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China Journal of Chinese Materia Medica ; (24): 5-12, 2023.
Article in Chinese | WPRIM | ID: wpr-970495


Multiple sclerosis(MS) shows the pathological characteristics of "inflammatory injury of white matter" and "myelin repair disability" in the central nervous system(CNS). It is very essential for MS treatment and reduction of disease burden to strengthen repair, improve function, and reduce disability. Accordingly, different from the simple immunosuppression, we believe that key to strengthening remyelination and maintaining the "damage-repair" homeostasis of tissue is to change the current one-way immunosuppression strategy and achieve the "moderate pro-inflammation-effective inflammation removal" homeostasis. Traditional Chinese medicine shows huge potential in this strategy. Through literature research, this study summarized the research on remyelination, discussed the "mode-rate pro-inflammation-effective inflammation removal" homeostasis and the "damage-repair" homeostasis based on microglia, and summed up the key links in remyelination in MS. This review is expected to lay a theoretical basis for improving the function of MS patients and guide the application of traditional Chinese medicine.

Humans , Multiple Sclerosis/pathology , Remyelination/physiology , Myelin Sheath/pathology , Inflammation/drug therapy , Homeostasis
Acta Pharmaceutica Sinica ; (12): 1593-1603, 2022.
Article in Chinese | WPRIM | ID: wpr-929433


The iron and inflammation homeostasis are closely coupled, forming an integrated functional unit under physiological conditions. "Iron transport balance" has become the key mechanism to maintain iron homeostasis through bidirectional regulation of iron uptake and release and dynamic management of transmembrane concentration. It is also the physiological basis for the inflammatory balance between promotion and resolution. Under pathological conditions, represented by inflammatory bowel disease (IBD), disturbed iron transportation was highly involved in almost every step of inflammatory diseases. Therefore, the iron transporting rebalancing provides the mechanistic basis and effective approach for the normalization of inflammatory microenvironment. Macrophage is the key regulator of inflammation homeostasis and determinant for iron transport balance. Unfortunately, the current clinical transformation based on iron transport balance theory has still been insufficient. Sometimes, this strategy even showed high complexity and contradiction, severely restricting its clinical application. By summarizing the theoretical research progress of iron transport balance, especially its relevance to macrophage phenotypic polarization, this review aims to explore the therapeutic value in inflammation intervention by targeting iron transporting balance. This review will provide the necessary knowledge and hints for the research and development of candidate drugs in treating inflammatory diseases.

Chinese Journal of Stomatology ; (12): 570-571, 2007.
Article in Chinese | WPRIM | ID: wpr-359691


<p><b>OBJECTIVE</b>To evaluate the clinical effect of acellular dermal matrix (ADM) on preventing Frey syndrome after parotidectomy.</p><p><b>METHODS</b>Fifty-seven patients were randomized into two groups, ADM group (30 patients) receiving acellular dermal matrix and control group (27 patients) without application of acellular dermal matrix. The incidence of Frey syndrome was evaluated after operation.</p><p><b>RESULTS</b>The incidences of Frey syndrome were 13.3% in ADM group and 55.6% in control group. There was significant difference in Frey syndrome incidence between the two groups (P < 0.01).</p><p><b>CONCLUSIONS</b>The application of acellular dermal matrix could effectively prevent Frey syndrome after parotidectomy.</p>

Adult , Aged , Female , Humans , Male , Middle Aged , Dermis , Transplantation , Follow-Up Studies , Parotid Gland , General Surgery , Parotid Neoplasms , General Surgery , Postoperative Complications , General Surgery , Surgical Mesh , Sweating, Gustatory , Tissue Engineering , Transplantation, Homologous , Treatment Outcome