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1.
Acta Pharmaceutica Sinica B ; (6): 3035-3059, 2021.
Article in English | WPRIM | ID: wpr-922741

ABSTRACT

Various boron-containing drugs have been approved for clinical use over the past two decades, and more are currently in clinical trials. The increasing interest in boron-containing compounds is due to their unique binding properties to biological targets; for example, boron substitution can be used to modulate biological activity, pharmacokinetic properties, and drug resistance. In this perspective, we aim to comprehensively review the current status of boron compounds in drug discovery, focusing especially on progress from 2015 to December 2020. We classify these compounds into groups showing anticancer, antibacterial, antiviral, antiparasitic and other activities, and discuss the biological targets associated with each activity, as well as potential future developments.

2.
Chinese Journal of School Health ; (12): 619-622, 2021.
Article in Chinese | WPRIM | ID: wpr-876416

ABSTRACT

Objective@#To analyze the epidemiological characteristics of plant and mushroom poisoning events among people aged 0-19 in Guizhou Province from 2015 to 2019, so as to provide the basis for prevention and control of food poisoning events among children and adolescents.@*Methods@#Data of people aged 0 to 19 involved in plant and mushroom poisoning incidents reported by the foodborne disease outbreak surveillance system in Guizhou Province from 2015 to 2019 were collected, verified, sorted and statistically analyzed.@*Results@#From 2015 to 2019, there were 590 cases of plant and mushroom poisoning among people aged 0 to 19 in Guizhou Province, 1 441 people were poisoned and 5 died. In May and September, family and collective dining halls were the places with the highest incidence of plant and poisonous mushroom poisoning incidents, accounting for 90.68% (535/590) of the total incidents. Poisonous mushrooms and masanberry accounted for 71.69% (423/590) of the food poisoning causes, and 5 people died of poisoning were caused by poisonous mushrooms.@*Conclusion@#In the cases of plant and mushroom poisoning among people aged 0-19 years in Guizhou Province,preschool primary and middle school students in rural areas are most vulnerable population of poisoning, so it is necessary to strengthen the publicity and education on the prevention and control of toxic plant and mushroom poisoning among children and teenagers in rural areas, so as to reduce the occurrence of relevant poisoning incidents.

3.
Acta Pharmaceutica Sinica ; (12): 652-668, 2020.
Article in Chinese | WPRIM | ID: wpr-820862

ABSTRACT

Hepatitis C virus (HCV) infection is one of the global public health issues. Approximately, 130-150 million individuals are chronically infected worldwide and a quarter of these patients are at increased risk of developing liver cirrhosis, hepatocellular carcinoma and even liver failure. A complete eradication of the virus is one of the most important treatment goals for antiviral research. From the point of view of medicinal chemistry, we summarize and discuss current endeavors towards the discovery and development of novel inhibitors with various scaffolds or distinct mechanisms of action.

4.
Journal of Medical Postgraduates ; (12): 169-173, 2018.
Article in Chinese | WPRIM | ID: wpr-700795

ABSTRACT

Objective To discuss the personality characteristics and blood lipid levels in patients with infertility and depression,and further analyze the relationship between the degree of depression and the two aspects.Methods We selected 190 infertility patients and they were tested with Self-Rating Depression Scale(SDS) in Tangshan Maternal and Child Health Care Hospital Affiliated to North China University of Science and Technology from December,2015 to December,2016.All the patients were allocated into depression group (with depression symptom) and non-depression group (without depression symptom).Blood lipid levels,including triglycerides (TG),total cholesterol(TC),low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were determined and the Eysenck Personality Questionnaire(EPQ) was applied to evaluate the personality traits in both groups.Results The patients in the depression group were mainly mild-to-moderate depression accouting for 64.4%,and patients with moderate to severe depression accouted for approximately 30.0%.The levels of TG and TC of patients in the depression group were significantly higher than those in the non-depression group(P<0.01).The scores of neuroticism(N),validity scale(L) and psychoticism(P) of patients in the depression group were significantly higher than those in the non-depression group,while there was no significant difference in exextraversion (E) between the two groups.TG,E dimension,P dimension and L dimension were effective predictors of depression in infertile patients,and the Beta coefficient were 0.199,-0.240,0.424 and 0.220.Pearson partial correlation analysis showed that TG was positively correlated with P,N and L dimensions.Conclusion Infertility patients with depression may have dyslipidemia and personality changes.The degree of depression is positively correlated to the level of TG and the score of P and N.

