ABSTRACT
Liver regenerative medicine can use functional liver cells to repair or replace damaged liver tissue and it is expected to be rapidly developed as an alternative treatment to liver transplantation. However, regenerative medicine requires cells with stable proliferation ability and liver cell characteristics. Liver organoids are derived from adult stem cells or pluripotent stem cells. They can be proliferated in large quantities and cultured for a long time in vitro, meanwhile maintain genetic stability, and simulate the structural and functional characteristics of organs in the body, providing a new strategy for liver regeneration. This article reviews liver organoids and their research progress in liver regenerative medicine, and discusses their application potential and existing limitations.
ABSTRACT
Mixed reality, as a new virtual simulation technology, has been initially applied in the field of surgery. In hepatectomy for primary liver cancer, mixed reality technology has its unique advantages in formulating and evaluating surgical plans before surgery, precise real-time navigation during surgery, and virtual liver teaching, making liver resections more accurate and personalized. This article summarizes the relevant literature at home and abroad in recent years, summarizes the research progress of mixed reality technology in assisted liver resection for primary liver cancer, and discusses its application potential and limitations.