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Article in Chinese | WPRIM | ID: wpr-839043


Objective To explore the feasibility and effectiveness of establishing an aortic valve regurgitation canine model by minimally invasive peripheral vascular catheter method. Methods A total of 10 healthy canines were selected in this study. An aortic insufficiency animal model was established by percutaneous femoral artery puncture and aortic dilatation. Aortic angiography and transthoracic echocardiography were used to evaluate aortic valve regurgitation immediately after operation. Results Aortic valve regurgitation animal models were successfully established in all the 10 canines. Two canines died of acute left ventricular failure due to the large aortic regurgitation after the operation. Six surviving canines had moderate aortic regurgitation and two had slight aortic regurgitation; they survived for more than 1 month. Conclusion It is feasible to establish an aortic regurgitation canine model by minimally invasive peripheral vascular catheter method.

Article in Chinese | WPRIM | ID: wpr-838999


Objective To study the choice of diagnostic and therapeutic strategy for young patients with acute myocardial infarction (AMI) according to the onset characteristics. Methods We retrospectively analyzed the clinical data of 36 young and 1 283 elderly patients with AMI, who were treated between Dec. 2006 and Jan. 2012 in our hospital. The risk factors, clinical characteristics and diagnosis/treatment strategies were analyzed. Results (1) The young patients accounted for 2.7% of all the AMI patients in our study, with most of them being male (97.2%). AMI with ST-segment elevation accounted for 94.4% (34/36) among the young AMI patients, often with risk factors like smoking and dyslipidemia, scarcely with hypertension or diabetes. In the young patients the incidence rates of cardiogenic shock, heart failure and arrhythmia were 5.6% (2/36), 16.7% (6/36), and 5.6% (2/36, respectively, and there was no death during treatment or follow-up. (2) Among the 33 young patients receiving coronary angiography, 21 (63.6%) had single vessel lesions, mostly involving the left anterior descending artery and resulting in anterior myocardial infarction. Among the 15 young AMI patients who received emergent coronary angiograpy, 6 (40%) had heavy thrombus burdern but had slighter coronary stenosis, and they did not receive stent treatment. Conclusion AMI should be considered when young male patients with smoking history, dyslipidemia and chest pain. Young AMI patients often have single vessel lesions and better prognosis, and they need timely revascularization.

Article in Chinese | WPRIM | ID: wpr-839203


Objective To investigate the relationship between autonomic nervous reflex and early recurrence of atrial fibrillation after radiofrequency catheter ablation (RFCA) using diving reflex test and cold pressor test. Methods A total of 102 patients with paroxysmal atrial fibrillation were recruited in the present study. All patients underwent diving reflex test and cold pressor test before and after RFCA. The relationship between mean heart rate and early recurrence of atrial fibrillation was observed. Results Circumferential pulmonary vein isolation was successfully achieved in all the 102 patients. The mean heart rate was decreased by diving reflex test and increased by cold pressor test. The diving reflex of the participants was significantly decreased after RFCA (P<0.05), and the cold pressor test results had no noticeable change. The diving reflex in patients with early recurrence of atrial fibrillation was more intensive than those without (P<0.05). Conclusion The parasympathetic activity is decreased in atrial fibrillation patients after RFCA, and the decrease may be related to the early recurrence of atrial fibrillation after RECA.