Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 20
Filter
1.
Laboratory Animal Research ; : 268-278, 2020.
Article | WPRIM | ID: wpr-836900

ABSTRACT

Baicalin is a natural flavonoid that exerts a variety of pharmaceutical effects such as anti-inflammatory and antioxidant. Lipopolysaccharide (LPS) is an endotoxin that releases inflammatory cytokines and induces inflammatory response. This study was investigated the anti-inflammatory mechanism of baicalin against LPS-induced inflammatory response in the hippocampus. Adult mice were randomly grouped into control, LPS-treated, and LPS and baicalin co-treated animals. LPS (250 μg/kg/day) and baicalin (10 mg/kg/day) were administered intraperitoneally for 7 consecutive days. We measured neuroglia cells activation and inflammatory factors activation using Western blot analysis and immunofluorescence staining techniques. Ionized calcium binding adaptor molecule-1 (Iba-1) and glial fibrillary acidic protein (GFAP) are widely used as microglia and astrocyte markers, respectively. LPS treatment increased Iba-1 and GFAP expression, while baicalin co-treatment attenuated this overexpression. Nuclear factor-kappa B (NF-κB) is a key mediator of inflammation. Baicalin co-treatment alleviated LPS-induced increase of NF-κB in the hippocampus. In addition, LPS treatment upregulated pro-inflammatory cytokines including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α). However, baicalin co-treatment prevented LPS-induced increases of IL-1β and TNF-α in the hippocampus. Results from the present study showed that baicalin suppresses LPS-induced neuroinflammation by regulating microglia and astrocyte activation and modulating inflammatory factors in the hippocampus. Thus, these results demonstrate that baicalin has neuroprotective effect by alleviates microglia and astrocyte activation and modulates inflammatory response by suppressing NF-κB expression in hippocampus with neuroinflammation caused by LPS.

2.
Laboratory Animal Research ; : 132-139, 2019.
Article in English | WPRIM | ID: wpr-786394

ABSTRACT

Lipopolysaccharide (LPS) acts as an endotoxin, releases inflammatory cytokines, and promotes an inflammatory response in various tissues. This study investigated whether LPS modulates neuroglia activation and nuclear factor kappa B (NF-κB)-mediated inflammatory factors in the cerebral cortex. Adult male mice were divided into control animals and LPS-treated animals. The mice received LPS (250 µg/kg) or vehicle via an intraperitoneal injection for 5 days. We confirmed a reduction of body weight in LPS-treated animals and observed severe histopathological changes in the cerebral cortex. Moreover, we elucidated increases of reactive oxygen species and oxidative stress levels in LPS-treated animals. LPS administration led to increases of ionized calcium-binding adaptor molecule-1 (Iba-1) and glial fibrillary acidic protein (GFAP) expression. Iba-1 and GFAP are well accepted as markers of activated microglia and astrocytes, respectively. Moreover, LPS exposure induced increases of NF-κB and pro-inflammatory factors, such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α). Increases of these inflammatory mediators by LPS exposure indicate that LPS leads to inflammatory responses and tissue damage. These results demonstrated that LPS activates neuroglial cells and increases NF-κB-mediated inflammatory factors in the cerebral cortex. Thus, these findings suggest that LPS induces neurotoxicity by increasing oxidative stress and activating neuroglia and inflammatory factors in the cerebral cortex.


Subject(s)
Adult , Animals , Astrocytes , Body Weight , Cerebral Cortex , Cytokines , Glial Fibrillary Acidic Protein , Humans , Injections, Intraperitoneal , Male , Mice , Microglia , Necrosis , Neuroglia , NF-kappa B , Oxidative Stress , Reactive Oxygen Species
3.
Laboratory Animal Research ; : 195-202, 2018.
Article in English | WPRIM | ID: wpr-718849