5.
Article in Chinese | WPRIM | ID: wpr-700734

ABSTRACT

From the perspective of standardization development of Traditional Chinese Medicine (TCM) information,the paper puts forward the categorizing and coding scheme of clinical TCM information,builds a frame of basic clinical TCM information classification,which consists of 6 Grade 1 categories,30 subcategories and a few detailed categories,to provide standardized support for informatization and standardization study in the area of TCM.

6.
Article in English | WPRIM | ID: wpr-690636

ABSTRACT

Nonalcoholic fatty liver disease (NAFLD) is a major public health issue worldwide. Immunoglobulin G (IgG) N-glycans are associated with risk factors for NAFLD, such as obesity and diabetes. A cross-sectional study involving 500 Han Chinese adults recruited from a community in Beijing was carried out to explore the association between IgG N-glycans and NAFLD. IgG N-glycosylation was significantly associated with NAFLD, with the disease showing a negative correlation with galactosylation (GP14, GP14n, and G2n), positive correlation with fucosylation (FBG2n/G2n), and positive correlation with bisecting N-acetylglucosamine (GlcNAc) [FBG2n/FG2n and FBG2n/(FG2n+FBG2n)], after controlling age, gender, and prevalence of obesity, type 2 diabetes mellitus, hypertension, and hyperlipidemia. In other words, the present study showed a possible association between NAFLD and the loss of galactose and elevations of fucose and bisecting GlcNAc. Aberrant IgG glycosylation might therefore be a potential biomarker for the primary or secondary prevention of NAFLD.


Subject(s)
Biomarkers , Blood , China , Cross-Sectional Studies , Diabetes Mellitus, Type 2 , Blood , Female , Glycosylation , Humans , Immunoglobulin G , Blood , Male , Middle Aged , Non-alcoholic Fatty Liver Disease , Blood , Obesity , Blood , Odds Ratio , Polysaccharides , Blood , Risk Factors
7.
National Journal of Andrology ; (12): 216-220, 2018.
Article in Chinese | WPRIM | ID: wpr-689774

ABSTRACT

<p><b>Objective</b>To investigate the relationship between seminal plasma zinc alpha-2 glycoprotein (ZAG) and semen quality in obese males.</p><p><b>METHODS</b>This study included 130 obese male patients with idiopathic infertility Based on the concentration of seminal plasma ZAG, we divided the patients into three tertile groups: tertile 1 (T1, 73.45-97.15 μg/ml, n = 43), T2 (97.16-115.46 μg/ml, n = 44), and T3 (115.47-220.11 μg/ml, n = 43). We measured the concentrations of seminal plasma zinc (SPZ) and ZAG of the patients by ELISA, obtained the semen parameters, and analyzed the correlation of semen quality with the levels of SPZ and ZAG and the influence of obesity on SPZ, ZAG and semen quality.</p><p><b>RESULTS</b>The mean level of seminal plasma ZAG in the 130 obese male patients was (111.29 ± 26.50) μg/ml. There were statistically significant differences in sperm concentration and total sperm count among the three tertile groups (P < 0.05). The level of seminal plasma ZAG was correlated negatively with the body mass index (BMI), waist circumference (WC), sperm concentration and sperm count (P < 0.01), that of SPZ positively with BMI and WC (P < 0.05) but negatively with semen volume and the percentage of progressively motile sperm (P < 0.05). The level of serum ZAG, however, exhibited no correlation with SPZ, seminal plasma ZAG or semen quality. Obesity was found to be associated with significantly decreased concentration of seminal plasma ZAG and percentage of progressively motile sperm but remarkably increased level of SPZ (P < 0.05).</p><p><b>CONCLUSIONS</b>Obesity may induce the metabolic disorder of SPZ and ZAG, change the microenvironment of seminal plasma, and consequently affect semen quality.</p>


