Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 95
Filter
1.
Article in English | WPRIM | ID: wpr-874184

ABSTRACT

Diagnosis of Kawasaki disease (KD) is occasionally delayed because it is solely based on clinical symptoms. Previous studies have attempted to identify diagnostic biomarkers for KD. Recently, patients with KD were reported to have elevated serum ferritin levels. We investigated the usefulness of the serum ferritin level as a diagnostic biomarker for distinguishing KD from other acute febrile illnesses. Blood samples were obtained from pediatric patients with KD (N = 77) and those with other acute febrile illnesses (N = 32) between December 2007 and June 2011 for measuring various laboratory parameters, including serum ferritin levels. In patients with KD, laboratory tests were performed at diagnosis and repeated at 2, 14, and 56 days after intravenous immunoglobulin treatment. At the time of diagnosis, serum ferritin levels in patients with KD (188.8 µg/L) were significantly higher than those in patients with other acute febrile illnesses (106.8 µg/L, P = 0.003). The serum ferritin cut-off value of 120.8 µg/L effectively distinguished patients with KD from those with other acute febrile illnesses, with a sensitivity and specificity of 74.5% and 83.3%, respectively. Serum ferritin may be a useful biomarker to distinguish KD from other acute febrile illnesses.

2.
Article in English | WPRIM | ID: wpr-874069

ABSTRACT

Severe respiratory difficulty can be more prominent, when combined with severe pectus excavatum and cardiovascular manifestations in infants with Marfan syndrome. There have been few reports on severe laryngomalacia as a cause of severe respiratory difficulty in an infant with Marfan syndrome. A 1-month-old boy was admitted due to severe respiratory difficulty. Immediately after birth, he had dysmorphic features, such as micrognathia, wrinkles on the forehead, and down-slanting palpebral fissures. On echocardiography, aortic root dilation with a mitral valve prolapse was observed. Due to severe laryngomalacia accompanied by severe respiratory difficulty and feeding difficulty, a partial epiglottectomy was performed at 1 month of age. After the surgery, suprasternal retraction and inspiratory stridor disappeared, and he started gaining weight with improvement in respiratory difficulty. On whole exome sequencing, a missense mutation on the FBN1 gene (c.3560A> C on exon 29, p.His1187Pro, calcium-binding epidermal growth factor-like #21) was identified. Despite higher perioperative risk due to comorbidities in Marfan syndrome, early intervention of laryngomalacia can be helpful in improving quality of life even in infants with Marfan syndrome.

3.
Article in English | WPRIM | ID: wpr-921370

ABSTRACT

OBJECTIVES@#This study was performed to fabricate a bionic coating with titanium (Ti) phosphate to promote the osseointegration of Ti substrate implants.@*METHODS@#Phosphorylated micro/nanocoating was prepared on the surface of pure titanium (i.e., TiP-Ti) by hydrothermal process under special pressure, and the untreated smooth pure titanium (cp-Ti) was selected as the control. To evaluate the characteristics of the coating surface, scanning electron microscopy, X-ray diffraction, atomic force microscopy, and contact-angle measurement were performed. In addition, the effects of TiP-Ti on the proliferation, adhesion, and differentiation of rat bone marrow mesenchymal stem cells (BMSCs) were investigated by using @*RESULTS@#The TiP-Ti surface presented a bionic structure with coexisting nanoscale 3D spatial structure and microscale pores. @*CONCLUSIONS@#A bionic structure with TiP-Ti micro/nanoscale coating was successfully fabricated, indicating a promising method for modifying the surface of implants.


Subject(s)
Animals , Dental Implants , Osseointegration , Osteogenesis , Oxides , Phosphates , Rats , Surface Properties , Titanium
4.
Article in English | WPRIM | ID: wpr-878440

ABSTRACT

The maxillofacial skeleton is the basis of the contour of the face. Orthognathic surgery and facial contouring surgery change jaw tissue and affect facial appearance in different manners. Orthognathic surgery is the main method to correct dental and maxillofacial deformities. It changes the shape of the jaw and improves the occlusal relationship by changing the three-dimensional position of the jaw. Facial contouring surgery mainly adopts the method of "bone reduction", which changes the "amount"of the jawbone by cutting a part of the bone tissue to improve the facial appearance, generally without changing oral function. The combined use of orthognathic surgery and facial contouring surgery is becoming increasingly common in clinical practice. This also requires oral and maxillofacial surgeons to have a holistic consideration of the comprehensive correction of maxillofacial bone deformity, and to perform comprehensive analysis of jaw deformities and jaw plastic surgery to achieve the most ideal results. The author's team has been engaged in the clinical work of orthognathic surgery and facial contouring surgery and accumulated rich clinical experience in the comprehensive correction of maxillofacial bone deformity. In this article, the indications, treatment goals, treatment modes, treatment methods, and key points in the surgical operations of comprehensive maxillofacial bone surgery were summarized.


