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1.
China Pharmacy ; (12): 1327-1333, 2024.
Article in Chinese | WPRIM | ID: wpr-1031708

ABSTRACT

OBJECTIVE To investigate the effects of Taohong siwu decoction modified granules on podocyte epithelial- mesenchymal-transition (EMT) and renal fibrosis in diabetic kidney disease (DKD) model rats. METHODS Eight rats were selected as normal group (ordinary feed); the remaining rats were given a high-glucose and high-fat diet combined with intraperitoneal injection of streptozotocin (35 mg/kg) to induce the DKD model. Model rats were randomly divided into model group, irbesartan group [positive control, 13.5 mg/(kg·d)] and modified Taohong siwu decoction group [6.48 g/(kg·d)], with 8 rats in each group. All groups were given relevant medicine intragastrically, once a day, for 16 consecutive weeks. Twenty-four- hour urinary total protein (24 h UTP) was detected at the end of the 4th, 8th, 12th and 16th week of administration. After the last medication, the body mass, water intake, food intake, urine output, the levels of fasting blood glucose, serum creatinine (Scr) and blood urea nitrogen (BUN) as well as mRNA and protein expressions of P-cadherin, nephrin, α -smooth muscle actin (α-SMA), Wilms’ tumor gene 1 (WT1), transforming growth factor-β1( TGF-β1) and type Ⅳ collagen (Col-Ⅳ) in renal tissue were determined. The pathological and morphological changes in renal tissue were observed and the thickness of the glomerular basement membrane was determined. RESULTS Compared with the model group, 24 h UTP of rats was significantly decreased in modified Taohong siwu decoction group since the 8th weekend (P<0.05); the body weight of rats increased significantly, but the amount of water intake and urine decreased significantly; Scr and BUN level, mRNA expression of α-SMA, mRNA and protein expressions of TGF-β1 and Col-Ⅳ were significantly reduced, while the mRNA expressions of P-cadherin, nephrin and WT1 were increased significantly (P<0.05); the protein deposition of α-SMA was reduced, protein depositions of P-cadherin, nephrin and WT1 were increased; the pathological damage and fibrosis of renal tissue were relieved; the thickness of glomerular basement membrane was decreased significantly (P<0.05). CONCLUSIONS Taohong siwu decoction modified granules can inhibit the EMT of podocyte in DKD model rats, and alleviate renal pathological damage and podocyte damage, thus protecting renal function, and delaying the process of renal fibrosis.

2.
China Pharmacy ; (12): 1327-1333, 2024.
Article in Chinese | WPRIM | ID: wpr-1031730

ABSTRACT

OBJECTIVE To investigate the effects of Taohong siwu decoction modified granules on podocyte epithelial- mesenchymal-transition (EMT) and renal fibrosis in diabetic kidney disease (DKD) model rats. METHODS Eight rats were selected as normal group (ordinary feed); the remaining rats were given a high-glucose and high-fat diet combined with intraperitoneal injection of streptozotocin (35 mg/kg) to induce the DKD model. Model rats were randomly divided into model group, irbesartan group [positive control, 13.5 mg/(kg·d)] and modified Taohong siwu decoction group [6.48 g/(kg·d)], with 8 rats in each group. All groups were given relevant medicine intragastrically, once a day, for 16 consecutive weeks. Twenty-four- hour urinary total protein (24 h UTP) was detected at the end of the 4th, 8th, 12th and 16th week of administration. After the last medication, the body mass, water intake, food intake, urine output, the levels of fasting blood glucose, serum creatinine (Scr) and blood urea nitrogen (BUN) as well as mRNA and protein expressions of P-cadherin, nephrin, α -smooth muscle actin (α-SMA), Wilms’ tumor gene 1 (WT1), transforming growth factor-β1( TGF-β1) and type Ⅳ collagen (Col-Ⅳ) in renal tissue were determined. The pathological and morphological changes in renal tissue were observed and the thickness of the glomerular basement membrane was determined. RESULTS Compared with the model group, 24 h UTP of rats was significantly decreased in modified Taohong siwu decoction group since the 8th weekend (P<0.05); the body weight of rats increased significantly, but the amount of water intake and urine decreased significantly; Scr and BUN level, mRNA expression of α-SMA, mRNA and protein expressions of TGF-β1 and Col-Ⅳ were significantly reduced, while the mRNA expressions of P-cadherin, nephrin and WT1 were increased significantly (P<0.05); the protein deposition of α-SMA was reduced, protein depositions of P-cadherin, nephrin and WT1 were increased; the pathological damage and fibrosis of renal tissue were relieved; the thickness of glomerular basement membrane was decreased significantly (P<0.05). CONCLUSIONS Taohong siwu decoction modified granules can inhibit the EMT of podocyte in DKD model rats, and alleviate renal pathological damage and podocyte damage, thus protecting renal function, and delaying the process of renal fibrosis.