Subject(s)
Body Mass Index , Humans , Infertility, Male , Metabolism , Male , Obesity , Metabolism , Semen , Chemistry , Semen Analysis , Seminal Plasma Proteins , Sperm Count , Sperm Motility , Spermatozoa , Metabolism , Waist Circumference
8.
National Journal of Andrology ; (12): 419-424, 2018.
Article in Chinese | WPRIM | ID: wpr-689740

ABSTRACT

<p><b>Objective</b>To investigate the correlation of the levels of reproductive hormones and oxidative stress in the seminal plasma with semen parameters in obese males.</p><p><b>METHODS</b>Based on the body mass index (BMI), we divided 138 infertile men into three groups: normal (BMI <24 kg/m2, n = 48), overweight (24 kg/m2≤BMI<28 kg/m2, n = 47), and obesity (BMI ≥28 kg/m2, n = 43). We determined the concentrations of follicle-stimulating hormone (FSH), luteotropic hormone (LH), prolactin (PRL), testosterone (T) and estradiol (E2) in the serum by electrochemiluminescence and measured the levels of superoxide dismutase (SOD), glutathione-S-transferases (GSTs), reactive oxygen species (ROS) and malondialdehyde (MDA) in the seminal plasma by ELISA, compared the above indexes among the three groups, and analyzed their correlation with the semen volume, sperm concentration, total sperm count, and percentage of progressively motile sperm (PMS).</p><p><b>RESULTS</b>The semen volume was significantly lower in the obesity than in the normal group ([2.63 ± 0.74] vs [3.37 ± 1.00] ml, P < 0.05), and so was the percentage of PMS in the overweight and even lower in the obesity than in the normal group ([47.91 ± 12.89] and [41.27 ± 15.77] vs [54.04 ± 13.29]%, P < 0.05). Compared with the normal group, both the overweight and obesity groups showed markedly decreased levels of serum T ([4.83 ± 1.42] vs [3.71 ± 1.22] and [3.49 ± 1.12] ng/ml, P<0.05), T/LH ratio (1.53 ± 0.57 vs 1.19 ± 0.54 and 0.97 ± 0.51, P<0.05), SOD ([112.05 ± 10.54] vs [105.85 ± 6.93] and [99.33 ± 8.39] U/ml, P<0.05), and GSTs ([31.75±6.03] vs [29.54±5.78] and [29.02±4.52] U/L, P<0.05), but remarkably increased seminal plasma ROS ([549.93±82.41] vs [620.61±96.13] and [701.47±110.60] IU/ml, P<0.05) and MDA ([7.46 ± 2.13] vs [8.72 ± 1.89] and [10.47 ± 2.10] nmol/L, P<0.05). BMI was correlated positively with ROS and MDA, but negatively with the semen volume, PMS, T, T/LH, SOD and GSTs (P<0.05); LH negatively with sperm concentration, total sperm count and GSTs (P<0.05); PRL negatively GSTs (P<0.05); E2 positively with SOD (P<0.05); T positively with SOD (P<0.05) but negatively with MDA (P<0.05); T/LH positively with PMS and SOD (P<0.05) but negatively with ROS and MDA (P<0.05); SOD positively with semen volume, PMS and GSTs (P<0.05) but negatively with ROS and MDA (P<0.05); GSTs negatively with sperm concentration; total sperm count and MDA (P<0.05); ROS positively with MDA (P<0.01) but negatively with PMS (P<0.05); and MDA negatively with semen volume (P<0.05). Multivariate logistic regression analysis showed that the independent factors influencing the semen volume were BMI and GSTs, those influencing the total sperm count were BMI and T, and those influencing PMS were BMI and MDA.</p><p><b>CONCLUSIONS</b>Increased BMI induces changes in the levels of male reproductive hormones and seminal plasma oxidative stress and affects semen quality, which may be associated with male infertility.</p>


