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1.
Chinese Critical Care Medicine ; (12): 885-888, 2021.
Article in Chinese | WPRIM | ID: wpr-909424

ABSTRACT

Regulated necrosis is a newly discovered new cell death pathway, including necroptosis, pyroptosis and ferroptosis. It has been reported to play a key role in acute kidney injury (AKI) induced by ischemia/reperfusion, cisplatin and other drugs, and rhabdomyolysis. Studying the role of regulated necrosis-related pathways in AKI is expected to provide a new direction for clarifying the pathogenesis and treatment of AKI, with potential therapy and application prospects. In this review, we summarize the related signaling pathways of necroptosis, pyroptosis and ferroptosis, and the related research progress in AKI, in order to provide potential targets for the prevention and treatment of AKI.

2.
Article in Chinese | WPRIM | ID: wpr-781449

ABSTRACT

OBJECTIVE@#To establise the bank of platelet donors with the human platelet antigen (HPA) 1-6, 15 genes so as to provide the HPA-matched platelets for the patients.@*METHODS@#The HPA genotyping of platelets donors and patients with platelet antibody positive confirmed by sercening was performed by using the SSP-PCR; the efficacy of transfusing the HPA-matched platelets for 37 cases platelet antibody positive was analyzed.@*RESULTS@#The most common genotype in platelet donors were HPA-1a/1a-2a/2a-3a/3b-4a/4a-5a/5a-6a/6a-15a/15b, followed by HPA-1a/1a-2a/2a-3a/3a-4a/4a-5a/5a-6a/6a-15a/15b; the most common genotype in 53 cases of platelet antibody positive confirened by screening were HPA-1a/1a-2a/2a-3a/3b-4a/4a-5a/5a-6a/6a-15a/15b. Among 37 patients with platelet antibody positive confirened by screeming, 28 showed that the transfusion of HPA-matched platelets was effective with statistically significant difference in comparison with random transfusion group. The HPA-3, HPA-15 were the main factors leading to polymorphisms.@*CONCLUSION@#HPA-3 and HPA-15 are polymorphic, which should be focused on. HPA-matched platelets can improve the efficiency of platelet transfusion, and avoid the waste of blood resources. The genotypes of platelet donors can basically meet the requirements for common genotype transfusion.

3.
Article in Chinese | WPRIM | ID: wpr-870730

ABSTRACT

Objectives:To investigate the risk factors of sarcopenia in patients receiving maintenance peritoneal dialysis (MPD).Methods:One hundred and thirteen patients receiving maintenance MPD for ≥3 months during January and December 2017 were enrolled in this study. According to the Asian Working Group for Sarcopenia(AWGS)algorithm, there were 26 patients with sarcopenia accounting for 23.0% of all MPD patients. Demographic and anthropometric data were collected; laboratory tests were conducted, Kt/V urea and normalized protein equivalent of total nitrogen appearance were calculated; the bioelectrical impedance analysis (BIA) was performed and grip strength was tested. The nutritional status was evaluated with Subjective Global Assessment (SGA). Logistic regression was used to analyze the risk factors of sarcopenia in MPD patients. Results:BMI and dialysis dose of patients with sarcopenia were significantly lower than those without sarcopenia [(20.35±2.35) kg/m 2vs. (23.81±3.14) kg/m 2, t=-5.181, P<0.01; (5.57±1.83) L/d vs. (6.66±1.71) L/d, t=-2.795, P<0.01]. The bioelectrical impedance analysis showed that the total water content of patients with sarcopenia was higher than that of patients without sarcopenia [(35.44±6.40) kg vs. (28.52±4.89) kg, t=5.077, P<0.01]; while the protein content[(7.46±1.31) kg vs. (9.24±1.63) kg, t=-5.080, P<0.01] and skeletal muscle content [(20.54±4.18) kg vs. (25.88±4.95) kg, t=-4.980, P<0.01] of patients with sarcopenia were lower than those without sarcopenia. Multivariate analysis showed that decreased BMI( OR=0.934, 95 %CI: 0.723-0.998, P<0.01) and body protein ( OR=0.927, 95 %CI: 0.698-0.996, P<0.01), increased total body water( OR=1.382, 95 %CI: 1.053-1.813, P=0.02) were independent risk factors for sarcopenia in MPD patients. Conclusion:The incidence of sarcopenia in MPD patients is high, which is associated with the excessive volume load and malnutrition of patients.

