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1.
Article in Korean | WPRIM | ID: wpr-875105

ABSTRACT

Purpose@#This study was conducted to develop a behavior program for reducing exposure to endocrine disrupting chemicals (EDCs), thereby to improve perceived benefits and self-efficacy as well as reduce the perceived barriers and prevalence of dysmenorrhea in unmarried women. @*Methods@#The study used a nonequivalent control group pretest-posttest design. Participants were randomly assigned to an experiment (n=18) or control group (n=18). The behavior program for reducing exposure to EDCs was developed based on Pender's health promotion model and previous research results. The program was conducted for 12 weeks, consisting of 4 weeks of face-to-face intervention and 8 weeks of mobile intervention. @*Results@#The behavior program we developed was verified as an effective intervention that could improve the perceived benefits and self-efficacy of reducing one's exposure to EDCs. It also decreases the perceived barriers and prevalence of dysmenorrhea in unmarried women. @*Conclusion@#Our results showed that the program was an effective nursing intervention in unmarried women. Therefore, this behavior program for reducing exposure to EDCs can be applied in the context of unmarried women.

2.
Article | WPRIM | ID: wpr-835832

ABSTRACT

Purpose@#The purpose of this study was to test the mediating effects of resilience in the relationship between role conflict and burnout in physician assistant nurses. @*Methods@#Participants were 144 physician assistant nurses recruited from 2 university hospitals. A questionnaire scale was used to collect the data. Data were analyzed using descriptive statistics, independent t-test, one-way ANOVA, Pearson correlation analysis. and liner regression analysis. @*Results@#There were significant positive relationships for burnout and role conflict (r=.45, p<.001), and a negative correlation with resilience (r=-.47, p<.001). There was a negative correlation (r=-.30, p<.001) between role conflict and resilience. In addition, resilience partial mediates role conflict and burnout. As a result of testing the significance of mediating effect using bootstrapping, the mediating effect was significant by resilience ((y=.11, p=.008). @*Conclusion@#In this study, role conflict and burnout of physician assistant nurses were the factors that had an impact on each other and resilience had a partial mediating effect in the relationship between role conflict and burnout. The results of this study can be used as basic data for establishing management plans on role conflict and burnout by improving the resilience of physician assistant nurses.

3.
Asian Oncology Nursing ; : 123-131, 2020.
Article | WPRIM | ID: wpr-830809

ABSTRACT

Purpose@#This study aimed to examine the effects of knowledge of Human Papilloma Virus (HPV) and health beliefs related to HPV vaccination on the intention of cervical cancer prevention behavior in Nurses. @*Methods@#Data were collected by conducting a survey of 222 nurses at a single tertiary hospital in J city from September 26 to October 02, 2019. The data were analyzed in SPSS WIN version 23.0 using descriptive statistics, t-test, ANOVA, Pearson’s correlation coefficient and Multiple linear regression. @*Results@#The mean score for HPV knowledge was 7.98. Regarding health beliefs about HPV vaccination, the mean score for the level of perceived benefit was 3.08, and for perceived sensitivity was 2.09. The factors influencing the intention of cervical cancer prevention behavior were perceived benefits, severity, contraception, clinical career, and experience with HPV testing. @*Conclusion@#The results of the study indicate that it is necessary to develop and apply education programs that enhance cervical cancer and HPV knowledge. Health beliefs related to HPV vaccination should be integrated when developing nursing intervention to improve the intention of cervical cancer prevention behavior in nurses.

4.
Immune Network ; : 43-2019.
Article in English | WPRIM | ID: wpr-785818

ABSTRACT

A full-length translational product of the trophinin gene, KIAA1114, is a distinctive marker of cancer stem cells in human hepatocellular carcinoma, and a mAb, Kiatomab, is specific to KIAA1114 antigen. In this study, we addressed the therapeutic potential of Kiatomab for treating both metastatic and solid tumors in mouse models. Kiatomab recognizes the linear epitope of KIAA1114, which is expressed on cell surfaces of various murine cancer cell lines. Kiatomab treatment induced potent antitumor responses in pulmonary metastasis models. Antitumor activity was mediated by the fragment crystallizable portion of Kiatomab and dependent on the host immune system. The use of Kiatomab alone as an antitumor therapy was ineffective in solid tumor models. However, in combination with cyclophosphamide, or by switching the isotype of the mAb, improved antitumor effects of Kiatomab were observed. These results suggest that Kiatomab can be used as a novel mAb for cancer immunotherapy.