ABSTRACT

Hyperglycemia is one of the major risk factors for stroke. Hyperglycemia can lead to a more extensive infarct volume, aggravate neuronal damage after cerebral ischemia. α-Synuclein is especially abundant in neuronal tissue, where it underlies the etiopathology of several neurodegenerative diseases. This study investigated whether hyperglycemic conditions regulate the expression of α-synuclein in middle cerebral artery occlusion (MCAO)-induced cerebral ischemic injury. Male Sprague-Dawley rats were treated with streptozotocin (40 mg/kg) via intraperitoneal injection to induce hyperglycemic conditions. MCAO were performed four weeks after streptozotocin injection to induce focal cerebral ischemia, and cerebral cortex tissues were obtained 24 hours after MCAO. We confirmed that MCAO induced neurological functional deficits and cerebral infarction, and these changes were more extensive in diabetic animals compared to non-diabetic animals. Moreover, we identified a decrease in α-synuclein after MCAO injury. Diabetic animals showed a more serious decrease in α-synuclein than non-diabetic animals. Western blot and reverse-transcription PCR analyses confirmed more extensive decreases in α-synuclein expression in MCAO-injured animals with diabetic condition than these of non-diabetic animals. It is accepted that α-synuclein modulates neuronal cell death and exerts a neuroprotective effect. Thus, the results of this study suggest that hyperglycemic conditions cause more serious brain damage in ischemic brain injuries by decreasing α-synuclein expression.


Subject(s)
alpha-Synuclein , Animals , Blotting, Western , Brain , Brain Injuries , Brain Ischemia , Cell Death , Cerebral Cortex , Cerebral Infarction , Humans , Hyperglycemia , Infarction, Middle Cerebral Artery , Injections, Intraperitoneal , Male , Middle Cerebral Artery , Neurodegenerative Diseases , Neurons , Neuroprotective Agents , Polymerase Chain Reaction , Rats, Sprague-Dawley , Risk Factors , Streptozocin , Stroke
4.
Pakistan Oral and Dental Journal. 2016; 36 (1): 35-37
in English | IMEMR | ID: emr-179042

ABSTRACT

The aim of the study is to determine the association of oral lichen planus with hepatitis C and diabetes mellitus


A retrospective cohort study was carried out at the Department of Oral and Maxillofacial Surgery, Sardar Begum Dental College, Peshawar from January 201 1 to July 2015. A total of 34 male and female patients having oral lichen planus were selected with age range 20-60 years and mean age 39.4 +/- 15.8 years. Only clinical features were included to diagnose oral lichen planus which was made through the clinical evaluation of patient's oral cavity by a specialist team at the Department as proposed by van der Meij et al in 2003 based on the WHO definition of oral lichen planus. The data were analyzed through SPSS 22 with significance level ofp-value <0.05 and chi-square statistics were applied for association


The results showed that the data was statistically not significant with p-value >0.05 for all diseases having lichen planus and chi-square statistics revealed that no association exist among lichen planus, diabetes mellitus and hepatitis C. This study fails to find any association between oral lichen planus, hepatitis C and diabetes mellitus


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Hepatitis C , Retrospective Studies , Cohort Studies , Diabetes Mellitus
5.
Pakistan Oral and Dental Journal. 2015; 35 (4): 578-580
in English | IMEMR | ID: emr-179579

ABSTRACT

The aim of the study was to evaluate the causes of common conditions leading to tooth extraction, male/female ratio in diabetic patients. This was a retrospective cohort study. Data were collected from previous records between January 2011 to July 2015 from the Department of Oral and Maxillofacial Surgery, Sardar Begum Dental College, Peshawar. Among 2,103 total diabetic patients presented to the department, 1,618 diabetic patients have their complete record for tooth extractions. The primary reasons for exodontia specified in the records were Caries, Periodontitis, others. Others include those patients who have extractions either due to preprosthetic purpose, trauma or fracture or any other reason other than caries and periodontitis. The data was analysed through SPSS 22. The mean age presentation was 47.50 +/- 19.82 years and the age range 25-70 years. There were 1,618 extractions carried out in 2,103 subjects [76.94%]. The female diabetic patients predominate n=983 [60.75%] the male patients n=635 [39.25%]. Caries was the dominant cause of tooth extraction in both subjects n= 1042 [64.40%] followed by periodontitis n= 416 [25.71%] and others n=160 [9.90%]. Caries is the dominant cause of extraction in diabetic patients and female diabetic patients predominate male diabetic patients in terms of tooth extraction

