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1.
Article in Chinese | WPRIM | ID: wpr-847078

ABSTRACT

BACKGROUND: Chitosan or collagen alone can improve the microvessel density in myocardial infarction area and participate in the short-term myocardial repair after myocardial infarction. Based on this research group, thermosensitive chitosan-collagen composite hydrogel was prepared, which confirmed that it had good physical and chemical properties and was suitable for myocardial tissue engineering scaffold materials. OBJECTIVE: To prepare the chitosan-collagen composite hydrogel loaded with basic fibroblast growth factor, and to analyze its physical and chemical properties, biocompatibility and prognosis in vivo after treatment of myocardial infarction in mice. METHODS: (1) Basic fibroblast growth factor was loaded in chitosan-collagen composite hydrogel and chitosan hydrogel separately, and the release efficiency of basic fibroblast growth factor in hydrogels was detected. (2) H9C2 cardiomyocytes were seeded in two hydrogels loaded with basic fibroblast growth factor, and cell proliferation was detected by CCK8 assay. (3) C57BL/6J mice model of myocardial infarction was established and randomly divided into three groups. The blank group was injected PBS into the myocardial infarction area. The control group was injected with chitosan hydrogel loaded with basic fibroblast growth factor. The experimental group was injected with chitosan-collagen composite hydrogel loaded with basic fibroblast growth factor. Echocardiography and myocardial histology were performed 28 days after operation. The experiment was approved by Ethics Committee of Shanxi Medical University. RESULTS AND CONCLUSION: (1) Compared with chitosan hydrogel, chitosan-collagen composite hydrogel could promote the release of basic fibroblast growth factor in gel. (2) Compared with the chitosan hydrogel loaded with basic fibroblast growth factor, the chitosan-collagen composite hydrogel loaded with basic fibroblast growth factor could promote the proliferation of cardiomyocytes. (3) Echocardiography showed that the left ventricular ejection fraction and the shortening rate of left ventricular short axis in the experimental group and the control group were higher than those in the blank group (P < 0.05). Left ventricular ejection fraction and the shortening rate of left ventricular short axis in the experimental group were higher than those in the control group (P < 0.05). (4) The myocardial histological observation showed that the infarct area of the experimental group and the control group was smaller than that of the blank group (P < 0.05). The infarct area wall thickness of the experimental group and the control group was larger than that of the blank group (P < 0.05). The infarct area of the experimental group was smaller than that of the control group (P < 0.05), and the infarct area wall thickness of the experimental group was larger than that of the control group (P < 0.05). (5) The results showed that the chitosan-collagen composite hydrogel loaded with basic fibroblast growth factor had good biocompatibility, and animal transplantation could significantly reduce the ventricular remodeling after myocardial infarction.

2.
Article in English | WPRIM | ID: wpr-880864

ABSTRACT

C18 ceramide plays an important role in the occurrence and development of oral squamous cell carcinoma. However, the function of ceramide synthase 1, a key enzyme in C18 ceramide synthesis, in oral squamous cell carcinoma is still unclear. The aim of our study was to investigate the relationship between ceramide synthase 1 and oral cancer. In this study, we found that the expression of ceramide synthase 1 was downregulated in oral cancer tissues and cell lines. In a mouse oral squamous cell carcinoma model induced by 4-nitroquinolin-1-oxide, ceramide synthase 1 knockout was associated with the severity of oral malignant transformation. Immunohistochemical studies showed significant upregulation of PCNA, MMP2, MMP9, and BCL2 expression and downregulation of BAX expression in the pathological hyperplastic area. In addition, ceramide synthase 1 knockdown promoted cell proliferation, migration, and invasion in vitro. Overexpression of CERS1 obtained the opposite effect. Ceramide synthase 1 knockdown caused endoplasmic reticulum stress and induced the VEGFA upregulation. Activating transcription factor 4 is responsible for ceramide synthase 1 knockdown caused VEGFA transcriptional upregulation. In addition, mild endoplasmic reticulum stress caused by ceramide synthase 1 knockdown could induce cisplatin resistance. Taken together, our study suggests that ceramide synthase 1 is downregulated in oral cancer and promotes the aggressiveness of oral squamous cell carcinoma and chemotherapeutic drug resistance.


