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1.
Article in Chinese | WPRIM | ID: wpr-259936

ABSTRACT

The detection of blood flow velocity has great significance for blood vessel monitoring and the research of cardiovascular pathogenesis. Blood flow velocity measurement based on ultrasonic is becoming more and more popular in doctors and patients compare to several other techniques in nowadays, as they are non-invasive, cheap and fast. Most of the traditional ultrasonic blood flow velocity measurement methods are based on the Doppler frequency shift, but theses methods have some limitations, such as angle dependence, limited spatial resolution and so on. Therefore, blood flow velocity techniques based on non-Doppler frequency shift also get rapid development in recent years. This article mainly summarizes the techniques of blood flow velocity estimation based on ultrasonic in these two aspects.


Subject(s)
Blood Flow Velocity , Humans , Ultrasonography
2.
Article in Chinese | WPRIM | ID: wpr-342959

ABSTRACT

By combining with informatics theory, ta system model consisting of feature selection which is based on redundancy and correlation is presented to develop disease classification research with five gene data set (NCI, Lymphoma, Lung, Leukemia, Colon). The result indicates that this modeling method can not only reduce data management computation amount, but also help confirming amount of features, further more improve classification accuracy, and the application of this model has a bright foreground in fields of disease analysis and individual treatment project establishment.


Subject(s)
Algorithms , Artificial Intelligence , Data Mining , Gene Expression Profiling , Methods , Informatics , Neoplasms , Classification , Genetics
3.
Article in Chinese | WPRIM | ID: wpr-342928

ABSTRACT

The protein spectrometry holds such characteristics of complex and large volumes of data that the general statistical methods can't satisfy the demand of disease prediction or classification. Several kinds of main methods of mass spectrometry data mining,such as decision tree analysis, partial least squares, artificial neural networks and support vector machines is overviewed in bioinformatics perspective. And examples of different methods used to diagnose disease are illustrated. These show an important role of mass spectrometry in identification and prediction of disease.


Subject(s)
Artificial Intelligence , Computational Biology , Data Mining , Decision Trees , Least-Squares Analysis , Mass Spectrometry , Neural Networks, Computer , Support Vector Machine
4.
Article in Chinese | WPRIM | ID: wpr-325924

ABSTRACT

Based on CC2530 SoC and Micro-SD card, the system consists of three acquisition nodes and a coordinator node. The former three nodes implement data collection and wireless transmission by collecting the data of blood pressure, body temperature and ECG, while the last one fulfills the tasks of fast network organization, data reception and assorted storage.


Subject(s)
Blood Pressure , Body Temperature , Computer Communication Networks , Data Collection , Methods , Electrocardiography , Equipment Design , Humans , Telemetry
5.
Chinese Medical Journal ; (24): 3260-3268, 2011.
Article in English | WPRIM | ID: wpr-319134

ABSTRACT

<p><b>BACKGROUND</b>Duloxetine is approved for the treatment of generalized anxiety disorder (GAD) in the United States and elsewhere. This study aimed to assess the efficacy, tolerability, and safety of duloxetine in Chinese patients with GAD.</p><p><b>METHODS</b>This 9-site study consisted of double-blind treatment for 15 weeks either with duloxetine 60 - 120 mg or with placebo. Patients with at least moderately severe GAD and a Sheehan Disability Scale (SDS) global functioning impairment total score ≥ 12 were included in this study. Patients who were randomly assigned to duloxetine received 60 mg for 7 weeks; at that point, for nonresponders the dose was increased to 120 mg for the remaining 8 weeks. The primary efficacy measure was mean change from baseline to endpoint on the Hospital Anxiety and Depression Scale-Anxiety subscale score (HADS-A). Secondary efficacy measures included the Hamilton Anxiety Rating Scale (HAMA), the SDS, and pain measures. Safety and tolerability were assessed.</p><p><b>RESULTS</b>Baseline characteristics did not differ significantly between treatment groups. Mean age of the subjects (n = 210) was 37.6 years, 50.5% were female, and 74.3% completed the 15 weeks treatment. Patients treated with duloxetine had significantly greater improvement compared to placebo on the HADS-A (mean change -6.6 vs. -4.9, respectively, P = 0.022). Improvement in anxiety was greater with duloxetine treatment at 7 weeks and continued through 15 weeks for both the HADS-A and the HAMA total score (0.01 ≤ P < 0.05). Compared with placebo, duloxetine was also associated with greater improvement on most secondary measures, but not on the SDS global functioning score. Nausea, dizziness, and somnolence occurred significantly more frequently as treatment-emergent adverse events with duloxetine treatment compared with placebo treatment.</p><p><b>CONCLUSIONS</b>Duloxetine 60 - 120 mg once daily is effective and well-tolerated for the treatment of patients with GAD in China.</p>