Subject(s)
Face/surgery , Facial Bones , Humans , Maxillofacial Abnormalities , Orthognathic Surgery , Orthognathic Surgical Procedures
5.
Article in Chinese | WPRIM | ID: wpr-774358

ABSTRACT

OBJECTIVE@#To investigate the clinical outcome of the patients with primary diffuse large B-cell lymphoma(DLBCL).@*METHODS@#Clinical data of 148 patients with DLBCL in our hospital and cancer hospital from March 2006 to April 2016 were retrospectively analyzed. Kaplan-Meier analysis was used to estimate progression-free survival(PFS)and overall survival(OS).@*RESULTS@#5-year OS and PFS rates were 85% and 69%,respectively. The survival analysis showed that 5-year OS rate of R-CHOP group was significantly higher than that of CHOP alone group(89% vs. 70%,P60 years),poor ECOG score(≥2),advanced stage(Ⅲ-Ⅳ),higher IPI score(≥3),CHOP alone and absence of radiotherapy related with poor survival rate. Furthermore,multivariate analysis showed that age>60 year significantly related with the worse OS.@*CONCLUSION@#Age >60 year is an important independent prognostic factor to predict worse OS or PFS.


Subject(s)
Antibodies, Monoclonal, Murine-Derived , Antineoplastic Combined Chemotherapy Protocols , Cyclophosphamide , Disease-Free Survival , Doxorubicin , Humans , Lymphoma, Large B-Cell, Diffuse , Prognosis , Retrospective Studies
6.
Childhood Kidney Diseases ; : 111-115, 2019.
Article in English | WPRIM | ID: wpr-785575

ABSTRACT

Vitamin D dependent rickets type 1A (VDDR1A) is an autosomal recessive disorder caused by mutations in CYP27B1 . Clinical findings are growth retardation, hypotonia, muscle weakness, hypocalcemic seizures, and radiological features of rickets. We aimed to present the VDDR1A case with a genetic study of CYP27B1 . The 14-month-old boy was admitted to the hospital due to a seizure. Serum calcium, phosphorus, alkaline phosphatase, parathyroid hormone (PTH), 25(OH) vitamin D, and 1,25(OH)2 vitamin D values were 5.1 mg/dL, 3.7 mg/dL, 705 IU/L, 429 pg/mL, 24.9 ng/mL, and 8.8 pg/mL, respectively. Radiological study showed cupping and fraying of the distal ulna and radius. The molecular genetic study revealed that the patient had a compound heterozygous mutation, Phe443Profs*24 and c.589+1G>A, in CYP27B1 . Genetic analysis of the family members presented that the mother was heterozygous for the mutation c.589+1G>A, and that the father was heterozygous for Phe443Profs*24. The patient was treated with calcium lactate and calcitriol. Until now, six Korean patients with VDDR1A have been studied. Including this case, Korean patients with VDDR1A were found to have only three different mutations in 14 alleles, indicating that the mutation in the CYP27B1 gene is homogeneous in the Korean population.


Subject(s)
25-Hydroxyvitamin D3 1-alpha-Hydroxylase , Alkaline Phosphatase , Alleles , Calcitriol , Calcium , Fathers , Humans , Infant , Lactic Acid , Male , Molecular Biology , Mothers , Muscle Hypotonia , Parathyroid Hormone , Phosphorus , Radius , Rickets , Seizures , Ulna , Vitamin D , Vitamins
7.
Chinese Journal of Epidemiology ; (12): 1381-1386, 2018.
Article in Chinese | WPRIM | ID: wpr-738156