3.
Article in Chinese | WPRIM | ID: wpr-985475

ABSTRACT

Excessive sodium/salt intake is the leading dietary risk factor for the loss of healthy life in the Chinese population. The "Healthy China 2030" Action Plan set the goal of reducing salt intake by 20% by 2030. However, salt intake in China is still at a very high level in the world, with adults reaching 11 g/d, more than twice the recommended limit of 5 g/d. The current policies and action plans of China have targeted catering workers, children, adolescents, and home chefs in salt, oil, and sugar reduction actions. However, there are still obvious deficiencies in the coordinated promotion and implementation. This study, therefore, proposed a set of comprehensive strategies (named CHRPS that is composed of communication and education, salt reduction in home cooking, salt reduction in restaurants, reducing salt content in pre-packaged food, and surveillance and evaluation) and key implementation points for further deepening the salt reduction action in China. These strategies were developed based on the main sources of dietary sodium for Chinese residents, the status of "knowledge, attitude and practice" in salt reduction, evidence of effective intervention measures, existing policies and requirements, and the salt reduction strategies of the World Health Organization and experience from some other countries. As a scientific reference, the CHRPS strategies will help the government and relevant organizations quickly implement salt reduction work and facilitate the earlier realization of China's salt reduction goal.


Subject(s)
Adult , Child , Adolescent , Humans , Sodium Chloride, Dietary , Sodium, Dietary , Diet , Food , China
4.
Article in Chinese | WPRIM | ID: wpr-989112

ABSTRACT

Noonan syndrome(NS)is an inherited disease involving multiple systems.The main clinical manifestations include distinctive facial features, short stature, heart defects, developmental delay and chest deformity.Short stature, reported in up to 70% of NS patients, is one of the main reasons NS patients seek medical treatment.The pathogenesis is associated with the up-regulation of RAS-mitogen activated protein kinase(RAS-MAPK)signal pathway.Further study is needed for some further specific mechanisms.Recombinant human growth hormone(rhGH)therapy has been approved for NS patients with short stature and has achieved a good therapeutic effect.However, the knowledge of drug dosage, influencing factors, long-term efficacy and risk of rhGH treatment is still insufficient.This paper reviews the pathogenesis and treatment of short stature in NS, providing help for the treatment and management of the disease.

5.
Article in Chinese | WPRIM | ID: wpr-888396

ABSTRACT

OBJECTIVE@#To explore the genetic basis for a sib pair featuring 17beta-hydroxysteroid dehydrogenase type 3 deficiency.@*METHODS@#Genomic DNA was extracted from the proband, her sister, and their parents, and was subjected to sequencing analysis with a gene panel for sexual development. Suspected variant was verified by Sanger sequencing and bioinformatic analysis.@*RESULTS@#Both the proband and her sister were found to harbor novel compound heterozygous missense variants of the HSD17B3 gene, namely c.839T>C (p.Leu280Pro) and c.239G>T (p.Arg80Leu), which were derived respectively from their mother and father. The variants were unreported previously and predicted to be deleterious by PolyPhen2, MutationTaster and other online software. Based on the American College of Medical Genetics and Genomics standards and guidelines, both c.839T>C(p.Leu280Pro) and c.239G>T (p.Arg80Leu) were predicted to be likely pathogenic (PM2+PP1+PP2+PP3+PP4, PM2+PM5+PP1+PP2+PP3+PP4).@*CONCLUSION@#The compound heterogeneous variants of the HSD17B3 gene probably underlay the disease in this sib pair. 17beta-hydroxysteroid dehydrogenase type 3 deficiency may lack specific clinical features and laboratory index, genetic testing can facilitate a definitive diagnosis.


