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1.
J. Health Biol. Sci. (Online) ; 8(1): 1-8, 01/01/2020. ilus
Article in Portuguese | LILACS | ID: biblio-1103268

ABSTRACT

Objetivo: apresentar os aspectos epidemiológicos, clínicos e terapêuticos da COVID-19. Método: trata-se de uma revisão narrativa da literatura, realizada por meio da busca por publicações científicas indexadas nas bases de dados: PubMed, Europe PMC, ScienceDirect e SciELO. Os seguintes descritores foram utilizados: "COVID-19", "diagnosis", "drug therapy", "pandemics" e "SARS-CoV-2". Ao final, foram selecionadas 32 publicações. Resultados: a análise dos estudos evidenciou que a rápida disseminação da COVID-19 pode estar relacionada à forma de transmissão, bem como à capacidade de o vírus permanecer estável em aerossóis e superfícies contaminadas. O diagnóstico de COVID-19 tem sido realizado mediante observação dos sintomas, e por um método de biologia molecular. Ainda não há medicamentos específicos e uma vacina contra a doença. No entanto, alguns medicamentos existentes no mercado, indicados para tratar outras patologias, estão sendo considerados como promissoras terapêuticas para a doença. Conclusão: a pandemia de COVID-19 já se configura como o maior desafio para saúde pública do século XXI, com elevadas taxas de morbidade e mortalidade em todo o mundo, principalmente devido à alta infectividade, e à severidade das manifestações clínicas em populações de risco, sendo mais letal. A falta de evidências científicas conclusivas quanto à eficácia e à segurança dos medicamentos off label no tratamento da doença tem gerado incertezas nos procedimentos de decisão clínica, sendo primordial a realização de ensaios clínicos randomizados, envolvendo um maior número de pacientes.


Objective: to present the epidemiological, clinical and therapeutic aspects of COVID-19. Method: this is a narrative review of the literature, performed through the search of scientific publications indexed in the databases: PubMed, Europe PMC, ScienceDirect and SciELO. The following descriptors were used: "COVID-19", "diagnosis", "drug therapy", "pandemics" and "SARS-CoV-2". At the end, 32 publications were selected. Results: the analysis of the studies showed that the rapid spread of COVID-19 may be related to the form of transmission, as well as to the ability of the virus to remain stable in aerosols and contaminated surfaces. The diagnosis of COVID-19 has been made through observation of symptoms, and by a molecular biology method. There are still no specific drugs and a vaccine against the disease. However, some drugs on the market, indicated to treat other pathologies, are being considered as promising therapeutics for the disease. Conclusion: the COVID-19 pandemic is already configured as the greatest public health challenge of the 21st century, with high morbidity and mortality rates worldwide, mainly due to high infectivity, and severity of clinical manifestations in populations at risk, being more lethal. The lack of conclusive scientific evidence regarding the efficacy and safety of off-label medications in the treatment of the disease, has generated uncertainties in clinical decision-making procedures, and it is essential to carry out randomized clinical trials, involving a greater number of patients.


Subject(s)
Coronavirus Infections , Betacoronavirus , Drug Therapy , Pandemics
2.
Motriz (Online) ; 26(3): e10200018, 2020. tab, graf
Article in English | LILACS | ID: biblio-1135330

ABSTRACT

Abstract Aim: To investigate the hypothesis that the resistance exercise (RE) may be safer if the blood pressure (BP) is properly controlled through antihypertensive pharmacological treatment in hypertensive middle-aged women. Methods: The final sample was comprised of 19 hypertensive women, with an average age of 58±5 years and a body mass index of 29±5 Kg/m2. They were divided into three groups: controlled (n=6), uncompensated (n=8), and untreated (n=5). The subjects from all groups were submitted to a test of maximal strength on extensor chair and held a session of RE (knee extension, 3x12 to 60% 1RM) and the cardiovascular response (BP and heart rate) was monitored continuously by photoplethysmography during exercise and until five minutes after exercise (recovery). Results: Systolic BP (SBP) and diastolic BP (DBP) responses were lower in the controlled group compared to the other groups (p<0.05). The heart rate was not different between groups, while the double product was lower in the controlled group compared to the untreated group (p<0.05). The SBP and DBP peaks were lower in the controlled group compared to the other groups (p<0.05). Conclusion: The BP increases significantly during RE when the hypertension is not controlled. Pharmacological control was shown to be effective in preventing the increase of BP during the performance of the RE.


