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1.
National Journal of Andrology ; (12): 430-433, 2019.
Article in Chinese | WPRIM | ID: wpr-816817

ABSTRACT

Objective@#To analyze the association of stored autologous blood transfusion (SABT) with tumor recurrence in PCa patients after radical prostatectomy and explore the application of SABT in this surgical procedure.@*METHODS@#Forty-five PCa patients underwent radical prostatectomy in our hospital in recent five years, of whom, 20 received SABT (group A) and the other 25 allogeneic blood transfusion (group B) intraoperatively. After surgery, we followed up the patients regularly for 3-66 months by examination of the levels of total PSA (tPSA) and free PSA (fPSA), digital rectal examination (DRE), and MRI to observe the biochemical recurrence of the tumor. We compared the data obtained between the two groups of patients.@*RESULTS@#In group A, 8 cases were in stages T1a-T1b and 12 in stages T2a-T2c, and in group B, 14 cases were in stages T1a-T1b and 11 in stages T2a-T2c. The volume of transfused blood was 800 ml in group A and 400-1 200 ml in group B. No statistically significant differences were observed between the two groups in the operation time, intraoperative blood loss or postoperative Gleason scores (P > 0.05), nor in the tPSA level or the results of DRE and MRI at 12, 24, 36, 48 and over 48 months (P > 0.05).@*CONCLUSIONS@#SABT is safe for PCa patients undergoing radical prostatectomy and does not increase the tumor recurrence rate after surgery.

2.
National Journal of Andrology ; (12): 724-728, 2015.
Article in Chinese | WPRIM | ID: wpr-276029

ABSTRACT

<p><b>OBJECTIVE</b>To study the expression of the Trp-p8 protein in the prostate tissue of the PSA "grey zone" with different PSA density of the transition zone (PSADTZ) and explore the value of determining Trp-p8 expression and PSADTZ in the early diagnosis of prostate cancer (PCa).</p><p><b>METHODS</b>This study involved 30 cases of benign prostatic hyperplasia (BPH) and another 30 cases of PCa with different PSADTZ values. Using a data imaging and analysis system, we determined the expression levels of Trp-p8 in BPH and PCa tissues and analyzed their correlation with PSADTZ.</p><p><b>RESULTS</b>The expression of Trp-p8 was weak or negative in the BPH but strong in the PCa tissue and even stronger in the PCa tissue with high PSADTZ (F = 34. 05, P < 0.05).</p><p><b>CONCLUSION</b>The Trp-p8 protein is expressed differently in BPH and PCa tissues of the PSA " grey zone" and its expression is positively correlated with PSADTZ. Determination of the Trp-p8 expression and PSADTZ contributes to the early diagnosis of prostate cancer.</p>


Subject(s)
Biomarkers, Tumor , Metabolism , Early Detection of Cancer , Methods , Humans , Male , Prostate , Metabolism , Prostate-Specific Antigen , Metabolism , Prostatic Hyperplasia , Diagnosis , Metabolism , Prostatic Neoplasms , Diagnosis , Metabolism , TRPM Cation Channels , Metabolism
3.
National Journal of Andrology ; (12): 338-341, 2014.
Article in Chinese | WPRIM | ID: wpr-309710

ABSTRACT

<p><b>OBJECTIVE</b>To search for a simple and effective surgical approach to the management of moderate to severe pediatric concealed penis in children.</p><p><b>METHODS</b>We used Devine's technique via incision between the penis and scrotum in the treatment of 68 cases of moderate to severe pediatric concealed penis. The patients were aged 3 -13 (mean 6.5) years, 30 with moderate and 38 with severe pediatric concealed penis.</p><p><b>RESULTS</b>This strategy achieved good near- and long-term effects and satisfactory appearance of the penis, which was similar to that of circumcision. At 3 months after surgery, the penile length was 3 - 5.2 cm, averaging (2.35 +/- 0.35) cm.</p><p><b>CONCLUSION</b>Devine's technique via incision between the penis and scrotum is a simple and effective surgical option for moderate to severe pediatric concealed penis in children.</p>


Subject(s)
Adolescent , Child , Child, Preschool , Humans , Male , Penis , Congenital Abnormalities , General Surgery , Scrotum , General Surgery , Urologic Surgical Procedures, Male , Methods
4.
Chinese Journal of Surgery ; (12): 369-371, 2006.
Article in Chinese | WPRIM | ID: wpr-317151

ABSTRACT

<p><b>OBJECTIVE</b>To discuss the effect of urine control after radical retropubic prostatectomy by preserve the membranous part of sphincter urethrae and the neurovascular bundle, or to rebuild the bladder neck.</p><p><b>METHODS</b>The radical retropubic prostatectomy was performed on a total of 32 cases of prostate cancer. We preserve the membranous part of sphincter urethrae and the neurovascular bundle lateral to the prostate. We evaginate the posterior wall of the bladder adequately and make an additional folding stitch to rebuild the bladder neck.</p><p><b>RESULTS</b>The follow up is of 6-72 months. All patients could void without difficulty, no tumor recurrence and only 2 cases occurred slight incontinence. Other 30 cases regained the ability of controlling their urinations within 6 months.</p><p><b>CONCLUSIONS</b>The incontinence after radical retropubic prostatectomy could be reduced by the method of preserving the membranous part of sphincter urethrae and preserving the neurovascular bundle lateral to the prostate in operation. It could also be avoided by evaginate the posterior wall of the bladder adequately and make an additional folding stitch to the bladder neck.</p>


Subject(s)
Aged , Follow-Up Studies , Humans , Male , Middle Aged , Postoperative Complications , Prostatectomy , Methods , Prostatic Neoplasms , General Surgery , Retrospective Studies , Urinary Incontinence
5.
Article in Chinese | WPRIM | ID: wpr-675919

ABSTRACT

Objective To investigate the changes of gastric emptying in awake rats after acute myocardial infarction(AMI). Methods The male Wistar rats were submitted to thoracotomy followed by or not by occlusion of the left coronary artery. After 24 h, AMI(n=12)and sham groups (n=9)were fed in gavage(1 ml)with ~(99m)-Tc-DTPA labeled test meal. Half gastric emptying time (GET1/2) and 50min residual rate were measured by single photon emission computed tomography. The rats of AMI group were sacrificed after 50 min. Plasma level of motilin was measured by radioimmunoassay in AMI and sham group respectively(n=9). Results GET1/2 was significantly higher in AMI group[(23.1?4.7)min] than in sham group[(16.0?4.0)min](P

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