Subject(s)
Female , Humans , 17-Hydroxysteroid Dehydrogenases/genetics , Genetic Testing , Genomics , Mutation , Mutation, Missense
6.
Article in Chinese | WPRIM | ID: wpr-864115

ABSTRACT

Objective:To study the clinical characteristics of growth development and metabolic disorders in obese children and adolescents with insulin resistance (IR).Methods:Normal weight or obese children and adolescents who hospitalized at the Department of Children′s Health Care of Children′s Hospital Affiliated to Nanjing Medical University from September 2015 to April 2018 were recruited.Children′s height, body weight and waist circumference were measured, and waist-to-height ratio (WHtR) and body mass index (BMI) were calculated.Puberty process was determined by Tanner stage.Blood glucose, blood lipid and insulin were measured in fasting state, and homeostasis model assessment of insulin resistance (HOMA-IR) was calculated based on fasting blood glucose and insulin levels.IR was considered when HOMA-IR was over 2.69.Non-alcoholic fatty liver (NAFLD) was diagnosed by abdominal ultrasound.Results:(1) A total of 691 subjects were included, including 183 cases with the age of (9.73±2.38) years in the normal weight group/normal group, and 508 cases with the age of (10.24±2.05) years old in the obese group.The rate of IR was higher in obese group than that in normal group (55.71% vs. 10.38%), and the difference was statistically significant ( P<0.001). (2)HOMA-IR was positively correlated with age ( r=0.256, P<0.001), BMI ( r=0.426, P<0.001), waist circumference ( r=0.454, P<0.001), and WHtR ( r=0.321, P<0.001). After the adjustment for age, sex, and puberty stage, HOMA-IR was also positively correlated with BMI ( r=0.418, P<0.001), waist circumference ( r=0.419, P<0.001) and WHtR ( r=0.375, P<0.001). (3) During puberty, HOMA-IR in both of obese group and normal group was increased, and HOMA-IR in obese group was more particularly serious compared to normal group[TannerⅠ: 2.60(1.49, 3.94) vs.1.28(0.80, 1.90); Tanner Ⅱ: 3.07(1.75, 5.17) vs.1.80(1.16, 2.96); Tanner Ⅲ: 4.33(2.80, 6.57) vs.2.47(1.41, 3.68); Tanner Ⅳ-Ⅴ: 3.49(1.04, 5.78) vs.1.91(0.54, 2.60)], and the differences were all statistically significant(all P<0.05). (4)Compared with the obese objects without IR, obese children and adolescents with IR had higher systolic blood pressure[112(104, 124) mmHg vs.109(98, 121) mmHg, 1 mmHg=0.133 kPa], triglyceride level [1.27(0.95, 1.81) mmol/L vs.1.09(0.79, 1.61) mmol/L], fas-ting blood glucose level [4.80(4.46, 5.01) mmol/L vs.4.48(4.16, 4.76) mmol/L] and fasting insulin level [21.27(16.21, 28.56) mmol/L vs.7.62(4.43, 10.83) mmol/L], and the differences were all statistically significant(all P<0.05). IR was a risk factor for NAFLD in obese children( OR=1.536, 95% CI: 1.049-2.247, P<0.05). Conclusions:Serious and abdominal obesity in children and adolescents is a major risk factor for the development of IR.HOMA-IR of obese children and adolescents is particularly serious during puberty.The obese children with IR are more likely to have metabolic disorders in blood glucose, serum lipid and blood pressure, and have the risk of NAFLD development.

7.
Article in Chinese | WPRIM | ID: wpr-905404

ABSTRACT

Objective:To investigate the effect of constant temperature blankets on intravascular hypothermia for severe traumatic brain injury (sTBI). Methods:A total of 112 inpatients with sTBI from January, 2013 to December, 2018 were reviewed. They were divided into control group (n = 58) and observation group (n = 54) according to whether a self-warming blanket was used. They were assessed with Bedside Shivering Assessment Scale (BSAS). Their dosages of anti-shivering medicine, coagulation and intracranial pressure were recorded. The scores of Glasgow Outcome Scale Extended (GOSE) and the mortality one, six and twelve months after discharge were observed. Results:The incidence and severity were less in the observation group than in the control group (χ2 = 16.212, P < 0.01). The dosage of anti-shivering medicine was less in the observation group than in the control group (t > 1.269, P < 0.05). The hypercoagulation relieved significantly six hours after hypothermia in the observation group, and it was stable twelve hours after hypothermia. For the control group, the hypercoagulation relieved significantly twelve hours after hypothermia, and it was stable 24 hours after hypothermia. The intracranial pressure decreased more in the observation group than in the control group. The GOSE score and the mortality were less in the observation group than in the control group (t > 1.168, P < 0.05) one, six and twelve months after discharge. Conclusion:Application of self-warming blankets in intravascular hypothermia for sTBI may relieve shivering, hypercoagulation and intracranial pressure, to improve the outcome of patients.