6.
JPMI-Journal of Postgraduate Medical Institute. 2015; 29 (4): 308-312
in English | IMEMR | ID: emr-179793

ABSTRACT

Objective: to find the frequency of complete heart block [CHB] in patients undergoing surgical perimembranous Ventricular septal defect [VSD] closure


Methodology: this was a Descriptive cross sectional study performed in Cardiovascular Department Lady Reading Hospital Peshawar. Data was collected from 28 January 2013 to 28 July 2013 with sample size of 103.Sampling technique was non probability consecutive. All patients with perimembranous ventricular septal defect, aged 5 years to 25 years with any gender were included in the study


Results:-mean age was 12.63 years +/- 6.63. Patients were divided in four categories according to their age. Over all complete heart block in the perimembranous ventricular septal defect after surgical closure was 10[9.71%]. Age wise distribution of complete heart block shows that majority of the complete heart block 6[12.8%] were found in age less than or equal to 10 years


Conclusion:-VSD closure is less often associated with CHB but there should be arrangements for pace maker to timely pace the patient in case of any emergency

7.
Pakistan Oral and Dental Journal. 2013; 33 (3): 464-467
in English | IMEMR | ID: emr-141059

ABSTRACT

Present study was carried out to determine the pattern of minor salivary gland tumors, diagnosed at City Medical Laboratory, Peshawar [Pakistan]. The study was conducted at Sardar Begum Dental College using the Anatomical pathology records of City Medical Laboratory, Peshawar from January 2003 to December 2012 and were analyzed by Statistical Program for Social Sciences version 16. A total of 78 cases were diagnosed as minor salivary gland tumors. Out of these 47 were benign and 31 malignant. The male to female ratio for both benign and malignant tumors was 1:1.7. The mean age was 40.39 years. The most common benign tumor was Pleomorphic adenoma [89.3%] and malignant was Adenoid cystic carcinoma [87.09%]. The hard palate was the most common affected site [57.4% in benign and 32.2% in malignant tumors]. The present study showed a different pattern of occurrence of malignant minor salivary gland tumors among the population of Khyber Pahktunkhwa as compared with the European and American population

8.
Pakistan Oral and Dental Journal. 2011; 30 (2): 283-286
in English | IMEMR | ID: emr-109884

ABSTRACT

The purpose of this study was to give an overview of drivers use of mobile phones while driving and its role in motor vehicle crashes and subsequent facial injuries. 200 patients who were either drivers or passengers involved in facial injuries as a result of road traffic crashes between January 2008 and November 2008 were included in this study. They were seen in the Department of Oral and Maxillofacial Surgery at Khyber College of Dentistry, Khyber Pakhtunkhwa, Pakistan. All relevant informations were collected on a specially designed Proforma and analysed using SPSS version 17. Male outnumbered female with a male to female ratio of 6:1. Passengers were injured more frequently [60%] as compared to the drivers [40%]. 32 drivers [40%] out of 80 had used mobile phone at the time of accident. Among those drivers [n=32] who had used mobile phone at the time of accident, the 3rd decade was the most commonly involved age group followed by 2nd decade. Mandible was the most common bone involved in 46.88% of the cases followed by Zygomatic complex fractures [21.88%].This study has highlighted the problem of road traffic injuries among drivers and passengers asa serious public health problem. Mobile phone users commit more errors and lapses than non-mobilephone users. It seems that cellular mobile phone bring extra workload to memory and share attention sources, which causes accidents by distracting the attention of drivers


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Cell Phone , Accidents, Traffic
9.
Pakistan Oral and Dental Journal. 2011; 30 (2): 291-294
in English | IMEMR | ID: emr-109886

