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1.
Rev. bras. med. esporte ; 29: e2022_0370, 2023. tab
Article in English | LILACS-Express | LILACS | ID: biblio-1407626

ABSTRACT

ABSTRACT Introduction: We should pay attention to physical and psychological training still in the growth phase of athletes to ensure a better overall performance quality. Psychological training can be an effective tool to improve the technical level and skills of swimming. Objective: This paper discusses the relationship between mental health education and training intensity in college swimmers. Methods: The mental health of professional swimmers in college sports is explored with study subjects undergoing a 10-week training trial. The comparison of clinical effects between various psychological training modalities and swimmers' self-management is analyzed. In a second step, this paper performs statistics and analysis on the questionnaire and experimental data. Results: The exercise ability of the control group was significantly improved after relaxation training, tension training, and thought control training (P<0.05). The results showed that the learning effect of the experimental group was significantly better than that of the control group (P<0.05). Conclusion: Psychological training and self-regulation in training have a good effect on improving the mental quality of competitive sports players. This approach improves athletes' performance more effectively than other approaches. The psychological self-regulation training method is one that swimming coaches should pay attention to and advocate vigorously. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.


RESUMO Introdução: Devemos prestar atenção aos exercícios físicos e psicológicos ainda na fase do crescimento dos atletas para garantir uma melhor qualidade geral de seu desempenho. O treinamento psicológico pode ser uma ferramenta eficaz para melhorar o nível técnico e as habilidades da natação. Objetivo: Este artigo discute a relação entre educação em saúde mental e intensidade de treinamento nos nadadores universitários. Métodos: A saúde mental de nadadores profissionais em esportes universitários é explorada com os sujeitos do estudo sendo submetidos a um teste de treinamento de 10 semanas. A comparação dos efeitos clínicos entre diversas modalidades de formação psicológica é executada e analisa-se a autogestão dos nadadores. Num segundo momento, este artigo realiza estatísticas e análises sobre o questionário e dados experimentais. Resultados: A capacidade de exercício do grupo controle foi significativamente melhorada após o treinamento de relaxamento, treinamento de tensão e treinamento de controle de pensamento (P<0,05). Os resultados mostraram que o efeito de aprendizagem do grupo experimental foi significativamente melhor do que o do grupo controle (P<0,05). Conclusão: O treinamento psicológico da autorregulação no treinamento tem um bom efeito na melhoria da qualidade mental dos jogadores esportivos competitivos. Essa abordagem melhora o desempenho do atleta de forma mais eficaz do que outras abordagens. O método de treinamento psicológico da autorregulação é um método que os treinadores de natação devem prestar atenção e defender vigorosamente. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.


RESUMEN Introducción: Debemos prestar atención al entrenamiento físico y psicológico todavía en la fase de crecimiento de los deportistas para garantizar una mejor calidad general de su rendimiento. El entrenamiento psicológico puede ser una herramienta eficaz para mejorar el nivel técnico y las habilidades de natación. Objetivo: Este trabajo analiza la relación entre la educación en salud mental y la intensidad del entrenamiento en nadadores universitarios. Métodos: Se explora la salud mental de los nadadores profesionales de deportes universitarios con sujetos de estudio sometidos a una prueba de entrenamiento de 10 semanas. Se realiza la comparación de los efectos clínicos entre varias modalidades de entrenamiento psicológico y se analiza la autogestión de los nadadores. En un segundo paso, este documento realiza estadísticas y análisis sobre el cuestionario y los datos experimentales. Resultados: La capacidad de ejercicio del grupo de control mejoró significativamente tras el entrenamiento de relajación, el entrenamiento de tensión y el entrenamiento de control del pensamiento (P<0,05). Los resultados mostraron que el efecto de aprendizaje del grupo experimental fue significativamente mejor que el del grupo de control (P<0,05). Conclusión: El entrenamiento psicológico de la autorregulación en el entrenamiento tiene un buen efecto en la mejora de la calidad mental de los jugadores deportivos de competición. Este enfoque mejora el rendimiento de los atletas de forma más eficaz que otros enfoques. El método de entrenamiento de autorregulación psicológica es uno de los que los entrenadores de natación deberían prestar atención y defender enérgicamente. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

2.
Asian Journal of Andrology ; (6): 287-295, 2023.
Article in English | WPRIM | ID: wpr-981942

ABSTRACT

Most prostate cancers initially respond to androgen deprivation therapy (ADT). With the long-term application of ADT, localized prostate cancer will progress to castration-resistant prostate cancer (CRPC), metastatic CRPC (mCRPC), and neuroendocrine prostate cancer (NEPC), and the transcriptional network shifted. Forkhead box protein A1 (FOXA1) may play a key role in this process through multiple mechanisms. To better understand the role of FOXA1 in prostate cancer, we review the interplay among FOXA1-targeted genes, modulators of FOXA1, and FOXA1 with a particular emphasis on androgen receptor (AR) function. Furthermore, we discuss the distinct role of FOXA1 mutations in prostate cancer and clinical significance of FOXA1. We summarize possible regulation pathways of FOXA1 in different stages of prostate cancer. We focus on links between FOXA1 and AR, which may play different roles in various types of prostate cancer. Finally, we discuss FOXA1 mutation and its clinical significance in prostate cancer. FOXA1 regulates the development of prostate cancer through various pathways, and it could be a biomarker for mCRPC and NEPC. Future efforts need to focus on mechanisms underlying mutation of FOXA1 in advanced prostate cancer. We believe that FOXA1 would be a prognostic marker and therapeutic target in prostate cancer.