Subject(s)
Adult , Antidepressive Agents , Therapeutic Uses , Anxiety Disorders , Drug Therapy , Double-Blind Method , Duloxetine Hydrochloride , Female , Humans , Male , Middle Aged , Thiophenes , Therapeutic Uses , Treatment Outcome
6.
Journal of Biomedical Engineering ; (6): 1227-1231, 2011.
Article in Chinese | WPRIM | ID: wpr-274921

ABSTRACT

Respiratory sinus arrhythmia (RSA) is known as fluctuations of heart rate associated with breathing. It has been increasingly used as a noninvasive index of cardiac vagal tone in psychophysiological research recently. Its analysis is often influenced or distorted by respiratory parameters, posture and action, etc. This paper reviews five methods of quantification, including the root mean square of successive differences (RMSSD), peak valley RSA (pvRSA), cosinor fitting, spectral analysis, and joint timing-frequency analysis (JTFA). Paced breathing, analysis of covariance, residua method and msRSA per liter tidal volume are adjustment strategies of measurement and analysis of RSA in this article as well. At last, some prospects of solutions of the problems of RSA research are given.


Subject(s)
Algorithms , Arrhythmia, Sinus , Artifacts , Calibration , Electrocardiography , Methods , Humans , Respiration , Signal Processing, Computer-Assisted , Tidal Volume , Physiology , Vagus Nerve , Physiology
7.
Chinese Medical Journal ; (24): 2063-2069, 2010.
Article in English | WPRIM | ID: wpr-352511

ABSTRACT

<p><b>BACKGROUND</b>Painful physical symptoms (PPS) may present as a component of major depressive disorder (MDD). Their effect in Chinese patients has not been investigated. This analysis reports the changes in disease severity, treatment patterns, quality of life and outcomes in a Chinese cohort according to the presence (PPS+) or absence (PPS-) of painful physical symptoms.</p><p><b>METHODS</b>A subgroup of Chinese patients from a large observational 3-month study of patients from Asian countries and regions of China were classified using the modified Somatic Symptom Inventory (SSI) as PPS+ (mean score >or= 2) or PPS- (mean score < 2). Depression severity was assessed with the Clinical Global Impression of Severity (CGI-S) scale and 17-item Hamilton depression rating scale (HAMD(17)). Pain severity was measured using a visual analogue scale (VAS), while the EuroQoL (EQ-5D) assessed patient well-being. Antidepressants were compared with regard to their efficacy.</p><p><b>RESULTS</b>Of the 299 Chinese patients enrolled in the study, 105 were classified as PPS+ (73/105, 70% women). At baseline, PPS+ patients reported greater pain severity (VAS, mean (SD): 49.56 (26.49) vs. 16.60 (20.99) for PPS-, P < 0.01), were more depressed (HAMD(17), mean (SD): 25.32 (5.47) vs. 23.33 (5.24) for PPS-, P = 0.002) and had poorer quality of life (EQ-5D Health State, mean (SD): 38.48 (22.38) vs. 49.57 (18.54) for PPS-, P < 0.001). PPS+ patients showed less overall improvement in depressive symptom severity (HAMD(17), change from baseline (95%CI): -17.38 (-18.65, -16.12) vs. -19.20 (-20.05, -18.35) for PPS-, P = 0.032; CGI-S, change from baseline (95%CI): -2.85 (-3.11, -2.58) vs. -3.20 (-3.38, -3.02) for PPS-, P = 0.044).</p><p><b>CONCLUSIONS</b>PPS were less frequent than expected compared with previous studies of Asian populations. PPS+ were associated with greater MDD severity and less improvement than PPS- when antidepressants were given.</p>