ABSTRACT

Objective To investigate the distribution patterns of mosquitoes,midges and related arboviruses in Sichuan province.Methods Blood-sucking insects were collected from houses and pens,using the ultraviolet lights.Mosquito samples were classified according to morphologic characteristics and then stored at liquid nitrogen.All samples were incubated with BHK-21 and C6/36 cells for virus isolation and then detected for their viral genes.Sequences of the virus were identified and analyzed by molecular biological software,such as BioEdit 7.0.5.3,MEGA 6.0.Results In total,17 019 mosquitoes from 3 genera and 4 species and 12 700 midges were collected from the southeast regions of Sichuan province in 2016 and 2017.Among them,79.4% (13 519/17 019) belonged to Culex tritaeniorhynchus with 11.1% (1 897/17 019) as Armigeres subalbatus,5.5% (930/17 019) were Anopheles sinensis and 4.0% (673/17 019) were Anopheles sinensis 3 virus strains that isolated from Culex tritaeniorhynchus were identified as type Ⅰ Japanese encephalitis virus.Seven pools of mosquitoes isolated from Hejiang county were identified Japanese encephalitis virus gene positive through PCR amplification.With 4 pool midges were detected positive for Akabane virus through PCR gene amplification while midges samples didn't have virus isolates.Conclusions Culex tritaeniorhynchus appeared the predominant species in the southeast regions of Sichuan.Japanese encephalitis virus transmitted by mosquitoes and Akabane virus by midges were prevalent in southeast Sichuan province.

8.
Chinese Journal of Epidemiology ; (12): 1381-1386, 2018.
Article in Chinese | WPRIM | ID: wpr-736688

ABSTRACT

Objective To investigate the distribution patterns of mosquitoes,midges and related arboviruses in Sichuan province.Methods Blood-sucking insects were collected from houses and pens,using the ultraviolet lights.Mosquito samples were classified according to morphologic characteristics and then stored at liquid nitrogen.All samples were incubated with BHK-21 and C6/36 cells for virus isolation and then detected for their viral genes.Sequences of the virus were identified and analyzed by molecular biological software,such as BioEdit 7.0.5.3,MEGA 6.0.Results In total,17 019 mosquitoes from 3 genera and 4 species and 12 700 midges were collected from the southeast regions of Sichuan province in 2016 and 2017.Among them,79.4% (13 519/17 019) belonged to Culex tritaeniorhynchus with 11.1% (1 897/17 019) as Armigeres subalbatus,5.5% (930/17 019) were Anopheles sinensis and 4.0% (673/17 019) were Anopheles sinensis 3 virus strains that isolated from Culex tritaeniorhynchus were identified as type Ⅰ Japanese encephalitis virus.Seven pools of mosquitoes isolated from Hejiang county were identified Japanese encephalitis virus gene positive through PCR amplification.With 4 pool midges were detected positive for Akabane virus through PCR gene amplification while midges samples didn't have virus isolates.Conclusions Culex tritaeniorhynchus appeared the predominant species in the southeast regions of Sichuan.Japanese encephalitis virus transmitted by mosquitoes and Akabane virus by midges were prevalent in southeast Sichuan province.

9.
Article in Chinese | WPRIM | ID: wpr-772454

ABSTRACT

Obstructive sleep apnea syndrome (OSAS) is a common clinical disease with high incidence and low treating proportion, difficult evaluation, and complicated nosogenesis. OSAS can cause systematic impairments. Various treatment methods were applied in clinical setting with the tendency of cross-disciplinary promotion. Oral treatment plays an exceedingly important role in OSAS research and therapy. This study reports the oral treatment involving OSAS therapy.


Subject(s)
Humans , Sleep Apnea, Obstructive , Therapeutics
10.
Article in Korean | WPRIM | ID: wpr-758530

ABSTRACT

PURPOSE: Recently, the number of late preterm infants are increasing, and they are prone to have many clinical problems. The purpose of this study is to emphasize the importance of perinatal care for the late preterm infants and their mothers. METHODS: Total admitted numbers of late preterm infants were 547 (from 464 mothers) and of term infants were 1,514 (from 1,470 mothers) in NICU, at Chonnam National University Hospital January 2014~December 2015. Maternal and neonatal mortality rate were calculated in the total admitted numbers. Exclusion criteria were death or transfer during admission, congenital anomaly, and etc. The enrolled numbers of late preterm infants were 493 (from 418 mothers) and of term infants were 1,167 (from 1,123 mothers). Retrospective chart review was conducted. In mothers, demographics, underlying illness, and obstetric complication, and in newborns, demographics, hospital days and morbidity were compared between late preterm group and term group. RESULTS: Maternal mortality rate was not different. However, neonatal mortality rate was higher in late preterm infants. In mothers of late preterm group, there was no difference in demographic characteristics, but the rates of autoimmune disease and obstetric complication were higher. In infants of late preterm group, body size was smaller, artificial conception and C-section rate were higher, and one and five-minute Apgar scores were lower, and hospital duration was longer. And the incidence of respiratory distress, transient tachypena of newborn, intraventricular hemorrhage and metabolic abnormalities were higher, but the incidence of meconium aspiration syndrome was lower compare to the term infant group. CONCLUSIONS: Maternal mortality was not different. However, neonatal mortality was higher in late preterm infants. In late preterm group, the mothers had higher rate of autoimmune disease and obstetric complication, and the infants had higher morbidity compare to the term group. When the obstetrician decides on delivery time in high risk pregnancy, maternal medical condition and neonatal outcome should be considered.