Subject(s)
Animals , Apoptosis , Carcinoma, Squamous Cell , Cell Line, Tumor , Down-Regulation , Endoplasmic Reticulum Stress , Head and Neck Neoplasms , Mice , Mouth Neoplasms , Oxidoreductases
3.
Chinese Journal of Biotechnology ; (12): 500-512, 2021.
Article in Chinese | WPRIM | ID: wpr-878578

ABSTRACT

Metabolic syndrome is a global chronic epidemic. Its pathogenesis is determined by genetic and environmental factors. Epigenetic modification is reported to regulate gene expression without altering its nucleotide sequences. In recent years, epigenetic modification is sensitively responded to environmental signals, further affecting the gene expression and signaling transduction. Among these regulators, chromatin remodeling SWI/SNF (SWItch/Sucrose non fermentable, SWI/SNF) complex subunit Baf60a plays an important role in maintaining energy homeostasis in mammals. In this paper, we described the pathophysiological roles of Baf60a in maintaining the balance of energy metabolism, including lipid metabolism, cholesterol metabolism, urea metabolism, as well as their rhythmicity. Therefore, in-depth understanding of Baf60a-orchestrated transcriptional network of energy metabolism will provide potential therapeutic targets and reliable theoretical supports for the treatment of metabolic syndrome.


Subject(s)
Animals , Energy Metabolism/genetics , Homeostasis , Lipid Metabolism , Signal Transduction , Transcription Factors/metabolism
4.
Article in Chinese | WPRIM | ID: wpr-847640

ABSTRACT

BACKGROUND: It has been shown that compared with stem cells from other sources, umbilical cord-derived mesenchymal stem cells have lower immunogenicity, and their application has significant effect in rats with myocardial infarction. OBJECTIVE: To systematically evaluate the effects of umbilical cord-derived mesenchymal stem cells on cardiac function of rats with myocardial infarction. METHODS: PubMed, Cochrane, Embase, CBM, CNKI, WanFang, VIP and CJD databases were retrieved for the literature concerning umbilical cord-derived mesenchymal stem cells for treating rats with myocardial infarction published before June 2019. Two researchers independently completed literature screening, data extraction and methodological quality evaluation according to the inclusion criteria. Meta-analysis was conducted on Stata 14.0. RESULTS AND CONCLUSION: A total of 9 articles were included, involving 216 rats. Meta-analysis showed that: (1) Umbilical cord-derived mesenchymal stem cells significantly increased the left ventricular ejection fraction after myocardial infarction in rats [95% confidence interval (CI) (3.16, 3.76), P < 0.001]. (2) Umbilical cord-derived mesenchymal stem cells significantly increased the left ventricular short axis shortening rate after myocardial infarction in rats [95%CI (0.18, 0.54), P < 0.001]. (3) Umbilical cord-derived mesenchymal stem cells significantly shortened the left ventricular end-diastolic internal diameter [95%CI (-1.90,-0.99), P=0.042] and left ventricular end-systolic internal diameter [95%CI (-6.56,-4.65), P < 0.001]. (4) Umbilical cord-derived mesenchymal stem cells significantly improved the left ventricular end-diastolic volume [95%CI (-2.01,-1.11), P < 0.001] and left ventricular end-systolic volume [95%CI (-3.44,-2.17), P < 0.001]. In summary, umbilical cord-derived mesenchymal stem cell transplantation is effective and safe in the treatment of myocardial infarction in rats. Due to the limitation of the quality of the included literature, the above conclusions need to be validated by high-quality and large-sample randomized controlled trials.

5.
Article in Chinese | WPRIM | ID: wpr-855869

ABSTRACT

The prescription and technology of pharmaceutical preparations are the basis for ensuring the quality and efficacy of medicines. Pharmaceutical excipients are important part of pharmaceutical preparations. As it's known to all that some pharmaceutical excipients can affect the activity of CYP3A, and then may influence the metabolism and bioavailability of its substrates in vivo. Relative bioavailability is a key element of generic drug research in China and the United States. Our country is advancing the quality and efficacy consistency evaluation of generic drugs. Therefore, it is of great practical significance to understand the impact of pharmaceutical excipients on CYP3A and its guiding role in consistency evaluation.