Subject(s)
Animals , Carcinoma, Hepatocellular , Cell Line , Cyclophosphamide , Humans , Immune System , Immunotherapy , Mice , Neoplasm Metastasis , Neoplastic Stem Cells
6.
Article in Korean | WPRIM | ID: wpr-758553

ABSTRACT

PURPOSE: The purpose of this study was to identify the relationships among nutritional supplement intake, subjective health status, health control level and health promotion behaviors and to investigate factors affecting health promotion behaviors in pregnant women. METHODS: A total of 153 pregnant women was recruited from a university hospital in J city in Korea. Data were collected using self-reported questionnaires. RESULTS: Most participants (91.5%) took nutritional supplements. Health promotion behavior had positive correlations with subjective health status (r=0.313, p < 0.001), internal control (r=0.229, p=0.004), powerful others locus of control (r=0.162, p=0.046), and doctors locus of control (r=0.215, p=0.008). There was a negative correlation between health promotion behavior and chance locus of control (r=−0.273, p=0.001). Health status (β=0.25, p=0.001), chance locus of control (β=−0.28, p < 0.001), doctors locus of control (β=0.20, p=0.009), and powerful others locus of control (β=0.16, p=0.033) were significant predictors for health promotion behavior. These variables explained 25.8% of the variance in health promotion behavior. CONCLUSION: The study results indicate that it is necessary to develop a nutrition education program and nursing intervention in order to promote health for pregnant women.


Subject(s)
Diagnostic Self Evaluation , Education , Female , Health Promotion , Humans , Internal-External Control , Korea , Nursing , Pregnant Women
7.
Article in Korean | WPRIM | ID: wpr-760376

ABSTRACT

PURPOSE: This study was conducted to develop an empowering education program for Maternal-Fetal Intensive Care Unit (MFICU) nurses who provide intensive care to high-risk mother and fetus at hospitals, to test effects of the education program on nursing care confidence and nursing knowledge, and to examine program satisfaction. METHODS: This study comprised of 2 phases: program development and evaluation. First, we have followed a process of program development to develop and refine an empowering education program for MFICU nurses through collaborative works among clinical obstetrics and gynecology doctors and nurses and academic nursing professors. Second, the empowering education program was provided to 49 nurses and evaluated from July 5 to 6, 2019. Levels of MFICU nursing care confidence and knowledge were measured. RESULTS: The empowering education program included 18 hours of lectures, discussion, and Q & A, which continued for 2 days. This program significantly improved high-risk maternal-fetal nursing care confidence and knowledge of nurses. The program was well met with nurses' education need and goals, and found to be highly satisfactory. CONCLUSION: The empowering education program was observed to be effective in terms of improve nursing care confidence and knowledge of nurses in MFICU. It is proposed that this program should be open regularly for nurses to obtain and improve their clinical knowledge, confidence, and competency. Further study is needed to develop and run 2-levels of education such as basic and advanced levels based on nurses' clinical background and competency.


Subject(s)
Critical Care , Education , Fetus , Gynecology , Humans , Intensive Care Units , Lecture , Mothers , Nursing , Nursing Care , Obstetrics , Pregnancy, High-Risk , Program Development
8.
Article in English | WPRIM | ID: wpr-728020

ABSTRACT

The authors note that on page 685, the acknowledgement of “This study was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (No. 2017R1D1A1B03031920),” should instead appear as “This study was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (No. 2017R1D1A1B03031920) and Chung-Ang University Research Grants in 2017.”

