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1.
Nutrition Research and Practice ; : 553-564, 2023.
Article in English | WPRIM | ID: wpr-977305

ABSTRACT

BACKGROUND/OBJECTIVES@#A meal companion is an important social determinant of eating behaviors and is related to what and how much a person will eat within the social context.This study examined the difference in diet quality according to the type of dining companion. @*SUBJECTS/METHODS@#This study included 15,074 adults (6,180 men and 8,894 women, ≥ 19 years) who participated in the 6th (2013–2015) Korea National Health and Nutrition Examination Survey. Korean Healthy Eating Index (KHEI) scores were calculated using the food frequency questionnaire data. Survey multivariate linear regression analysis was used to assess the association of dining companions (ordinary type, eating with family members, eating alone, and eating with others) and the total and component scores of KHEI. @*RESULTS@#People who exclusively ate with someone other than family or exclusively ate alone had lower total KHEI scores in both men (57.23 ± 0.67, 58.56 ± 0.73 vs. 62.71 ± 0.26) and women (57.6 3±0.97, 63.89±0.58 vs. 65.79±0.22) compared to people with the ordinary type (all P < 0.05). Both men and women who ate exclusively with someone other than family had lower KHEI component scores for breakfast, whole grains, and fruit, excluding juice, compared to the ordinary type and family eating group. Compared to the eating alone group, the component scores for breakfast and whole grains were lower in the eating with others group. @*CONCLUSION@#The diet quality differed according to the meal companion type. People who always ate with someone other than family members and men who ate alone showed lower diet quality scores than the ordinary type. More research will be needed to improve their adherence to dietary recommendations.

2.
Nutrition Research and Practice ; : 516-527, 2021.
Article in English | WPRIM | ID: wpr-902868

ABSTRACT

BACKGROUND/OBJECTIVES@#This study examined the association of depressive symptoms, stress perception, and suicidal ideation with overall dietary quality using the newly developed Korean healthy eating index (KHEI). @*SUBJECTS/METHODS@#This study included 9,607 adults (3,939 men and 5,668 women, ≥ 19 years) who participated in the 6th Korea National Health and Nutrition Examination Survey 2013 and 2015. The KHEI scores were calculated using the food frequency questionnaire data. Survey logistic regression analyses were performed to analyze the association between psychiatric distress and dietary quality. @*RESULTS@#The percentage of subjects with experience of depressive mood, higher stress perception, and suicidal ideation was 8.2%, 25.0%, and 3.7% in men and 15.4%, 27.3%, and 6.0% in women, respectively. The mean KHEI score was 61.5 ± 0.29 in men and 64.8 ± 0.24 in women (P 0.05 for all). @*CONCLUSIONS@#Poor adherence to dietary recommendations is associated with psychological distress, especially in women.

3.
Nutrition Research and Practice ; : 516-527, 2021.
Article in English | WPRIM | ID: wpr-895164

ABSTRACT

BACKGROUND/OBJECTIVES@#This study examined the association of depressive symptoms, stress perception, and suicidal ideation with overall dietary quality using the newly developed Korean healthy eating index (KHEI). @*SUBJECTS/METHODS@#This study included 9,607 adults (3,939 men and 5,668 women, ≥ 19 years) who participated in the 6th Korea National Health and Nutrition Examination Survey 2013 and 2015. The KHEI scores were calculated using the food frequency questionnaire data. Survey logistic regression analyses were performed to analyze the association between psychiatric distress and dietary quality. @*RESULTS@#The percentage of subjects with experience of depressive mood, higher stress perception, and suicidal ideation was 8.2%, 25.0%, and 3.7% in men and 15.4%, 27.3%, and 6.0% in women, respectively. The mean KHEI score was 61.5 ± 0.29 in men and 64.8 ± 0.24 in women (P 0.05 for all). @*CONCLUSIONS@#Poor adherence to dietary recommendations is associated with psychological distress, especially in women.