6.
Article in Chinese | WPRIM | ID: wpr-743724

ABSTRACT

Objective: To evaluate the color effect of esthetic rehabilitation of anterior teeth restored with the minimal and no-preparation veneers and to analyze the influence factors of satisfaction. Methods: 30 patients were divided into group A (9 patients with tetracycline discoloured teeth treated with 72 veneers) and group B (21 patients with non-tetracycline teeth treated with 66 veneers) . All the selected teeth were restored with the minimal and non-preparation veneers. Before the teeth were prepared and after veneers were cemented, Olympus Crystaleye was employed to obtain L*, a*, b*values of each tooth. The shade was selected according to the patients' expectation and dentist's advice. The color difference (ΔE) before and after restoration of group A and group B, the color difference (ΔE1) between the tooth color after restoration and the expectation color of the patients, the relationship of the satisfaction degree and the color difference (ΔE1), the lightness difference (ΔL*), Δa*and Δb*were analyzed by SPSS 20. 0. Results: After cemented, the color of teeth-veneer-complex obviously improved in both groups. The color difference (ΔE1) between the tooth color before and after restoration, and the expected color between the 2 group was significant (P < 0. 05) . ΔE1, ΔL*, Δa*had great influence on the satisfaction of dentists and patients (P < 0. 05) . Conclusion: The appearance of non-tetracycline teeth restored with the minimal and no-preparation veneers was excellent. The more of the color of the teeth-veneer-complex matched the expectation color, the higher the patients are satisfied with the restorations. The less of the lightness difference, the higher the patients are satisfied with the restorations.

7.
Chinese Journal of Rheumatology ; (12): 449-453,封3, 2019.
Article in Chinese | WPRIM | ID: wpr-754912

ABSTRACT

Objective To analyze the clinicopathological features and prognosis of immunoglobulin G (IgG)4-related diseases with interstitial nephritis. Methods Forty cases of IgG4-related diseases diagnosed by pathology in our hospital from 2014 to 2018 were collected and their clinicopathological features were analyzed. Four patients with IgG4-related disease with interstitial nephritis were analyzed, including clinical laboratory tests and histopathological features, and immunohistochemical analysis of the type and proportion of renal interstitial infiltrating cells. At the same time, the treatment and prognosis of the patients were analyzed. Results Among 40 cases of IgG4-related diseases, 11 cases had parotid submandibular gland involvement (accounted for 28%), labial gland involvement (7 cases, 18%) and lymph node enlargement (6 cases, 15%). Patients with kidney involvement (4 cases, 10%) all presented with IgG4-related tubulo-interstitial nephritis (IgG4-TIN). All of them were elderly males, and 2 had glomerulopathy. One of them had anti-neutrophil cytoplasmic antibodies (ANCA)-related vasculitis renal damage. The number of CD4-positive cells in renal interstitium was more than CD8-positive cells. Another case complicated with IgA nephropathy. Renal dysfunction occurred in all 4 cases, and serum IgG4 level ranged from 4.65 g/L to 23.8 g/L. All 4 patients received glucocorticosteroid and symptomatic treatment, and the prognosis was good. Conclusion IgG4-related diseases may involve mul-tiple organs, renal dysfunction may occur when the kidney is involved. Interstitial nephritis is the major clinical manifestation. Glomerular lesions may accelerate the progress of IgG4-TIN. Corticosteroid therapy is effective.

8.
Chinese Journal of Stomatology ; (12): 209-213, 2019.
Article in Chinese | WPRIM | ID: wpr-804816

ABSTRACT

Insufficient bone quantity in the posterior region of the maxilla is one of the difficulties for dental implant placement. Maxillary sinus augmentation is considered to be a reliable treatment to solve the problem of insufficient bone quantity. With the increase of researches on maxillary sinus elevation, the debate over osteogenesis potential of Schneiderian membrane is getting more attention. Therefore, this article will review the current research on osteogenic potential of the Schneiderian membrane and its influence factors.