Subject(s)
Body Mass Index , Estradiol , Blood , Follicle Stimulating Hormone , Blood , Humans , Infertility, Male , Blood , Classification , Metabolism , Luteinizing Hormone , Blood , Male , Malondialdehyde , Obesity , Blood , Metabolism , Oxidative Stress , Prolactin , Blood , Reactive Oxygen Species , Reproduction , Semen , Metabolism , Semen Analysis , Sperm Count , Testosterone , Blood
9.
National Journal of Andrology ; (12): 695-699, 2018.
Article in Chinese | WPRIM | ID: wpr-689728

ABSTRACT

<p><b>Objective</b>To investigate the influence of insulin resistance on male reproductive hormones and semen quality.</p><p><b>METHODS</b>Using the electrochemiluminescence method, we measured the levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), estradiol (E2) and testosterone (T) in the serum of 83 infertile males. We detected the levels of fasting plasma glucose (FPG) and fasting insulin (FINS) and calculated the insulin resistance index presented as homeostasis model assessment of insulin resistance (HOMA-IR). Based on HOMA-IR, we divided the patients into three tertile groups, T1 (HOMA-IR 0.36-0.55, n = 27), T2 (HOMA-IR 0.56-0.80, n = 28) and T3 (HOMA-IR 0.81-1.97, n = 28), obtained their semen parameters by computer-assisted semen analysis (CASA) and analyzed the correlation of HOMA-IR with male reproductive hormone levels and semen parameters.</p><p><b>RESULTS</b>With the elevation of HOMA-IR, the patients of the T1, T2 and T3 groups showed significant decreases in the serum T level ([14,26 ± 4.27] vs [14.75 ± 5.00] vs [11.62 ± 3.68] nmol/L, P <0.05) and the percentage of progressively motile sperm (PMS) ([51.04 ± 15.10]% vs [48.04 ± 16.24]% vs [37.84 ± 18.23]%, P <0.05). HOMA-IR was correlated negatively with the serum T level (r = -0.333, P = 0.002), semen volume (r = -0.23, P = 0.029) and PMS (r = -0.27, P = 0.015), and so was FINS with the serum T level (r = -0.327, P = 0.003) and PMS (r = -0.315, P = 0.004), while the semen volume was correlated positively with the levels of serum T (r = 0.221, P = 0.048) and FSH (r = 0.222, P = 0.047). Multivariate linear regression analysis showed that HOMA-IR was an independent influencing factor for PMS and the body mass index (BMI) was that for the semen volume and total sperm count.</p><p><b>CONCLUSIONS</b>Insulin resistance may reduce semen quality by changing the levels of male reproductive hormones.</p>

10.
National Journal of Andrology ; (12): 745-750, 2017.
Article in Chinese | WPRIM | ID: wpr-812884

ABSTRACT

Metabonomics is an emerging branch of science for the study of endogenous small molecule metabolites in organisms, which plays an important role in evaluatingthediagnosis and treatment of male infertility by exploring the metabolites of body fluids, cells and tissues. With its advantages ofmass information, noninvasiveness, and celerity, metabonomics will be widely applied to clinical researches in the future. This review introducesmetabonomics and its analytical techniques and data processing procedures,its latest application in the studies of the etiology, diagnosis and the treatment of male infertility, and the prospect of its future application in the researches of male reproduction.


Subject(s)
Body Fluids , Metabolism , Humans , Infertility, Male , Diagnosis , Metabolism , Therapeutics , Male , Metabolomics
11.
National Journal of Andrology ; (12): 894-898, 2017.
Article in Chinese | WPRIM | ID: wpr-812861

ABSTRACT

Objective@#To investigate the influence of inflammatory factors on semen parameters in the seminal plasma of obese men.@*METHODS@#Based on the body mass index (BMI), 171 males were divided into a normal group (BMI 0.05).@*CONCLUSIONS@#The levels of TNF-α and IL-6 are increased and that of VEGF decreased in the seminal plasma of obese males, which may affect the semen quality.


