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1.
Article in Chinese | WPRIM | ID: wpr-868098

ABSTRACT

Objective:To evaluate the placental villus blood flow in different pregnancy using superb microvascular imaging(SMI).Methods:Fifty single pregnant women were randomly selected from early pregnancy pregnant women with outpatient examinations from January 2019 to June 2019. The SMI technique was used to monitor the villus blood flow of the placenta during routine ultrasound examination in early, middle and late pregnancy. The blood flow of the placental villus at the insertion point of the placenta umbilical cord and the edge of the placenta was explored, and the corresponding arterial blood flow spectrum was collected, and the values of systolic/diastolic velocity ratio(S/D), pulsatility index(PI), resistance index(RI) and peak systolic velocity(PSV) were recorded. The correlation between the measurement rate of villus blood flow spectrum and the placenta position, fetal position, and pregnancy period were analyzed by Spearman correlation. Chi-square test was used compare the difference of the display rates of placental villus blood flow and the measurement rates of blood flow spectrum during different pregnancy periods. The consistency analysis of the results between the two inspectors was performed using Kappa test.Results:Finally, 30 pregnant women were enrolled. SMI showed 98.9% (89/90) of placental villus blood flow. The consistency of the examination results between the two examiners was good. The measurement rate of villus artery blood flow spectrum was not correlated with the placenta and fetal position ( P>0.05), but correlated with defferent trimesters ( r s=0.478, P<0.05). There was no difference in the display rate of villus blood flow at the insertion point of the placenta umbilical cord and at the edge of the placenta in each trimester( P>0.05). The measurement rate of blood flow spectrum was statistically different ( P<0.05). And the measurement rate of early pregnancy (33.3%/3.3%) was lower than the middle (70.0%/50.0%) and late pregnancy (56.6%/60.0%). The consistency of the examiners results between the two examiner is good (Kappa=0.55-0.92, P<0.05). Conclusions:SMI can display the blood flow of placental villus in different stages of pregnancy and can measured blood flow accordingly. The different pregnancy stages affect the measurement results. Placental villus blood flow measurement in the middle and late pregnancy is easier to measure than in the early pregnancy. The fetal position and placental position do not affect blood flow measurement.

2.
Article in Chinese | WPRIM | ID: wpr-756156

ABSTRACT

We reported a female fetus diagnosed with X-linked dominant chondrodysplasia punctata 2 with severe phenotype. The fetus was found with abnormal short limbs, thick metaphysis on the right lower limb and a narrow and small thorax by prenatal ultrasound at 24+5 weeks of gestation. Non-invasive prenatal test indicated the risks of trisomies 21, 18 and 13 were low. The pregnancy was terminated at 27 weeks of gestation and postnatal X-ray imaging showed that the fetus had short femur and humerus, a narrow and small thorax, thickened metaphysis with a "splashed paint spot" pattern, and asymmetric shortened lower limbs. Whole-exome analysis showed that the fetus carried a heterozygous pathogenic mutation c.440G>A (p.Arg147His) in the EBP gene. The mutation was confirmed to be a de novo mutation as neither of her parents carried the same mutation. Thus, the patient was diagnosed as having X-linked dominant chondrodysplasia punctata 2. The severe phenotype of this case migh be related to random X chromosome inactivation.

3.
Article in Chinese | WPRIM | ID: wpr-755353

ABSTRACT

Objective To analyze the clinical and pathological features of chronic hepatitis B (CHB) patients with hepatic steatosis.Methods Clinical and pathological data of 841 patients with CHB who underwent liver biopsy in Zhejiang Provincial People’s Hospital during September 2015 to September 2018 were retrospectively reviewed.One hundred and thirty five gender and age-matched pairs of steatosis and non-steatosis patients entered the analysis.Multivariable Logistic regression and rank sum test were used to analyze the clinical features and risk factors of hepatic steatosis in CHB patients .Spearman correlation test was used to analyze the correlation between hepatic steatosis and HBV DNA , hepatic inflammation and fibrosis status.Results Logistic regression analysis showed that overweight /obesity ( χ2 =3.947, OR =1.436, 95%CI 1.005-2.051, P<0.05) and hyperlipidemia (χ2 =4.277,OR=1.803,95%CI 1.031-3.151, P<0.05) were the risk factors for hepatic steatosis in CHB patients.There was no correlation of hepatic steatosis with serum HBeAg and HBV DNA levels (Z=-1.762,r=-0.011, both P>0.05). However, hepatic steatosis was negatively correlated with inflammatory grade and fibrosis grade of the liver (r=-0.146 and -0.192, both P<0.05).Conclusions Overweight/obesity and hyperlipidemia are associated with steatosis in CHB patients.Hepatic steatosis may not aggravate the degree of liver inflammation and fibrosis in CHB patients.