9.
Chinese Journal of Epidemiology ; (12): 1461-1469, 2019.
Article in Chinese | WPRIM | ID: wpr-801166

ABSTRACT

Objective@#The aim of the present study was to investigate the survival rate and its prognostic factors for patients with biliary tract cancer, and then a prognostic risk prediction model was constructed to predict the survival probability of patients.@*Methods@#A total of 14 005 patients with biliary tract cancer (including gallbladder cancer, extrahepatic bile duct cancer, and ampulla of Vater cancer), who were diagnosed between 2010 and 2015 in the US National Cancer Institute Surveillance, Epidemiology, and End Results Program (SEER) were included in the development cohort. The prognostic risk factors of biliary tract cancer were investigated using multivariate Cox regression models. The predictive nomograms were then constructed to predict the overall survival probability of 1, 3, and 5 years, and the predictive discrimination and calibration ability of the nomograms were further evaluated. Meanwhile, 11 953 patients who were diagnosed during 2004 to 2009 from SEER Program were then selected to validate the external predictive accuracy of the prediction models.@*Results@#The 1, 3 and 5-year cumulative survival rates of patients with biliary tract cancer were 41.9%, 20.4% and 15.3%, respectively, in the development cohort. Age greater than 50 years, African Americans and Native Americans and Alaska Natives, higher T, N and M stage and poor histological differentiation grade were risk factors for death, while married status, Asia-Pacific Islanders, insured status and surgery on primary site were protective factors. Gender was not significantly associated with the overall survival. The C statistic of the prediction model was 0.73 (95%CI: 0.72-0.74), and the calibration curve showed that the interaction curves of predictive and actual survival rates of 1, 3 and 5 years were close to the 45 degree diagonal. Results in the validation cohort were similar with those in the construction cohort, with a C statistic of 0.70 (95%CI: 0.69-0.72), indicating high external applicability of the prediction model. Findings from gallbladder cancer, extrahepatic bile duct cancer, and ampulla of Vater cancer are in consistent with the overall biliary tract cancer.@*Conclusions@#The survival rate of patients with biliary tract cancer is relatively poor, and the survival prediction model based on prognostic factors has high prediction accuracy. In the future, this prognostic prediction model could be applied to clinical practice to guide individualized treatment for patients with biliary tract cancer.

10.
Article in Chinese | WPRIM | ID: wpr-734951

ABSTRACT

Objective To investigate maternal awareness and knowledge of obstructive sleep apnea syndrome (OSAS) and their compliance with polysomnography monitoring in snoring gravidas.Methods This study enrolled 589 volunteered gravidas who were treated at the 908th Hospital of Chinese People's Liberation Army Joint Logistic Support Force or Maternal and Child Health Hospital of Jiangxi Province from April 2016 to April 2017.The maternal knowledge of OSAS (0 point:complete lack of knowledge of OSAS;1 to 4 points:with partial knowledge of OSAS;5 points:correct understanding of OSAS) and the way of obtaining this knowledge were studied using a self-designed questionnaire.Influencing factors,including gestational weeks,educational background,snoring and high-risk pregnancy,were also analyzed.Chi-square test was used for statistical analysis.Results The 589 gravidas had few knowledge of OSAS and only 11 of them [1.9% (11/589)] were able to fully understand OSAS (5 points).The proportion of women who were completely lack the knowledge of OSAS (0 point) in those less-educated women was higher than in those well-educated group [61.9% (78/126) vs 52.0% (241/463),x2=3.873,P=0.049].Among the gravidas who were unaware of their snoring condition,those completely lack the knowledge of OSAS (0 point) accounted for 67.0% (209/312),which was higher than the percentage among gravidas knowing they had or did not have snoring problem [35.6% (21/59),40.8% (89/218);x2=20.755,35.687;both P<0.017].There was no significant difference in OSAS awareness among gravidas regardless of their gestations and whether they were classified as high-risk or not (all P>0.05).Of 59 gravidas with snoring,only 15 (25.4%) accepted polysomnography monitoring.Eight out of the 589 gravidas (1.4%) were diagnosed with OSAS during pregnancy.Conclusions Gravidas have poor knowledge and awareness of OSAS,especially those with low educational background and not knowing their snoring condition,resulting in poor compliance with polysornnography monitoring and low diagnostic rate of OSAS during pregnancy.

