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1.
Pakistan Journal of Pharmaceutical Sciences. 2018; 31 (4 [Special]): 1761-1766
in English | IMEMR | ID: emr-199282

ABSTRACT

Recent studies have shown that statins can inhibit the apoptosis of vascular endothelial cells. Many Pharmacological actions of statins have nothing to do with thier cholesterol lowering effects. These effects are called non lipid lowering cardiovascular protective effects. In this study, by establishing a high glucose induced vascular endorhelial cell apoptosis model, we explored the mechanism of the non lipid - related cardiovascular protective effect of atorvastatin. The results showed that atorvastatin could protect human umbilical vein endothelial cells from damage induced by new high glucose and inhibit apoptosis. High concentration atorvastatin can up regulate the expression of Bcl-2 and down regulate the expression of Baxprotein [P<0.05]. This suggests that statins may play a role in cardiovascular protection by inhibiting endothelial cell apoptosis. This results is confirmed by experiments, which can provide clues for clinical treatment, and combine drug therapy and lifestyle intervention to reduce blood sugar

2.
China Modern Doctor ; (36): 59-61, 2015.
Article in Chinese | WPRIM | ID: wpr-1037378

ABSTRACT

Objective To evaluate the effect of early intervention in preschool children anxiety. Methods Children with Spence anxiety preschool scale score≥48 points were randomly divided into the intervention group and monitor group. The parents of children in intervention group were educated with a total of 6 collective curriculum of children's anxiety management, while the monitor group were followed up only. All the children were evaluated by scale on the third month, sixth month, one year and one and a half years respectively, and then the differences of the two groups were compared. Results The average score of the intervention group decreased continuously on the third month, sixth month,one year and one and a half years,and the differences of the two groups were statistically significant(P<0.05). Conclusion Early short-term education for parents can relieve their preschool children's anxiety effectively with long term effect.

3.
Journal of Clinical Pediatrics ; (12): 186-188, 2014.
Article in Chinese | WPRIM | ID: wpr-439523

ABSTRACT

Anxiety disorders are the commonest emotional disorders in children, who may be at increased risk of the later develop-ment of other types of mental disorder. Early diagnosis and intervention should be applied. In this article, epidemiology, major factors rele-vant and effective therapy of anxiety disorders in preschool children are summarized.

4.
Chinese Journal of Radiology ; (12): 741-744, 2014.
Article in Chinese | WPRIM | ID: wpr-455630

ABSTRACT

Objective To investigate MRI features of heat stroke (HS) and 1H-MRS in monitoring clinical outcome.Methods Six cases(4 males,2 females) of HS patients,aged 43-75 years old were retrospectively studied.The patients were divided into 4 severe cases (2 cases with coma for 4 hours,2 patients with persistent coma) and 2 moderate cases according to initial Glasgow coma scale (GCS) at the time of hospital admission.All patients underwent T1WI,T2WI,FLAIR,DWI,SWI,multi voxel 1H-MRS scans and the ratios of NAA/Cr,Cho/Cr,and NAA/Cho were calculated.One case of severe coma died on the next day.Follow-up imaging and brain 1H-MRS were performed on other 5 patients on the 7th and 15th day after the first examination.The imaging results were compared with clinical outcome.Results MRI features of HS for severe coma patients were iso-intensity on T1WI,hyper-intensity on T2WI,FLAIR and DWI,heterogeneous signal intensity on ADC.The infratentorial lesions distributed in the cerebellum,dentate nucleus and cerebellar arm (3 cases),and the supratentorial lesions distributed in the parahippocampal gyrus (2 cases),parietal lobe (2 cases),and temporal lobe (1 cases).The lesions could be multiple,and the cerebellum and the parahippocampal gyrus were most common involved.SWI showed focal hemorrhage in 2 cases,which located in the brainstem and parietal lobe.No obvious MRI abnormality was found in 2 cases of moderate coma patients.The ratios of NAA/Cr,Cho/Cr,and NAA/Cho for severe coma patients were 0.67 ±0.09,0.94 ±0.16 and 0.70±0.12,respectively,which for moderate coma patients were 0.87±0.12,0.95±0.13,and 0.94±0.08,respectively.The NAA/Cr and NAA/Cho ratios decreased and Cho/Cr mild decreased in the severe coma patients when compared with the moderate coma patients.One patient with persistent coma had expanded lesions on follow-up study.NAA/Cr,NAA/Cho and Cho/Cr were 0.63± 0.07,0.67 ±0.10,and 0.96 ±0.05,respectively.Two cases had smaller lesions on follow-up study with NAA/Cr and NAA/Cho ratio increased,which were 1.02±0.13 and 0.96±0.11,respectively.GCS was turned to 14.NAA/Cr and NAA/Cho for moderate coma patients were 1.17±0.10 and 1.21 ±0.07,respectively.Conclusions Severe HS patients present with cerebral edema and hemorrhage.1H-MRS can be an important index for monitoring the severity of HS.The longer the duration of coma,the worse prognosis may happen.

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