8.
Article in Chinese | WPRIM | ID: wpr-690132

ABSTRACT

<p><b>OBJECTIVE</b>To study the clinical value of red blood cell distribution width (RDW) in the early prediction of acute kidney injury (AKI) in children with sepsis.</p><p><b>METHODS</b>A total of 126 children with sepsis were divided into an AKI group (n=66) and a non-AKI group (n=60) according to the presence or absence of AKI. These patients were also classified into high-RDW and low-RDW groups according to the mean RDW. The groups were compared in terms of age, male-to-female ratio, body mass index (BMI), Acute Physiology and Chronic Health Evaluation II (APACHE II) score, Sequential Organ Failure Assessment (SOFA) score, serum blood urea nitrogen (BUN), creatinine (Cr), uric acid (UA), serum C-reactive protein (CRP), and routine blood test results. Independent factors associated with RDW were analyzed by multiple linear regression.</p><p><b>RESULTS</b>Age, male-to-female ratio, BMI, CRP, SOFA score, and APACHE II score did not differ significantly between the AKI and non-AKI groups (P>0.05), but the AKI group had significantly higher BUN, Cr, UA, and RDW levels than the non-AKI group (P<0.05). Age, male-to-female ratio, and BMI did not differ significantly between the high-RDW and low-RDW groups (P>0.05), but the high-RDW group had significantly higher BUN, Cr, UA, CRP, SOFA score, APACHE II score, Hb, and mean corpuscular volume (MCV) than the low-RDW group (P<0.05). The multiple linear regression analysis showed that age, sex, APACHE II score, Cr, Hb, and MCV were independent factors associated with RDW.</p><p><b>CONCLUSIONS</b>RDW has a certain clinical value in the early prediction of AKI in children with sepsis.</p>


Subject(s)
Adolescent , Child , Child, Preschool , Female , Humans , Infant , Male , APACHE , Acute Kidney Injury , Blood , Diagnosis , Creatinine , Blood , Erythrocyte Indices , Erythrocytes , Cell Biology , Retrospective Studies , Sepsis , Blood , Diagnosis
9.
Article in Chinese | WPRIM | ID: wpr-811802

ABSTRACT

@#Determination of exact total protein bonding quantity is often a key step in the preparation of protein-immobilized chiral monolith. In this study, we developed and evaluated a bovine serum albumin(BSA)modified monolith based on glycidyl methacrylate(GMA)and ethylene dimethacrylate(EDMA)for chiral separation. The epoxy groups of the polymer were used directly for the covalent bonding of BSA. A Coomassie brilliant blue(CBB)protein assay(Bradford method)was established to determine the protein bonding quantity, and the influence of some key aspects such as ionic strength, pH value and reaction time were studied. The method was validated with respect to linearity, precision, accuracy and robustness. The maximum amount of immobilized BSA was 11. 90 mg/g, obtained using 65 ∶35 cyclohexanol/dodecanol as the porogen. The monolith was successfully applied in the chiral separation of R/S-warfarin and D/L-tryptophan in only 1-20 min. Furthermore, the chromatographic conditions like pH and organic additive of the mobile phase were optimized. The chiral separation performance of this BSA-immobilized monolith is positively correlated to the protein bonding quantity.

10.
Journal of Clinical Pediatrics ; (12): 730-733, 2015.
Article in Chinese | WPRIM | ID: wpr-476889

ABSTRACT

ObjectiveThe aim of this study is to analyze the etiology and status of bone age of children with short stat-ure.MethodsAnthropological and physical examination data were retrospectively collected and studied in 2132 children with short stature in the department of endocrinology between 2009 and 2014. Growth hormone (GH) levels were determined by ar-ginine-clonidine test. Bone age was determined by CHN scoring.ResultsAmong the 2132 patients, 1333 were males and 799 were females. Mean age is 9.03 ± 3.04 years old, mean bone age is 6.81 ± 3.05 years. Of them, 324 cases (15.2%) were diagnosed complete GH deifciency, 780 cases (36.59%) were partial GH deifciency, 27cases (1.27%) were multiple pituitary hormone de-ifciency, 13 cases (1.64%) were hypothyroidism, 893 cases (41.89%) were idiopathic short stature, 19 cases (0.89%) were small for gestational age (SGA), 40 cases (1.88%) were chromosomal disorders, etc. Signiifcant difference in age and bone age was found using t test (P<0.05). Signiifcant differences in Δage were found between etiological categories using ANOVA (P=0.000). Δage was signiifcantly and negatively associated with peak GH using Pearson's correlation.ConclusionsGH deifciency is the most common cause of short stature. Bone age of children with short stature is commonly delayed. Δage was signiifcantly and negatively associated with peak GH. Multiple pituitary hormone deifciency has a signiifcant effect on bone age. The etiology of patients with short stature cannot be determined just by bone age.