11.
Article in Chinese | WPRIM | ID: wpr-710083

ABSTRACT

Objective To investigate the prevalence and risk factors of diabetes and prediabetes in Jingyuan County in Ningxia. Methods A cross-sectional survey including 10 639 participants (18-88 years of age) with a multistage sampling was conducted in Jingyuan County between January, 2014 and April, 2015. Questionnaires, physical examinations, and laboratory tests were included in the survey. Results Among all the subjects, 10 491 participants (men: 4 826, women: 5 665) with complete data were included in the analysis. The standardized prevalence of diabetes and prediabetes was 4.2% (men: 3.9%, women: 4.5%) and 8.8% (men: 7.6%, women 10.3%), respectively, in which the standardized prevalence of diabetes was higher in Hui (4.5%) than that in Han (3.5%) (P<0.05). Logistic regression analyses showed that age, family history of diabetes, overweight/obesity, hypertriglyceridemia and hypertension were positively associated with prediabetes and diabetes with the odds ratios being 1.60 and 2.14 (age, P<0.001), 1.40 and 3.32 (family history, P< 0.05), 1.47 and 1.57 (overweight/obesity, P< 0.001), 1.88 and 2.55 (hypertriglyceridemia, P<0.001), 1.44 and 1.89 (hypertension, P<0.001), respectively. Conclusions The prevalence of diabetes was relatively low in the rural area in Ningxia. However, it is still essential to take active interventions in people at high risk of diabetes in order to prevent the incident diabetes.

12.
Article in Chinese | WPRIM | ID: wpr-660243

ABSTRACT

Objective To compare the difference of simple-rapid identification method and automatic biochemical identification method in the identification of Escherichia coli .Methods The strains of Escherichia coli isolated from clinical samples were identi-fied by the simple-rapid method and automatic biochemical method .The consistency of result and the time of two methods were compared .Results Among 492 suspected strains ,248 strains were identified as Escherichia coli by simple-rapid method ,and other 244 strains were not .Meanwhile ,231 strains of these 248 Escherichia coli strains and 7 strains of 244 non Escherichia coli strains were identified as Escherichia coli by automatic biochemical method .The positive and negative predictive value of simple-rapid method were 93 .1% (231/248) and 97 .1% (237/244) .2 .5-7 .0 h [average(4 .12 ± 1 .08) h] were used to identify Escherichia coli by automatic biochemical method while0 .5-2 .0 h[average(1 .08 ± 0 .45) h] were used by simple-rapid method ,the difference was statistically significant(t= -40 .252 ,P<0 .001) .Conclusion The result of simple-rapid method is close to that of automatic bio-chemical identification method on Escherichia coli ,and simple-rapid method used less time .

13.
Article in Chinese | WPRIM | ID: wpr-611832

ABSTRACT

Based on melamine-Cu conjugate and subsequent interruption of formation of polythymine (Poly T)-templated copper nanoclusters (CuNCs), a novel fluorescent strategy was developed for detection of melamine.The method relied on the principle that the coordination of melamine to copper would be unfavorable for the reduction of Cu2+ in the poly T-CuNCs synthesis process, and thereby resulting in the decrease of fluorescence intensity of CuNCs.By this method, the fluorescence response of CuNCs displayed an linear relationship with melamine concentration in the range from 5 μmol/L to 120 μmol/L.The detection limit was 1.5 μmol/L.Furthermore, the assay was successfully applied in the detection of melamine in milk samples with good recoveries.

14.
Article in Chinese | WPRIM | ID: wpr-662538

ABSTRACT

Objective To compare the difference of simple-rapid identification method and automatic biochemical identification method in the identification of Escherichia coli .Methods The strains of Escherichia coli isolated from clinical samples were identi-fied by the simple-rapid method and automatic biochemical method .The consistency of result and the time of two methods were compared .Results Among 492 suspected strains ,248 strains were identified as Escherichia coli by simple-rapid method ,and other 244 strains were not .Meanwhile ,231 strains of these 248 Escherichia coli strains and 7 strains of 244 non Escherichia coli strains were identified as Escherichia coli by automatic biochemical method .The positive and negative predictive value of simple-rapid method were 93 .1% (231/248) and 97 .1% (237/244) .2 .5-7 .0 h [average(4 .12 ± 1 .08) h] were used to identify Escherichia coli by automatic biochemical method while0 .5-2 .0 h[average(1 .08 ± 0 .45) h] were used by simple-rapid method ,the difference was statistically significant(t= -40 .252 ,P<0 .001) .Conclusion The result of simple-rapid method is close to that of automatic bio-chemical identification method on Escherichia coli ,and simple-rapid method used less time .