4.
The Korean Journal of Helicobacter and Upper Gastrointestinal Research ; : 62-65, 2017.
Article in Korean | WPRIM | ID: wpr-66974

ABSTRACT

In Korea, the prevalence of obesity as defined by body mass index(BMI) ≥25 kg/m² has been steady in the recent years; however, the prevalence of severe (BMI ≥30 kg/m²) and extreme obesity (BMI ≥35 kg/m²) has rapidly increased during the past decade. The change in the prevalence of abdominal obesity showed a similar trend to the prevalence of obesity. Based on the Korean data, the list of obesity-related diseases in Korea resembles those for the Western countries. The association between BMI and all-cause mortality in Koreans displayed a ‘U’ or inverted ‘J’ curve pattern. However, these curves have changed, and the BMI nadir of these curves exhibits a change to a higher BMI point during the past decades. Recent change in the obesity epidemic in Korea seems to resemble the previous changes in the obesity epidemics seen in the Western populations.


Subject(s)
Comorbidity , Korea , Mortality , Obesity , Obesity, Abdominal , Prevalence
5.
Journal of Korean Medical Science ; : 434-438, 2017.
Article in English | WPRIM | ID: wpr-179968

ABSTRACT

We investigated trends of obesity prevalence among adult Koreans. Data from 110,280,952 participants who underwent medical examination provided by the National Health Insurance System from 2002–2013 were analyzed. The prevalence of moderate obesity (body mass index [BMI] 25.0–29.9 kg/m2) was slightly increased from 2002 (30.7%) through 2010 (33.1%) and reached a plateau since 2010 among men but continuously decreased from 22.5% in 2002 to 20.9% in 2013 among women. However, severe obesity (BMI ≥ 30.0 kg/m2) was rapidly increased and the prevalence in 2013 (4.2%) was almost doubled the prevalence in 2002 (2.5%). We observed a steep rise of severe obesity as well as potentially right shifting of the obese category.


Subject(s)
Adult , Female , Humans , Male , Body Mass Index , Korea , National Health Programs , Obesity , Obesity, Morbid , Prevalence
6.
Journal of the Korean Academy of Child and Adolescent Psychiatry ; : 313-318, 2016.
Article in Korean | WPRIM | ID: wpr-213693

ABSTRACT

OBJECTIVES: The purpose of this study was to investigate the clinical utility of the Korean Wechsler Intelligence Scale for Children-Fourth Edition (K-WISC-IV) and General Ability Index (GAI) in children with attention-deficit hyperactivity disorder (ADHD). METHODS: The GAI and Full Scale IQ (FSIQ) in K-WISC-IV were compared for a group of 79 children with ADHD and 234 normal children. The mean differences within each group were testified by the t-test and Cohen's d. The Wechsler's descriptive classifications for each GAI and FSIQ score were analyzed in the children with ADHD. Additionally, the critical value for the difference between the means of the FSIQ and GAI was calculated in the normal children. RESULTS: The score on the GAI was higher than that on the FSIQ in the children with ADHD, with a mean difference of 2.19 points. The implications of these findings are discussed regarding the cognitive characteristics of the children with ADHD. According to Wechsler's descriptive classification, the application of the GAI showed a lower (7.59%), equal (61.65%) or higher (60.76%) prevalence of ADHD compared to the application of FSIQ. CONCLUSION: The implications of these findings are discussed regarding the cognitive characteristics of the children with ADHD. The GAI reflecting the attention and behavioral problems in children with ADHD could be utilized as an alternative global intelligence estimate that considers their potential for development.


Subject(s)
Child , Humans , Classification , Intelligence , Prevalence , Problem Behavior
8.
Journal of the Korean Academy of Child and Adolescent Psychiatry ; : 226-235, 2015.
Article in Korean | WPRIM | ID: wpr-119750

ABSTRACT

OBJECTIVES: The purpose of this study was to examine the factor structure of the Adolescent Personality Assessment Inventory (PAI-A) in a standardized adolescent sample using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). METHODS: For this purpose, three models about factor structure of the PAI-A were explored with EFA in 490 adolescents and then were evaluated with CFA in 268 young offenders. RESULTS: The results showed that the five factor model was considered to be most appropriate for factor structures of the PAI-A in EFA. However, none of the factor models were appropriate for the factor structures of the PAI-A in CFA. CONCLUSION: These findings suggest that the "five factor model" is thought to explain the PAI-A the best, but further studies are needed.