9.
Article in English | WPRIM | ID: wpr-786378

ABSTRACT

PURPOSE: The study aimed to examine the effects of sleep pattern, stress, and attitude towards menstruation, and behavior that causes a reduction in exposure to endocrine disrupting chemicals (EDCs) in the course of premenstrual syndrome (PMS) in female adolescents.METHOD: In total, 200 girls attending middle school in K city were recruited via convenience sampling between December 11 and 31, 2018, and 192 subjects were selected for the analysis. Data were analyzed using descriptive statistics, an independent t-test, ANOVA, Pearson's correlation coefficient, and multiple regression.RESULTS: Overall, 9 (4.7%), 152 (79.2%), and 31 (16.1%) students had morning-, intermediate-, and evening-type sleep pattern, respectively. The mean scores for school-related stress were highest. Scores for stress regarding relationships with friends were the lowest. The mean score for attitudes toward menstruation was 72.33 out of 147. The mean score for behavior that led to a reduction in EDCs exposure was 56.57 out of 85. The mean scores for PMS severity were 25.30 and 38.39 out of 60. Analysis of factors affecting PMS revealed that severity of menstrual pain (β=.28), use of analgesics during menstruation (β=.17), family history of PMS (β=−.16), stress (β=.19), and behavior that reduces EDCs exposure (β=−.17) exerted significant effects on PMS. The explanatory power of these variables was 37%.CONCLUSION: The findings propose the necessity of a health intervention program including educational information, which can reduce PMS in adolescents, induce the behaviors which can decrease exposure to EDCs, and activities for managing the stress levels.


Subject(s)
Adolescent , Analgesics , Dysmenorrhea , Endocrine Disruptors , Female , Friends , Humans , Menstruation , Methods , Premenstrual Syndrome
10.
Article in English | WPRIM | ID: wpr-741544

ABSTRACT

BACKGROUND: Fibrous dysplasia (FD) is characterized by the replacement of normal bone by abnormal fibro-osseous connective tissue and typically treated with surgical contouring of the dysplastic bone. When dysplastic lesions involve occlusion, not only is surgical debulking needed, orthognathic surgery for correction of dentofacial deformity is mandatory. However, the long-term stability of osteotomized, dysplastic bone segments is a major concern because of insufficient screw-to-bone engagement during surgery and the risk of FD lesion re-growth. CASE PRESENTATION: This case report reviewed two patients with non-syndromic FD that presented with maxillary occlusal canting and facial asymmetry. Le Fort I osteotomy with recontouring of the dysplastic zygomaticomaxillary region had been performed. The stability of osseous segments were favorable. However, dysplastic, newly formed bone covered the previous plate fixation site and mild bony expansion was observed, which did not influence the facial profile. Including the current cases, 15 cases of orthognathic surgery for FD with dentition have been reported in the literature. CONCLUSION: The results showed that osteotomy did not appear to significantly reduce the long-term stability of the initial fixation insufficiency of the screw to the dysplastic bone. However, based on our results and those of the others, long-term follow-up and monitoring are needed, even in cases where the osteotomized segment shows stable results.


Subject(s)
Connective Tissue , Dentition , Dentofacial Deformities , Facial Asymmetry , Follow-Up Studies , Humans , Orthognathic Surgery , Osteotomy
11.
Article in Korean | WPRIM | ID: wpr-760076

ABSTRACT

BACKGROUND AND OBJECTIVES: Diagnostic features of peritonsillar abscess are an asymmetrically enlarged palatine tonsil with peripheral rim enhancement and central low density in the post-contrast computed tomography (CT). Although it is necessary to differentiate tumorous conditions of tonsils to compare pre- and post-contrast CT, pre-contrast CT may be less useful in the diagnosis of peritonsillar abscess. This study aims to evaluate of the efficacy of single post-contrast CT for diagnosis and treatment of peritonsillar abscess. SUBJECTS AND METHOD: We retrospectively compared 29 patients with peritonsillar abscess, who were diagnosed by single post-contrast CT, with 36 patients diagnosed by pre- and post-contrast CT to determine the success rates of pus drainage and hospital days. Additionally, two otorhinolaryngologists made a judgment of abscess presence for sixty randomly mixed CT images of peritonsillar abscess or tonsillitis with pre- and post-contrast CT or single post-contrast CT. RESULTS: There were no significant differences in the success rate of drainage (p=0.622) and hospital days (p=0.504) between groups with/without pre-contrast CT. Abscess presence was judged by raters with/without pre-contrast CT. Inter-rater agreement value (Cohen's kappa) was 0.825 (p<0.01). CONCLUSION: Single post-contrast CT of peritonsillar abscess may be a good alternative for diagnosis and treatment and may reduce unnecessary exposure to radiation.