Subject(s)
Autoimmune Diseases , Body Size , Demography , Fertilization , Hemorrhage , Humans , Incidence , Infant , Infant Mortality , Infant, Newborn , Infant, Premature , Maternal Mortality , Meconium Aspiration Syndrome , Mortality , Mothers , Perinatal Care , Pregnancy, High-Risk , Premature Birth , Retrospective Studies
11.
Chinese Traditional Patent Medicine ; (12): 2255-2258, 2017.
Article in Chinese | WPRIM | ID: wpr-669050

ABSTRACT

AIM To explore the effects of Shexiang Wulong Pills (Moschus Artifactus,Aconiti Radix Cocta,Pheretima,etc.) drug serum on the expression levels of miR-146a,miR-130 and miR-223 in peripheral blood mononuclear cells (PBMCs) of patients with rheumatoid arthritis (RA).METHODS PBMCs were extracted from blood of 30 cases of RA patients,cells were divided into three groups,blank control group,serum-free groupand Shexiang Wulong Pills drug serum group.After 48 hours,total RNA was extracted,then the expression levels of three miRs were detected by RT-PCR.RESULTS Compared with the serum-free group,the expression levels of miR-146a,miR-130 and miR-223 in the Shexiang Wulong Pills drug serum group were significantly decreased (P < 0.01).CONCLUSION Shexiang Wulong Pills can inhibit inflammation in RA patients by down-regulating the expression levels of miR-223,miR-130 and miR-146a in PBMCs.

12.
Chinese Health Economics ; (12): 88-90, 2017.
Article in Chinese | WPRIM | ID: wpr-661685

ABSTRACT

It discussed the methods,coverage,data resources,implementation process,result analysis and practical significance of the full cost accounting for medical service items,so as to provide references for improving the delicacy management in hospitals and constructing the price dynamitic adjustment mechanism based on item cost structure.

13.
Chinese Health Economics ; (12): 88-90, 2017.
Article in Chinese | WPRIM | ID: wpr-658766

ABSTRACT

It discussed the methods,coverage,data resources,implementation process,result analysis and practical significance of the full cost accounting for medical service items,so as to provide references for improving the delicacy management in hospitals and constructing the price dynamitic adjustment mechanism based on item cost structure.

14.
Article in Chinese | WPRIM | ID: wpr-852902

ABSTRACT

Objective: To investigate the chemical constituents from Paris thibetica and their antitumor activities. Methods: The separations and purifications were taken by column chromatography over silica gel, Sephadex LH-20, ODS-C18, and semi-preparative HPLC. The in vitro antitumor activities of the isolated compounds were studied by MTT method. Results: Fourteen compounds were isolated from ethanol extract of the rhizomes of P. thibetica, which were identified as paris saponin V (1), paris saponin I (2), paris saponin II (3), paris saponin VI (4), pennogennin-3-O-α-L-arabinofuranosyl-(1→4)-β-D-glucopyranoside (5), paris saponin H (6), pennogennin-3-O-α-L-rhamnopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside (7), paris saponin VII (8), parisyunnanoside G (9), trikamsteroside E (10), stigmasterol-3-O-β-D-glucopyranoside (11), β-sitosteryl palmitate (12), β-amyrin (13), and 4-hydroxy-5-methylfuran-3-carboxylic acid (14). Conclusion: All compounds are firstly reported from P. thibetica, and this is the first report of compounds 10 and 12-14 from the genus Paris L. Compounds 1-8 show cytotoxicities against BEL-7402. Among the tested compounds, compound 3 exhibits the strongest cytotoxicity with IC50 value of 0.48 μmol/L.