ABSTRACT

The purpose of the study was to highlight the etiology, age, gender and site distribution, treatment options available and complications occurring as a result of condylar fractures in growing children. This retrospective study was carried out on a total of 57 patients from Jan 2008 to Oct 2009 at the department of oral and maxillofacial surgery, Khyber College of Dentistry, Peshawar, Khyber Pakhthunkhwa province of Pakistan. Fifty seven patients were recruited in this study. The male to female ratio was 1.6:1. Fall was the most common cause of condylar fractures i.e., [73.7%]. The peak incidence of condylar fracture was high among 6-10 years age group i.e. 26 [45.6%]. Forty one patients [71.9%] had unilateral condylar fractures and [28.1%] had bilateral. Maxillomandibular fixation [MMF] was performed in 28 patients [49.2%] to correct occlusal disturbance, minor deviations and to reduce the pain associated with it, while occlusion was disregarded in 29 patients [50.8%] but were put on close follow up. Overall 41 patients [71.9%] were treated successfully with conservative treatment approach but 16 patients [28.1%] have reported after 1-2 years with complications of temporomandibular joint [TMJ] Ankylosis. Among these 10 patients [62.5%] had unilateral TMJ Ankylosis. Gap arthroplasty with disc interpositioning was performed in patients with established complication of temporomandibular joint ankylosis


Subject(s)
Humans , Male , Female , Adolescent , Child , Infant , Child, Preschool , Retrospective Studies , Sex Distribution , Incidence , Mandibular Condyle/surgery , Age Distribution
10.
Pakistan Oral and Dental Journal. 2011; 30 (2): 299-302
in English | IMEMR | ID: emr-109888

ABSTRACT

The aim of this study was to evaluate and analyze the occurrence, characteristics and treatment outcome of oroantral fistula in 29 patients from Sept 2004 to Nov 2009. These patients were examined both clinically and radio-logically for oroantral fistula. Data regarding the age, gender, cause and site of fistula and treatment outcome was evaluated and reviewed. The age range was 18-60 years with high frequency occurring in 31-40 years. Male outnumbered female. The common cause of OAF was extraction of teeth [n=25, 86.5%] followed by cysts [n=2, 6.7%]. The most common involved tooth in the causation of OAF was upper first molar [n=13, 52%]. Surgical technique used to close the fistula was buccal advancement flap. Recurrence of fistula occurred in 2 patients [6.7%] and were re-operated using the palatal flap. The merits and demerits of the procedure are discussed


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Oroantral Fistula/etiology , Treatment Outcome
11.
Pakistan Oral and Dental Journal. 2011; 30 (2): 313-316
in English | IMEMR | ID: emr-109891

ABSTRACT

The purpose of the present study was to evaluate the incidence of associated skeleton fractures with maxillofacial fractures and to list age gender and bone involved with poly trauma patients. The study is first of its kind in the region and will help to develop a better poly trauma management team. A Descriptive study was carried out in Oral and Maxillofacial Surgery Department of Khyber College of Dentistry, Peshawar, Pakistan for a period of one year i.e., from 20[th] June 2009 to 19[th] June 2010. All the patients presenting with maxillofacial injures and associated fractures of the skeleton were included in this study. Age, gender distribution, aetiology, associated injuries and treatment modalities undertaken in these patients were recorded. A total of 505 patients reported to oral and maxillofacial surgery unit of Khyber College of Dentistry, Peshawar, and amongst them 54 [10.6%] had associated fractures of the rest of the skeleton of the body. The most commonly involved bone was mandible [67%] followed by zygomatic complex fratures i.e. 15% in these patients. 50% of the fractures resulted because of Road Traffic Accidents. Upper limb fractures were the most common bone fractures associated with maxillofacial trauma i.e., 53.25% of the cases


Subject(s)
Humans , Male , Female , Aged , Child , Adolescent , Adult , Middle Aged , Fractures, Bone , Upper Extremity/injuries , Mandibular Injuries
12.
Pakistan Oral and Dental Journal. 2011; 30 (2): 317-322
in English | IMEMR | ID: emr-109892

ABSTRACT

The purpose of the study was to compare the treatment outcome of extractions and nonextractions of teeth in the lines of mandibular fractures and to determine the most common complications. A Quasi-experimental study was undertaken in the Department of Oral and Maxillofacial surgery, Khyber college of Dentistry Peshawar from January 2007 to January 2008. A total of 100 patients having tooth in the line of mandibular fracture were recruited in the study. The patients were divided into two groups of 50 patients each. In Group A the tooth was retained in the line of fracture, and while in Group B the tooth was extracted. Each patient was evaluated for postoperative results and the differences between them assessed. Statistical analysis included chi-square test. Results were considered significant if p d" 0.05. Majority of the patients were young adults. The most common site was parasymphysis while the most commonly involved teeth in the fracture line were incisors. The major operative morbidity proved to be infection followed by malunion and maloclusion. Both groups were not different in relation to postoperative infection [P= 0.461], malocclusion [P= 0.5577], malunion [P= 0.5577] delayed union and non-union. There was no significant difference in the outcome between the extraction and non-extraction of a tooth in the line of fracture