Subject(s)
Abscess , Contrast Media , Diagnosis , Drainage , Humans , Judgment , Methods , Palatine Tonsil , Peritonsillar Abscess , Retrospective Studies , Sensitivity and Specificity , Suppuration , Tonsillitis
12.
Article in English | WPRIM | ID: wpr-727857

ABSTRACT

Autism spectrum disorders (ASDs) are neurodevelopmental disorders that share behavioral features, the results of numerous studies have suggested that the underlying causes of ASDs are multifactorial. Behavioral and/or neurobiological analyses of ASDs have been performed extensively using a valid model of prenatal exposure to valproic acid (VPA). Abnormal synapse formation resulting from altered neurite outgrowth in neural progenitor cells (NPCs) during embryonic brain development has been observed in both the VPA model and ASD subjects. Although several mechanisms have been suggested, the actual mechanism underlying enhanced neurite outgrowth remains unclear. In this study, we found that VPA enhanced the expression of brain-derived neurotrophic factor (BDNF), particularly mature BDNF (mBDNF), through dual mechanisms. VPA increased the mRNA and protein expression of BDNF by suppressing the nuclear expression of methyl-CpG-binding protein 2 (MeCP2), which is a transcriptional repressor of BDNF. In addition, VPA promoted the expression and activity of the tissue plasminogen activator (tPA), which induces BDNF maturation through proteolytic cleavage. Trichostatin A and sodium butyrate also enhanced tPA activity, but tPA activity was not induced by valpromide, which is a VPA analog that does not induce histone acetylation, indicating that histone acetylation activity was required for tPA regulation. VPA-mediated regulation of BDNF, MeCP2, and tPA was not observed in astrocytes or neurons. Therefore, these results suggested that VPA-induced mBDNF upregulation was associated with the dysregulation of MeCP2 and tPA in developing cortical NPCs.


Subject(s)
Acetylation , Astrocytes , Autism Spectrum Disorder , Brain , Brain-Derived Neurotrophic Factor , Butyric Acid , Histones , Methyl-CpG-Binding Protein 2 , Neurites , Neurodevelopmental Disorders , Neurons , RNA, Messenger , Stem Cells , Synapses , Tissue Plasminogen Activator , Up-Regulation , Valproic Acid
13.
Article in Korean | WPRIM | ID: wpr-717152

ABSTRACT

PURPOSE: The purpose of this study was to investigate the status of use of menstrual hygiene products and genital organ hygiene management in unmarried women. METHODS: Data from 161 unmarried women were used for analysis. The instruments consisted of self-reported questionnaires that included 40 items: 20 on General Characteristics & Sexual Health Related Characteristics, 8 on Using Status of Menstrual Hygiene Products, 12 on Genital Organ Hygiene Management. RESULTS: The subjects used disposable sanitary napkin as the most frequently but the satisfaction was low, while the use of reusable sanitary napkin and tampons were few, but satisfaction was high. Sixty-seven percent of the unmarried women had sex experience, and more than 60% experienced abnormal symptoms in the genital organ. There was a significant difference in genital organ hygiene management according to sex experience. Among subjects of this study, 44.1% wanted to use menstrual cup, and 98.8% wanted to have education for their menstrual hygiene products. CONCLUSION: Based on results of this study, a nationwide survey of the demand for menstrual hygiene products used by Korean women is needed, it is necessary to educate about the proper use of menstrual hygiene products and genital organ hygiene management.


Subject(s)
Education , Female , Genitalia , Humans , Hygiene , Menstrual Hygiene Products , Menstruation , Reproductive Health , Single Person
14.
Article in Korean | WPRIM | ID: wpr-717002

ABSTRACT

PURPOSE: To develop Pregnancy Risk symptom Perception Scale (PRPS) and evaluate its validity and reliability. METHODS: A preliminary 30-item version of PRPS was developed through literature review, in-depth interview, and Content Validity. Each item was scored on a four-point Likert scale. The preliminary scale was developed based on 301 pregnant women who visited a hospital. Date were analyzed using item analysis, factor analysis, confirmatory factor analysis, Pearson's correlation coefficients, and Cronbach's α (0.90 for total item, 0.80 to 0.88 for factors). RESULTS: The PRPS consisted of 27 items. Three factors (physical, environmental, and emotional factors) explained 55% of the total variance. Cronbach's Criterion validity was supported by comparison with the Perception of Pregnancy Risk Questionnaire (r=0.34). In reliability test, the reliability coefficient of pregnancy risk symptom perception was high at 0.90. CONCLUSION: These results suggest that the pregnancy risk symptom perception scale developed in this study comprises items that can assess the level of pregnant women's pregnancy risk symptom perception in Korea. Its validity and reliability were proven. PRPS can be utilized to measure pregnant women's risk symptom perception during pregnancy. PRPS will contribute to the development of systematic prenatal care and effective risk management.