Subject(s)
Body Mass Index , Enzyme-Linked Immunosorbent Assay , Humans , Interleukin-6 , Male , Obesity , Overweight , Semen , Chemistry , Semen Analysis , Methods , Sperm Count , Sperm Motility , Spermatozoa , Tumor Necrosis Factor-alpha , Vascular Endothelial Growth Factor A
12.
National Journal of Andrology ; (12): 997-1001, 2017.
Article in Chinese | WPRIM | ID: wpr-812843

ABSTRACT

Objective@#To study the changes of the serum zinc alpha 2 glycoprotein (ZAG) level in men and its relationship with blood lipid male reproductive hormones.@*METHODS@#We enrolled 297 men aged 25- 65 years in this study, 152 with hyperlipemia (HL) and the other 145 with normal blood lipid (normal control). We divided them into four age groups (25-35 yr, 36-45 yr, 46-55 yr, and 56-65 yr) and three tertile groups (Q1, Q2, and Q3) according to the tertiles of the serum ZAG level, and examined their blood lipid, blood glucose, serum ZAG, and reproductive hormones.@*RESULTS@#The serum ZAG level was decreased gradually with the increase of age in both the HL patients and normal controls, significantly in the 36-45 and 56-65 yr age groups (P <0.05), and markedly lower in the HL than in the control men in the 25-35 and 36-45 yr groups (P <0.05). The levels of follicle-stimulating hormone (FSH) and total testosterone (TT) changed significantly with the ZAG level. The level of serum ZAG was correlated negatively with age (r = -0.58, P<0.05), waist circumference (r = -0.21, P <0.05), body mass index (BMI) (r = -0.22, P <0.05), fasting blood glucose (r = -0.16, P <0.05) , and triglyceride (TG) (r = -0.27, P <0.05) but positively with TT (r = 0.36, P <0.05). Age, BMI and TG were independent factors influencing the serum ZAG level.@*CONCLUSIONS@#The serum ZAG level is decreased with the increase of age and associated with lipid metabolism, abdominal obesity, and reproductive hormone levels in males.


Subject(s)
Adult , Age Factors , Aged , Blood Glucose , Body Mass Index , Follicle Stimulating Hormone , Gonadal Steroid Hormones , Blood , Humans , Lipids , Blood , Male , Middle Aged , Obesity, Abdominal , Reproduction , Seminal Plasma Proteins , Blood , Triglycerides , Blood
13.
National Journal of Andrology ; (12): 974-978, 2016.
Article in Chinese | WPRIM | ID: wpr-262278

ABSTRACT

<p><b>Objective</b>To investigate the aging-related changes of reproductive hormones in hyperlipemia men in the urban area of Shijiazhuang and the relationship between the levels of reproductive hormones and that of blood lipid.</p><p><b>METHODS</b>We enrolled 297 males aged 25-65 years in this study, determined the levels of serum total testosterone (TT), luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), prolactin (PRL), triglyeride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and fasting blood glucose (FBG), and compared the parameters among different age groups.</p><p><b>RESULTS</b>The level of serum TT was decreased while that of FSH increased significantly in the 36-45 years group and that of LH elevated only in the 56-65 years old hyperlipemia males(P<0.05). No statistically significant changes were observed in PRL and E2 among different age groups. Spearman correlation analysis manifested that age was correlated negatively with TT, FSH, and LH (r=-0.266, 0.514, and 0.350, P<0.05), TT weakly negatively with TC and TG (r=-0.215 and -0.286, P<0.05) but weakly positively with HDL-C (r=0.281, P<0.01), and FSH and LH weakly positively with TG (r=0.282 and 0.343, P<0.05). Regression analysis showed age to be an independent influencing factor of TT, FSH and LH, while HDL-C to be that of TT.</p><p><b>CONCLUSIONS</b>The levels of serum TT and FSH gradually change with aging and low TT and high FSH and LH are closely related to hyperlipemia in adult men.</p>