Subject(s)
Adolescent , Humans , Criminals , Factor Analysis, Statistical , Neuropsychological Tests , Personality Assessment , Psychometrics
9.
Endocrinology and Metabolism ; : 418-426, 2014.
Article in English | WPRIM | ID: wpr-126657

ABSTRACT

Abdominal obesity is associated closely with insulin resistance, diabetes, and cardiovascular disease. Waist circumference (WC) is a useful surrogate marker commonly used for abdominal adiposity. The determination of WC cutoff levels is important in the prevention and treatment of obesity, type 2 diabetes, and related cardiovascular diseases. Recent epidemiological evidence suggested that appropriate optimal cutoffs for Koreans ranged over 80 to 89.8 cm in males and 76.1 to 86.5 cm in females. We analyzed the data from two large cohorts using receiver operating characteristic curve analysis with the incidences of diabetes, hypertension, dyslipidemia, cerebrovascular disease, myocardial infarct, angina, coronary artery disease, and multiple metabolic risk factors as outcome variables. Optimal WC cutoff points for Koreans were 85 cm in males and 80 cm in females. However, considering the prevalence of abdominal obesity and the health costs for its prevention and management, 90 cm in males and 85 cm in females are probably more appropriate thresholds for abdominal obesity. These values may be modified once better research is performed through prospective studies using representative populations, common health outcomes, and proper analytical approaches.


Subject(s)
Adult , Female , Humans , Male , Adiposity , Cardiomyopathies , Cardiovascular Diseases , Cohort Studies , Coronary Artery Disease , Diagnosis , Dyslipidemias , Health Care Costs , Hypertension , Incidence , Insulin Resistance , Obesity , Obesity, Abdominal , Prevalence , Risk Factors , ROC Curve , Sensitivity and Specificity , Waist Circumference , Biomarkers
10.
Journal of Nutrition and Health ; : 145-156, 2014.
Article in Korean | WPRIM | ID: wpr-87494

ABSTRACT

PURPOSE: The purpose of this study was to establish accreditation systems of reliable educational materials for nutrition and dietary life which could be used in schools, workplace, and health promotion. METHODS: The study was conducted from April 2011 to October 2011. Literature reviews, institutional visits, and telephone interviews were conducted. Expert meetings and advisory councils were held in order to receive feedback on development of the accreditation systems. A survey was conducted for the accreditation procedures on 143 professionals, including professors, researchers, health and medical experts, teachers, nutrition teachers, dietitians, and clinical nutritionists. RESULTS: The final procedure of the developed accreditation system was finalized as follows: 1) receiving application twice per year 2) complete desk review (written evaluation) by three reviewers within two months, 3) board review (all board members) and decision, and 4) no-tification of results. The accreditation system is set for printed materials, web-site, and materials for activities. The certificate and accreditation mark is issued to the final certified educational materials. Expiration date is established only for the web-site form. The accreditation length lasts for two years, and can be extended by renewal application. CONCLUSION: The dietary and nutrition related materials, which are certificated by this accreditation system, could impart reliable information and knowledge to both learners and educators, and help them in effective selection of educational materials. Therefore, this accreditation system might be expected to increase satisfaction for teaching and learning about nutrition and healthy dietary life.