Subject(s)
Adult , Antidepressive Agents , Therapeutic Uses , Asians , Depressive Disorder, Major , Drug Therapy , Pathology , Female , Humans , Male , Middle Aged , Pain , Drug Therapy , Pathology , Quality of Life , Severity of Illness Index
8.
Article in Chinese | WPRIM | ID: wpr-323215

ABSTRACT

<p><b>OBJECT</b>Scientific guided breathing technology is to be studied based on the cardiopulmonary interaction.</p><p><b>METHODS</b>Heart rate variability was used as the target function to study the smoothly respiratory relaxation procedure in order to acquire the common pattern of regular and slow breathing.</p><p><b>RESULTS</b>Music based on the acquired common pattern was created and a musical pattern temporally-related to the breathing movement monitored by a sensor could be chosen to guide the breathing interactively.</p>


Subject(s)
Breathing Exercises , Heart Rate , Physiology , Humans , Respiration
9.
Article in Chinese | WPRIM | ID: wpr-323289

ABSTRACT

A new type of respiratory inductive plethysmography (RIP) has keen designed based on digital demodulation technique with equal relative error. Compared with former amplitude demodulation, digital modulation RIP can obtain more accurate measurements of respiration and reduce the signal interference and distortion. But the system's power consumption is still a problem which needs to be solved in the future design.


Subject(s)
Plethysmography , Methods , Signal Processing, Computer-Assisted , Tidal Volume
10.
Article in Chinese | WPRIM | ID: wpr-585490

ABSTRACT

This paper summarizes the core issues, realization scheme and key technologies of electronic retina with its status and advance reviewed. On the basis of the relationship between the information processing in visual cortex and retinal nerve coding, the prospect of electronic retina is predicted, and thus our futural orientation is determined.

11.
Article in Chinese | WPRIM | ID: wpr-737344

ABSTRACT

Objective To summarize and analyze human rabies epidemic situation in the last five years in China and to explore the possible factors causing the rising of epidemics to provide reference for the prevention and control of rabies in the future. Methods Collecting and analyzing data of rabies epidemics in the last five years in whole nation. Results Human rabies is continuing going up in the last five years in China with an increase of 44.65%, 1.74% and 45.93% in 1997, 1998, 1999. Human rabies incidence was also seen an increase from 0.013 4/100 000 in 1996 to 0.027 08/100 000 in 1999. The provinces of rabies increase were mainly located in south China. Among them, Jiangsu province reported 40 human cases in 1999, which increased 207.69% than the corresponding period in 1998. The cases in these high epidemic provinces took up 75% of the whole nation's cases. Number of reported rabies case was also rising. Conclusion Facts as increasing number of dog raising, having not been injected with rabies vaccine and antirabies serum timely or full course after exposure, unstrictly controlling the quality of rabies vaccine as well as lacking good cooperation in different official department on rabies control might serve as factors responsible for the recurrent increase of human rabies.

12.
Article in Chinese | WPRIM | ID: wpr-735876

ABSTRACT

Objective To summarize and analyze human rabies epidemic situation in the last five years in China and to explore the possible factors causing the rising of epidemics to provide reference for the prevention and control of rabies in the future. Methods Collecting and analyzing data of rabies epidemics in the last five years in whole nation. Results Human rabies is continuing going up in the last five years in China with an increase of 44.65%, 1.74% and 45.93% in 1997, 1998, 1999. Human rabies incidence was also seen an increase from 0.013 4/100 000 in 1996 to 0.027 08/100 000 in 1999. The provinces of rabies increase were mainly located in south China. Among them, Jiangsu province reported 40 human cases in 1999, which increased 207.69% than the corresponding period in 1998. The cases in these high epidemic provinces took up 75% of the whole nation's cases. Number of reported rabies case was also rising. Conclusion Facts as increasing number of dog raising, having not been injected with rabies vaccine and antirabies serum timely or full course after exposure, unstrictly controlling the quality of rabies vaccine as well as lacking good cooperation in different official department on rabies control might serve as factors responsible for the recurrent increase of human rabies.

13.
Article in Chinese | WPRIM | ID: wpr-586308

ABSTRACT

With known visual knowledge, the first generation of wavelet transform is employed to decompose and reconstruct images. The experiment results demonstrate that there are mechanisms of time-sharing repeat-using and time coding in visual imaging principle. Therefore relatively complete image data can be achieved when the visual cortex is stimulated by limited electrodes.

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