14.
Article in Chinese | WPRIM | ID: wpr-502735

ABSTRACT

Objective To investigate the gene mutation of epithelial growth factor receptor(EGFR) and the expressions of hu‐man epiderma1 growth factor receptor 2(HER‐2) and vascular endothelial growth factor(VEGF) in lung adenocarcinoma and their relationships with the clinical pathological factors .Methods ARMS‐PCR method was used to detect the gene mutation of EGFR in 49 lung adenocarcinoma specimens and 10 normal tissue specimens .Immunohistochemical method was also used to detect the ex‐pressions of the HER‐2 and VEGF in them .Results (1) The mutation rates of EGFR and the positive rates of HER‐2 and VEGF in lung adenocarcinoma were significantly higher than those in the normal tissues(P0 .05) .The HER‐2 and VEGF protein expressions in lung adenocarcinoma were correlated with differential ,the size of tumor ,TNM stages ,lymph nodes metastasis and pleural invasion(P0 .05) .(3) The expressions of HER‐2 and VEGF protein in the lung adenocarcinoma were positively correlated with each other(P<0 .01) .Conclusion EGFR mutation is closely related to the occurrence of lung ade‐nocarcinoma ,its high expressions in the women ,non smoking people have important clinical significance .HER‐2 and VEGF could promote the lung adenocarcinoma′s occurrence ,development and transfer .They could be used to evaluate the patients′prognosis ,and provide new molecular targeted therapy .

15.
Chinese Journal of Epidemiology ; (12): 792-795, 2012.
Article in Chinese | WPRIM | ID: wpr-288104

ABSTRACT

Objective To explore the relationship of sensation seeking,self-efficacy,deviant peers and refusal skills related to strategy on drugs among middle school students.Methods A total of 502 students from two high schools and two vocational schools in Baise city were recruited with age distribution between 14 and 20 years.The study objects were asked to fill the sensation seeking scale,the general self-efficacy scale questionnaire on drug refusal strategies and behavior among peers.Results ( 1 ) Adolescents were more likely to use the Refuse (78.29%) and Leave strategy (77.89%) for initial drug offers and follow-up drug offers; (2)The general self-efficacy was negatively associated with the Explain and Leave strategies for initial drug offers and Explain strategy for follow-up drug offers.Sensation seeking was negatively related to the strategies on Explain and Leave for initial drug offers and follow-up drug offers.Peer influence was positively associated with both Refuse and Leave strategies for initial drug offers and follow-up drug offers; (3)Results from the logistic regression analysis showed that self-efficacy and sensation seeking were significant variables that could predict the results from the use of Explain strategy (β =-0.055 and -0.029 ) for both initial drug refusals and follow-up drug refusals and the use of Leave strategy(β =-0.057 and-0.041 ) for initial drug refusals.Conclusion There were significant effects of sensation seeking and self-efficacy in predicting Explain or Leave strategies for drug refusals among middle students.

16.
Article in Chinese | WPRIM | ID: wpr-313781

ABSTRACT

<p><b>OBJECTIVE</b>To study the clinical effects of Achillon for the treatment of acute Achilles tendon rupture (AATR).</p><p><b>METHODS</b>From April 2009 to April 2010, 19 patients with AATR who were treated with Achillon were retrospectively analyzed. There were 17 males and 2 females, with an average age of 40.2 years (30 to 58 years). There were 9 cases of sports injury, and 2 case of fall injury. The time from injury to surgery ranged from 0 to 8 days (2.2 days on average). The results of Thompson test and single heel rise test were positive in 19 cases. Clinical data were assessed with the patient satisfaction and the AOFAS hindfoot score during follow-up.</p><p><b>RESULTS</b>All the patients were followed up, and the duration ranged from 12 to 28 months (19.9 months on average). The average operation time was 41 minutes. There were no wound infections, recurrent rupture, or sural nerve complications. At the latest follow-up, 18 patients were totally satisfied with the surgical result, 1 patient feel generally due to mild pain when running. None of the patients were dissatisfied with the final results the latest follow-up. At the latest follow-up, the AOFAS score was 98.42 +/- 3.29 (89 to 100). All the patients regained normal range of motion and were able to resume their previous activities at six months after operation, with a high rate of satisfaction. Average decreased of mid-calf circumference was (0.82 +/- 0.85) cm (ranged from 0 to 3 cm).</p><p><b>CONCLUSION</b>Treatment with Achillon is safe, effective for AATR with low incidence of complications and early active rehabilitation can be carried out. It is a good method to treat AATR.</p>


