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1.
Zhongguo Zhong Yao Za Zhi ; (24): 2396-2405, 2023.
Article in Chinese | WPRIM | ID: wpr-981316

ABSTRACT

As arsenic widely exists in nature and has been used in the pharmaceutical preparations, the traditional Chinese medicine(TCM) with arsenic include realgar(As_2S_2 or As_4S_4), orpiment(As_2S_3), and white arsenic(As_2O_3). Among the above representative medicine, the TCM compound formulas with realgar are utilized extensively. Just in Chinese Pharmacopoeia(2020 edition), there are 37 Chinese patent medicines including realgar. The traditional element analysis focuses on the detection of the total amount of elements, which neglects the study on the speciation and valence of elements. The activity, toxicity, bioavailability, and metabolic pathways of arsenic in vivo are closely related to the existence of its form, and different forms of arsenic have different effects on organisms. Therefore, the study on the speciation and valence of arsenic is of great importance for arsenic-containing TCMs and their compound formulas. This paper reviewed four aspects of the speciation and valence of arsenic, including property, absorption and metabolism, toxicity, and analytical assay.


Subject(s)
Arsenic/analysis , Arsenicals/analysis , Sulfides , Arsenic Trioxide , Medicine, Chinese Traditional , Drugs, Chinese Herbal/analysis , Biological Products
2.
Article in Chinese | WPRIM | ID: wpr-873129

ABSTRACT

Objective::To optimize the matrix prescription of Fufang Huangqi cream and evaluate its rheological properties. Method::With appearance, spreadability and stability as evaluation indexes, the weighting coefficient of each evaluation index was determined by analytic hierarchy process (AHP), criteria importance through intercriteria correlation method (CRITIC) and AHP-CRITIC mixed weighting method. The formulation of Fufang Huangqi cream was optimized by D-optimal mixture design and its rheological properties were evaluated. Result::The weight coefficients of appearance, spreadability and stability according to AHP-CRITIC mixed weighting method were 0.185, 0.282 and 0.532, respectively. According to D-optimal mixture design based on AHP-CRITIC analysis, the optimized formulation of Fufang Huangqi cream was liquid paraffin of 3.70 g, vaseline of 2.00 g, stearic acid of 2.00 g, sodium dodecyl sulfate of 5.90 g, glycerin of 6.00 g and extract of 20.40 g. The rheological parameters of Fufang Huangqi cream was non-newtonian index<1, storage modulus>loss modulus. Conclusion::The preferred matrix formulation is stable and feasible. Fufang Huangqi cream has good appearance and is a shear thinning non-newtonian fluid. Its viscosity and ductility meet the needs of industrial production and clinical application.

3.
Yao Xue Xue Bao ; (12): 1976-1985, 2018.
Article in Chinese | WPRIM | ID: wpr-780080

ABSTRACT

The multiple drug delivery system of components of traditional Chinese medicine is a system composed of multiple components and multiple units. According to the characteristics of each component, different drug delivery units are designed and combined to achieve the purpose of improving bioavailability and enhancing drug efficacy. In this study, supercritical extracts, phenolic acids, and polysaccharides derived from Angelica sinensis were examined as research objects, and a pellet-based vehicle was applied to construct a multiple drug delivery system for the treatment and chemoprevention of colitis and colorectal cancer. The extrusion-spheronization method was used to prepare pellets of Angelica polysaccharides which should be released in the stomach. The yield in 18-24 mesh and plane critical angle served as the index. The Box-Behnken design and the orthogonal design were used to optimize the formulation and parameters of pellets. According to a previous study, the colon specific pellets loading supercritical extracts and phenolic acid extracts were prepared by the optimized process. These two units of pellets were combined into the multiple drug delivery system of effective components of Angelica sinensis, and the quality evaluation and in vitro release study were conducted. The dynamic observation of pellets in mice was evaluated using small animal in vivo imaging system. The prescription of the Angelica polysaccharides gastric releasing pellets was:microcrystalline cellulose 6.5 g, polysaccharide 3.3 g, silica 0.2 g and 7 mL of 60% ethanol as wetting agent. The process parameters were as follows:extrusion rate at 75 r·min-1, rounding rate at 1 800 r·min-1, and rounding time for 3 min. Both in vivo and in vitro studies indicate that the prepared multiple drug delivery system of effective components of Angelica sinensis produced good release properties. The polysaccharide pellets could be rapidly released in the artificial gastric fluid and in the stomach. The colon specific pellets showed good targeting. They released little in the artificial gastric fluid within 2 hours, released less than 20% in the artificial intestinal fluid for 4 hours, and released more than 90% in artificial colon fluid for 6 hours.

4.
Zhongcaoyao ; Zhongcaoyao;(24): 325-329, 2018.
Article in Chinese | WPRIM | ID: wpr-852243

ABSTRACT

Objective To optimize extraction process route of Compound Huangqi Water Extract by using fuzzy analytic hierarchy process (FAHP). Methods The multi-level index evaluation model was established and divided into target layer, criterion layer and index layer. The criterion layer included indicative components and pharmacodynamics index. The index layer consisted of transfer rate of astragaloside and geniposidic acid, volume of ascites, content of VEGF in ascites and thymus index. All the indexes were weighted by using FAHP, and the comprehensive score of each extraction process route was obtained. Results The important degrees (w) of each index from high to low were: volume of ascites (w = 0.255), content of VEGF in ascites (w = 0.215), thymus index (w = 0.200), transfer rate of Astragaloside (w = 0.170), and transfer rate of geniposidic acid (w = 0.160). The scores from high to low were: route a > route c > route b. Hence, the optimized extraction process route of Compound Huangqi Water Extract was reflux extraction with water. Conclusion This experiment combined chemical index and pharmacodynamics index as evaluation index. Weighting coefficient of all the indexes was decided by FAHP-based evaluation. It can provide research ideas and methods for optimizing extraction process of clinical empirical formula in the development of patent medicine.

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