4.
Article in Chinese | WPRIM | ID: wpr-805302

ABSTRACT

Objective@#To evaluate the effect of a tobacco control intervention for college students under the advocate-promoting model, and to provide evidence for methods to improve smoking control and health decisions.@*Methods@#Four colleges were selected from the list of colleges that participated in a survey of college student tobacco use in Zhejiang Province in 2015, and we conducted a tobacco control intervention with them under the advocate-promoting model for two years. A total of 1 007 students were selected using a random sampling method and surveyed before intervention, and 991 students were selected using a random sampling method and surveyed after the intervention. A chi-square test was used to compare the differences between tobacco use, second-hand smoke exposure, and tobacco knowledge among students before and after the intervention.@*Results@#After the tobacco control intervention, the attempted smoking rate among students in the four colleges dropped from 34.36% to 22.30%, the current smoking rate dropped from 12.12% to 7.87%, the second-hand smoke exposure rate decreased from 75.47% to 70.53%, the difference was statistically significant (χ2=37.73, 9.99, 6.18, P<0.05). After intervention, the proportion of students who had seen tobacco advertisements in the past 30 days decreased from 60.38% to 54.4%, the proportion of students who "saw smoking scenes in video media" decreased from 25.02% to 19.58%, and the proportion of students who "learned smoking control knowledge in class" increased from 14.20% to 18.16%, the difference was statistically significant (χ2=7.08, 8.55, 5.79, P<0.05).@*Conclusion@#The advocate-promoting model of "advocacy alliance" can help colleges to establish a smoke-free campus environment and improve college students’ tobacco knowledge and reduce their attempted and current smoking rates.

5.
Journal of Medical Research ; (12): 25-28, 2018.
Article in Chinese | WPRIM | ID: wpr-700958

ABSTRACT

Objective To investigate the expression of PLP2 protein in the process of cardiac remodeling.Methods Mice were subjected to left anterior descending coronary artery ligation to induce cardiac remodeling model.Mice were subjected to isoproterenol (ISO) subcutaneous injection for 2 weeks to establish acute cardiac injury model.Mice were subjected to aortic banding (AB) surgery to establish a myocardial hypertrophy model.Cardiac myocytes hypertrophy model was induced by phenylephrine (PE) stimulation.Transforming growth factor (TGF) beta was used to stimulate cardiac fibroblasts.The PLP2 transcription level was detected by RT-PCR.Results PLP2 expression was significantly increased in 2 weeks after myocardial infarction (P < 0.05),as well as in acute cardiac injury induced by ISO injection (P < 0.05).After 1 week of AB surgery,the PLP2 expression began to increase (P < 0.05),peaked at 2 weeks post AB (P < 0.05),preserved to 8 weeks after AB (P < 0.05).The expression of PLP2 in PE stimulated cardiomyocytes was increased as well as TGFβ stimulated fibroblast.Conclusion The expression of PLP2 were dynamically changed significantly in different cardiac remodeling model,suggesting that it may be involved in the occurrence and development of cardiac remodeling.

6.
Article in Chinese | WPRIM | ID: wpr-700202

ABSTRACT

Objective To study the role of serum S100 calcium binding protein (S100A12) in preterm premature rupture of membrane induced chorioamnionitis. Methods Thirty-six patients with preterm premature rupture (preterm premature rupture group), 48 patients with term birth premature rupture (term birth premature rupture group) and 17 normal pregnant women (control group) were selected. The blood routine, S100A12, C response protein (CRP), glycohemoglobin (GHB) levels were detected and compared. Results The S100A12 in preterm premature rupture group was significantly higher than that in term birth premature rupture group and control group: (1 193.6 ± 443.1) ng/L vs. (787.7 ± 482.6)and(610.5 ± 449.0)ng/L,and there was statistical difference(P<0.01);but there was no statistical difference between term birth premature rupture group and control group(P<0.05).In preterm premature rupture group, S100A12 levels in the gestational diabetes mellitus (GDM) and non-GDM patients were significantly higher than those in control group:(1 225.4 ± 422.5)and(1 168.2 ± 468.2)ng/L vs. (610.5 ± 449.0) ng/L, and those in GDM patients were significantly higher than those in non-GDM patients, and there were statistical differences (P<0.05). In preterm premature rupture group, the S100A12 showed significant positive correlation with CRP, neutral granulocyte percent and GHB (r =0.236, 0.222 and 0.378; P<0.05 or <0.01). Conclusions S100A12 would have an important role in the mechanism of preterm premature rupture of membrane combined with GDM induced chorioamnionitis.