Subject(s)
Achilles Tendon , Wounds and Injuries , General Surgery , Acute Disease , Adult , Female , Humans , Male , Middle Aged , Minimally Invasive Surgical Procedures , Retrospective Studies , Rupture , Suture Techniques , Tendon Injuries , General Surgery
17.
Chinese Journal of Epidemiology ; (12): 123-125, 2009.
Article in Chinese | WPRIM | ID: wpr-329517

ABSTRACT

Objective To understand the relationship of tendency on drug abuse and related influencing factors for middle school students.Methods A total of 603 students wcre assessed with self-made copying style scale,consciousness to resistance of smoking,drinking and resistance ability through a questionnaire.A relationship model was set up by structure equation modeling.Results Copying style and resistance ability had significantly direct influence on tendency of drug abuse(with standardized coefficients were 0.202 and 0.092 respectively).Consciousness to resistance of smoking and drinking had significantly indirect influence on tendency of drug abuse.The goodneSS of fit for the structural equation model was satisfactory,with GFI,AGFI,RMSEA as 0.981,0.972 and 0.014 respectively.Conclusion It Was meaningful to grasp some copying skills and resistance ability to lower the tendency of drug abuse in middle school students.

18.
Article in Chinese | WPRIM | ID: wpr-349397

ABSTRACT

OBJECTIVE: To evaluate the therapeutic effect of the herbal plaster Tangshangxiaobagao on partial thickness burn wound. METHODS: A randomized controlled trial was conducted with two herbal plasters: Tangshang-xiaobagao and Jingwanhong in 57 hospitalized burn patients. Both the effect and safety of two herbal plasters were noted in patients with partial thickness burns. RESTULTS: In superficial second degree burns, the 7 d healing rate of both groups was (61.35+/-36.26)%and (51.21+/-37.24)% and the healing time (10.56+/-3.43)d and (11.98+/-4.13)d P<0.05 respectively. While in deep second degree burns, the 14 d healing rate of both groups was (62.9+/-36.0) % and (53.9+/-32.2) % and the healing time (19.4+/-4.9)d and (21.5+/-5.5)d, respectively. Study group had lower VAS(visual analogue scale)score than control group. No obvious side effects were observed in study group. CONCLUSION: Tangshangxiaobagao is safe and may be an effective adjunct for treatment of partial thickness burn wounds.

19.
Article in Chinese | WPRIM | ID: wpr-685991

ABSTRACT

Objective To investigate the relationship between the disorder of learning and memory in lead rats and the argnine vasopressin (AVP) and the somatotatin (SS) of hippocampus.Methods Sixty healthy 2-month old Sprague-Dawley rats were randomly divided into normal control group and lead group. Normal control group was given deionized water and the lead group was given 0.1% lead acetate deionized water for 3 months to make chronic lead rat. Learning and memory ability was tested by the Y-maze test. The content of AVP and SS in hippocampus were tested by the immunohistochemical method. Results The learning memory ability and the content of AVP and SS in hippocampus CA1 section of the lead group were degraded obviously than the control group(all P0.05)in hippocampus CA3 section of the lead group were degraded also.Conclusion The disorder of the learning and memory of the lead exposure rats may be due to the decrease of the content of AVP and SS in hippocampus.

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