15.
Article in Chinese | WPRIM | ID: wpr-823265

ABSTRACT

Objective @#To investigate the effects of intra-articular injection of alendronate on the mandibular condyle in ovariectomized rats.@*Methods @#Sixty female rats were randomly divided into five groups: ovariectomy with vehicle treatment alone, early alendronate treatment at ovariectomy, late alendronate treatment at 4 weeks after ovariectomy, shamoperation with vehicle treatment, and the normal control rats. The changes in subchondral bone were evaluated by micro-computed tomography (Micro-CT), tartrate-resistant acid phosphatase (TRAP) staining and real-time quantitative polymerase chain reaction (RT-PCR). @*Results @# Compared with late alendronate treatment, early alendronate treatment improved microstructural properties of the subchondral bone, with higher bone volume ratio (46.4 + 2.5 vs 37.5 + 2.1; P= 0.038), increased trabecular thickness (47.3 + 1.7 vs 34.6 + 1.4; P = 0.029), elevated trabecular number (8.5 + 0.6 vs 6.2 + 0.3; P = 0.041) and lower trabecular separation (30.2 + 1.6 vs 37.7 + 2.6; P = 0.034). Fewer TRAP-positive cells (4.2 + 0.2 vs 6.8 + 0.4; P = 0.019) and a higher OPG/RANKL ratio (0.38 + 0.01 vs 0.25 + 0.03; P = 0.043) in the subchondral bone were observed in the animals with early treatment group compared to late treatment or ovariectomy/vehicle treatment group. @*Conclusion @#Our results suggest the therapeutic potential of intra-articular alendronate injection in the treatment of osteoporosis-associated temporomandibular disorders.

16.
Article in Chinese | WPRIM | ID: wpr-822608

ABSTRACT

Objective@# To investigate the expression of Notch signaling molecules in temporomandibular joint arthritis (TMJOA), and to explore the role and mechanism of Notch signaling pathway in the development and progression of TMJOA. @*Methods @#72 Kunming mice were randomly divided into experimental group, sham-surgery group and normal group. In experimental group, discs on the right TMJ were subjected to total discectomy, sham-operation group underwent the same procedure without disc removal, while normal group serve as blank control. All the left temporomandibular joint discs were not treated. 8 mice in each group were sacrificed respectively at 1 week, 2 week, 4 week after surgery. Histological examinations were performed to assess success of TMJOA model, according to the pathological standard of osteoarthritis diagnosis. Immunochemistry techniques were performed in the successful TMJOA cartilages to evaluate the expression levels of Notch1 (NICD1), Jagged1, Hes1 and Hes5. The scores were evaluated by semi-quantitative method. @*Results @#Notch1 (NICD1), Jagged1 and Hes5 were activated in the experimental group with the expression levels increased dramatically over time. While Hes1 expression was suppressed at the beginning of osteoarthritis but was up-regulated afterwards.@*Conclusion @# Notch pathway-related molecular expression changed greatly in TMJOA model, indicating that the pathway in the occurrence and development of TMJOA plays an important role.

17.
Journal of Preventive Medicine ; (12): 782-785,789, 2017.
Article in Chinese | WPRIM | ID: wpr-792646

ABSTRACT

Objective To investigate the effects of dendrobium officinale leaves on sperm quality and testicular tissue morphology in parent(P)and offspring(F1、F2)rats.Methods P、F1、F2 rats were fed with dendrobium officinale leaves at the dose of 0,2.0,4.0,6.4g/kg·bw for two generation reproduction,and the testicular and epididymal viscera coefficients,the quantity and quality of sperm were examined and the histopathological assessment was carried out. Results There were no statistical differences in the testicular and epididymal viscera coefficients,sperm quantity,sperm motility rate and sperm malformation rate compared with the control group in P,F1,F2 rats(P>0.05). There were no differences between 0 and 6.4 g/kg·bw groups on the testicular and epididymal tissue morphology in P,F1,F2 rats. Conclusion Dendrobium officinale leaves didn't show obvious adverse effects on sperm quality and testicular tissue morphology in P,F1,F2 rats.

18.
Journal of Preventive Medicine ; (12): 443-448, 2017.
Article in Chinese | WPRIM | ID: wpr-792617

ABSTRACT

Objective To evaluate the safety of the Eucommia folium and to provide the basis of the rational use ofEucommia folium resource.Methods According to < Technical Standards for Testing & Assessment of Health Food>,version 2003, acute safety test/micronucleus test of born marrow in mice/sperm shape abnormality test in mice/Ames test andthirty-day feeding test were all performed after water extract concentrations of Eucommia folium treatment (1 mLconcentrations equal to 1.5 g Eucommia folium) . Results On the acute toxicity test, the MTD of rats and mice were both40.0 mL/kgbw. The results of genetic toxicity test were all negative in the dosage of 10 g/kg bw(according to the dosage ofEucommia folium) .The results of thirty-day feeding test indicated that there have no significant differences in body weight,blood cytology indexes, blood biochemical indexes, organ/body ratio and pathematology examination in the rats in all thegroups (0.83, 1.67, 3.30 mL/kg) as compared to the control group(P>0.05) . Conclusion Under this experimentalcondition, no obvious abnormity and toxic reaction were observed.

