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Article in English | AIM | ID: biblio-1256177


Ethyl acetate(EA) extract of the stem bark of Cylicodiscus gabunensis (CG) was analysed phytochemically and evaluated for its antimicrobial activity against 17 pathogenic species isolated from patient: Escherichia coli; Klebsiella pneumoniae; Shigella dysenteriae; Shigella flexneri; Morganella morganii; Proteus vulgaris; Proteus mirabilis; Salmonella typhi; Citrobacter freundii; Enterobacter cloacae; Enterobacter agglomerans; Staphylococcus aureus; Streptococcus feacalis; Pseudomonas aeruginosa; Bacillus cereus T; Candida albicans and Candida glabrata. Flavonoids; saponins; tannins; polyphenols; coumarins; triterpenes and/or sterols and reducing sugars were detected in the (EA) extract of CG. The best MIC and MBC values for the microorganisms sensitive to the extract were 0.00078 and 0.00315 mg/ml respectively. The greater and remarkable antimicrobial activity of the (EA) extract of CG was recorded with Staphylococcus aureus; Proteus vulgaris and Bacillus cereus T. These results provide a rationalization for the traditional use of this plant for the treatment of infections diseases

Braz. j. med. biol. res ; 38(7)July 2005. ilus
Article in English | LILACS | ID: lil-403864


Dorstenia barteri and D. convexa extracts and some isolated components of the former were investigated for effectiveness against Trichomonas gallinarum and compared with quercetin and quercitrin. The antioxidant activity of the extracts/compounds was also determined. The minimum lethal concentrations (MLCs) for the extract of D. barteri leaves and twigs at 24 h were found to be 15.625 and 15.625 æg/ml, respectively. However, the MLCs of the leaf and twig extract of D. convexa were 125 and 437.5 æg/ml, respectively. The prenylated and geranylated chalcones were as active as the prenylated flavones, 6-prenylapigenin and the diprenylated derivative 6,8-diprenyleridictyol. The order of the antitrichomonal activity of the compounds at 24 h was: quercetin (0.121 æg/ml) > quercitrin (0.244 æg/ml) > or = bartericin B (0.244 æg/ml) > bartericin A (0.73 æg/ml) > stigmasterol (0.98 æg/ml) > 6,8-diprenyleridictyol = isobavachalcone = dorsmanin F (31.25 æg/ml). D. barteri extracts, quercitrin, and bartericin A, and the prenylated flavonoids had potent antioxidant properties. The twig extract of D. barteri was more potent than the leaf extract. Moderate (EC50 >50 æg/ml) and high (EC50 <50 æg/ml) antioxidant activities were detected in the leaf and twig extracts of D. barteri and the prenylated flavonoids. Prenylated flavonoids and the isolated compounds with antioxidant properties described here may account for the anti-inflammatory action of these extracts. The antitrichomonal and antioxidant activities shown by the extracts and compounds in this study are consistent with the ethnomedicinal and local use of the Dorstenia species studied.

Animals , Antioxidants/pharmacology , Antitrichomonal Agents/pharmacology , Flavonoids/pharmacology , Moraceae/chemistry , Trichomonas/drug effects , Antioxidants/chemistry , Antioxidants/isolation & purification , Antitrichomonal Agents/chemistry , Antitrichomonal Agents/isolation & purification , Drug Evaluation, Preclinical , Flavonoids/chemistry , Flavonoids/isolation & purification , Parasitic Sensitivity Tests , Plant Extracts/pharmacology , Quercetin/analogs & derivatives , Quercetin/pharmacology