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Article in Chinese | WPRIM | ID: wpr-906430

ABSTRACT

Objective:To observe the clinical efficacy of Yishen Tongluofang in treating oligosperm type male infertility with kidney deficiency and blood stasis syndrome and explore its effect on serum sex hormones and seminal plasma microenviro. Method:One hundred and four patients were randomly divided into observation group and control group with 52 cases each. Patients in control group took compound Xuanju capsules orally, 3 capsules/time, 3 times/day. Patients in observation group took Yishen Tongluofang, 1 dose/day. Treatment courses continued three months and followed up for three months in both groups. The pregnancy situations of spouses within six months were recorded. Examination of semen parameters before and after treatment and score of kidney deficiency and blood stasis syndrome were conducted. The levels of seminal plasma zinc, fructose, elastase, acid phosphatase and <italic>α</italic>-glucosidase, serum follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRT) and testosterone (T) were detected before and after treatment. Result:During the observation period of six months, the pregnancy rate of spouses in the observation group was 22.00%, higher than 10.00% in the control group, but the difference was not statistically significant (<italic>χ</italic><sup>2</sup>=2.678,<italic>P</italic>>0.05). The clinical efficacy in the observation group was better than that of the control group (<italic>Z</italic>=2.326,<italic>P</italic><0.01). Sperm concentration, sperm motility, sperm motility, normal morphological sperm and linear movement speed of the observation group were all superior to those of the control group<italic> </italic>(<italic>P</italic><0.01). The levels of zinc and fructose in seminal plasma of the observation group were higher than those of the control group (<italic>P</italic><0.01), and the score of kidney deficiency and blood stasis syndrome was lower than that of the control group (<italic>P</italic><0.01). Serum FSH, LH and PRT levels in the observation group were lower than those in the control group (<italic>P</italic><0.01), and the T level was higher than that in the control group (<italic>P</italic><0.01). The seminal plasma elastase of the observation group was lower than that of the control group, while the levels of acid phosphatase and <italic>α</italic>-glucosidase were higher than those of the control group (<italic>P</italic><0.01). Conclusion:Yishen Tongluofang can significantly improve sperm parameters, regulate the level of sex hormones and seminal plasma environment in patients with oligosperm type male infertility, and improve the tendency of spouse pregnancy. Its clinical efficacy is better,so it is worthy of further research and application.

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