7.
Article in Chinese | WPRIM | ID: wpr-712074

ABSTRACT

Objectives To investigate the features of thyroid ultrasonographic manifestations in patients with subclinical thyroid serological anomalies during pregnancy. Methods In present study, a total of 53 women who attended the obstetrics clinic in Beijing Obstetrics and Gynecology Hospital from January 2014 to December 2015 underwent thyroid ultrasound scanning. All women included in this study were checked up for the serological levels of thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroid peroxidase antibody (TPoAb) in the first trimester and were diagnosed as thyroid dysfunction or abnormal level of serological antibody for the first time. The χ2test was used to compare the incidences of abnormal thyroid echogenicity and increased blood flow in thyroid between groups with serological TPoAb level≥1300 IU/L and<1300 IU/L. Results Among 53 cases, 21 were subclinical hyperthyroidism, 10 were subclinical hypothyroidism, and 22 were isolated elevated serum TPoAb cases. Among 21 subclinical hyperthyroid patients, 16 cases without elevated TPoAb were unremarkable on thyroid scanning, while 2 out of the rest 5 cases (40.0%) with increased serum TPoAb demonstrated mild thyroid diffuse abnormal echogenicity. Among 10 subclinical hypothyroid cases, 2 out of 5 cases (40.0%) without elevated TPoAb manifested mild thyroid diffuse abnormal echogenicity, while 4 of 5 cases (80.0%) with elevated TPoAb showed diffuse abnormal echogenicity of thyroid. In 22 women with isolated elevated serum TPoAb, 11(50.0%) demonstrated diffuse thyroid abnormal echogenicity. In all 32 cases with elevated serum TPoAb, the serum TPoAb level was ≥ 1300 IU/L in 9 cases and < 1300 IU/L in 23 cases. The incidence of thyroid abnormal echogenicity was higher in women with serum TPoAb level≥1300 IU/L than in women with<1300 IU/L (8/9 vs 9/23), which was statistically significant ( χ2=6.432, P=0.018); while no significant difference in the incidence of increased blood flow in both groups was identified(6/9 vs 9/23, χ2=1.970, P=0.080). Conclusion The thyroid ultrasonographic manifestations varied in patients with thyroid serologic anomalies during pregnancy, and were not closely consistent with the serological findings.

8.
Article in Chinese | WPRIM | ID: wpr-712062

ABSTRACT

Objective Cotyledonoid dissecting leiomyomawas a rare type of uterus tumors. Because of the lack of knowledge about the ultrasonic patterns of this kind of disease, misdiagnosis frequently happens. Reviewing the cases and relevant researches was helpful to understand the disease and figure it out in ultrasonic images. Methods Six cases of patients with dissecting leiomyoma were reviewed which were hospitalized in Beijing Obstetrics and cotyledonoid Gynecology Hospitalduring 2011 to 2016. All of the patients underwent ultrasound examinations before surgery. The ultrasound findings, clinical presentations and pathological features of the 6 patients were evaluated. Results In 6 patients with CDL, 5 cases were typical intramural dissecting leiomyomas, the inhomogeneous solid masshad irregular boundaries with muscle, color Doppler revealed intenseblood flow signals in the mass. One case exophytic component was in continuity with a lobulated, multinodular myometrial tumor with an irregular border, resembling cotyledon of the placenta. Conclusions Cotyledonoid dissecting leiomyoma was found to be inhomogeneous solid masswith irregular boundariesin some cases, exophytic component was multinodular myometrial tumor, resembling cotyledon of the placenta. Due to bizarre, sarcoma-like gross appearances. Thusit is hard to be diagnosed before surgery by ultrasonography, this type of lesion should be subjected tocareful ultrasonic examination in order to avoid over treatmentand preserve the fertility in young women.

