ABSTRACT
Objective:To investigate the relationship between hemodynamics with hepatic reserve function in cirrhosis patients complicated with portal hypertension (PHT), and to explore the significances of the two in evaluating the disease.Methods:According to the Child score, 80 cirrhosis patients complicated with PHT from January 2016 to January 2018 in our hospital were divided into three grades: A, B and C, 35 healthy persons in the same period were selected as normal control group. The parameters of liver hemodynamics were detected by color Doppler ultrasound, and the items of liver reserve function were detected by automatic biochemical analyzer. The correlation between hemodynamic indexes and liver reserve function was analyzed by Pearson method, and the risk factors of liver cirrhosis with PHT were analyzed by logistic multiple regression.Results:The diameter of portal inner vein (DPV), maximum speed of blood flow in the portal vein (PVX), mean speed of blood flow in the portal vein (PVM), quantity of blood flow in the main portal vein (QPV), albumin (ALB), cerealthirdtransaminase (ALT), aspartate transaminase (AST) and prothrombin time (PT) in the observation group were significantly higher than those in the control group ( P<0.05), while the total bilirubin (TBIL) was significantly lower than that in the control group ( P<0.05). The levels of DPV, PVX, PVM and QPV in patients with grade C were significantly higher than those in grade A and grade B ( P<0.05); the levels of DPV, PVX, PVM and QPV in patients with grade B of liver function were significantly higher than those in grade A ( P<0.05). The level of TBIL in patients with grade C liver function was significantly lower than that in grade A and grade B patients ( P<0.05); ALB, ALT, AST and PT were significantly higher than those of grade A and grade B ( P<0.05); the level of TBIL in patients with grade B of liver function was significantly lower than that of grade A ( P<0.05), while the ALB, ALT, AST and PT were significantly higher than those in group A ( P<0.05). DPV, PVM and QPV were significantly positively correlated with PT in cirrhosis patients with and PHT ( P<0.05), PVM and QPV were significantly negatively correlated with TBIL ( P<0.05). Regression analysis showed that hemodynamic indexes in DPV, PVX, PVM, QPV and liver reserve function indexes TBIL, ALB, ALT, AST, PT were risk factors for portal hypertension in cirrhosis. Conclusions:Hemodynamics and hepatic reserve function indicators have certain regularity in different degrees of cirrhosis complicated with PHT patients, they are closely related and can be used as an important index in the evaluation and monitoring of cirrhosis with PHT.
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AIM To investigate the influences of Astragalus and Hurido effective components on apoptosis of rat glomerular mesangial cells.METHODS The proliferation of rat mesangial cells was induced by LPS and then intervened with Astragalus (astragalus polysaccharide,astragaloside Ⅳ,calycosin) and Hurido (hirudin).The cells were collected after 24 h.4',6-Diamidino-2-phenylindole (DAPI) staining was used to observe cell nuclear changes.Quantitative and qualitative expressions of Bcl-2 were detected by streptavidin-biotin complex (SABC).RESULTS Astragalus and Hurido effective components could induce the apoptosis of rat glomerular mesangial cells,and decrease the expression of Bcl-2.CONCLUSION Astragalus and Hurido effective components can induce the mesangial cell apoptosis by down-regulating Bcl-2 expression,which can be used for the treatment of mesangial proliferative glomerulonephritis.
ABSTRACT
CDX2 plays an important role in the development, maintaining shape, structural characteristics of intestinal epithelial cells. Intestinal type gastric cancer is thought to develop a multi-step and multiphase process from normal gastric mucosa,intestinal metaplusia and dysplasia, ultimately to gastric cancer. So far, more and more studies have found that the abnormal expression of CDX2 gene plays an important role in development of intestinal metaplasia, dysplasia and intestinal carcinoma.