Subject(s)
Humans , Male , Androgen Antagonists/therapeutic use , Androgens/metabolism , Hepatocyte Nuclear Factor 3-alpha/metabolism , Mutation , Prostatic Neoplasms, Castration-Resistant/drug therapy , Receptors, Androgen/metabolism
3.
Chinese Journal of Hospital Administration ; (12): 6-10, 2022.
Article in Chinese | WPRIM | ID: wpr-934553

ABSTRACT

In the era of the new healthcare reform, high-quality cost accounting can effectively enhance the business performance of public hospitals. Compared with single-campus hospitals, the cost accounting of multi-campus hospitals is faced with greater complexity and challenges. The authors analyzed cost accounting problems found in the latter, namely the lack of top-level design in the construction of a fine multi-campus cost accounting system, difficulty of reasonable collection and allocation of various costs, lack of strong information support, outdated research methods used in item cost accounting among others, as well as their causes. On such basis, the authors put forward countermeasures for high-quality cost accounting in multi-campus hospitals, for the purpose of fully leveraging the leadership of cost control in the high-quality development of public hospitals.

4.
Chinese Pharmacological Bulletin ; (12): 209-214, 2022.
Article in Chinese | WPRIM | ID: wpr-1014196

ABSTRACT

Aim To study the effect of tetrandrine derivative HL-49 on the conformation and biological ac-tivity of Bloom helicase ( BLM ) , and to explore its antitumor mechanism.Methods The effect of HL-49 on the conformation of BLM helicase was studied by ultra- violet spectroscopy.The effects of HL-49 on DNA binding activity, DNA chain dissociation activity and ATPase activity of HL-49 on BLM DNA helicase were analyzed by fluorescence polarization and malachite green-ammonium phosphomolybdate colorimetric method.Results HL-49, a tetrandrine derivative, indirectly inhibited the ATPase activity of BLM DNA heli- case and DNA unwinding activity by reversible binding with DNA.The results of fluorescence polarization experiments showed that HL-49 could not affect the bind ing activity of BLM DNA helicase to DNA (dsDNA/ss- DNA) , but could bind to DNA in a concentration-de- pendent manner (P < 0.01).With the increase of HL- 49 concentration, the DNA unwinding ability of BLM DNA helicase decreased, and the Kobs value decreased gradually.The results of malachite green-ammonium phosphomolybdate colorimetry showed that HL-49 could significantly inhibit the ATPase activity of BLM DNA helicase.Conclusions HL49 can inhibit the ATPase activity and DNA unwinding activity of BLM DNA helicase by the reversible binding with DNA.

5.
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery ; (12): 467-472, 2022.
Article in Chinese | WPRIM | ID: wpr-923442

ABSTRACT

@#Objective    To investigate the effect of optimized arterial perfusion strategy on total arch replacement for acute type A aortic dissection (AAAD) with malperfusion syndrome (MPS). Methods    From 2017 to 2019, 51 patients with AAAD and MPS who had received total arch replacement with optimized arterial perfusion strategy in our hospital were included in the optimized perfusion group, including 40 males and 11 females, with an average age of 47.43±13.39 years. A total of 40 patients with AAAD and MPS who had been treated with traditional Sun's surgery were taken as the traditional control group, including 31 males and 9 females, with an average age of 50.66±12.05 years. The perioperative clinical data of the two groups were compared. Results    The preoperative baseline data of the two groups were basically consistent (P>0.05). The comparison of operative data between the optimized perfusion group and the traditional control group showed that in the optimized perfusion group, the extracorporeal circulation time, aortic occlusion time, and circulation-out cerebral perfusion time were significantly less than those in the traditional control group (223.64±65.13 min  vs. 266.77±87.04 min, 114.48±27.28 min vs. 138.20±39.89 min, 8.28±3.81 min vs. 50.53±23.60 min, all P≤0.05). The lowest intraoperative nasopharyngeal temperature in the optimized perfusion group was significantly higher than that in the traditional control group (27.10±1.18℃ vs. 23.6±3.30℃, P=0.000). Postoperative wakefulness time of the optimized perfusion group was earlier than that of the traditional control group (4.50±1.35 h vs. 5.27±1.15 h, P=0.019). The volume of blood transfusions in the optimized perfusion group was significantly less than that in the traditional control group (13.25±9.06 U vs. 16.95±7.53 U, P=0.046). There was no significant difference in ICU time and invasive ventilation time between the two groups (P>0.05). Postoperative complications of the two groups showed that the incidence of postoperative continuous renal replacement therapy in the optimized perfusion group was significantly lower than that in the traditional control group, with a statistically significant difference (21.6% vs. 42.5% P=0.003). The incidence of postoperative delirium, coma, low cardiac row syndrome and limb ischemia in the optimized perfusion group was lower than that in the traditional control group, but the difference was not statistically significant (P>0.05). The incidence of postoperative hemiplegia, sepsis, and secondary thoracotomy in the optimized perfusion group was higher than that in the traditional control group, and the difference was not statistically significant (P>0.05). Postoperative mortality in the optimized perfusion group was significantly lower than that in the traditional control group (13.7% vs. 27.5%), but the difference was not statistically significant (P=0.102). Conclusion    Optimized arterial perfusion strategy and its related comprehensive surgical technique reduce surgical trauma, shorten the operation time, reduce perioperative consumption of blood products. Postoperative wakefulness is rapid and the incidence of complications of nervous system, kidney and limb ischemia is low. Optimized arterial perfusion strategy is suitable for operation of AAAD with MPS by inhibiting the related potential death risk factors to reduce operation mortality.