Subject(s)
Female , Humans , Korea , Pregnancy , Pregnant Women , Prenatal Care , Reproducibility of Results , Risk Management
15.
Article in English | WPRIM | ID: wpr-787111

ABSTRACT

BACKGROUND: Brain volume is associated with dementia and depression in the elderly. An easy way to predict relative brain volume is to measure head circumference. In this study, we investigated the relationship between head circumference and cognition as well as depression in a non-demented elderly community.METHODS: Baseline and follow-up surveys were conducted in 2007 and 2010. At baseline, community residents aged 65 years or over (n=382) within a rural area of South Korea were screened for dementia and symptoms of depression and were followed using the same screening battery after 3 years (n=279). Data from anthropometric measurements (head circumference, height, and body weight), demographics, and blood tests were gathered. Neuropsychological tests, including the Korean version of mini-mental state examination (K-MMSE), clinical dementia rating (CDR) including the CDR-sum of boxes, the Korean version of instrumental activities of daily living, and geriatric depression scale (GDS), were performed. None of the 279 subjects followed were demented.RESULTS: Baseline performance on the K-MMSE and GDS was poorer for participants with smaller head circumferences. Follow-up performance on the MMSE was also poorer for participants with smaller head circumferences. Interestingly, participants with smaller head circumference showed worse GDS scores at baseline but on follow-up examination, participants with larger head circumference showed rapid worsening than those with smaller head circumference with marginal significance by ANOVA test. In regression coefficient analysis, GDS decline showed significant difference.CONCLUSION: Head circumference was not associated with cognitive change but was associated with symptoms of depression in non-demented community residents.


Subject(s)
Activities of Daily Living , Aged , Brain , Cognition , Dementia , Demography , Depression , Follow-Up Studies , Head , Hematologic Tests , Humans , Korea , Mass Screening , Neuropsychological Tests , Prospective Studies
16.
Journal of Rhinology ; : 74-80, 2017.
Article in English | WPRIM | ID: wpr-123306

ABSTRACT

BACKGROUND AND OBJECTIVES: Recently, the swinging door and grafting techniques have been heavily used for straightening and holding the caudal septum. However, reconstructive septoplasties require more extensive dissection of septal structures. Extensive anatomical dissection and complicated procedures may affect the probability of postoperative bleeding and infection. MATERIALS AND METHOD: We retrospectively reviewed the records of 141 consecutive patients who underwent septal surgeries from February 2013 to December 2015. The patients were classified into two groups according to surgical technique: those who underwent submucous resection with or without endoscopy were classified as the “resection” group, while those who underwent the swinging door or batten graft technique were classified as the “reconstruction” group. The resection and reconstruction groups were matched using the propensity score. The incidence of postoperative septal abscesses (PSAs) was analyzed between the two groups. RESULTS: For the two groups, 36 patients were matched with 36 patients (1:1) using the propensity score. Of the 72 patients, PSAs developed in 5 patients (6.9%). One patient was in the resection group (2.8%), while the other four patients were in the reconstruction group (11.1%). However, the incidence of PSAs was not significantly higher in the reconstruction group according to Fisher's exact test (p=0.164). CONCLUSION: Reconstructive septoplasty resulted in more septal abscesses than resection, but the difference was not significant.


Subject(s)
Abscess , Endoscopy , Hemorrhage , Humans , Incidence , Methods , Nasal Septum , Postoperative Complications , Propensity Score , Retrospective Studies , Transplants , Wound Infection
17.
Article in Korean | WPRIM | ID: wpr-39223

ABSTRACT

We found an error in this article.