4.
Article in Chinese | WPRIM | ID: wpr-870612

ABSTRACT

Volume management is recognized as an important determinant of dialysis adequacy. The optimal ultrafiltration and sodium removal will improve the volume management and reduce the cardiovascular mortality. Automated peritoneal dialysis (APD), as one of renal replacement therapies, has become a choice for more and more patients with end-stage renal disease. APD allows an individualized dialysis prescription by providing more dialysis doses and more exchange times to improve ultrafiltration and sodium removal, achieving or even exceeding the efficacy of continuous ambulatory peritoneal dialysis. New strategies for volume control have emerged, including adapted APD, using icodextrin and low-sodium dialysate, to provide new ideas for APD prescription adjustment.

5.
Article in Chinese | WPRIM | ID: wpr-798587

ABSTRACT

Volume management is recognized as an important determinant of dialysis adequacy. The optimal ultrafiltration and sodium removal will improve the volume management and reduce the cardiovascular mortality. Automated peritoneal dialysis (APD), as one of renal replacement therapies, has become a choice for more and more patients with end-stage renal disease. APD allows an individualized dialysis prescription by providing more dialysis doses and more exchange times to improve ultrafiltration and sodium removal, achieving or even exceeding the efficacy of continuous ambulatory peritoneal dialysis. New strategies for volume control have emerged, including adapted APD, using icodextrin and low-sodium dialysate, to provide new ideas for APD prescription adjustment.

6.
Organ Transplantation ; (6): 192-2019.
Article in Chinese | WPRIM | ID: wpr-780514

ABSTRACT

Objective To explore the treatment strategies of pleuroparenchymal fibroelastosis (PPFE). Methods A 22-year-old male patient was complicated with PPFE after receiving chemotherapy in combination with stem cell transplantation for lymphoma. He underwent thoracoscopic left lung tongue wedge resection, bilateral pleurodesis followed by allogeneic left lung transplantation. Literature review was performed to analyze the etiology, pathogenesis, imaging features, pathological features and treatment of PPFE. Results The PPFE patient required the non-invasive ventilator for 24 h before lung transplantation. After lung transplantation, the shortness of breath and respiratory failure were cured and the quality of life was significantly improved. No eligible studies was found in the domestic database, and 26 literatures published in English were found in the international databases. Among them, 9 literatures (case reports) were finally included after screening. PPFE could be divided into the primary and secondary categories according to the etiology. The clinical manifestations of PPFE mainly included dry cough, dyspnea on exertion, chest pain, repeated pneumothorax and body weight loss. Chest CT scan demonstrated irregular thickening of the pleura in bilateral upper lungs. Pathological manifestations consisted of evident thickening of the visceral pleura, fibroelastosis and arrangement disorder in the pleura and the underlying pulmonary interstitium. PPFE could progress rapidly. Adrenocortical hormone and other immunosuppressive agents yielded low clinical efficacy and poor clinical prognosis. Lung transplantation was a necessary treatment for PPFE. Conclusions PPFE cannot be effectively treated by conservative therapy. It is recommended to deliver lung transplantation as early as possible.