6.
International Journal of Surgery ; (12): 563-566, 2022.
Article in Chinese | WPRIM | ID: wpr-954252

ABSTRACT

Hilar cholangiocarcinoma is the most common extrahepatic malignant tumor in clinic, accounting for about 50%-60% of bile duct tumors. Currently, radical surgical resection is regarded as the best treatment for early hepatic hilar cholangiocarcinoma, but, it’s early lesions have no obvious clinical symptoms. Most patients are already in the advanced stage of the disease when they are admitted to hospital. The surgical resection rate is low, and the 5-year survival rate does not exceed 25%. Locally advanced hepatic hilar cholangiocarcinoma are treated with neoadjuvant chemoradiation therapy followed by surgery, it can prolong survival time of the patient. At the same time, the recurrence rate after surgery can reach 50%-70%, and the cancer easily invades microvessels, lymphatic vessels, peripheral nerves and liver, which is one of the most challenging problems in the field of biliary surgery. Therefore, early diagnosis, perioperative management, adequate and accurate preoperative staging assessment, intraoperative standardized resection, postoperative adjuvant therapy of hilar cholangiocarcinoma, it is of great significance to improve the rate of radical surgical resection and prolong the survival time of patients.

7.
Journal of Integrative Medicine ; (12): 265-273, 2022.
Article in English | WPRIM | ID: wpr-929220

ABSTRACT

OBJECTIVE@#It has been reported that local vibration therapy can benefit recovery after peripheral nerve injury, but the optimized parameters and effective mechanism were unclear. In the present study, we investigated the effect of local vibration therapy of different amplitudes on the recovery of nerve function in rats with sciatic nerve injury (SNI).@*METHODS@#Adult male Sprague-Dawley rats were subjected to SNI and then randomly divided into 5 groups: sham group, SNI group, SNI + A-1 mm group, SNI + A-2 mm group, and SNI + A-4 mm group (A refers to the amplitude; n = 10 per group). Starting on the 7th day after model initiation, local vibration therapy was given for 21 consecutive days with a frequency of 10 Hz and an amplitude of 1, 2 or 4 mm for 5 min. The sciatic function index (SFI) was assessed before surgery and on the 7th, 14th, 21st and 28th days after surgery. Tissues were harvested on the 28th day after surgery for morphological, immunofluorescence and Western blot analysis.@*RESULTS@#Compared with the SNI group, on the 28th day after surgery, the SFIs of the treatment groups were increased; the difference in the SNI + A-2 mm group was the most obvious (95% confidence interval [CI]: [5.86, 27.09], P < 0.001), and the cross-sectional areas of myocytes in all of the treatment groups were improved. The G-ratios in the SNI + A-1 mm group and SNI + A-2 mm group were reduced significantly (95% CI: [-0.12, -0.02], P = 0.007; 95% CI: [-0.15, -0.06], P < 0.001). In addition, the expressions of S100 and nerve growth factor proteins in the treatment groups were increased; the phosphorylation expressions of ERK1/2 protein in the SNI + A-2 mm group and SNI + A-4 mm group were upregulated (95% CI: [0.03, 0.96], P = 0.038; 95% CI: [0.01, 0.94], P = 0.047, respectively), and the phosphorylation expression of Akt in the SNI + A-1 mm group was upregulated (95% CI: [0.11, 2.07], P = 0.031).@*CONCLUSION@#Local vibration therapy, especially with medium amplitude, was able to promote the recovery of nerve function in rats with SNI; this result was linked to the proliferation of Schwann cells and the activation of the ERK1/2 and Akt signaling pathways.


