ABSTRACT
Objective To compare the differences in lower limb force line between degenerative medial meniscus injuries and lateral meniscus injuries and investigate their correlation.Methods A total of 90 patients who underwent arthroscopic treatment for meniscal injuries between March 2019 and March 2022 were enrolled in the study.They were 45 males and 45 females,at a median age of 52 years(ranging from 40 to 59 years).Of these patients,47 had medial meniscus injuries,while 43 had lateral meniscus injuries.The hip-knee-ankle(HKA)angle was measured on full-length films,and the differences were compared between the 2 groups.Results There were no significant differences in terms of gender,age,lower limb laterality,body mass index,site of injury,and type of injury between the medial meniscus injury group and the lateral meniscus injury group.Statistical difference was observed in the mean HKA angle,with a value of(177.20±2.46)° in the medial meniscus injury group and of(181.05±3.13)° in the lateral meniscus injury group(P＜0.01).Conclusion There is a significant difference in HKA angle between medial meniscus injury group and the lateral meniscus injury group.A correlation is found between lower limb alignment and degenerative meniscus injury.
ABSTRACT
Objective: Study the toxicology damage of melamine(cyanuric acid) to rats' kidney.Methods: Divided the newborn rats and adult rats into high dose group of melamine(NM,M),low dose group of melamine(Nm,m),high dose group of cyanuric acid(NA,A),low dose group of cyanuric acid(Na,a),high dose group of melamine-cyanuric acid(NMA,MA),low dose group of melamine-cyanuric acid(Nma,ma) and normal control group(NN,N).The corresponding dose of melamine(cyanuric acid) was given by oral gavage and lasted two months.Rats were killed at 3 day,15 day and 60 day.The body weight and kidney weight were collected.Renal function was detected and the microscopic and ultra-microscopic renal histology structural changes were observed.Results: The body weight of NMA group and Nma group increased first,and then reduced.The body weight of MA group and ma group reduced gradually.The number of kidney crystal increased with the administration time extension.The electron microscope demonstrated that the tubules which contained stones microvilli reduced or disappeared,granulocyte infiltration and other inflammatory response.The kidney weight/body weight,urea nitrogen,creatinine,uric acid value increased in administration groups.Conclusion: Melamine(cyanuric acid) could produce insoluble crystals in rat kidney and lead to renal dysfunction.The toxicity of melamine(cyanuric acid) was greater in adult rats than in newborn.The number of melamine(cyanuric acid) crystals was positively correlated with dose and time.The toxicity of melamine was greater than cyanuric acid.Melamine(cyanuric acid) mixture toxicity was greater than the monomer.Melamine(cyanuric acid) toxicity had individual differences and brood diffenence.