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Autops. Case Rep ; 6(4): 27-33, Oct.-Dec. 2016. ilus
Article in English | LILACS | ID: biblio-905080

ABSTRACT

Histoplasmosis is the most common endemic mycoses among HIV-infected people. Patients with suppressed cell immunity mainly due to HIV are at increased risk of disseminated disease. Dermatological manifestations of immune reconstitution inflammatory syndrome (IRIS) and cutaneous manifestations of histoplasmosis similar to an IRIS event have been previously described. We report the case of a 43-year-old male who presented with cutaneous disseminated histoplasmosis due to Histoplasma capsulatum var. capsulatum 4 months after the onset of the antiretroviral therapy and some improvement in the immune reconstitution. After 2 weeks of amphotericin B and itraconazole therapy, the scheduled treatment involved fluconazole maintenance therapy, which resulted in an improvement of his skin lesions.


Subject(s)
Humans , Male , Adult , Histoplasmosis/drug therapy , Immune Reconstitution Inflammatory Syndrome/drug therapy , Amphotericin B/therapeutic use , Antiretroviral Therapy, Highly Active , Fluconazole/therapeutic use , Itraconazole/therapeutic use , Skin/injuries
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