Subject(s)
Animals , Male , Rats , Peripheral Nerve Injuries/therapy , Proto-Oncogene Proteins c-akt/pharmacology , Rats, Sprague-Dawley , Sciatic Nerve/metabolism , Sciatic Neuropathy/metabolism , Vibration/therapeutic use
8.
Journal of Southern Medical University ; (12): 163-170, 2022.
Article in Chinese | WPRIM | ID: wpr-929073

ABSTRACT

Objective Circular RNAs (circRNAs) are non-coding RNAs (ncRNA) circularized without a 3' polyadenylation [poly-(A)] tail or a 5' cap, resulting in a covalently closed loop structure. circRNAs were first discovered in RNA viruses in the 1970s, but only a small number of circRNAs were discovered at that time due to limitations in traditional polyadenylated transcriptome analyses. With the development of specific biochemical and computational methods, recent studies have shown the presence of abundant circRNAs in eukaryotic transcriptomes. circRNAs play vital roles in many physiological and pathological processes, such as acting as miRNA sponges, binding to RNA-binding proteins (RBPs), acting as transcriptional regulatory factors, and even serving as translation templates. Current evidence has shown that circRNAs can be potentially used as excellent biomarkers for diagnosis, therapeutic effect evaluation, and prognostic assessment of a variety of diseases, and they may also provide effective therapeutic targets due to their stability and tissue and development-stage specificity. This review focuses on the properties of circRNAs and their immune relationship to disease, and explores the role of circRNAs in immune-related diseases and the directions of future research.


Subject(s)
Biomarkers , MicroRNAs/genetics , RNA, Circular , Transcriptome
9.
Chinese Journal of Infectious Diseases ; (12): 2-8, 2021.
Article in Chinese | WPRIM | ID: wpr-884181

ABSTRACT

Objective:To systematically review the severe risk in common chronic diseases and coronavirus disease 2019 (COVID-19) cases.Methods:PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, Wanfang Database, China Biology Medicine disc, medRxiv, SSRN and ChinaXiv were searched for clinical and epidemiological studies that reported chronic diseases in patients with COVID-19. Only studies of severe COVID-19 in comparison with non-severe controls were included. The prevalence rates of chronic diseases including chronic obstructive pulmonary disease (COPD), diabetes mellitus, hypertension, malignant tumor, cardiovascular diseases, cerebrovascular disease, chronic kidney disease, and chronic liver disease were estimated. Pooled odds ratio ( OR) with 95% confidence interval ( CI) between patients with severe COVID-19 and non-severe groups were calculated. R 3.6.3 software was used for meta-analysis. Results:The search yielded 2 455 articles. A total of 19 eligible comparative studies with 4 792 patients were included in a quantitative analysis. Meta-analysis showed that there was a proportion of 55.0% (95% CI 40.0%-80.0%) male among patients with COVID-19, and the overall pooled prevalence of any chronic diseases in COVID-19 cases was 30.4% (95% CI 24.0%-37.0%). The most prevalent comorbidity was hypertension (16.9%(95% CI 14.0%-20.0%)), followed by diabetes mellitus (8.3%(95% CI 8.0%-9.0%)). The proportion of male patients with severe COVID-19 was higher than that of male patients with non-severe COVID-19 (64.4% vs 52.8%, OR=1.49, 95% CI 1.08-2.05, Z=4.63, P<0.01). The prevalence rates of COPD, cerebrovascular disease, diabetes mellitus, chronic kidney disease, hypertension, cardiovascular diseases and malignant tumor in severe COVID-19 patients were higher than those of non-severe patients ( OR=5.77, 95% CI 3.80-8.74; OR=4.47, 95% CI 2.71-7.38; OR=3.55, 95% CI 2.86-4.40; OR=3.05, 95% CI=1.76-5.28; OR=2.82, 95% CI=1.96-3.97; OR=2.39, 95% CI=1.77-3.23; OR=2.15, 95% CI 1.27-3.66, respectively, Z=8.37, 6.01, 11.60, 4.20, 5.46, 5.71, 3.12, all P<0.01). There was no significant difference in the prevalence of chronic liver disease between severe and non-severe patients ( OR=1.35, 95% CI 0.84-2.17, P=0.11). Conclusion:COVID-19 patients with chronic diseases have higher risk of developing severe disease, and the ORs from high to low are COPD, cerebrovascular disease, diabetes mellitus, chronic kidney disease, hypertension, cardiovascular diseases and malignant tumor.

10.
Acta Academiae Medicinae Sinicae ; (6): 271-277, 2021.
Article in Chinese | WPRIM | ID: wpr-878731

ABSTRACT

With the upsurge of medical artificial intelligence,the use of computer vision technology to study medical images,which can effectively help doctors to identify and screen diseases,has become a focus of researchers.This paper summarizes the basic situation,specific information,related research,and data sharing and utilizing ways of foreign breast image datasets.This review provides inspirations for the opening of Chinese medical and health data.