7.
China Pharmacy ; (12): 1623-1628, 2019.
Article in Chinese | WPRIM | ID: wpr-817110

ABSTRACT

OBJECTIVE: To study the effects of cimetidine on low dose rate irradiation-induced liver cell apoptosis in Beagle dogs. METHODS: Healthy male Beagle dogs were randomly divided into normal control group, model control group, positive drug group (lentinan, 21.33 mg/kg) and cimetidine low-dose, medium-dose and high-dose groups (5.33, 10.67, 21.33 mg/kg), with 4 Beagle dogs each. Except for normal control group, other groups were given 60Co-γ accumulative irradiation (dosage rate: 0.040 8 mGy/min) for 23 d; the medication groups were given relevant medicine orally before irradiation, once a day. Twenty-four hours after stopping irradiation, TUNEL method was used to detect the apoptosis of liver cells in Beagle dogs. The percentage of apoptotic cells was calculated. The expression level of apoptosis-related proteins (Bax, Bcl-2, Caspase-3, p53) in liver tissue was detected by immunohistochemistry. RESULTS: Compared with normal control group, apoptotic cells and Bax, Caspase-3, p53 positive cells were increased significantly in liver tissue of Beagle dogs in model control group; the percentage of apoptotic cells, protein expression levels of Bax, Caspase-3 and p53 were increased significantly; Bcl-2 positive cells were decreased significantly, and its protein expression level was decreased significantly (P<0.05 or P<0.01). Compared with model control group, above positive cells of liver tissue in Beagle dogs were changed to different extents in medication groups; the percentage of apoptotic cells and protein expression levels of p53 in medication groups, protein expression levels of Bax in positive drug group, cimetidine low-dose and high-dose groups as well as protein expression levels of Caspase-3 in cimetidine groups were decreased significantly; protein expression levels of Bcl-2 were increased significantly in cimetidine groups. The percentage of apoptotic cells in cimetidine medium-dose and high-dose groups as well as protein expression levels of Caspase-3 in cimetidine groups were all lower than positive control group. Protein expression level of p53 in cimetidine low-dose group was significantly higher than positive drug group (P<0.05 or P<0.01). CONCLUSIONS: Cimetidine can inhibit the low dose rate irradiation-induced apoptosis of liver cells in Beagle dogs, and certainly protect liver cells against irradiation. The mechanism of it may be associated with up-regulating the protein expression of Bcl-2 and down-regulating the protein expression of Bax, Caspase-3 and p53 in liver cells.

8.
Article in Chinese | WPRIM | ID: wpr-694080

ABSTRACT

Objective To develop a detergent for decontamination of Co2+ and Mn2+ on skin.Methods Single-factor experimental and orthogonal experimental designs were performed to study the formula composition of the decontaminant.The skin irritation experiment was performed and assessed according to the standard method.The detergent was prepared according the conventional process of showering gel.The pH,ethylenediaminetetraacetic acid (EDTA) level,total active substances of the detergent,and its stability were evaluated according to the chemical method recommended in the national standard GB/T 13173-2008.The decontamination efficiency on stable isotopes of Co2+ and Mn2+ contamination was measured on the back of hand skin of volunteers.Results The formula composition of the decontaminant was obtained through the orthogonal experiment.The pH value of the detergent was 6.99,total active substance was 20.49% and the content of EDTA was 5.99%.After being kept at-5 ℃ and 40℃℃ for 24h,the decontaminant showed no strange smell,no precipitation,no discoloration and still kept transparent.The decontamination effects on Co2+ and Mn2+ contaminated on hand skin were 103.13% ± 0.05% and 100.62% ± 0.09%,respectively,which was significantly higher than that of distilled water (81.77% ± 0.23% and 79.63% ± 0.23%,P<0.01,respectively).Conclusion The decontaminant has a high effect on decontamination of Co2+ and Mn2+ polluted on skin,and is hopeful to be developed as an effective detergent on radioactive isotopes contamination.

9.
Article in Chinese | WPRIM | ID: wpr-692342

ABSTRACT

Secondary ion mass spectrometry ( SIMS) as a powerful surface analysis technique has been widely applied in semiconductor industry and geology research. Recently, with the development of instrumental technology, SIMS is attracting more and more attention in life sciences. SIMS can provide surface MS spectra, 2D/3D chemical images and depth profiling of substances simultaneously. The minimal lateral resolution of 2D SIMS imaging is 80 to 100 nm, and the longitudinal resolution of 3D SIMS imaging is about 1-5 nm. However, due to lack of specific ions to render the structures of organelles, SIMS imaging for single cells still has great challenges. Optical microscopy, in particular laser scanning confocal microscopy ( LSCM) , has been emerged to be an indispensable technique for single cell imaging and can obtain high spatial 2D/3D imaging to visualize the structures of organelles. Thus, the combinational use of SIMS and LSCM, which takes advantages of SIMS for molecular imaging and LSCM for morphological imaging, has greatly extended the application of SIMS imaging and ensured its accuracy at single cells level, providing novel insights into better understanding of the biological events inside cells. In this review, we focus on the development and application of SIMS imaging and the correlated SIMS and LSCM imaging in the research of cell biology and drug discovery. We anticipate that the combinational use of SIMS and LSCM imaging has promising future in biomedicine and life sciences.