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Mandibular Injuries , Treatment Outcome
13.
JPDA-Journal of the Pakistan Dental Association. 2010; 19 (3): 158-163
in English | IMEMR | ID: emr-143766

ABSTRACT

The purpose of this study was to document the characteristics of maxillofacial fractures resulting from road traffic accidents. The study was carried on 250 patients presenting with maxillofacial fractures resulting from road traffic accidents. On the basis of history, clinical and radiological examination, fractures were classified as dentoalveolar fracture, mandibular fracture, maxillary fracture [Lefort I, II and III], isolated zygomatic arch fracture, zygomatic complex fracture, nasal bone and orbital fractures. Data was analysed by statistical analysis tool using SPSS version 17. Males in their 2[nd] and 3[rd] decades were the most common victims. Among the isolated bone fractures [n=208], mandible was the most commonly fractured bone [n=104] followed by zygomatic complex [n=50]. The frequently observed pattern among mandibular fracture was parasymphysis [31.6%], among zygomatic complex was Group IV [n=29] while maxillary fractures showed a pattern of combined Lefort I, II and III [n=21]. Road traffic accidents are predictable and preventable. Basic knowledge regarding road safety measures and its implementation is necessary. It can be concluded from this study that majority of the patients were young adult males. The most common bone fractured was mandible both in isolation and combination


Subject(s)
Humans , Female , Male , Maxillofacial Injuries/classification , Accidents, Traffic , Maxillofacial Injuries/epidemiology , Maxillofacial Injuries/pathology , Mandibular Fractures , Maxillary Fractures , Zygomatic Fractures , Nasal Bone/injuries , Orbital Fractures
14.
JKCD-Journal of Khyber College of Dentistry. 2010; 1 (1): 25-29
in English | IMEMR | ID: emr-146326

ABSTRACT

To evaluate the age, gender, site distribution and associated systemic debelitating conditions [if any] of the patients with Cancrum Oris. A. descriptive retrospective study was undertaken in the Oral and Maxillofacial Surgery unit of Khyber College of Dentistry from January 2005 to January 2010. Information regarding the variables of the study i.e., age, gender, site distribution and associated systemic debilitating conditions, was collected from the ward charts during the study period. A. total of 13 patients reported to the unit during the study period, 8 males and 5 females with male to female ratio of 1.6:1. The age range of the patient was from 9 to 70years with the mean age of 37.69 SD + 22.65. The first and the third decade of life was the most common age group affected with Cancrum Oris i.e., 23.07% each, with another peak in the sixth decade of life i.e., 23.07%. bilateral anterior maxilla was affected in 30.76% cases. Uncontrolled diabetes was the common associated systemic debilitating condition i.e., 72%. All of the patients were from low socio-economic class. Cancrum oris is a disease of low-socioeconomic group. In our series of patients the most common associated debilitating systemic condition was diabetes melitis with a bimodal age distribution


Subject(s)
Humans , Male , Female , Retrospective Studies , Maxilla , Diabetes Mellitus
15.
JKCD-Journal of Khyber College of Dentistry. 2010; 1 (1): 30-33
in English | IMEMR | ID: emr-146327

ABSTRACT

To determine the frequency of dental caries, the gender distribution, the most commonly involved deciduous and permanent tooth in dental caries and to evaluate tooth brushing habits in school going children of Peshawar. This descriptive study consisted of 1000 children aged between 6 to 14years old. The information was gathered by taking a detailed history and clinical examination of the students and noted in a structured questionnaire. Brief biodata and oral hygiene levels were recorded in descriptive form while the carious teeth were recorded in tabulated form. Data was analysed using SPSS 10. Out of a 1000 students, 642 [64.2%] had caries. The caries distribution was more in boys [54%] as compared to girls [46%], with male to female ratio 1:0.85. The highest prevalence of caries was found in 12 year old children [77%]. Highest numbers of caries were found in first molar in both primary [262] and permanent dentition [188]. Thirty eight percent children claimed to have brushed their teeth once daily and 11.5% did not brush their teeth at all. Our study showed that there is a lack of awareness of oral hygiene and its importance has not been emphasised enough to the school going children