Subject(s)
Humans , Accreditation , Education , Health Promotion , Interviews as Topic , Learning , Nutritionists
11.
Nutrition Research and Practice ; : 213-219, 2014.
Article in English | WPRIM | ID: wpr-183199

ABSTRACT

BACKGROUND/OBJECTIVES: There is little information on the association between weight misperception and eating behavior in Korean adolescents. Therefore, we investigated the association of food intake habits and dieting method and disturbed eating behavior (DEB) in relation to weight misperception. SUBJECTS/METHODS: Data was collected by using a nationwide online panel survey from 6,943 adolescents enrolled in middle/high school. DEB was measured with the Eating Attitudes Test (EAT-26) and those who scored > or = 20 on the EAT-26 were considered to have eating disorder. Logistic regressions were conducted to examine the association between weight misperception based on self-reported weight status and dieting method and eating behaviors. RESULTS: The proportion of weight underestimation was 23.5% and that of overestimation was 24.0%. Weight overestimating girls were more likely to engage in various unhealthy dieting practices (OR = 1.69 for fasting; OR = 1.88 for laxative or diuretic use; OR = 2.05 for self-induced vomiting after meals; P < 0.05). Moreover, there was a strong association between overestimation and undesirable eating behaviors, especially among girls, e.g.: having breakfast (OR = 0.85), high consumption of fast foods (OR = 1.28) and regular sodas (OR = 1.39), but not among boys. In both genders, weight overestimation appears to be a major risk factor for DEB (OR = 1.34 for boys and OR = 1.41 for girls; P < 0.05). CONSLUSIONS: Weight overestimation is associated with unhealthy weight control practices and eating behaviors. We particularly found a significant association between weight overestimation and DEB among nationwide Korean adolescents.


Subject(s)
Adolescent , Female , Humans , Breakfast , Diet , Feeding and Eating Disorders , Eating , Fast Foods , Fasting , Feeding Behavior , Logistic Models , Meals , Risk Factors , Vomiting , Weight Perception
12.
Journal of Korean Medical Science ; : 555-563, 2013.
Article in English | WPRIM | ID: wpr-71533

ABSTRACT

The present study evaluated the response of blood pressure (BP) by dietary sodium in sodium resistant (SR) subjects. One hundred one subjects (mean age, 46.0 yr; 31 hypertensives) were admitted and given low sodium-dietary approaches to stop hypertension (DASH) diet (LSD, 100 mM NaCl/day) for 7 days and high sodium-DASH diet (HSD, 300 mM NaCl/day) for the following 7 days. On the last day of each diet, 24 hr ambulatory BP was measured. Morning systolic BP (SBP) and diastolic BP (DBP) were elevated after HSD in all subjects (P 0.05). In hypertensive subjects, morning DBP elevation was greater than daytime DBP elevation (P = 0.036), although both DBPs were significantly elevated after HSD. The augmented elevation of morning DBP in hypertensive subjects was contributed by the absolute elevation of morning DBP (P = 0.032) and relative elevation to daytime DBP (P = 0.005) in sodium resistant (SR) subjects, but not by sodium sensitive subjects. Although there was no absolute elevation, SR subjects with normotension showed a relative elevation of morning SBP compared to daytime SBP change after HSD (P = 0.009). The present study demonstrates an absolute and relative elevation of morning BP in SR subjects by HSD.


Subject(s)
Adult , Humans , Middle Aged , Blood Pressure/drug effects , Diet, Sodium-Restricted , Hypertension/physiopathology , Sodium, Dietary/pharmacology , Time Factors
13.
Journal of Korean Medical Science ; : 1482-1488, 2013.
Article in English | WPRIM | ID: wpr-212601

ABSTRACT

The objective of this study was to examine the relationship between dairy product intake and the incidence of metabolic syndrome (MetS) and its components among middle-aged Koreans. We examined 7,240 adults aged 40-69 yr without MetS at baseline over a 45.5-month follow-up period. They were taken from the Anseong and Ansan cohort of the Korean Genome and Epidemiology Study. Dairy product intake including milk, yogurt, and cheese was assessed with food frequency questionnaire. At the follow-up, the incidence of MetS was 17.1%. The incidences of MetS components were as follows: low HDL cholesterol (16.2%), abdominal obesity (14.0%), hypertriglyceridemia (13.8%), hyperglycemia (13.3%), and hypertension (13.1%). Adjusting for potential confounders, dairy product consumption frequency was inversely associated with the risk of MetS and abdominal obesity. Hazard ratio (HR) (95% confidence interval) for dairy product consumption more than 7 times/week compared to never was 0.75 (0.64-0.88, P for trend < 0.001) for MetS and 0.73 (0.61-0.88, P for trend < 0.001) for abdominal obesity. HR for milk intake was 0.79 for MetS and 0.82 for abdominal obesity. The results of this study suggest that daily intake of dairy products protects against the development of MetS, particularly abdominal obesity, in middle-aged Koreans.


Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Cholesterol, HDL/blood , Cohort Studies , Dairy Products , Diet , Follow-Up Studies , Hypertension/epidemiology , Hypertriglyceridemia/epidemiology , Incidence , Metabolic Syndrome/epidemiology , Obesity, Abdominal/epidemiology , Proportional Hazards Models , Surveys and Questionnaires , Republic of Korea/epidemiology , Risk Factors
14.
Journal of Nutrition and Health ; : 470-481, 2013.
Article in Korean | WPRIM | ID: wpr-102271

ABSTRACT

This study provides standardized scientific criteria for education materials on nutrition and diet that could be used in schools, workplaces, and health and medical facilities. The study was conducted from April 2011 to October 2011. Literature reviews, institutional visits, and telephone interviews were conducted for the first draft of the accreditation criteria. Expert meeting and advisory councils were conducted in order to obtain feedback after development of the first draft of accreditation criteria. In order to verify the validity and reliability of the first draft on certification criteria, a survey was sent out to 143 professionals, including professors, researchers, health and medical experts, teachers, nutrition teachers, dietitians, and clinical nutritionists. After several modifications, the final accreditation criteria were established for 1) printed materials (authority, credibility, objectivity, organization, editing, real-life usability, activities and participation, and public interest), 2) web-sites (authority, credibility, objectivity, design, real-life usability, accessibility, currency, and public interest) and 3) materials with activities (credibility, organization, design, convenience of utilizing, safety, and public interest). Out of several criteria, contents (authority, credibility. and objectivity) and publicity (public interest) areas are mandatory requirements. For the accreditation, books for learning and materials with activities are required to meet more than six evaluation components, and the other materials are required to meet more than five evaluation components, including the required area. Accreditation criteria developed in this study could be used as a standard for development or selection of good education materials for nutrition and dietary life.


Subject(s)
Humans , Accreditation , Certification , Diet , Interviews as Topic , Learning , Reproducibility of Results
15.
The Korean Journal of Internal Medicine ; : 417-425, 2012.
Article in English | WPRIM | ID: wpr-168864

ABSTRACT

BACKGROUND/AIMS: Falls among older people are a major public health problem and may result in fracture, medical complications that require hospitalization, and fear of additional falls. Given the prevalence and impact of the fear of falling again, reducing the incidence of falls is important to prevent additional falls. This study analyzed whether exercise programs decrease the fear of future falls in elderly patients who have fallen previously. METHODS: A randomized controlled study was performed that included 65 elderly community-dwelling subjects who had fallen in the previous year. Subjects were randomized into two groups: an exercise group (EG, n = 36) and a control group (CG, n = 29). The EG participated in three exercise sessions per week for 12 weeks. Muscle strength, balance, agility, flexibility, and muscular endurance were measured at baseline and after 12 weeks. RESULTS: After the 12-week exercise program, the subjects in the EG demonstrated remarkable improvement in their walking speed, balance (p = 0.003), back strength (p = 0.08), lower extremity strength (p = 0.004), and flexibility (p < 0.001). When asked whether they were afraid of falling, more participants in the EG than in the CG responded "not at all" or "a little." CONCLUSIONS: The 12-week exercise program described here reduced the fear of falling (p = 0.02). It also improved the balance, flexibility, and muscle strength of the participants and was associated with improved quality of life.