15.
Article in Chinese | WPRIM | ID: wpr-607309

ABSTRACT

Professor TANG Wei-yong's treatment for children acute tonsillitisis from the three aspects oftreating symptoms, treating muscle and reconciliation, namely three-solution method. In addition, he modified three ancient prescriptions to create three-solution prescription. He applied the prescription into clinical practice and obtained a lot of good efficacy.

16.
Article in English | WPRIM | ID: wpr-72756

ABSTRACT

This retrospective case-control study explored the factors associated with anaphylactic shock during surgery for cystic echinococcosis (CE) at the First Affiliated Hospital of Xinjiang Medical University between October 2008 and September 2013. Patients who suffered from anaphylactic shock (n=16) were age-matched 3:1 to patients who did not (n=43). Multivariate analysis suggested that IL-4 levels (odds ratio=1.096; 95% confidence interval=1.015–1.185; P=0.02) and cyst size (odds ratio=3.028, 95% confidence interval=1.259–7.283, P=0.013) were independently associated with CE-induced perioperative anaphylactic shock. Using the receiver operating characteristic (ROC) curves and a cut-off value of 415.7 ng/ml, IL-4 showed an area under the ROC (AUC) of 0.926, sensitivity of 75.0%, and specificity of 97.7%. Using a cut-off value of 7.8 cm, cyst size showed an AUC of 0.828, sensitivity of 81.3%, and specificity of 76.7%. In conclusion, results suggest that levels of IL-4 and cyst size were independently associated with echinococcosis-induced perioperative anaphylactic shock. These results could help identifying patients with echinococcosis at risk of anaphylactic shock in whom appropriate prophylaxis could be undertaken.


Subject(s)
Anaphylaxis , Area Under Curve , Case-Control Studies , Echinococcosis , Echinococcus granulosus , Humans , Interleukin-4 , Multivariate Analysis , Retrospective Studies , ROC Curve , Sensitivity and Specificity , Zoonoses
17.
Article in Chinese | WPRIM | ID: wpr-495352

ABSTRACT

miRNAs are a class of small endogenous RNAs that degrade target mRNAs or repress their translation process. Several miRNAs in glioma are up?regulated, while some others down?regulated. Some miRNAs promote tumorigenesis; some others, however, play a similar function of tumor suppressor genes. Therefore, studies on the expression profiles of miRNAs in glioma may afford auxiliary basis for early clinical diagnosis and novel srtategies for therapy of glioma. This paper will review on researches about the expression levels of miRNAs and their targets in glioma.

18.
Chinese Medical Journal ; (24): 1074-1077, 2003.
Article in English | WPRIM | ID: wpr-294167

ABSTRACT

<p><b>OBJECTIVES</b>To compare the gene expression profiles of acute promyelocytic leukemia cell line NB(4) before and after 12 hours of realgar treatment using cDNA microarray.</p><p><b>METHODS</b>Two cDNA probes were prepared through reverse transcription from mRNA of both untreated and realgar treated NB(4) cells. The probes were labeled with Cy3 and Cy5 fluorescence dyes individually, hybridized with cDNA microarray representing 1003 different human genes, and scanned for fluorescent intensity. The genes were screened through the analysis of the difference in two gene expression profiles.</p><p><b>RESULTS</b>The analysis of gene expression profiles indicates that 9 genes were up-regulated and 37 genes were down-regulated. Among the 9 up-regulated genes, 2 genes were involved in a proteasome degradation pathway. Some genes related to protein synthesis, signal transduction and cell receptors were down-regulated.</p><p><b>CONCLUSION</b>PSMC2 and PSMD1 genes may play an important role in the apoptosis and partial differentiation of NB(4) cells.</p>


Subject(s)
Arsenicals , Pharmacology , Down-Regulation , Gene Expression , Humans , Leukemia, Promyelocytic, Acute , Genetics , Oligonucleotide Array Sequence Analysis , Sulfides , Pharmacology , Tumor Cells, Cultured , Up-Regulation
19.
Article in Chinese | WPRIM | ID: wpr-540596

ABSTRACT

Objective To determine the association between fatty liver and coronary risk fcators in elderly men. Methods A cross-sectional study of 920 elderly men with or without fatty liver and obesity was performed in 2002. Age, body mass index (BMI), GPT, cholesterol, triglyceridemia, fast glucose, mean blood pressure, smoking and drinking consumption were analyzed. Results The prevalence of fatty liver was 11.1% in the non-obese participants (BMI

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