Subject(s)
Artificial Intelligence , Breast/diagnostic imaging
11.
Chinese Journal of Primary Medicine and Pharmacy ; (12): 1296-1302, 2021.
Article in Chinese | WPRIM | ID: wpr-909208

ABSTRACT

Objective:To investigate the effects of thrombolytic therapy time on serum inflammatory factors, cathepsin S, connective tissue growth factor (CTGF), left ventricular ejection fraction (LVEF) and left ventricular end diastolic diameter (LVEDD) in patients with acute ST-elevation myocardial infarction.Methods:The clinical data of 119 patients with acute ST-elevation myocardial infarction who received thrombolytic therapy in the People's Hospital of Taierzhuang District of Zaozhuang from January 2019 to May 2020 were retrospectively analyzed. These patients were assigned to three groups according to different time points at which thrombolytic therapy was performed: group A (the time from onset to thrombolytic therapy ≤ 3 hours, n = 27), group B (3 hours < the time from onset to thrombolytic therapy ≤ 6 hours, n = 39), group C (6 hours < the time from onset to thrombolytic therapy ≤ 12 hours, n = 53). Recanalization rate, recanalization time, ST segment resolution rate at 2 and 12 hours, serum levels of inflammatory factors [including interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) and high-sensitivity C-reactive protein (hs-CRP)], cathepsin S, CTGF, LVEF, and LVEDD, and incidence of cardiovascular adverse events. Results:Recanalization time in group C was (148.73 ± 15.37) minutes, which was significantly longer than that in groups A and B [(89.34 ± 8.95) minutes, (98.76 ± 9.33) minutes]. Recanalization rate and ST segment resolution rate at 2 and 12 hours in group C were 45.28%, (40.17 ± 4.77) %, (73.92 ± 8.24) %, respectively, which were significantly lower than those in the groups A and B [96.30%, 79.49%, (47.42 ± 5.12)%; (83.68 ± 9.33)%, (43.56 ± 4.87)%, (78.73 ± 8.44)%] ( t/ χ2 = 248.088, 4.244, 20.204, 11.146, 18.508, 19.861, 6.271, 4.789, 17.995, 10.932, 3.339, 4.111, 4.100, 3.828, 3.100, 2.244, all P < 0.05). At 2 and 12 hours after thrombolytic therapy, IL-6, TNF-α and hs-CRP levels in group C were (23.29 ± 2.12) ng/L, (27.03 ± 2.75) ng/L, (6.49 ± 2.37) mg/L, (22.73 ± 2.05) ng/L, (26.24 ± 2.37) ng/L and (6.01 ± 2.53) mg/L, respectively, which were significantly higher than those in groups A and B ( t = 54.578, 54.578, 10.638, 8.584, 8.735, 5.199, 7.909, 7.171, 3.597, 1.382, 1.584, 1.008, 7.237, 5.190, 4.364, 8.829, 11.114, 2.585, 3.172, 6.815, 2.196, all P < 0.05). At 2 and 12 hours after thrombolytic therapy, cathepsin S and CTGF levels in group C were (29.97 ± 3.98) μg/L, (30.03 ± 4.79) μg/L, (28.05 ± 2.13) μg/L, (28.29 ± 4.31) μg/L, respectively, which were significantly higher than those in groups A and B [(31.74 ± 3.56) μg/L, (29.87 ± 4.91) μg/L; (20.81 ± 2.35) μg/L, (16.94 ± 3.46) μg/L; (30.95 ± 3.79) μg/L, (29.93 ± 4.95) μg/L; (26.37 ± 2.44) μg/L, (21.46 ± 4.79) μg/L, t = 93.870, 68.555, 15.039, 12.562, 6.345, 7.679, 3.096, 1.966, 13.882, 3.514, 11.863, 7.164, 9.239, 4.199, all P < 0.05). At 2 and 12 hours after thrombolytic therapy, LVEF and LVEDD in group C were (42.81 ± 4.77)%, (52.64 ± 4.71) mm, (43.13 ± 5.11)%, (51.57 ± 4.01) mm, respectively, which were significantly lower than those in groups A and B [(42.61 ± 4.58)%, (52.31 ± 4.47) mm, (46.33 ± 4.35)%, (47.75 ± 3.41) mm, (42.73 ± 4.79)%, (52.79 ± 4.76) mm, (44.79 ± 4.44)%, (49.93 ± 3.73) mm, t = 4.285, 9.193, 3.060, 4.214, 1.970, 2.953, 0.333, 1.259, 2.779, 1.626, 4.229, 1.996, 1.404, 2.416, all P < 0.05). The total incidence of cardiovascular adverse events was 7.41%, 12.82% and 33.96% in groups A, B and C, respectively ( χ2 = 4.383, all P < 0.05). Conclusion:The earlier the thrombolytic therapy time after acute ST-elevation myocardial infarction, the higher the recanalization rate and ST segment resolution rate, the milder the inflammatory reaction, atherosclerosis, the better the cardiac remodeling, the better the recovery of cardiac function, and the lower the incidence of cardiovascular adverse events.