Subject(s)
Aged , Female , Humans , Male , Middle Aged , Accidental Falls/prevention & control , Exercise Therapy/methods , Fear , Muscle Strength , Postural Balance , Republic of Korea
16.
Korean Journal of Community Nutrition ; : 555-578, 2012.
Article in Korean | WPRIM | ID: wpr-155765

ABSTRACT

This study was conducted to investigate which food items are perceived as HANSIK (Korean food) in Korea. 562 males and females aged 20-70 were surveyed on 512 most frequently consumed dish items from 4th Korean National Health and Nutrition Survey if they perceive it as HANSIK. Dish items in kimchi, namul - sukchae (cooked and seasoned vegetable) and jeotgal (salt-fermented food) category showed high response rate to be perceived as HANSIK. The response rate of twigim (frying foods) as HANSIK was low showing less than 70%. The response rate as HANSIK for foreign origin foods such as ramen and jjajangmyeon (black bean paste noodle) were lower than 25%. In jang . yangnyum (seasoning) category, doenjang (soybean paste) and gochujang (red pepper paste) showed high response rate as HANSIK more than 90%. Females showed a higher response rate as HANSIK than males for most food items except several items of myen . mandu (noodle and dumpling). The younger age group had higher HANSIK perception on many items of recently consumed foods, especially budae-jjigae (spicy sausage stew) (p < 0.001) and jwipo-jorim (braised dried filefish) (p < 0.001), implying that they already accept the common foods as HANSIK regardless of the origin. These results provide an information on the foods perceived as HANSIK among currently consumed common foods in Korea and these results can be utilized for establishment of HANSIK concept reflecting transition of dietary life in Korea.


Subject(s)
Adult , Aged , Female , Humans , Male , Korea , Nutrition Surveys , Seasons
17.
Korean Journal of Hospice and Palliative Care ; : 155-161, 2012.
Article in Korean | WPRIM | ID: wpr-92249

ABSTRACT

PURPOSE: In this study, we evaluated the effects of training for survival prediction of terminally ill patients in terms of medical professionals' confidence, accuracy and knowledge of survival prediction. METHODS: Twenty-nine participants completed a self-administered questionnaire where they scored their confidence, accuracy and knowledge of survival prediction before and after the training session. The training was provided in July 2009 at a university hospital located in Gyeonggi province, Republic of Korea. The participants were instructed by a professor of family medicine specialized in hospice palliative medicine to predict survival of a case using the palliative prognostic score and objective prognostic score. The training was provided in the form of a PowerPoint presentation for 40 minutes. RESULTS: Participants' confidence in survival prediction significantly increased from 4.00+/-1.73 (mean+/-SD) (0~10, visual analogue scale) to 5.83+/-1.71 after the training (P<0.001). Before training, participant's level of confidence significantly correlated with their age (P=0.04). The training significantly improved the correlation between the confidence level and the number of terminal cancer patients whom they have experienced (P=0.005 before training, P=0.017 after training). Participant's accuracy in survival prediction also significantly improved from 14 of 29 (48%) to 27 of 29 (93.1%) (P<0.001). The change in knowledge of survival prediction was too small to be statistically analyzed. CONCLUSION: After training, the confidence and accuracy scores significantly improved. Further study with a greater number of participants is needed to generalize this finding.


Subject(s)
Humans , Hospices , Palliative Care , Prognosis , Republic of Korea , Terminally Ill , Surveys and Questionnaires
18.
Diabetes & Metabolism Journal ; : 561-566, 2011.
Article in English | WPRIM | ID: wpr-191395

ABSTRACT

In Korea, a person with a body mass index (BMI) > or =25 kg/m2 is considered obese, and a person with a BMI > or =30 kg/m2 is classified as severely obese. Central obesity is defined as a waist circumference > or =90 cm for Korean men and > or =85 cm for Korean women. Recent epidemiologic data show that the prevalence of severe obesity and metabolic syndrome is steadily increasing. These epidemics increased morbidity and mortality of type 2 diabetes, cardiovascular diseases, and obesity-related cancers such as breast, colorectal, and other cancers in Korea. Decreased physical activity, increased fat and alcohol consumption, heavy smoking, and stress/depressed mood are the primary modifiable life-style risk factors for Koreans. Recently, public health interventions to encourage life-style changes have shown promising results in reducing the prevalence of severe obesity and metabolic syndrome.