9.
Article in Chinese | WPRIM | ID: wpr-709096

ABSTRACT

Objective To study the mechanism of cucurbitacin B (CuB) underlying pressure over load-induced myocardial fibrosis.Methods Sixty C57 mice were divided into sham operation group,CuB treatment group,aorta ligation group,CuB+aorta ligation group (15 in each group).The animals received intragastric gavage (0.2 mg/kg · 2 d) one week after operation and a myocardial fibrosis model of mice was induced by aorta ligation 4 weeks after operation.Microvascular density (MVD) was detected with immunohistochemical staining.Expressions of α-SMA,CD31,CD34,vimentin and endothelial-mesenchymal transition (EndMT) were detected by Western blot with immunofluorescence staining.Results No significant difference was found in cardiac MVD,and expression level of α-SMA,vimentin,CD31 and CD34 between sham operation group and CuB group 4 weeks after operation (P>0.05).The cardiac MVD and expression level of CD31 and CD34 were significantly lower while the expression level of α-SMA and vimentin was significantly higher in aorta ligation group than in sham operation group 4 weeks after operation (P<0.05).The cardiac MVD and expression level of CD31 and CD34 were significantly higher while the expression level of α-SMA and vimentin was significantly lower in CuB+aorta ligation group than in aorta ligation group 4 weeks after operation (P<0.05).Conclusion CuB can attenuate cardiac fibrosis by regulating EndMT.

10.
China Pharmacist ; (12): 193-197, 2018.
Article in Chinese | WPRIM | ID: wpr-705487

ABSTRACT

Objective:To investigate the protective effect of evodiamine on cardiomyocytes hypoxia injury. Methods:H9c2 myo-cardial cells were exposed to hypoxia for 24 h to induce myocardial cell injury model. The cells were pretreated with different concentra-tions of evodiamine for 12 h. The cardiomyoctes viability was detected by CCK-8 assay. The transcription of inflammatory cytokines was detected by RT-PCR. The cardiomyocyte apoptosis was detected with Tunel staining. The alteration of signal pathway was detected by immunoblotting. Results:Four concentrations of evodiamine did not affect the activity of cardiomyocytes in the basal condition (P>0.05). After 24-hour hypoxia,the viability of cardiomyocytes decreased significantly when compared with that in the control group with significant difference (P<0.05) among 1,5 and 10 μmol·L-1evodia in a dose-dependent manner. The transcription of pro-inflam-matory cytokines(TNF-α,IL-1 and IL-6) significantly increased and the cells apoptosis increased. Evodiamine pretreatment increased the cell viability after hypoxia injury, reduced the transcription of inflammatory cytokines and reduced the number of apoptotic cells when compared with that in the control group with significant differences(P<0.05) between 1 μmol·L-1and 10 μmol·L-1evodia. The results of western blot showed that evodiamine activated AMPKα and AKT, inhibited the activity of NF- kappa B, and compared with the control group,there were significant differences(P<0.05) between 1 μmol·L-1and 10 μmol·L-1of evodia. Conclusion:Evodiamine can protect cardiomyocytes from hypoxia injury and may become a new anti-myocardial ischemia drug.

11.
Article in Chinese | WPRIM | ID: wpr-806292

ABSTRACT

Objective@#To evaluate the effectiveness of a text message for smoking cessation among male smokers before their wives' pregnancy, and to provide evidence for smoking cessation strategies.@*Methods@#A prospective observational study was conducted in four cities of Zhejiang province from April to October 2016. A total of 552 male smokers were assessed using data from structured questionnaires at baseline and were followed up at 1 and 6 months. A total of 307 participants were provided a text message (SMS) for smoking cessation intervention, along with wives' involvement in husbands' quitting programs. The intervention group was compared with the control group without intervention. Outcomes were self-reported 7-day point prevalence abstinence rates at 1-month and 6-months follow up.@*Results@#In the intervention group, the proportion of participants who self-reported to be healthy reduced from 26.4% to 15.3% at 1-month follow-up and increased to 21.8% at 6-month follow-up; in the control group, it was reduced from 19.2% to 11.4% at 1-month follow-up, and increased to 20.4% at 6-month follow-up. The 7-day point prevalence abstinence rate of the intervention group at 1 and 6 months were higher than that of the control group: at 1-month follow-up, 13.0% vs. 8.2%; at 6-month follow-up, 16.3% vs. 8.2%, respectively. Compared to the control group, the intervention group considered "determination" as the most important support (61.9% at 1 month, 60.9% at 6 months); "addiction cycle" was the main barrier (47.2% at 1 month, 48.9% at 6 months), and they were less influenced by other smokers (8.1% at 1 month, 5.2% at 6 months).@*Conclusion@#SMS smoking cessation intervention, along with wife's involvement in husband's quitting programs had a positive effect on the quitting rates.