19.
Article in English | WPRIM | ID: wpr-80177

ABSTRACT

BACKGROUND: Bronchopulmonary dysplasia (BPD) may result in chronic pulmonary artery hypertension and right ventricular (RV) dysfunction. Various echocardiographic assessments of RV dysfunction have been used to determine whether echocardiographic measurements of premature infants with BPD could provide sensitive measures of RV function that correlates with BPD severity. METHODS: Twenty-eight control subjects without BPD (non BPD group), 28 patients with mild BPD, 11 patients with moderate BPD, and six patients with severe BPD underwent echocardiograms with standard measurement such as ejection fraction by M-mode, tricuspid regurgitation pressure gradient, myocardial performance index (MPI) derived from pulse Doppler, and tissue Doppler imaging (TDI) measurements. BPD severity was classified by the NICHD/NHLBI/ORD workshop rating scale. Twenty-eight control subjects without BPD (non BPD group), 28 patients with mild BPD, 11 patients with moderate BPD, and six patients with severe BPD underwent echocardiograms with standard measurement such as ejection fraction by M-mode, tricuspid regurgitation pressure gradient, myocardial performance index (MPI) derived from pulse Doppler, and TDI measurements. BPD severity was classified by the NICHD/NHLBI/ORD workshop rating scale. RESULTS: None of the standard echocardiographic findings was significantly different between the control group and BPD groups. However, mean septal TDI-MPI of the severe BPD group (0.68 ± 0.06) was significantly (p < 0.01) higher than that of the non-BPD (0.58 ± 0.10) or the mild BPD group (0.59 ± 0.12). In addition, mean RV TDI-MPI of the severe BPD group (0.71 ± 0.13) was significantly (p < 0.05) higher than that of the non-BPD group (0.56 ± 0.08) or the mild BPD group (0.60 ± 0.125). Linear regression showed a good correlation between the severity of BPD and RV TDI-MPI (p = 0.01, R = 0.30) or septal TDI-MPI (p = 0.04, R = 0.24). CONCLUSION: Echocardiographic evaluation of RV function based on an assessment of RV TDI-MPI can provide RV dysfunction parameter in premature infants with BPD.


Subject(s)
Bronchopulmonary Dysplasia , Child , Diagnosis , Echocardiography , Education , Humans , Hypertension , Infant, Newborn , Infant, Premature , Linear Models , Prognosis , Pulmonary Artery , Tricuspid Valve Insufficiency , Ventricular Function, Right
20.
Journal of Experimental Hematology ; (6): 1705-1709, 2016.
Article in Chinese | WPRIM | ID: wpr-332625

ABSTRACT

<p><b>OBJECTIVE</b>To explore the therapeutic efficacy for patients aged over 70 years with acute myeloid leukemia(non-APL).</p><p><b>METHODS</b>Clinical data of 19 acute myeloid leukemia patients aged over 70 years admitted in our hospital from March 2006 to April 2016 years were analyzed retrospectively. Among them 15 patients received priming regimen and 4 patients received best supportive treatment. The overall survival time between patients with priming regimen and patients with best supportine treatment was compared by Kaplan-Meier analysis. The prognostic factors were evaluated by using multivariate analysis. Out of the 19 patients, 9 were males and 10 were females, with median age of 75 years (70-84).</p><p><b>RESULTS</b>After 2 cycles of induction chemotherapy, the complete response rate was (7/15)46.6% and overall response rate was (11/15) 73%. Significant longer median survival time was observed in priming regimen group, compared with that in best supportive treatment group (11 months vs 2 months)(χ=17.077, P<0.001). The patients were well tolerant to side-effect of chemotherapy. Multivariate analysis showed that only receiving induction chemotherapy or not was the independent prognostic factor of the survival time(P<0.05), while the sex, age, ECOG index, CD34, HLA-DR, WBC count and ratio of blast cells in bone marrow were factor affecting the prognosis.</p><p><b>CONCLUSION</b>The priming regimen may be practicable and effective for the treatment of patients with acute myeloid leukemia aged over 70 years (non-APL) and prolong the survival time of these patients.</p>

SELECTION OF CITATIONS
SEARCH DETAIL