ABSTRACT
Objective To investigate the correlations between serum levels of IL-6,IL-8 and TNF-α and acute cerebral infarction (ACI) caused by hypertension. Methods This study enrolled 102patients with hypertensive ACI (group A),30 patients with simple ACI (group B) and 30 healthy adults (group C) who sought medical intervention or check-up in our hospital between June 2007 and June 2009.Group A was further divided into 3 sub-groups by the infarction volume (30 cases in the small subgroup,45 cases in the intermediate subgroup and 27 cases in the large subgroup).The serum levels of IL-6,IL-8 and TNF-α in groups A,B and C were measured on 1,3,5,7,14 days post-admission and compared.The correlation of the serum levels of IL-6,IL-8 and TNF-α with the infarction volumes in group A was analyzed. Results The serum levels of IL-6,IL-8 and TNF-α decreased significantly on the first day post-admission from group A to group C (P＜0.05).The serum levels of IL-6,IL-8 and TNF-αsignificantly increased,in turn,from group C,the small subgroup,the intermediate subgroup to the large subgroup on 1, 3, 5, 7, 14 days post-admission except for the levels of IL-6 and IL-8 on 14 days post-admission (P＜0.05).In group A,the serum levels of IL-6 and IL-8 were positively correlated with the infarction volume on 1,3,5, 7 days post-admission while the serum level of TNF-α was positively correlated with the infarction volume on 1,3,5,7,14 days post-admission. Conclusions IL-6,IL-8,TNT-α and hypertension play a joint role in cerebral infarction.Serum levels of IL-6,IL-8 and TNT-α are closely related to the volume of cerebral infarction in ACI patients.