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1.
Article in English | WPRIM | ID: wpr-713364

ABSTRACT

Intradialytic hypotension during dialysis adversely affects a patient's prognosis and increases mortality. We report a case in which intradialytic hypotension that persisted after the administration of midodrine was relieved after the use of fludrocortisone. Administration of 0.2 mg of fludrocortisone occurred 30 minutes before dialysis. We compared 45 sessions of dialysis without fludrocortisone administration and 45 sessions of dialysis with fludrocortisone administration in one patient. The number of times in which systolic blood pressure became lower than 80 mmHg and the number of early terminations of dialysis due to a decrease in systolic blood pressure were higher in the sessions without fludrocortisone administration than in the sessions with fludrocortisone administration (P < 0.05). Fludrocortisone may be helpful for the treatment of intradialytic hypotension that does not respond to midodrine administration.


Subject(s)
Blood Pressure , Dialysis , Fludrocortisone , Humans , Hypotension , Midodrine , Mortality , Prognosis , Renal Dialysis
2.
Article in English | WPRIM | ID: wpr-174341

ABSTRACT

Klinefelter's syndrome is the most common congenital abnormality that causes primary hypogonadism. It is associated with diseases that predominantly affect women, such as systemic lupus erythematosus (SLE), and it can sometimes cause veno-occlusive disease. We experienced a case of Budd-Chiari syndrome (BCS) in a 33-year-old man with Klinefelter's syndrome presented with hematemesis and edema in both lower extremities. The clinical and laboratory findings were compatible with SLE, antiphospholipid syndrome, and BCS. To the best of our knowledge, this is the first case report to describe a simultaneous presentation of these four clinical syndromes in a single patient.


Subject(s)
Adult , Antiphospholipid Syndrome , Budd-Chiari Syndrome , Congenital Abnormalities , Edema , Female , Hematemesis , Humans , Hypogonadism , Klinefelter Syndrome , Liver Cirrhosis , Lower Extremity , Lupus Erythematosus, Systemic
3.
Article in English | WPRIM | ID: wpr-787064

ABSTRACT

Klinefelter's syndrome is the most common congenital abnormality that causes primary hypogonadism. It is associated with diseases that predominantly affect women, such as systemic lupus erythematosus (SLE), and it can sometimes cause veno-occlusive disease. We experienced a case of Budd-Chiari syndrome (BCS) in a 33-year-old man with Klinefelter's syndrome presented with hematemesis and edema in both lower extremities. The clinical and laboratory findings were compatible with SLE, antiphospholipid syndrome, and BCS. To the best of our knowledge, this is the first case report to describe a simultaneous presentation of these four clinical syndromes in a single patient.


Subject(s)
Adult , Antiphospholipid Syndrome , Budd-Chiari Syndrome , Congenital Abnormalities , Edema , Female , Hematemesis , Humans , Hypogonadism , Klinefelter Syndrome , Liver Cirrhosis , Lower Extremity , Lupus Erythematosus, Systemic
4.
Article in English | WPRIM | ID: wpr-189579

ABSTRACT

Palonosetron is a 5-hydroxytryptamine-3 (5-HT-3) receptor antagonist used for preventing postoperative nausea and vomiting. Compared with ondansetron and granisetron, it is a better drug because of prolonged action and minimal side effects. Some adverse effects of palonosetron have been reported. In this report, we describe a 37-year-old male who developed severe hypersensitivity reactions to palonosetron during surgery for kidney donation. His medical history was unremarkable, except for inguinal hernia with herniorrhaphy 8 years ago. The surgery was uneventful until 2 hours 20 minutes. After palonosetron injection, his blood pressure dropped to 80/50 mm Hg, and facial edema, rash, conjunctival swelling, and wheezing developed. The patient was resuscitated by administration of ephedrine, hydrocortisone, and peniramine. Following the surgery, the patient was monitored for 3 days, and there were no subsequent anaphylactic reactions or other complications. The skin test on postoperative day 54 was positive for hypersensitivity to palonosetron. Although palonosetron is known for its safety, other hypersensitivity events have been reported. Ondansetron is another widely used 5-HT-3 antagonist, which has been reported to cause anaphylaxis. Therefore, clinicians should be aware of the possibility of patients experiencing severe adverse reactions to palonosetron.


