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Article | IMSEAR | ID: sea-211806


Background: HIV/ AIDS is one of the major global health issue, resulting an epidemic. Understanding the socio-demographic profile with magnitude of risky behavior might include positive messages in the routine HIV/AIDS care and treatment. Objective of this study was to find out the socio-demographic, behavioural characteristics among patients receiving second line ART (Anti-Retroviral therapy) in a tertiary centre of North-East India.Methods: A cross sectional study was carried out among 90 PLWHA patients receiving second line ART in Regional Institute of Medical Sciences (RIMS), Imphal from March 2016 to August 2017. A predesigned and pretested schedule was used as study tool to collect required information.Results: Majority participants (43.3%) belonged to 30-40 years age group, mean age 39.96±8.021 years; 51.1% were female. Majority (58.9%) got infected with HIV through heterosexual route followed by IV drug use (31.1%). Nearly half (51.1%) were diagnosed with HIV for 11-15 years duration and majority (61.1%) were under 2nd line ART for 6-10 years duration. Here, 3.3% subjects had Hepatitis B and 7.8% were infected with hepatitis C.Conclusions: Young population were most affected group and heterosexual route being the commonest mode of transmission. Combination of socio-demographic, behavioural risk factor and unawareness are responsible for rapid spread of HIV/AIDS. So, people need to be educated for primary and secondary prevention.

Article | IMSEAR | ID: sea-203312


Objectives: To study the correlation between CD4 count &HIV-1 viral load among ART Naive patients attending ICTCSMS Medical College, Jaipur.Material and Methods: This study was conducted on 250 HIVserologically confirmed, ART Naive cases from ICTC, SMSJaipur. RNA extraction was done from plasma samples byQiagen Viral RNA Mini Kit then HIV-1 Viral load wasdetermined by Qiagen HIV-1 viral load kit on ABI 7500 Fast dxReal Time PCR, while CD4 count was done on FACSCALIBUR flowcytometer (BD Biosciences). SPSS ver. 21.0was used to determine correlation between CD4 count & HIV-1viral load.Results: Out of 250, 216 (86.4%) cases were found in whichviral RNA was detected. These samples were correlated withtheir CD4 Count. The mean of viral load was 194746.2791 ±550442.61805 IU/ml while CD4 count was 282.7674 ±217.56456 cells/ul. Females were having Avg. Viral load228506.7273 & CD4 count 337.21 and males were found tohave Avg. Viral load 179791.9866 & CD4 count 258.65Conclusion: This study concluded a negativecorrelation between HIV-1 RNA viral load and CD4 count inHIV-seropositive ART naïve patients of this part of the country.Our study confirmed that HIV-1 RNA viral load levels aresignificantly higher in women than in men, but no suchsignificant gender difference in the CD4 count was found.

Article | IMSEAR | ID: sea-203363


Objectives: To identify cause of HIV seropositive but ViralRNA undetected naive cases in Rajasthan.Materials and Methods: This study included 250 HIV seropositive cases from ICTC Centre, SMS Jaipur .HIV Viral loadwas done by Qiagen HIV-1 viral load kit on ABI 7500 Fast dxReal Time PCR, while CD4 count was done on FACSCALIBUR flowcytometer (BD Biosciences).Results: A total of 250 HIV Serological confirmed positivesamples were tested for HIV-1 RNA viral load & CD Count inthe period of 2014-19. Out of 250, 26 (10.4%) cases werefound in which viral RNA were undetected. out of 26seropositive but HIV RNA undetected case, 16(61.5%) wereMale while 10 (38.5%) were females. Mean of CD4 in Femalewas 565 while 650 in males.Conclusion: HIV‑1 seropositive patients but undetected viralload is not uncommon in society. HIV sero-positive but viralRNA undetected males CD4 count were higher than females. Itwas also observed that all the cases of seropositive withundetected viral load had higher CD4 count comparative withseropositive with viral RNA detected patients. It is concludedthat RNA viral load test is a prognosis test, although suchpatients who had seropositive but viral load undetected needfurther investigations after 3-4 weeks to monitor the status ofthe disease

Article in English | IMSEAR | ID: sea-166695


Abstracts: Background & Objective: A prospective comparative study was done to see the prevalence of Dengue, Malaria and mix infections in the patients attending in tertiary care hospital during a period of March 2013- February 2014. Study also included the pattern of changing Hematological parameters during infections. Methodology: Patients suffering from fever of more than 4-5 days were investigated for Dengue, Malaria and concurrent infections. Peripheral blood smear examination was done for Malaria while Rapid card and IgM & IgG ELISA were done for Dengue. Hematological investigations- CBC, Platelet count was done by sysmex auto analyzer. Results: Total 3650 samples of suspected cases tested for Dengue and Malaria. Out of 3650 samples 934 were positive of Dengue, Malaria and mix infections. Out of 934, 105 were Malaria, 816 Dengue and 13 cases of mix infections were found. In Malaria positive cases Hematological parameters showed anaemia, thrombocytopenia and Eosinophilia while in Dengue cases thrombocytopenia was observed. Conclusion: Prevalence of Dengue is more than Malaria in Moradabad during the study period. Hematological parameters of the cases Dengue, Malaria now are changing their patterns that are a serious matter of concerned. Even mix infections are also building up in the society that’s why Hematological parameters must be monitored regularly.