Subject(s)
Female , Humans , Male , Alcohol Drinking , Body Mass Index , Breast , Cardiovascular Diseases , Korea , Life Style , Motor Activity , Obesity , Obesity, Abdominal , Prevalence , Public Health , Risk Factors , Smoke , Smoking , Waist Circumference
19.
Journal of Korean Medical Science ; : 1061-1067, 2011.
Article in English | WPRIM | ID: wpr-100575

ABSTRACT

Sodium sensitivity (SS) is a variable response of blood pressure (BP) to changes in sodium intake. The present study evaluated the existence and the characteristics of subjects with SS in Koreans. One hundred one subjects with (n = 31, 57.7 +/- 9.8 yr) or without hypertension (n = 70, 40.8 +/- 16.5 yr) were given a low-sodium dietary approache to stop hypertension (DASH) diet (LSD) for 7 days and a high-sodium DASH diet (HSD) for the following 7 days. The prevalence of SS in the present study population was 27.7% (17.6% in the non-hypertensive subjects and 51.6% in the hypertensive subjects). Analysis of the non-hypertensive subjects showed that systolic BP, diastolic BP, and mean arterial pressure at baseline and after HSD were higher in the subjects with SS than the subjects without SS, and there were no differences after LSD. In the hypertensive subjects, there was no difference in the BP at baseline and after HSD whether or not the subjects had SS. However, the systolic BP of hypertensive subjects with SS was lower than hypertensive subjects without SS after LSD. In the present study population, subjects with SS have distinctive BP features unlike to subjects without SS.


Subject(s)
Adult , Aged , Humans , Middle Aged , Young Adult , Blood Chemical Analysis , Blood Pressure/drug effects , Diet, Sodium-Restricted/methods , Hypertension/diet therapy , Republic of Korea , Sodium, Dietary/adverse effects , Urinalysis
20.
Journal of Korean Medical Science ; : 265-271, 2010.
Article in English | WPRIM | ID: wpr-109859

ABSTRACT

It has been suggested that Helicobacter pylori eradication may influence production of some peptides in the stomach, which can affect appetite. This hypothesis is controversial. To verify the hypothesis, we conducted this randomized controlled trial using H. pylori infected subjects without any gastrointestinal symptoms. The treatment group received triple H. pylori eradication therapy for 7 days and the control group received no medication. We measured ghrelin, obestatin and the tumor necrosis factor-alpha (TNF-alpha) mRNA levels in endoscopic biopsy specimens and the changes from baseline to follow-up. The plasma active n-octanoyl ghrelin and obestatin levels were measured in both groups. The ghrelin/obestatin ratios in plasma and gastric mRNA expression were calculated at baseline and follow-up. Ghrelin mRNA expression in the fundic mucosa after H. pylori eradication increased significantly compared to the control group (4.47+/-2.14 vs. 1.79+/-0.96, P=0.009), independent of inflammatory changes. However, obestatin mRNA expression decreased in the antral mucosa (-0.57+/-1.06 vs. 0.41+/-0.72, P=0.028). The treatment group showed a marginal increase (P=0.060) in plasma ghrelin/obestatin ratio. The TNF-alpha mRNA expression also decreased significantly with treatment. This randomized controlled trial demonstrates that H. pylori eradication increases ghrelin mRNA expression, independent of inflammatory cell changes.


Subject(s)
Adult , Aged , Female , Humans , Male , Anti-Bacterial Agents/therapeutic use , Gastric Mucosa/metabolism , Gastroscopy , Ghrelin/blood , Helicobacter Infections/drug therapy , Helicobacter pylori , RNA, Messenger/metabolism , Tumor Necrosis Factor-alpha/genetics
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