Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add filters








Language
Year range
1.
Article in Chinese | WPRIM | ID: wpr-905081

ABSTRACT

Objective:To systematically evaluate the efficacy and safety of modified Buyang Huanwu Tang in the treatment of chronic heart failure. Method:CNKI database,Wanfang database,VIP database,Pubmed,MEDLINE,EMBASE and Cochrane database were retrieved systematically. The literature retrieval period is from no limit to December 2019,with "Buyang Huanwu Tang" and "chronic heart failure" "heart failure" as the key words for full-text retrieval of Chinese and English databases. Literatures of randomized controlled trials(RCTs) for chronic heart failure were included, and the data were extracted. Cochrane system evaluation method was used to score the quality of literature. Stata 14.0 was applied in Meta-analysis on the retrieval results. TSA0.9 was applied in test sequential analysis. Sensitivity analysis was made to explain heterogeneity,and funnel chart was used to evaluate publication bias. Result:A total of 2 037 patients were included in 21 RCT studies. The article quality risk assessment was generally unclear risk of bias. The results of meta-analysis showed that the left ventricular ejection fraction (LVEF) in the experimental group was significantly higher than that in the control group,with statistically significant differences [MD=0.901,95% CI (0.772,1.029),P<0.01],the left ventricular end diastolic diameter (LVEDd) in the experimental group was significantly lower than that in the control group,with statistically significant differences [OR=-0.650,95% CI=(-0.854,-0.446),P<0.01],BNP in the experimental group was significantly lower than that in the control group,with statistically significant differences [MD=-1.212,95% CI=(-1.359,-1.066),P<0.01],6-minute walk test (6MWT) in the experimental group was significantly higher than that in the control group,with statistically significant differences [MD=0.797, 95% CI=(0.447,1.146),P<0.01],and the effective rate in the experimental group was significantly improved,with statistically significant differences [OR=1.840,95% CI=(1.680,2.016),P<0.01]. Conclusion:Modified Buyang Huanwu Tang combined with conventional western medicine treatment of chronic heart failure is more effective than single administration of western medicine treatment,and can improve clinical efficacy, effectively improve the LVEF of patients with chronic heart failure,reduce the LVEDd reduces plasma BNP levels,prolong the 6-minute walking distance,and reduce the incidence of adverse reactions.

SELECTION OF CITATIONS
SEARCH DETAIL