12.
Article in English | WPRIM | ID: wpr-277874

ABSTRACT

Objective To investigate the effects of low-intensity pulsed ultrasound (LIPUS) on the mandibular remodeling following inferior alveolar nerve transection (IANX) and to optimize the parameters of LIPUS in the treatment of nerve injury. Methods IANX was performed in male Sprague-Dawley rats. Four weeks after IANX,the effect of daily LIPUS (from day 1) on the transected inferior alveolar nerve was examined in terms of sensitivity to mechanical stimulation. Moreover,histopathologic changes of mandibles were analyzed by micro-CT,HE staining,Masson trichrome staining,and immunohistochemical staining. Results LIPUS promoted the recovery of inferior alveolar nerve injury after transection. HE staining displayed the improvement of trabecular thickness and continuity. LIPUS with higher duty ratios had more obvious effect on bone remodeling. Conclusion LIPUS promotes the mandibular remodeling following IANX.

13.
Article in Chinese | WPRIM | ID: wpr-620462

ABSTRACT

Objective To understand the effectiveness of peroral endoscopic myotomy(POEM)for achalasia and secondary severe malnutrition in children and the effectiveness of nutrition support before and after POEM.Method Treatment of POEM,nutrition support(tube feeding by percutaneous endoscopic gastrostomy three months before operation)in one case were recorded and analyzed.Results POEM was successful without any complication such as perforation,bleeding,and pneumoderm.The child suffered from fever after surgery,which was dissolved after symptomatic treatment three days later.Chest pain was relieved after changing position.The diet was changed from liquid to semifluid,and then to normal diet.The child did not have dysphagia.During the 6-month follow-up,the patient had normal diets by oral route.The weight was 32 kg before achalasia and decreased to 18 kg after 9 months(at admission);it then increased to 29 kg after short-time(12 days)parenteral nutrition and long-time(3 months)enteral nutrition by percutaneous endoscopic gastrostomy,and then the patient received POEM.His weight was 30,31,31,29,and 31 kg 1,4,6,9,and 13 months,respectively,after POEM.Conclusion POEM can effectively cure achalasia in pediatric patients and improve the quality of life.Rational enteral nutrition can improve nutrition status and facilitate a successful POEM.

14.
Chinese Journal of Epidemiology ; (12): 1358-1362, 2017.
Article in Chinese | WPRIM | ID: wpr-737833

ABSTRACT

Objective To study the effect of adult tobacco use after the implementation of an intervention program,in Zhejiang province from 2010 to 2013.Methods A total of 2 000 residents aged 15-69 years from 15 counties were selected,using a stratified multi-stage cluster sampling method and a face to face interview on questionnaire,in 2010 and 2013.Intervention program was then implemented.Results The current smoking prevalence rates were 25.77% and 25.64% respectively in the above-said two years.Comparing data gathered from the 15-69 year olds in Zhejiang province in 2010 and 2013,no statistically significant differences were found in male population,in the 45-64 age group,in the rural population,and in the junior middle school students,regarding the current smoking prevalence rates.42.11% and 40.56% of the current daily smokers started daily smoking within 30 minutes after waking up in the morning,in 2010 and 2013,and the difference was not significant.Conclusion Prevalence of smoking in males in Zhejiang remained high,suggesting that publicity and education intervention methods of tobacco control should be effectively improved.