11.
Article in Chinese | WPRIM | ID: wpr-246141

ABSTRACT

This study is to establish an UPLC fingerprint of Resina Draconis from different manufacturers, which can provide a comprehensive evaluation for its quality control. The analysis was performed on a Phenomenex Kinetex 2.6 μ C18 100A column by agradientelution program with acetonitrile-water as mobile phase at a flow rate of 1.7 mL x min(-1). The column temperature was 40 degrees C and the detection wavelengthwas 280 nm. The fingerprints of 18 batches of Draconis Resina were further evaluated by chemometrics methods including similarity analysis (SA), hierarchical clustering analysis (HCA) and principal component analysis (PCA). As a result, there were 15 common peaks, 13 of which had been identified by LC-Q-TOF MS, and the similarity degrees of 15 batches of the samples was more than 0.9, and the samples were divided into 4 clusters by their quality difference. The method is reproducible, simple and reliablethat it can be used for quality control and evaluation of Resina Draconis from different manufacturers.


Subject(s)
Chromatography, High Pressure Liquid , Methods , Dracaena , Chemistry , Drugs, Chinese Herbal , Principal Component Analysis , Quality Control
12.
Article in Chinese | WPRIM | ID: wpr-236866

ABSTRACT

<p><b>OBJECTIVE</b>To study the role of procalcitonin (PCT) in the diagnosis of acute pyelonephritis (APN) in children.</p><p><b>METHODS</b>Retrospective analysis was performed on the clinical records of children aged under 3 years who were diagnosed with primary urinary tract infection (UTI) from September 2011 to February 2012. These children were divided into those with upper UTI (UUTI) (APN) and those with lower UTI (LUTI) (non-APN) based on 99mTc-dimercaptosuccinic acid (DMSA) renal scan results as a gold standard. The UUTI and LUTI groups were compared in terms of serum levels of PCT and C-reactive protein (CRP). Receiver operating characteristic (ROC) curves were drawn to evaluate the diagnostic values of serum PCT and CRP.</p><p><b>RESULTS</b>Sixty-five children with UTI, including 39 cases of APN and 26 cases of LUTI, were included in this study. The APN cases had significantly higher serum levels of PCT (3.08 ng/mL vs 0.37 ng/Ml; P<0.01) and CRP (6.25 mg/L vs 3.01 mg/L; P<0.01) than the LUTI cases. The sensitivity and specificity of serum PCT level for APN were 84.6% and 88.5%, respectively, with an area under the ROC curve (AUC) of 0.873 (95%CI=0.781-0.965) and an optimal threshold point of 1.03 ng/mL. The sensitivity and specificity of serum CRP level for APN were 71.8% and 69.2%, respectively, with an AUC of 0.735 (95%CI=0.612-0.858) and an optimal threshold point of 3.91 mg/L.</p><p><b>CONCLUSIONS</b>As a result of its high sensitivity and specificity for the disease, serum PCT can be used as a marker in the early diagnosis of APN in children.</p>


Subject(s)
Child, Preschool , Female , Humans , Infant , Infant, Newborn , Male , C-Reactive Protein , Calcitonin , Blood , Calcitonin Gene-Related Peptide , Protein Precursors , Blood , Pyelonephritis , Blood , Diagnosis , ROC Curve , Sensitivity and Specificity
13.
Article in English | WPRIM | ID: wpr-235561