Subject(s)
Adult , Anaphylaxis , Anesthesia, General , Blood Pressure , Drug Hypersensitivity , Edema , Ephedrine , Exanthema , Granisetron , Hernia, Inguinal , Herniorrhaphy , Humans , Hydrocortisone , Hypersensitivity , Kidney , Male , Ondansetron , Postoperative Nausea and Vomiting , Respiratory Sounds , Skin Tests
5.
Korean Journal of Medicine ; : 191-196, 2016.
Article in Korean | WPRIM | ID: wpr-101517

ABSTRACT

17α-hydroxylase deficiency is a rare cause of congenital adrenal hyperplasia and is characterized by primary amenorrhea, delayed puberty and hypertension. Although 17α-hydroxylase deficiency mimics mineralocorticoid-induced hypertension, impaired sexual development can aid in the differential diagnosis of this disease. A 32-year-old woman, who had a history of testicular feminization syndrome, presented with hypertension. Her aldosterone level was elevated whereas plasma renin activity was reduced, and her computed tomography scan showed a left adrenal adenoma, which was thought to be an aldosterone producing adenoma. A left adrenalectomy was performed to treat hypertension; however, the condition did not improve. The hormonal tests revealed high levels of plasma progesterone, mineralocorticoid and adrenocorticotropic hormone, and low levels of 17a hydroxyprogesterone, cortisol and sex hormones. The patient was diagnosed with 17α-hydroxylase deficiency and commenced on prednisolone, which controlled hypertension. Here, we report a case of 17α-hydroxylase deficiency mimicking hyperaldosteronism via aldosterone-producing adrenal adenoma.


Subject(s)
Adenoma , Adrenal Hyperplasia, Congenital , Adrenalectomy , Adrenocortical Adenoma , Adrenocorticotropic Hormone , Adult , Aldosterone , Amenorrhea , Androgen-Insensitivity Syndrome , Diagnosis, Differential , Female , Gonadal Steroid Hormones , Humans , Hydrocortisone , Hyperaldosteronism , Hypertension , Male , Plasma , Prednisolone , Progesterone , Puberty, Delayed , Renin , Sexual Development
6.
Article in Korean | WPRIM | ID: wpr-123569

ABSTRACT

A 65-year-old female visited the emergency room for severe back pain radiating to the neck. Aortic dissection computed tomography revealed a ruptured liver abscess and large pneumoperitoneum. Although emergent percutaneous drainage of the liver abscess and aggressive resuscitation were performed, massive hemolytic anemia and disseminated intravascular hemolysis developed and she subsequently died, 11 hours after her visit to the emergency room. Clostridium perfringens was identified in a blood culture obtained at the emergency room. We report this case because refractory septic shock due to a liver abscess and massive intravascular hemolytic anemia caused by Clostridium perfringens in a healthy female is rare.


Subject(s)
Aged , Anemia, Hemolytic , Back Pain , Clostridium perfringens , Clostridium , Disseminated Intravascular Coagulation , Drainage , Emergency Service, Hospital , Female , Hemolysis , Humans , Liver Abscess , Liver , Neck , Pneumoperitoneum , Resuscitation , Shock, Septic
7.
Article in Korean | WPRIM | ID: wpr-123564

ABSTRACT

Hemophagocytic lymphohistiocytosis (HLH), associated with acute myelocytic leukemia (AML), is a very rare disease. We here report a case of HLH occurring after induction chemotherapy for AML. AML-associated HLH can be triggered by AML itself, by chemotherapeutic agents, or by infectious complications. Our patient developed a high-grade fever of unknown cause, bilateral pulmonary infiltrates, and shock after successful treatment of AML with induction chemotherapy, and had high serum ferritin, hypertriglyceridemia, hypofibrinogenemia, hemophagocytic histiocytes in bone marrow, low natural killer cell activity, and elevated soluble interleukin-2 receptor levels. A diagnosis of HLH was made. Dexamethasone, cyclosporine, and etoposide were given and allogeneic hematopoietic stem cell transplantation was performed. Careful suspicion of HLH may be warranted if a patient experiences fever of unknown etiology, high ferritin levels, and liver dysfunction during AML treatment.


Subject(s)
Bone Marrow , Cyclosporine , Dexamethasone , Diagnosis , Etoposide , Ferritins , Fever , Hematopoietic Stem Cell Transplantation , Histiocytes , Humans , Hypertriglyceridemia , Induction Chemotherapy , Interleukin-2 , Killer Cells, Natural , Leukemia, Myeloid, Acute , Liver Diseases , Lymphohistiocytosis, Hemophagocytic , Rare Diseases , Shock
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