by themselves, and 1.2% received non-treatment. The two-week morbidity, sick frequencies, average medical expenses per time and days of sick leave were 12.6%, (1.34±0.81) times, 10.0 yuan, and (0.39±0.98) days, respectively. The two-week sick frequencies, average medical expenses per time and days of sick leave among primary or secondary students were (1.37±0.87) or (1.26±0.69) times, 12.0 or 9.0 yuan, and (0.44±1.14) or (0.30±0.55) days, respectively. There was a positive correlation between two week sick frequencies and medical fees per time, or days of sick leave (r=0.301, r=0.275 for primary students, respectively, P<0.01; r=0.334, r=0.290 for secondary students, respectively, P<0.01). The positive correlation between medical fees per time and days of sick leave was also found (r=0.312, r=0.343 for primary students and secondary students, respectively, P<0.01).
 Conclusion: Characteristics of two-week illness among primary and secondary students possess common symptoms, frequent, low medical expenses per time. The frequencies, medical expenses and days of sick leave in primary students were increased compared with that in secondary students.


Subject(s)
Adolescent , Child , Digestive System Diseases , Epidemiology , Therapeutics , Fees, Medical , Female , Humans , Male , Respiratory Tract Diseases , Epidemiology , Therapeutics , Schools , Sick Leave , Students , Surveys and Questionnaires
19.
Chongqing Medicine ; (36): 1542-1545,1548, 2016.
Article in Chinese | WPRIM | ID: wpr-604017

ABSTRACT

Objective To understand the epidemiological characteristics of injury in college students in north jiangsu area ,a‐nalysis its related factors .Methods With the method of random cluster sampling ,1 857 students as the research object .Using self‐made questionnaire survey ,choose Chinese college students′ mental health scale (CCSM HS ) and Chinese perceived stress scale (CPSS) to investigate the mental health status of the research object .Results In 1 857 students ,639 students had more than once hurt ,harm the annual incidence of 34 .41% ;Incidence rate of injury was highest in junior college student(38 .94% ) ,lowest in gradu‐ate student(31 .75% ) .The highest constituent ratio of hurt types was fall/collision injury(34 .64% ) ,and lower extremity injuries was the main injured area .Education ,age ,ranking in the home ,parents′marital status ,students and their parents′physical condi‐tion ,the relationship with the students ,and the roommate to the occurrence of friction ,go out to work ,as well as the psychological stress test ,10 factors of college students′psychological scale ,10 factors oftotal pressure and tension factor were influencing factors of injury .Conclusion Damage and mental health problems is closely related .Safety education ,psychological education and interven‐tion should be carried out in order to effectively prevent and reduce the incidence of injury .

20.
Article in Chinese | WPRIM | ID: wpr-498293

ABSTRACT

Objective To characterize the clinical manifestations, laboratory findings of patients with occult sys?temic malignant neoplasms, whose initial manifestation presented as multiple acute cerebral infarcts including coagula?tion function,radiological imaging and microembolic signals (MES) detection by transcranial Doppler sonography (TCD) and to explore the possible underlying mechanisms. Methods All clinical records, laboratory hematological tests includ?ing hypercoagulable states measured by D-dimer levels, brain MRI including DWI, and TCD monitoring MES, the treat?ment and prognosis were retrospectively reviewed in 12 patients with multiple acute cerebral infarcts as the first manifes?tation of occult systemic malignancy. Results The clinical manifestations presented as localized neurological dysfunction, e.g. hemiparesis, aphasia, hemiparesthesia, dysarthria, vertigo and seizures, etc. DWI revealed multiple disseminated acute cerebral infarcts in multiple arterial territories such as the bilateral anterior or anterior plus posterior cerebral circu?lation in all patients. Eleven of 12 patients tested had elevated D-dimer. TCD detected MES in 5 of 7 patients. There were 12 patients diagnosed with occult systemic malignancy including 5 lung cancer, 3 pancreatic cancer, 1 gastric can?cer, 1 colon cancer, 1 endometrial adenocarcinoma and 1 metastatic poorly differentiated mucinous adenocarcinoma with unknown primary. Ten patients already had remote metastasis at diagnosis. The prognosis was usually poor and there were 7 cases with ischemic stroke recurrence, 4 cases with acute myocardial infarction, 3 cases died during hospitaliza?tion. Conclusions When patients present with multiple disseminated acute cerebral infarcts involving multiple arterial territories as initial manifestation, the underlying occult systemic malignancy should be considered. Hypercoagulopathy and MES might provide the clues to the diagnosis.

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