12.
Journal of Central South University(Medical Sciences) ; (12): 8-16, 2020.
Article in English | WPRIM | ID: wpr-812994

ABSTRACT

OBJECTIVES@#To detemine preventive effects of compound formula Rhizoma Coptidis and Atractylodes on mice with gastric-ulcer.@*METHODS@#The mice were randomly divided into a normal group, a gastric ulcer group, a ranitidine positive drug group, a Rhizoma Coptidis group, an Atractylodes group, and a Rhizoma Coptidis plus Atractylodes group (the ratios of Coptidis to Atractylodes were 9꞉1, 8꞉2, 7꞉3, 6꞉4, 5꞉5, or 4꞉6, respectively). Gastric ulcer models were established by intragastric administration of anhydrous ethanol after 6 days of preventive infusion. The mice were killed 6 days after the treatments. The whole stomach was opened to observe gross morphology of gastric mucosa. The pathological changes of gastric tissue were observed under microscope, and serum samples were collected to detect the contents of superoxide dimutase (SOD), malondialdehyde (MDA), NO, and endothelin-1 (ET-1).@*RESULTS@#The Rhizoma Coptidis and Atractylodes decoction significantly decreased ulcer area (<0.001), and the effects of compound formula are better than those of Coptidis and Atractylodes alone (<0.05, <0.01, or <0.001). The anti-ulcer effect of compound formula (Coptidis꞉Atractylodes=6꞉4) was the best one, and the anti-gastric ulcer effect of the high-dose group was significantly better than that of the ranitidine-positive group (<0.001). The ranitidine positive drug group, the high-dose group of Rhizoma Coptidis, the high-dose group of Atractylodes, and the high-dose group of Rhizoma Coptidis-Atractylodes (6꞉4) significantly reduced MDA, ET-1 (<0.01 or <0.001), and significantly increased SOD, NO in serum (<0.01 or <0.001).@*CONCLUSIONS@#Rhizoma Coptidis and Atractylodes decoction exerts the effect on preventing ethanol-induced gastric ulcer in mice in a ratio-dependent and dose-dependent manner. The mechanism might be related to anti-oxidation and relaxion of blood vessels. The combination of the two drugs shows a synergistic effect.


Subject(s)
Animals , Mice , Atractylodes , Drugs, Chinese Herbal , Gastric Mucosa , Stomach Ulcer
13.
Chinese Journal of School Health ; (12): 1295-1298, 2020.
Article in Chinese | WPRIM | ID: wpr-826286

ABSTRACT

Objective@#To explore the visuospatial memory characteristics of school-age children with exotropia and to analyze associated factors.@*Methods@#Based on a case-control study,45 exotropia children aged 8-12 years and 45 normal control children were recruited from 2017-2019. The "tapping test" was used to evaluate the visuospatial short-term and working memory of children.@*Results@#There was no significant differences in the scores of visuospatial short-term memory between the exotropia group and the control group [(7.64±1.69)(8.00±1.66),t=-1.00,P=0.32)]. The scores of visuospatial working memory in the control group were higher than those in the exotropia group [(5.98±1.23)(6.80±1.53),t=-2.81,P=0.01)]. In the reverse tapping test,the better the near stereopsis was,the higher the score was (B=0.78,95%CI=0.23-1.33,P=0.01),and the constant exotropia children performed better than the intermittent exotropia children(B=1.25,95%CI=0.16-2.24,P=0.03).@*Conclusion@#Visuospatial working memory is impaired in school-age children with exotropia,and the visuospatial working memory of exotropia children is affected by the near stereopsis and exotropia constancy.

14.
Chinese Journal of School Health ; (12): 1303-1306, 2020.
Article in Chinese | WPRIM | ID: wpr-829113

ABSTRACT

Objective@#To understand the characteristics of rapid naming in exotropia children, and to analyze the influence of clinical indicators related to exotropia on the rapid naming.@*Methods@#A total of 45 exotropia children were recruited according to the diagnostic criteria of consensus of strabismus classification experts (2015) from the Zhongshan ophthalmic center as the case group, and 45 children of the same age, gender and parental educational status were recruited as the control group without any ocular diseases. All children were evaluated the ability of the rapid naming by classical rapid naming test.@*Results@#The letter rapid naming time of children with exotropia was longer than that in control group [(26.87±10.18)(21.98±7.29)s], and the difference was statistically significant (t=2.73, P=0.01), however there was no significant correlation between strabismus degree, symptom duration, AC/A ratio, disease classification, simultaneous vision, the near stereopsis, the far stereopsis and the letter rapid naming in the clinical indicators of exotropia (r=-0.16, 0.23, 0.20, 0.06, 0.09, 0.05, 0.20, P>0.05).@*Conclusion@#Rapid naming might be impaired among children with exotropia, with no significant correlation between this defect and its clinical indicators.