10.
Frontiers of Medicine ; (4): 726-734, 2018.
Article in English | WPRIM | ID: wpr-771271

ABSTRACT

Bromodomain-containing 4 (BRD4) has been considered as an important requirement for disease maintenance and an attractive therapeutic target for cancer therapy. This protein can be targeted by JQ1, a selective small-molecule inhibitor. However, few studies have investigated whether BRD4 influenced acute promyelocytic leukemia (APL), and whether BRD4 had interaction with promyelocytic leukemia-retinoic acid receptor α (PML/RARα) fusion protein to some extent. Results from cell viability assay, cell cycle analysis, and Annexin-V/PI analysis indicated that JQ1 inhibited the growth of NB4 cells, an APL-derived cell line, and induced NB4 cell cycle arrest at G1 and apoptosis. Then, we used co-immunoprecipitation (co-IP) assay and immunoblot to demonstrate the endogenous interaction of BRD4 and PML/RARα in NB4 cells. Moreover, downregulation of PML/RARα at the mRNA and protein levels was observed upon JQ1 treatment. Furthermore, results from the RT-qPCR, ChIP-qPCR, and re-ChIP-qPCR assays showed that BRD4 and PML/RARα co-existed on the same regulatory regions of their target genes. Hence, we showed a new discovery of the interaction of BRD4 and PML/RARα, as well as the decline of PML/RARα expression, under JQ1 treatment.


Subject(s)
Apoptosis , Azepines , Pharmacology , Cell Differentiation , Down-Regulation , Gene Expression Regulation, Neoplastic , Humans , Leukemia, Promyelocytic, Acute , Drug Therapy , Genetics , Nuclear Proteins , Genetics , Promyelocytic Leukemia Protein , Genetics , RNA, Messenger , Genetics , Retinoic Acid Receptor alpha , Genetics , Transcription Factors , Genetics , Triazoles , Pharmacology , Tumor Cells, Cultured
11.
Article in English | WPRIM | ID: wpr-772781

ABSTRACT

In aged patients, acute kidney injury (AKI) is a common clinical complication after percutaneous coronary intervention (PCI), highlighting the need for timely and certain diagnosis of this disease. A single centre, nested case-control study was conducted, which assessed the usefulness of urinary liver-type fatty acid-binding protein (uL-FABP), neutrophil gelatinase-associated lipocalin (uNGAL), and kidney injury molecule-1 (uKIM-1) for early detection of AKI. One hundred and thirty-two patients at or over 60 years old undergoing PCI were included. Serum creatinine (SCr) was measured before PCI, 24 and 48 h after PCI; uL-FABP, uNGAL, and uKIM-1 were measured before PCI, 6, 24, and 48 h after PCI. We identified 16 AKI patients and selected 32 control patients matched by admission time (<1 week), age (±5 years), and gender. In the receiver operating characteristic (ROC) curve analysis, the areas under the curve (AUCs) for the relative measurements of uL-FABP, uNGAL, and uKIM-1 were 0.809, 0.867, and 0.512 at 6 h after PCI, and 0.888, 0.840, and 0.676 at 24 h after PCI, respectively. AUC for the combination of uL-FABP and uNGAL was 0.899 at 6 h after PCI, and 0.917 at 24 h after PCI. Thus, measurement of uL-FABP and uNGAL levels at 6 and 24 h after PCI may be useful in detecting AKI in aged patients. Measurement of uKIM-1 levels provides inferior predictive power for early diagnosis of AKI.


Subject(s)
Acute Kidney Injury , Diagnosis , Urine , Aged , Aged, 80 and over , Early Diagnosis , Fatty Acid-Binding Proteins , Urine , Female , Hepatitis A Virus Cellular Receptor 1 , Humans , Lipocalin-2 , Urine , Male , Percutaneous Coronary Intervention
12.
Chinese Journal of Geriatrics ; (12): 594-597, 2018.
Article in Chinese | WPRIM | ID: wpr-709316

ABSTRACT

Sarcopenia is a degenerative syndrome mainly characterized by the atrophy of skeletal muscle,along with the decrease of muscle strength and function.Chronic kidney disease,especially in patients undergoing maintenance hemodialysis,can accelerate muscle consumption and increase the incidence rate of sarcopenia.Several factors were correlated with sarcopenia occurrence in chronic kidney disease,including inflammation,malnutrition,increased angiotensin Ⅱ,abnormal insulinsignaling pathway,abnormalities in myogenic regulatory factors,decreased hypogonadism,increased myostatins,mitochondrial disorders,decreased physical activity,etc.This paper has reviewed the research progress on the pathogenesis of sarcopenia in chronic kidney disease.