Subject(s)
Humans , Male , Female , Child , Schools , Surveys and Questionnaires , Oral Hygiene
16.
Pakistan Oral and Dental Journal. 2010; 30 (1): 36-40
in English | IMEMR | ID: emr-98518

ABSTRACT

This study was designed to determine the pattern of zygomatic bone fracture, etiology and treatment options. The term pattern in this study was used for the sites/processes of zygomatic bone fracture. The variables evaluated were age, gender, sites of fracture and treatment options. A total of 81 patients with zygomatic bone fracture were treated in Oral and Maxillofacial Surgery unit, Khyber College of Dentistry, Peshawar for a period of one year from July 2007 to June 2008. Majority of patients were young males in 3rd and 4th decade. Male to female ratio was 12.5:1. Road traffic accidents [76.5%] were the most common and interpersonal violence 2.5% as the least common etiology of zygomatic bone fracture. In 28.4% patients, zygomatic bone was fractured at single site while in 71.6% it was fractured at more than one. Fracture at zygomatic buttress and infraorbital rim [27.2%] in combination was most common finding. Twenty three percent patients did not require treatment, 32.1% zygomatic bone fractures were reduced indirectly and 44.4% were reduced directly by open reduction and internal fixation


Subject(s)
Humans , Male , Female , Zygomatic Fractures/etiology , Zygomatic Fractures/therapy , Zygoma
17.
JPDA-Journal of the Pakistan Dental Association. 2009; 18 (3): 98-101
in English | IMEMR | ID: emr-101331

ABSTRACT

Maxillary bone is an important component of mid face guarding three vital cavities including oral, nasal and orbital. It plays an important role in aesthetics of a person. Maxillary fractures are very important when it comes to management because posterior and downward displacement of fractured maxilla can lead to airway blockage and death. A prospective study was undertaken to determine the factors leading to and pattern of presentation of isolated maxillary fractures over a period of One year from 4 th October 2006 to 3 rd October 2007 at Department of Oral and Maxillofacial Surgical Unit Khyber College of Dentistry Peshawar. The study was carried out on 60 patients with maxillary fractures to identify factors leading to maxillary fractures and to describe the pattern of presentation of maxillary fractures. They were inquired about the factor causing injury and thoroughly examined both clinically and radiologically for pattern of fracture as well as for any other facial bone fracture. The age, gender, factors and pattern of maxillary fracture of the patients were determined. Maxillary fractures occur over age, ranging from 4 years to 70 years with mean age of 28.1 years SD +/- 14.54. Male to female ratio was 13.28:1. This shows that male patients were predominantly affected. Road traffic accidents [RTA] contributed for 65% of maxillary fractures. Le Fort II was the most common maxillary fracture i.e 45%, followed by Le fort I 26.7%, while Le Fort III was the least common 11.7% and no isolated palatal split was found. The maxillary Le Fort II fractures are the most common fractures in Peshawar. Such injuries are resulted mostly because of Road Traffic Accidents. Implementation of strict Road traffic legislations are important to prevent such injuries


Subject(s)
Humans , Male , Female , Maxillary Fractures , Maxillofacial Injuries/epidemiology , Prospective Studies , Accidents, Traffic
18.
JPMI-Journal of Postgraduate Medical Institute. 2009; 23 (4): 363-368
in English | IMEMR | ID: emr-134381