15.
Chinese Journal of Cardiology ; (12): 567-571, 2020.
Article in Chinese | WPRIM | ID: wpr-941081

ABSTRACT

Objective: To evaluate the cardiovascular damage of patients with COVID-19, and determine the correlation of serum N-terminal pro B-type natriuretic peptide (NT-proBNP) and cardiac troponin-I (cTnI) with the severity of COVID-19, and the impact of concomitant cardiovascular disease on severity of COVID-19 was also evaluated. Methods: A cross-sectional study was designed on 150 consecutive patients with COVID-19 in the fever clinic of Tongji Hospital in Wuhan from January 19 to February 13 in 2020, including 126 mild cases and 24 cases in critical care. Both univariate and multivariate logistic regression were used to analyze the correlation of past medical history including hypertension, diabetes and coronary heart disease (CHD), as well as the levels of serum NT-proBNP and cTnI to the disease severity of COVID-19 patients. Results: Age, hypersensitive C-reactive protein(hs-CRP) and serum creatinine levels of the patients were higher in critical care cases than in mild cases(all P<0.05). Prevalence of male, elevated NT-proBNP and cTnI, hypertension and coronary heart disease were significantly higher in critical cases care patients than in the mild cases(all P<0.05). Univariate logistic regression analysis showed that age, male, elevated NT-proBNP, elevated cTnI, elevated hs-CRP, elevated serum creatinine, hypertension, and CHD were significantly correlated with critical disease status(all P<0.05). Multivariate logistic regression analysis showed that elevated cTnI(OR=26.909,95%CI 4.086-177.226,P=0.001) and CHD (OR=16.609,95%CI 2.288-120.577,P=0.005) were the independent risk factors of critical disease status. Conclusions: COVID-19 can significantly affect the heart function and lead to myocardial injury. The past medical history of CHD and increased level of cTnI are 2 independent determinants of clinical disease status in patients with COVID-19.


Subject(s)
Female , Humans , Male , Betacoronavirus , Biomarkers/blood , COVID-19 , Cardiovascular Diseases/virology , China , Coronavirus Infections/pathology , Cross-Sectional Studies , Myocardium/pathology , Natriuretic Peptide, Brain/blood , Pandemics , Peptide Fragments , Pneumonia, Viral/pathology , Prognosis , SARS-CoV-2 , Troponin I/blood
16.
Chinese Journal of Rehabilitation Theory and Practice ; (12): 766-770, 2020.
Article in Chinese | WPRIM | ID: wpr-905385

ABSTRACT

Diffusion tensor imaging is a magnetic resonance imaging technology, based on the diffusion motion of water molecules, to obtain anisotropy informations of different tissues, which is used for early identification, accurate localization and grading in various fields of peripheral nerve injury, such as peripheral nerve injury repair, micro-lesion recognition and neuro-tumor. However, since diffusion tensor imaging is still at the early stage of clinical research, and the measurements are influenced by various factors such as technical settings and sequence specifications, the standardization of clinical measurement protocols and the quantification of parameters remain to be further studied.

17.
Chinese Journal of Anesthesiology ; (12): 1325-1327, 2018.
Article in Chinese | WPRIM | ID: wpr-745600

ABSTRACT

Objective To evaluate the efficacy of erector spinae plane block (ESPB) combined with general anesthesia when used for thoracoscopic radical resection of lung cancer.Methods Forty patients of both sexes,aged 30-64 yr,with body mass index of 18-24 kg/m2,of American Society of Anesthesiologists physical status Ⅰ or Ⅱ,scheduled for elective thoracoscopic radical resection of lung cancer,were divided into 2 groups (n =20 each) using a random number table method:ESPB combined with general anesthesia group (group EG) and general anesthesia group (group G).ESPB was performed before anesthesia induction,and 20 min later the effect was evaluated by testing the area of block in group EG.Anesthesia was induced with midazolam,propofol,sufentanil and cisatracurium and maintained with sevoflurane and remifentanil to maintain the bispectral index value between 40 and 60.Patient-controlled intravenous analgesia was applied in both groups at the end of operation,flurbiprofen axetil 100 mg was intravenously injected as a remedy for analgesia when necessary,and the visual analog scale score was maintained less than or equal to 3.The intraoperative consumption of sulfentanil and remifentanil,emergence time from anesthesia and time of tracheal extubation were recorded.The development of adverse effects within 48 h after operation,postoperative length of hospital stay,requirement for rescue analgesia and patients' overall satisfaction with postoperative analgesia were also recorded.Results Compared with group G,the intraoperative consumption of sulfentanil and remifentanil was significantly decreased,the emergence time from anesthesia and time of tracheal extubation were shortened,the incidence of nausea and vomiting within 48 h after operation was decreased,the first occurrence time was prolonged,the requirement for rescue analgesia was decreased,postoperative length of hospital stay was shortened,and patients' satisfaction scores were increased in group EG (P<0.05).Conclusion ESPB combined with general anesthesia can reduce the perioperative consumption of opioids and is helpful in improving prognosis when used for thoracoscopic radical resection of lung cancer.