18.
Article in English | WPRIM | ID: wpr-147784

ABSTRACT

A 21-year-old woman presented with facial asymmetry. Crepitus and clicking of the temporomandibular joint were noted. The midline deviated 5.5 mm to the left, and secondary malocclusion was observed. Panoramic and cone-beam computed tomographic images showed an irregular and exophytic bony mass on the anteromedial surface of the right mandibular condyle. A 3-phase bone scan revealed increased tracer uptake on the affected side. The lesion was treated with excision and reshaping under the diagnosis of osteochondroma confirmed by a histopathological examination. The lesion recurred after 3 years, and the patient underwent condylectomy. Mandibular condylar osteochondroma is often resected because it causes functional and aesthetic problems, but it rarely recurs. To the best of our knowledge, only 2 cases of recurrent osteochondromas of the mandibular condyle have been reported previously. Surgical treatment of the osteochondroma should be performed considering the possibility of recurrence, and long-term follow-up is recommended.


Subject(s)
Diagnosis , Facial Asymmetry , Female , Follow-Up Studies , Humans , Malocclusion , Mandibular Condyle , Osteochondroma , Recurrence , Temporomandibular Joint , Young Adult
19.
Article in Korean | WPRIM | ID: wpr-23877

ABSTRACT

PURPOSE: This study was done to clarify attributes, antecedents, and consequences of spirituality. METHODS: Rodgers's evolutionary concept analysis was used to analyze fifty seven studies from the literature related to spirituality as it appears in systematic literature reviews of theology, medicine, counseling & psychology, social welfare, and nursing. RESULTS: Spirituality was found to consist of two dimensions and eight attributes: 1) vertical dimension: ‘intimacy and connectedness with God’ and ‘holy life and belief’, 2) horizontal dimension: ‘self-transcendence’, ‘meaning and purpose in life’, ‘self-integration’, and ‘self-creativity’ in relationship with self, ‘connectedness’ and ‘trust’ in relationship with others·neighbors·nature. Antecedents of spirituality were socio-demographic, religious, psychological, and health related characteristics. Consequences of spirituality were positive and negative. Being positive included ‘life centered on God’ in vertical dimension, and among horizontal dimension ‘joy’, ‘hope’, ‘wellness’, ‘inner peace’, and ‘self-actualization’ in relationship with self, ‘doing in love’ and ‘extended life toward neighbors and the world’ in relationship with others·neighbors·nature. Being negative was defined as having ‘guilt’, ‘inner conflict’, ‘loneliness’, and ‘spiritual distress’. Facilitators of spirituality were stressful life events and experiences. CONCLUSION: Spirituality is a multidimensional concept. Unchangeable attributes of spirituality are ‘connectedness with God’, ‘self-transcendence’, ‘meaning of life’ and ‘connectedness with others·nature’. Unchangeable consequences of spirituality are ‘joy’ and ‘hope’. The findings suggest that the dimensional framework of spirituality can be used to assess the current spiritual state of patients. Based on these results, the development of a Korean version of the scale measuring spirituality is recommended.


Subject(s)
Counseling , Humans , Nursing , Psychology, Social , Spirituality , Theology , Vertical Dimension
20.
Article in Korean | WPRIM | ID: wpr-740249

ABSTRACT

BACKGROUND: This study purposed to analyze regional factors related to gastric cancer screening rate provided by national cancer screening program in Korea. METHODS: The unit of analysis was administrative districts of si∙gun∙gu level. Dependent variable was regional gastric cancer screening rate provided by national cancer screening program, and regional variables were selected to represent the regional characteristics such as demographic, health behavior and status, socioeconomic, and health resource. Tobit regression was applied for the analysis. RESULTS: Analysis results showed that gastric cancer screening rate was varied depending on regions from 47.8% to 69.1%. Tobit regression showed that gastric cancer screening rate had negative relationships with smoking rate, financial independence rate, and National Health Insurance premium per capita. And regional gastric cancer screening rate had positive relationships with sex ratio and number of gastric cancer screening center. CONCLUSION: Regional characteristics should be considered in establishing regional policies for increasing the gastric cancer screening rate.


Subject(s)
Early Detection of Cancer , Health Behavior , Health Resources , Korea , Mass Screening , National Health Programs , Sex Ratio , Smoke , Smoking , Social Class , Stomach Neoplasms
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