13.
Chinese Journal of Geriatrics ; (12): 474-478, 2018.
Article in Chinese | WPRIM | ID: wpr-709287

ABSTRACT

Chronic heart failure,especially the end-stage heart failure,is often accompanied by the loss of muscle mass,strength and functions of muscle.A large amount of trust evidences supported that sarcopenia was linked to poor prognosis of heart failure.This paper has reviewed the epidensiological features,medchanisms,prognosis,and treatment of heart failure-related sarcopenia.

15.
The Journal of Practical Medicine ; (24): 2496-2500, 2017.
Article in Chinese | WPRIM | ID: wpr-611904

ABSTRACT

Objective To investigate the difference in clinical features and chest HRCT findings between idiopathic nonspecific interstitial pneumonia(INSIP)and connective tissue disease-associated nonspecific interstitial pneumonia(CTD-NISP). Methods Totally 73 cases of NISP from 2011 to 2016 were retrospectively reviewed ,whose final diagnosis all were made after clinico-radiologic-pathologic discussion and 52 cases of them were diag-nosed as INSIP and 21 cases as CTD-NSIP. Clinical features ,lung function test results and chest HRCT findings of INSIP and CTD-NSIP were compared. Results Common underlying diseases of CTD-NSIP were poly-/dermato-myositis(PM/DM),rheumatoid arthritis(RA)and Sjogren syndrome(SS). The mean age of CTD-NSIP[(47.14 ± 9.24)y]was younger than that of INSIP[(59.09 ± 11.20)y](P<0.05). Compared to CTD-NSIP,expectoration was more common in patients with INSIP,while dry mouth/eyes,arthralgia and erythra were less common in INSIP (P < 0.05). Lung function test1 showed restrictive ventilatory dysfunction with dispersion function decline was found in both groups. There were no significant differences in lung function test results between INSIP and CTD-NSIP. In HRCT,the subpleural vertical line was more common in INSIP than that in CTD-NSIP,while patchy consolidation,subpleural curvilinear shadow,pleural effusion and esophageal dilation were less common in INSIP(P<0.05). Conclusions Specific difference of clinical and HRCT features between CTD-NSIP and INSIP are conducive to differentiating the two from each other.

16.
Article in Chinese | WPRIM | ID: wpr-509054

ABSTRACT

Acute kidney injury (AKI) is a frequent syndrome in hospitalized patients .Recently, a number of studies have been reported that the close relationship exists between genetic polymorphism and AKI .The current research on genetic polymorphism related with AKI is reviewed in this article .

17.
Article in Chinese | WPRIM | ID: wpr-351355

ABSTRACT

High-throughput sequencing was performed for the peripheral blood DNA from two probands in the family with tuberous sclerosis complex (TSC) to determine the sequences of TSC-related genes TSC1 and TSC2 and their splicing regions and identify mutation sites. Amplification primers were designed for the mutation sites and polymerase chain reaction and Sanger sequencing were used to verify the sequences of peripheral blood DNA from the probands and their parents. The two probands had c.3981-3982 insA (p.Asp1327AspfsX87) and c.4013-4014 delCA (p.Ser1338Cysfs) heterozygous mutations, respectively, in the TSC2 gene. The parents of proband 1 had no abnormalities at these two loci; the mother of proband 2 had c.4013-4014 delCA heterozygous mutation in the TSC2 gene, while the father and the grandparents of proband 2 had no abnormalities. c.3981-3982 insA mutation may cause early coding termination of amino acid sequence at the 1413th site, and c.4013-4014 delCA mutation may cause early coding termination of amino acid sequence at the 1412th site. These two mutations are the pathogenic mutations for families 1 and 2, respectively, and both of them are novel frameshift mutations, but their association with the disease needs to be further verified by mutant protein function cell model and animal model.