ABSTRACT

Major and profound changes have taken place in China over the past 30 years. Rapid socioeconomic progress has exerted a great impact on lifestyle, ranging from food, clothing, working and living conditions, and means of transportation to leisure activities and entertainment. At the same time, new health problems have emerged, and health services are facing new challenges. Presently, cardiovascular diseases (CVD) are among the top health problems of the Chinese people, and pose a serious challenge to all engaged in the prevention and control of these diseases. An epidemic of CVD in China is emerging as a result of lifestyle changes, urbanization and longevity. Both national policy decision-making and medical practice urgently need an authoritative report which comprehensively reflects the trends in the epidemic of CVD and current preventive measures. Since 2005, guided by the Bureau of Disease Prevention of the Ministry of Health of the People's Republic of China and the National Center for Cardiovascular Diseases of China, nationwide experts in the fields of epidemiology, clinical medicine and health economics in the realms of CVD, cerebrovascular disease, diabetes and chronic kidney disease, completed the Report on Cardiovascular Diseases in China every year. The report aims to provide a timely review of the trend of the epidemic and to assess the progress of prevention and control of CVD. In addition, as the report is authoritative, representative and readable, it will become an information platform in the CVD field and an important reference book for government, academic institutes, medical organizations and clinical physicians. This publication is expected to play a positive role in the prevention and control of CVD in China. We present an abstract from the Report on Cardiovascular Diseases in China (2010), including trends in CVD, morbidity and mortality of major CVDs, up-to-date assessment of risk factors, as well as health resources for CVD, and a profile of medical expenditure, with the aim of providing evidence for decision-making in CVD prevention and control programs in China, and of delivering the most authoritative information on CVD prevention and control for all citizens.


Subject(s)
Humans , Arrhythmias, Cardiac , Epidemiology , China , Epidemiology , Coronary Disease , Epidemiology , Mortality , Diabetes Complications , Epidemiology , Diet , Dyslipidemias , Epidemiology , Epidemics , Heart Failure , Epidemiology , Mortality , Hypertension , Epidemiology , Kidney Failure, Chronic , Epidemiology , Mortality , Metabolic Syndrome , Motor Activity , Nutritional Physiological Phenomena , Overweight , Epidemiology , Peripheral Arterial Disease , Epidemiology , Risk Factors , Smoking , Stroke , Epidemiology , Mortality
14.
Article in Chinese | WPRIM | ID: wpr-323888

ABSTRACT

<p><b>OBJECTIVE</b>To compare the plasma proteome among male normotensive, prehypertensive, and hypertensive subjects.</p><p><b>METHODS</b>Plasma proteome was analyzed by two-dimensional electrophoresis combined with MALDI-TOF mass spectrometry in this case-control study among well matched male normotensive, prehypertensive and hypertensive subjects (n = 26 each).</p><p><b>RESULTS</b>The results showed that there were 22 differentially expressed protein spots among the protein samples derived from the 3 groups which corresponded to 18 proteins associated with inflammation and immunity, lipid metabolism, transport, coagulation and fibrinolysis, cell proliferation and apoptosis, and antioxidation.</p><p><b>CONCLUSION</b>Proteins were differentially expressed in male subjects with various blood pressure levels.</p>


Subject(s)
Adult , Humans , Male , Middle Aged , Blood Pressure , Case-Control Studies , Hypertension , Genetics , Prehypertension , Genetics , Proteomics , Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
15.
Chinese Journal of Cardiology ; (12): 934-938, 2010.
Article in Chinese | WPRIM | ID: wpr-244112

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the relationship between serum non-HDL-C and incidence of various cardiovascular disease (CVD) in Chinese population aged 35-64 years.</p><p><b>METHODS</b>This prospective study was performed from 1992 to 2004 in 11 provinces of China and the association between baseline non-HDL-C level with the risk of various CVD events was analyzed in 29 937 subjects aged 35-64 years using Cox multivariate proportional hazards regression. CVD events in this study including acute coronary events (ACE), ischemic stroke, hemorrhagic stroke and ischemic cardiovascular disease (ICVD).</p><p><b>RESULTS</b>(1) Adjusted for age, gender, smoking status, diabetes, body mass index and blood pressure, the relative risk of ACE, ischemic stroke and ICVD in groups of non-HDL-C 3.37 - 4.13 mmol/L (130 - 159 mg/dl), 4.14 - 4.91 mmol/L (160 - 189 mg/dl) and ≥ 4.92 mmol/L (190 mg/dl) was 1.24 (0.91 - 1.70), 1.78 (1.25 - 2.53), 2.23 (1.48 - 3.35); 1.34 (1.07 - 1.68), 1.38 (1.04 - 1.83), 1.38 (0.97 - 1.94) and 1.37 (1.12 - 1.63), 1.52 (1.22 - 1.90), 1.70 (1.30 - 2.22), respectively. The risk of hemorrhagic stroke was declined obviously in group > 4.92 mmol/L (190 mg/dl). (2) The correlation between VLDL-C and ACE was the strongest in four CVD events when VLDL-C and LDL-C were joint analyzed, ICVD events ranked the second. The risk for ischemic stroke also borderline increased with increasing VLDL-C and LDL-C (P > 0.05).</p><p><b>CONCLUSION</b>Increased non-HDL-C is associated with increased risk of suffering ACE, ischemic stroke and ICVD and VLDL-C plays a critical role in the development of ICVD events, especially ACS, in middle aged Chinese population.</p>