ABSTRACT

To describe post traumatic pseudoaneurysms and its association to causes, presentation and conventional surgical treatment modalities. This Descriptive study carried out in the Department of Cardiovascular Surgery, Lady Reading Hospital, Peshawar from January 2003 to December 2007. Patients with associated arteriovenous fistula were excluded from this study. All the demographics including age, sex, type of injury, site, associated complications operative details, pen operative morbidity and mortality were prospectively recorded in a data base. The total number of patients was seventy five. All the patients underwent conventional surgical procedures. Reverse saphenous graft was received by 34%, 24% had end to end anastomosis, 12% had interposition synthetic graft, 8% had rent repair while 21.33% had primary ligation of the involved artery. There was no pen operative mortality. Six patients had post operative complication in the form of graft, thrombosis and or infection. Three patients had amputation, two in lower limb and one in the upper limb. Majority of them were male 90.66%. Age ranged from 7 years to 75 years. Most of the patients [77.3%] were in second to fourth decade of life. The most common cause of injury was gunshot wound [56%] followed by stab wounds [13.33%] and road traffic accidents [12%]. Few cases of bomb blast [6.66%], Post cardiac catheterization [4%], glass injury [4%] and intravenous drug abusers [2.66%] were also reported. The commonest site of injury was fern oral artery [37.33%].In this study majority of patients were male with gunshot wound as commonest cause. Reverse saphenous vein graft was treatment of choice. Infection and thrombosis were the commonest postoperative complications


Subject(s)
Humans , Male , Female , Aneurysm, False/diagnosis , Postoperative Complications , Peripheral Vascular Diseases , Wounds and Injuries , Prospective Studies , Aneurysm, False/surgery
19.
Pakistan Oral and Dental Journal. 2007; 27 (1): 85-88
in English | IMEMR | ID: emr-93936

ABSTRACT

The study was carried out on a total of 13 biopsy confirmed fibrous dysplasia patients reported to Oral and Maxillofacial surgery Unit of Khyber College of Dentistry, Peshawar over a period of 3 years i.e., from January 2004 to December 2005. The aim of the study was to evaluate the clinical and radiographic features and management of the patients with mono-ostotic fibrous dysplasia of the jaw bones. The age range of the patients suffering from mono-ostotic fibrous dysplasia was from 10 to 35 years with the mean age of years 19.78 years SD + 7.53. There were more females [62%] as compared to males [38%], with male to female ratio of 1:1.6. The maxillary bone [69%] was more frequently affected than the mandibular [31%]. While the condition has affected most of the patients in their second decade of life i.e. 53.85%. Swelling has been the most common presenting complaint [76.9%]. All the cases were treated with surgical shaving or re-contouring. Two cases of recurrent fibrous dysplasia were also reported within the study period


Subject(s)
Humans , Male , Female , Fibrous Dysplasia, Monostotic/therapy , Disease Management , Jaw , Jaw Diseases
20.
JPMI-Journal of Postgraduate Medical Institute. 2006; 20 (4): 379-384
in English | IMEMR | ID: emr-164163

ABSTRACT

To study the outcome of various surgical procedures performed for intestinal tuberculosis. This Study was carried out from July 2004 to June 2005 at Lady Reading Hospital, Peshawar on 30 operated patients of intestinal tuberculosis provisionally diagnosed on history, physical examination and x-ray findings. Emergency patients had a short work up including routine hamatological, biochemical and chest radiography while those admitted electively, had an ESR and upper gastrointestinal barium studies in addition to routine investigations. Final diagnosis was made after histopathology. Different operative procedures were performed according to the available facilities and preoperative condition of the patient. Study included 10 males and 20 females, ranging in age from 15-60 years with mean of 23.5 years. Twenty Seven patients [90%] were operated in emergency and 3 patients [10%] as elective cases. In 19 cases [63%],. ileum was involved while combined ileum and jejunum in 6 cases [20%]. Twenty patients [66%] had strictures in small gut. The most commonly performed procedures were resection and end to end anastamosis in the form of segmental resection [11 cases], stricturoplasty in 7 cases and loop ileostomy [5 cases]. Wound infection was the main post-operative complication [7 cases]. The average hospital stay was 10 days. Mortality was 10% [3 cases]. Resection of the diseased segment is the standard procedure to relieve obstruction but in the presence of multiple strictures and limited bowel length, stricturoplasty is a better alternative


Subject(s)
Humans , Male , Female , Treatment Outcome , Surgical Procedures, Operative , Constriction, Pathologic
SELECTION OF CITATIONS
SEARCH DETAIL