15.
Journal of Medical Research ; (12): 124-127, 2017.
Article in Chinese | WPRIM | ID: wpr-618745

ABSTRACT

Objective To investigate the expression changes of SSR in the process of cardiac remodeling.Methods Myocardial infarction (MI) was induced by left anterior descending coronary artery ligation in mice to establish cardiac remodeling model.Mice subjected to isoproterenol (ISO) subcutaneous injection for 2 weeks to establish acute cardiac injury model.Mice subjected to aortic banding (AB) to establish a mouse model of cardiac hypertrophy.RT-PCR was used to detect the expression change of SSR in various cardiac remodeling models.Results The expression levels of SSR subunit 1 (SSR1) and 3 (SSR3) were significantly decreased in mice after 2 weeks of MI (P < 0.05),and were also decreased in acute cardiac injury induced by 2 weeks of ISO injection (P < 0.05),and reduced afterl week of AB operation (P < 0.05).However,the expression of SSR1 and SSR3 increased at 2 weeks after AB (P < 0.05),and sustained to 8 wccks after AB (P < 0.05).Conclusion The expression of SSR3 and SSR1 in different models of cardiac remodeling were significantly changed,and showed dynamic changes,suggesting that it may participate in the occurrence and development of cardiac remodeling.

16.
Chinese Journal of Zoonoses ; (12): 617-623, 2017.
Article in Chinese | WPRIM | ID: wpr-611961

ABSTRACT

We studied the effect of the Mycobacterium tuberculosis prokaryotic ubiquitin-like protein-proteasome system on mono-resistant to rifampin resistance to M.tuberculosis.A resazurin-based assay was employed to evaluate minimum inhibitory concentration (MIC) and comparative research on mono-resistant to rifampin MTB with Pup,Dop,PafA,Mpa genes expression and deletion of the difference.Above testing strains,respectively,carbonyl cyanide chlorobenzene hydrazone (CCCP),reserpine (RP),verapamil (VP)and chlorpromazine (CPZ) were tested.We compared and analyzed the change of rifampicin MICs on the various strains.Compared with rifampin resistant MTB,overexpression of Pup,Dop,PafA and Mpa genes were able to make monorifampicin of M.tuberculosis to enhance resistance to rifampin.Deletion of Pup gene,Mpa gene,Dop gene,PafA gene significantly decreased the resistance to rifampicin alone MTB,and the P value was <0.05.Results indicated that 4 kinds of efflux pump inhibitors can reduce the degree of rifampin MIC in different strains.Through the factorial analysis,there were some interactions between MTB and PPS efflux pump inhibitors,and the P value was <0.05.MTB PPS has influence on mono-rifampin resistance to MTB and it may regulate the efflux pathway related protein to influence its resistance.

17.
Article in Chinese | WPRIM | ID: wpr-669252

ABSTRACT

Objective To discuss the prenatal ultrasound manifestations of intrauterine intussusception.Methods An analysis of prenatal ultrasound findings and postnatal features was performed on five cases of fetuses with intrauterine intussusception that were identified by ultrasonography at Beijing Obstetrics and Gynecology Hospital,in the period of January 2014 to December 2016.Results The 5 fetuses with intrauterine intussusception were diagnosed based on the typical "target sign","telescope sign","doughnut sign" and "crescent-in-doughnut sign "in ultrasonography.Indirect and non-specificultrasonographic signs included dilatation of intestine and ascites.Three cases of emergency caesarian section were performed,and infants underwent surgeries.The intraoperative findings confirmed the prenatal diagnosis,and postoperativelythe infantsrecovered uneventfully.In another 2 cases,whichwere suspected the presence of meconium peritonitis,fetus prematurely bomvia a spontaneous vaginal delivery,and the intraoperative findings confirmed the prenatal diagnosis.However,intestinal atresia occurred,and the neonates died postoperatively.Conclusions Fetuses with intrauterine intussusceptionshad characteristic "target sign","telescope sign","doughnut sign" and "crescent-in-doughnut sign" in ultrasonography.Ultrasonography may be used as the first choice for prenatal diagnosis of this disease.Prenatal diagnosis of intrauterine intussusception can provide guidance for clinical obstetrical management and postnatal treatment.

18.
Article in Chinese | WPRIM | ID: wpr-669250

ABSTRACT

Objective Uterine intravenous leiomyomatosiswas a rare type of uterus tumors.Because of the lack of knowledge about the ultrasonic patterns of this kind of disease,misdiagnosis frequently happens.Reviewing the cases and relevant researcheswas helpful to understand the disease and figure it out inultrasonic images.Methods Six cases of patients with uterine intravenous leiomyomatosis were reviewed which werehospitalized in Beijing Obstetrics and Gynecology Hospital during 2014 to 2016.All of the patients underwentultrasound examinations before surgery.The ultrasound findings,clinical presentations and pathological features of the 6 patients were evaluated.Results In 6 patients with uterine intravenous leiomyomatosis,3 cases were solid tumors,located in the cervix region and para uterine region,withirregular veinvascular inside;3 cases performance as multiple tumorlocated in dilated uterine vein,active tumor embolus were found in inferior vena cavain one of the 3 cases.Conclusions Uterine intravenous leiomyomatosisis found to be a solid mass located in the cervix region and para uterine region.The internal fissure of solid tumor is an important feature.Tumor extending to the iliac vein and inferior vena cava in some cases.Thusit is hard to be diagnosed before surgery by ultrasonography.Moreover,transvaginal ultrasound combined with inferior vena cava ultrasonography and echocardiography has a more obvious advantage in the diagnosis of the uterine intravenous leiomyomatosis.