Subject(s)
Adult , Female , Humans , Male , Middle Aged , Cardiovascular Diseases , Blood , Epidemiology , China , Epidemiology , Cholesterol , Blood , Cholesterol, LDL , Blood , Incidence , Prospective Studies , Risk Factors
16.
Chinese Journal of Epidemiology ; (12): 366-369, 2010.
Article in Chinese | WPRIM | ID: wpr-267369

ABSTRACT

Objective To explore the association between risk factors of cardiovascular diseases (CVD) and insulin resistance in a cross-sectional study.Methods An investigation on risk factors of CVD was carried out using stratified-random sampling method among 1475 participants in Beijing.Homeostasis model assessment index(HOMA) was calculated to assess the insulin resistance in 1359 non-diabetic subjects aged 25-64 years.Insulin resistance was defined as HOMA index (fasting glucose in mmol/L×fasting insulin in mU/L/22.5) in the top quartile of the studied population.Results The degree of correlation between risk factors and natural logarithm of HOMA index in descending order were glucose,body mass index (BMI),triglyceride ( TG ),waist circumstance,high density lipoprotein- cholesterol (HDL-C),uric acid,diastolic blood pressure,systolic blood pressure and total cholesterol(TC) (all P<0.01 ).After adjusting factors as sex and age,glucose (r=0.49),BMI(r=0.44),TG (r=0.44),waist circumstance (r=0.41),uric acid (r=0.33) and HDL-C (r=-0.32),the systolic blood pressure (r=0.20),diastolic blood pressure (r=0.18) and TC (r=0.16) were independently correlated with HOMA index (P<0.001).Sex(OR=1.75) ,low HDL-C(OR= 1.80),hyperuricemia(OR=2.11 ),high TG(OR=2.14) and central obesity(OR=2.68)appeared to be independently correlated to insulin resistance in multiple logistic regression analysis.Conclusion The risk factors of CVD as low HDL-C,high TG,central obesity and hyperuricemia were independently correlated to insulin resistance.

17.
Chinese Journal of Cardiology ; (12): 940-943, 2008.
Article in Chinese | WPRIM | ID: wpr-355860

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the association between serum triglyceride (TG) and the cardiovascular diseases (CVD) risk in Chinese population.</p><p><b>METHODS</b>A total of 30, 378 men and women aged 35 - 64 years old were recruited in the Chinese-Chinese Multi-provincial Cohort Study (CMCS). The serum TG and other CVD risk factors were measured. All subjects were followed up annually or biannually for acute CVD events from 1992 to 2004. A Cox regression model was established to identify the association between TG and risk of CVD events.</p><p><b>RESULTS</b>The accumulative incidence rate of acute coronary heart disease (CHD) events increased from 62.6/100 000 in the low TG groups to 168.4/100 000 in the high TG group divided by the quartile. TG was identified as an independent risk factor for CHD after adjustment for the confounding risk factors by a Cox regression model. Compared subjects with TG < 0.81 mmol/L, CHD risk increased 81% and 59% in subjects with TG 1.15 - 1.59 mmol/L and TG >/= 1.60 mmol/L, respectively (all P < 0.05). There was no significant association between TG level and the risks of hemorrhagic and ischemic stroke events (P > 0.05).</p><p><b>CONCLUSION</b>Serum TG is an independent risk factor for acute CHD events in Chinese population aged 35 - 64.</p>


Subject(s)
Humans , Cohort Studies , Coronary Disease , Epidemiology , Myocardial Ischemia , Risk Factors , Triglycerides , Blood
18.
Chinese Journal of Cardiology ; (12): 655-658, 2008.
Article in Chinese | WPRIM | ID: wpr-355919