18.
Chinese Pharmacological Bulletin ; (12): 97-102, 2018.
Article in Chinese | WPRIM | ID: wpr-664480

ABSTRACT

Aim To investigate the protective role of salvianolic acid B ( Sal B ) on cardiac hypertrophy in type 2 diabetes mice , and to explore its influence on peroxisome proliferator activated receptors-α( PPARα) .Methods The type 2 diabetes melitus ( T2DM) mouse model was established by 4 weeks ' high fat diets feeding and one time STZ intraperitoneal injection .The animals were randomly divided into:control, T2DM, T2DM+SalB(100 mg· kg -1 · d-1 ) and Sal B(100 mg· kg -1 · d-1 ) groups.Eight weeks later, heart weight, tibial length, cross section area of cardiomyocytes , protein expression of PPARαin heart tissue were recorded .In vitro, high glucose and high insulin ( HGI ) were used to induce hypertrophic growth in cultured neonatal rat cardiomyocytes ( NRC-Ms) .And cell surface area , 3 H-leucine incorporation , 3 H-D-glucose uptake and PPARαprotein level were measured to observe the effect of Sal B and MK 886, a PPARαinhibitor.Results In T2DM model mice, Sal B could lower heart weight/tibial length and cross sec-tion area of cardiomyocytes , while PPARαprotein level in hearts were improved .In cultured cardiomyocytes , Sal B ( 10 ~100 μmol · L-1 ) ameliorated the in-creased levels of cell surface area ,3 H-leucine incorpo-ration and improved the decreased 3 H-D-glucose up-take and PPARαexpression induced by HGI . But those function could be abolished by MK 886.Conclu-sion Sal B ameliorates cardiac hypertrophy in T 2DM mice, which may be related to its function on PPARαactivation .

19.
Chinese Journal of Rehabilitation Theory and Practice ; (12): 410-415, 2018.
Article in Chinese | WPRIM | ID: wpr-702507

ABSTRACT

Neuromuscular electrical stimulation(NMES)is one of the electrotherapy that exerts a low-frequency current over the targeted nerves and muscles to induce skeletal muscle contractions to treat skeletal muscle dysfunction in patients.As an alternative rehabilitation modality,NMES is essential for patients with chronic obstructive pulmonary disease(COPD) who are unable to participate in conventional rehabilitation program.NMES could effectively improve the skeletal mus-cle strength,endurance,exercise capacity and quality of life of the patients with COPD.It may be related to remodeling skeletal muscle structure,reducing oxidative stress in skeletal muscle,and improving balance of skeletal muscle protein metabolism.

20.
Journal of Medical Postgraduates ; (12): 158-162, 2018.
Article in Chinese | WPRIM | ID: wpr-700793

ABSTRACT

Objective Previously we have reported the early and midterm benifit of autologous pulmonary patch in repairing aortic coarctation of hypoplastic aortic arch.This study aimed to assess its reliability and midterm and longterm outcomes.Methods We retrospectivly analyzed 42 pediatric patients with coarctation of the aorta (CoA) with hypoplastic aortic arch undergoing surgical repair with autologous pulmonary patch from May 2009 to May 2017 in General Hospital of Guangzhou Military Command of PLA.All the patients were allocated into either senior group (> 1 years) or junior group (≤1 years) according to the age of operation.The trans-coarctation gradient,pulmonary pressure and aortic Z value change were compared between two groups before and after the repair.Results There were 8 cases had early postoperative complications.However,no death had been reported during the postoperative time and the followed up period ranged from 4 months to 106 months (40.0± 15.5) months).The average pressure gradient of coarctation segment for all the patients was (11.9±6.4) mmHg,including 5 cases more than 25 mmHg.The pressure gradient and mean pulmonary arterial pressure after operation were significantly lower than those before operation (P<0.05),The postoperative aortic arch Z value was greater than the preoperative value (P<0.05).Compared with the preoperative period,the Z value of proximal transverse arch increased significantly(-0.64±0.44) vs (1.27±0.66),P<0.05.Compared with junior group,the senior group had higher preoperative and postoperative pulmonary artery pressure (P<0.05),and longer CPB time,aortic block time,ventilation time,ICU time and hospital stay time (P<0.05).However,patients in the junior group had a higher pressure gradient through the aorta arch(P<0.05) and a smaller Z value transverse arch aortic proximal and isthmus(P<0.05) during the long-term period.The time of selective cerebral perfusion had no statistical difference between the two groups (P> 0.05).Conclusion Early surgery for coarctation of aorta with hypoplastic aortic arch,autologous pulmonary patch aortoplasty is a relatively ideal option with better midterm and longterm outcomes.

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