Subject(s)
Humans , Female , Middle Aged , Endurance Training , Heart Rate , Hypertension/drug therapy , Antihypertensive Agents/administration & dosage
3.
Rev. bras. cineantropom. desempenho hum ; 19(2): 139-149, Mar.-Apr. 2017. tab
Article in English | LILACS | ID: biblio-843436

ABSTRACT

Abstract The registration or insertion of older adults in Community Physical Activity Programs does not guarantee their stay over time. The purpose of this study was to analyze the length of stay of elderly in a Community Physical Activity Program and associated factors. This epidemiologic observational study of retrospective cohort performed in Aracaju City, Brazil, included a sample of 526 older adults (477 females) aged 66.4 ± 5.4 years. To characterize the profile and length of stay of individuals, descriptive statistics was used. To analyze the length of stay, the Kaplan-Meier non-parametric survival, estimator was used. To verify the association between variables in the observed time, the Cox regression model was applied. Inverse ratio equation (1/OR) was used to facilitate the understanding of significant values when necessary. In all analyses, 95% confidence interval and p≤0.05 were used. In the first three months, stay rate of 58.1% (95% CI = 54.6 - 61.3) was observed, with a risk estimative = 41.82%. Females presented a 45% chance of stay (OR = 0.69; 95% CI = 0.51 – 0.93) and individuals identified with osteoporosis had 32% more chances of stay (OR = 0.74, 95% CI, = 0.60-0.91). Only 1% of subjects remained until the end of the cohort. The stay rate was low throughout all series; the period with higher quitting rates was the 3rd and the 12th months, being associated with the female stay sex and undiagnosed osteoporosis.


Resumo A matrícula ou inserção de idosos em Programas Comunitários de Atividade Física não garante sua permanência ao longo do tempo. Objetivou-se analisar o tempo de permanência em idosos participantes de um Programa Comunitário de Atividade Física e seus fatores associados. Estudo observacional epidemiológico de coorte retrospectiva, realizado no Nordeste do Brasil, com amostra de 526 idosos (477 do sexo feminino), apresentando 66,4 ± 5,4 anos. Para caracterização do perfil e permanência da amostra foi utilizado estatística descritiva. Para analisar o tempo de permanência utilizou-se o estimador de sobrevivência não paramétrico Kaplan-Meier. Para verificar a associação entre as variáveis no tempo observado foi aplicado o modelo de regressão de Cox. Utilizou-se a análise inversa (1/OR) para facilitar a compreensão dos valores significativos quando necessário. Em todas as análises foi utilizado o intervalo de confiança de 95% e p≤0,05. Os primeiros três meses apresentaram uma taxa de permanência de 58,1% (IC95% = 54,6 – 61,3), com Estimativa de Risco = 41,82%. O sexo feminino apresentou chance de permanência de 45% (OR = 0,69; IC95% = 0,51 – 0,93) e os sujeitos identificados com osteoporose apresentaram 32% mais chances de permanência (OR = 0,74; IC95% = 0,60 – 0,91). Apenas 1% dos sujeitos permaneceram até o fim da coorte. A taxa de permanência foi baixa ao longo da série; O período onde houve maior desistência foi o 3º e o 12º mês, estando associados à permanência o sexo feminino e osteoporose não diagnosticada.


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Brazil/epidemiology , Exercise , Health of the Elderly , Socioeconomic Factors , Health Behavior , Healthy Lifestyle , Motivation
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