19.
Article in Chinese | WPRIM | ID: wpr-510420

ABSTRACT

Objective To investigate the relationship between the expression of CC chemokine ligand 5(CCL5)and S100 calcium binding protein A4 (S100A4)protein in breast cancer tissues with clinicopathological features and prognosis.Methods The expression of CCL5 and S100A4 in 40 cases of normal breast tissues and 120 cases of breast cancer were detected by immunohistochemistry,and the relationship between the degree of expres-sion and the clinicopathological features and prognosis of breast cancer was analyzed.Results The expression posi-tive rates of CCL5 and S100A4 in breast cancer tissues were 56.67% and 62.50% respectively,which were not expressed in normal breast tissues,and the differences were statistically significant (χ2CCL5 =39.403,P 0.05 ).And the expression of S100A4 was statistically correlated with clinical staging(χ2 =44.311,P 0.05).The expression of CCL5 and S100A4 in breast cancer was positively correlated(r =0.301, P <0.01).CCL5 was positively correlated with the recurrence of breast cancer(OR =6.270,P <0.01),and S100A4 was not correlated with the recurrence of breast cancer(OR =1.103,P =0.768).Survival analysis showed that the disease -free survival time of patients with positive CCL5 expression was significantly shorter than the patients with negative CCL5 expression(χ2 =11.851,P <0.01 ),and the disease -free survival time of patients with positive S100A4 expression was significantly shorter than the patients with negative S100A4 expression(χ2 =5.433,P =0.021).The joint detection showed that the disease -free survival time in CCL5(+)+S100A4(+)group was sig-nificantly lower than that of CCL5(+)or S100A4(+)group(χ2 =15.341,P <0.01)and CCL5 (-)+S100A4 (-)group(χ2 =15.341,P <0.01).Conclusion The expression of CCL5 and S100A4 in breast cancer can reflect the metastasis and staging of breast cancer,which can be used to judge the clinical pathological characteristics and prognosis of breast cancer.

20.
Article in Chinese | WPRIM | ID: wpr-505797

ABSTRACT

Objective To understand the prevalence of tobacco use among college students in different populations by sex,age and major,and to provide evidence for smoking control and health decision.Methods A total of 4 638 college students selected in 21 colleges through stratified multi-stage cluster sampling from Zhejiang Province were surveyed by using questionnaire analysis.Indicators such as tried smoking,current smoking,and secondhand smoke exposure,etc.,were calculated by weight on age proportions from the numbers of college students in Zhejiang.Results The prevalence of tried smoking and currcut smoking among college students were 29.72% and 10.57%,respectively.The prevalence of tried smoking was 46.52% for men,18.25% for women;28.57% for undergraduate,31.53% for junior college;the prevalence of current smoking was 18.86% for men,3.86% for women;8.88% for undergraduate,13.23% for junior college students.The snoking rate in college students increased with age,the group of ≥21 Years was the highest (37.87%,16.09%).The lowest level of smoking was medical student (21.76%,2.19%).The prevalence of secondhand smoke exposure in outdoor and indoor places,and dormitory among students were 65.49%,60.33%,and 23.66%,respectively.In the past 30 days,college students have seen tobacco advertisement (47.38%),smoking scenes (60.20%),and got tobacco related gifts (10.40%),free tobacco products (8.93%);college students have seen information about tobacco control (60.50%),cigarette pack warning labels (58.45%),and learned the tobacco knowledge in class in the past 12 months (14.03%).Conclusion Current prevalence of smoking in college students in Zhejiang province remained at a high level,the rate of secondhand smoke exposure is high and in college students there was lack of tobacco control education in class.The results indicated that the policy about tobacco control in school was not enough and the task of health promotion should be taken more arduously.

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