ABSTRACT
<p><b>OBJECTIVE</b>To assess the efficacy and safety of bifid triple viable bacterial tablet in treatment of infantile diarrhea.</p><p><b>METHODS</b>According to the requirements of Cochrane systematic review, a thorough literature search was performed among Chinese Digital Hospital Library (www.chkd.cnki.net) and Chinese Biomedical Literature Disk Database (CBMdisk). A meta analysis was performed on a total of 1326 patients involved in 12 papers which met the inclusion criteria.</p><p><b>RESULTS</b>Publication bias analysis showed that the funnel plot was symmetrical. Test for heterogeneity showed that the groups treated with bifid triple viable bacterial tablet and antibiotics or anti-viral agents or placebo control had clinical homogeneity and statistical homogeneity (P = 0.66, 0.67, 0.85, respectively, I(2) = 0%), which allowed to use fixed effect model analysis. The bifid triple viable bacterial tablet and Smecta did not have statistical homogeneity (P = 0.02, I(2) = 70.9%), therefore random effect model analysis was applied. Incorporation analysis showed that in comparison of the bifid triple viable bacterial tablet versus antibiotics or anti-viral agents or placebo control, the odds ratios were 5.34, 4.74 and 6.43, respectively, and 95% CIs were [2.81, 10.16], [2.47, 9.09], and [2.61, 15.83], on test for overall effect, Z = 5.11, 4.67 and 4.04, P < 0.00001. In the forest plot the 95% CI horizontal line of incorporation odds ratio droped to the right side of the vertical line indicating the border of effectiveness. However, no statistically significant difference was found between bifid triple viable bacterial tablet and Smecta.</p><p><b>CONCLUSION</b>The clinical evidences available so far indicated that treatment of infantile diarrhea with bifid triple viable bacterial tablet is safe and effective although rigorously designed large sample size randomized double blind clinical trials are required to further demonstrate and support the conclusion.</p>
Subject(s)
Child, Preschool , Humans , Infant , Administration, Oral , Anti-Bacterial Agents , Therapeutic Uses , Anti-Infective Agents , Therapeutic Uses , Antiviral Agents , Therapeutic Uses , China , Controlled Clinical Trials as Topic , Diarrhea, Infantile , Drug Therapy , Odds Ratio , Tablets , Treatment OutcomeABSTRACT
<p><b>OBJECTIVE</b>To evaluate the therapeutic effect and safety of acupoint sticking therapy for facial paralysis.</p><p><b>METHODS</b>Search the literatures in the whole paper databank of China figure medical library (Jan. 1994-Dec. 2004) and China Biomedical Literature Disk Databank (Jan. 1995-Dec. 2004). Meta-analysis was conducted with RevMan 4. 2. 5 software.</p><p><b>RESULTS</b>Sixteen controlled trials involving 2 157 patients were included. Meta-analysis indicated that there was high statistically difference between the acupoint sticking therapy and simple acupuncture therapy or Western medicine therapy.</p><p><b>CONCLUSION</b>The acupoint sticking therapy is effective and safe for facial paralysis.</p>
Subject(s)
Humans , Acupuncture Points , Acupuncture Therapy , China , Facial ParalysisABSTRACT
0.05).Conclusions:Facial nerve excited threshold detection was a simple and effective method of conjecturing TCM syndrome and severity and prognosis of facial paralysis patients.
ABSTRACT
0. 05); The long-term effective rate was 84. 21% in the treatment group and 54. 55% in the control group with a significant difference between the two groups (P