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the predictive value of the combined measurements of body mass index (BMI) and waist circumference (WC) for the risk of cardiometabolic diseases (including diabetes, hypertension, and dyslipidemia) and ischemic cardiovascular disease.</p><p><b>METHOD</b>A total of 30,378 Chinese people from 11 provinces were studied in this prospective study conducted from 1992 to 2003. Multivariable logistic and Cox regression were used respectively to determine the predictive value of WC for cardiometabolic diseases and ischemic cardiovascular disease within each BMI categories.</p><p><b>RESULTS</b>(1) The prevalence of obesity were 10% defined by BMI. Among them, 76.4% had abdominal obesity defined by WC. The prevalence of abdominal obesity was 17.5% by WC categories, and 43.4% of them were classified as obesity by BMI. (2) The prevalence rates of cardiometabolic diseases were higher in individuals with elevated WC within each BMI category. (3) Compared with subjects with normal BMI and WC, the risk of ischemic cardiovascular disease increased by 38% (RR = 1.383, 95% CI 1.083 - 1.765) in overweight subjects with elevated WC and by 57% (RR = 1.570, 95% CI 1.226 - 2.010) in obese subjects with elevated WC.</p><p><b>CONCLUSION</b>Combined measurements of BMI and WC provide a better prediction for the risk of cardiometabolic diseases and ischemic cardiovascular disease.</p>


Subject(s)
Adult , Female , Humans , Male , Middle Aged , Body Mass Index , Body Weight , Cardiovascular Diseases , Epidemiology , China , Epidemiology , Obesity , Epidemiology , Predictive Value of Tests , Prospective Studies , Risk Assessment , Waist Circumference , Waist-Hip Ratio
19.
Chinese Journal of Epidemiology ; (12): 652-655, 2008.
Article in Chinese | WPRIM | ID: wpr-313122

ABSTRACT

Objective To investigate the risk of cardiovascular diseases(CVD)incidence related to different combinations of the metabolic syndrome(MS)components.Methods A total of 30 378 subjects aged 35 to 64 years were recruited from 11 provinces in a Chinese Multi-provincial Cohort Study and of Dyslipidemia for Chinese Adults',issued in 2007.CVD incidence rates and relative risks(RR)were estimated by different MS components and by their various combinations.Results (1)According to the new criteria.the prevalence of MS was 11.8% for Chinese middle-age adults.The prevalence was 12.4% in men,significantly higher than that in women(9.0%).(2)Risk of CVD increased in proportion to the number of MS components after adjusting for other risk factors.If only 1 component was present,elevated blood pressure was the only significant predictor of CVD.When 2 components were present.5 of the 10 combinations were associated with significantly higher risk.All combinations with≥3 components(MS)had significant contribution except for those rare traits(<0.5% of the whole sample).Among the 16 combinations of≥3 components.the feature of"central obesity and elevated blood pressure"was found in all the 7 combinations with the highest risk.Conclusion CVD risk associated with various number and combinations of MS components seemed to be heterogeneous.The clustering of≥3 disorders,especially those with central obesity and elevated blood pressure could significantly predict the future development of CVD.

20.
Chinese Journal of Cardiology ; (12): 453-457, 2008.
Article in Chinese | WPRIM | ID: wpr-243759

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the association between white blood cell count and the risk of cardiovascular diseases (CVD) in subjects aged 35 - 64 years.</p><p><b>METHODS</b>This prospective study was carried out in 11 provinces from 1992 to 2003. The association of baseline white blood cell count and cardiovascular disease occurrence was analyzed in 30 384 subjects aged 35 - 64 years using Cox multivariate proportional hazards regression.</p><p><b>RESULTS</b>(1) Compared with the group of 4.0 - 4.9 x 10(9)/L, multivariate-adjusted relative risk of ischemic cardiovascular disease (ICVD, including coronary heart disease and ischemic stroke) increased continuously in proportion to increased white blood cell count. (2) White blood cell count had different impact on different types of CVD. Positive association was observed between white blood cell count and the risk of ischemic stroke, but the relationship between white blood cell count and the risk of hemorrhagic stroke was not significant. Compared with the referent group (4.0 - 4.9 x 10(9)/L), the risk of coronary heart disease of the group of white blood count > 9.0 x 10(9)/L increased by 70% (RR = 1.71, P < 0.05) and that of ischemic stroke increased by 80% (RR = 1.85, P < 0.01).</p><p><b>CONCLUSION</b>The risk of ICVD and CVD increases continuously in proportion to increased white blood cell count, the white blood cell count might be used to predict future risk of CVD, especially risk for ICVD.</p>


Subject(s)
Adult , Female , Humans , Male , Middle Aged , Asian People , Cardiovascular Diseases , Epidemiology , China , Epidemiology , Leukocyte Count , Prospective Studies , Risk Assessment , Risk Factors
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