Subject(s)
Child , Child, Preschool , Female , Frameshift Mutation , Humans , Tuberous Sclerosis , Genetics , Tumor Suppressor Proteins , Genetics
18.
Military Medical Sciences ; (12): 723-726, 2017.
Article in Chinese | WPRIM | ID: wpr-665689

ABSTRACT

Objective To establish a new dialysis washing method for human frozen platelets and to evaluate a new type of washing machine based on dialysis.Methods Twenty bags of platelets(1U)were divided into two groups:centrifugation group and dialysis group.The effect of the washing machine was evaluated by measuring platelet function in vitro.Results After the platelets were treated by the two methods, the recovery rate of dialysis group[(73.57 ± 12.49)%]was significantly better than that of centrifugal group[(62.21 ±7.07)%].The osmotic pressure of dialysis group was 305.8 ±5.27mOsm/kg, compared to 383.2 ±22.00 mOsm/kg in centrifugation group.There was significant differences in the recovery rate and osmotic pressure(P<0.05), but there was no significant difference between dialysis group and centrifugation group in the mean platelet volume[(9.44 ±0.93)vs(9.23 ±0.50)fl], ADP-induced aggregation rate[(20.7 ±8.00)%vs(27.7 ±11.83)%],thrombin-induced platelet aggregation rate[(84.1 ±7.88)%vs(92.9 ±5.28)%], hypotonic shock responses[(19.02 ±4.42)% vs(23.19 ±9.08)%], CD62p activation rate [(16.00 ±9.40)%vs(21.86 ±8.14)%]or apoptosis rate[(46.31 ±10.28)% vs(54.59 ±16.76)%](P>0.05). Conclusion Compared to centrifugation group,the frozen platelet washing machine can not only improve platelet recovery,but also solve the problem of excessive DMSO residues.

19.
China Pharmacy ; (12): 4510-4513, 2017.
Article in Chinese | WPRIM | ID: wpr-704448

ABSTRACT

OBJECTIVE:To investigate the characteristics and the regularity of ADR induced by Low-molecular dextran and amino acid injection,and to provide reference for safe use of drugs in clinic.METHODS:Among 35 cases of ADR induced by Low-molecular dextran and amino acid injection were collected from our hospital during Jan.2010-Jan.2017.Those ADR cases were analyzed statistically in respects of patients'gender and age,type and occurrence time of ADR cases,primary disease,aller gic history,organs/systems involved in ADR,clinical manifestations,outcomes,etc.RESULTS:Among 35 cases of ADR induced by Low-molecular dextran and amino acid injection,there were 18 male (51.43%) and 17 female (48.57%).The youngest patient was 11 years old,the oldest patient was 80 years old,the average age was 48.2 years.There were 4 cases of severe ADR (11.43 %) and 31 cases of common ADR (88.57 %).ADR mostly occurred 10 min-1 h after medication (71.43 %).Bone fractures (14 cases,40.00%) and knee inflammation (8 cases,22.86%) were main original disease involved in ADR.Main organs or systems involved in ADR were digestive system(34.29%),circulatory system(22.86%),skin and its appendants (20.00%),etc.All cases were recovered or cured after drug withdrawal and systematic treatment.CONCLUSIONS:Low-molecular dextran and amino acid injection induce low incidence of ADR but can induce severe ADR.The nursing staff should strengthen ADR monitoring to reduce the occurrence of complications and avoid medical statf-patient dispute.

20.
Chinese Mental Health Journal ; (12): 964-970, 2017.
Article in Chinese | WPRIM | ID: wpr-703957

ABSTRACT

Objective:To investigate the dyadic coping and intimacy in gynecological cancer patients and their partners,and to explore the association between the two aspects.Methods:A total of 180 postoperative couples with gynecological cancer from 4 tertiary hospitals were investigated with Dyadic Coping Inventory (DCI) and Short Marital Adjustment (MAT).The relationship between couples,dyadic coping and intimacy were analyzed with the Actor-Partner Interdependence Model (APIM).Results:APIM result showed that in the actor effect patients' and spouses'supportive dyadic coping,delegated dyadic coping and common dyadic coping were positive associated with their own intimacy (B =1.77-4.41),patients'and spouses'negative dyadic coping were both adversely associated with their own intimacy (B =-2.81,-2.66).The partner effect showed that patients' supportive dyadic coping and delegated dyadic coping were both positive associated with spouses'intimacy (B =1.00,4.07),spouses'delegated dyadic coping and common dyadic coping were both positive associated with patients' intimacy (B =2.67,2.60),patients' and spouses'negative dyadic coping were negatively associated with partner'intimacy (B =-1.67,-1.40).Conclusion:It suggests that the dyadic coping may be associated with both patients'and partners' intimacy.

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