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China Occupational Medicine ; (6): 548-551, 2021.
Article in Chinese | WPRIM | ID: wpr-923086


OBJECTIVE: To establish a method for the determination of formic acid in urine by automatic headspace-gas chromatography-mass spectrometry. METHODS: The urine sample was added with 3 mL 15.00%(V/V) sulfuric acid ethanol and heated in an automatic headspace sampler. The formic acid and ethanol underwent an esterification reaction to produce ethyl formate which was separated by gas chromatographic column and detected by mass spectrometer. The quantification was based on external standard method. RESULTS: The linear range of the method was 2.93-97.60 mg/L, with the regression equation correlation coefficient of 0.999 5. The detection limit was 0.65 mg/L and the minimum quantitative limit was 2.17 mg/L, with the recoveries of 95.61%-106.47%. The within-run relative standard deviation(RSD) ranged from 2.52% to 8.05% and the between-run RSD ranged from 6.58% to 8.42%. CONCLUSION: The method has simple pretreatment, good specificity, high precision and has little interference. It is suitable for large scale rapid determination of formic acid in urine in occupational contact population, patients with acute methanol poisoning and general population.

Article in Chinese | WPRIM | ID: wpr-773816


With the serious aging of the population, the incidence of fragility fractures of the pelvis(FFPs) has gradually increased, which has become a public problem affecting the living quality of the elderly. When a surgical treatment is chosen, the procedure should be as minimal invasive as possible and avoid all surgical complications. In recent years, different techniques for percutaneous or less invasive fixation of the posterior pelvic ring have been developed. Their advantages and limitations are presented: sacroplasty, iliosacral screw osteosynthesis, cement augmentation, transiliac internal fixation, transsacral osteosynthesis, lumbopelvic fixation. The purpose of this paper is to review the classification and minimally invasive treatment of FFP.

Aged , Bone Screws , Fracture Fixation, Internal , Fractures, Bone , General Surgery , Humans , Pelvic Bones , Pelvis
Article in Chinese | WPRIM | ID: wpr-838252


Objective To investigate the sleep quality and life quality of soldiers in a navy warship troop, and to explore the correlation between sleep quality and life quality and their influencing factors. Methods Random cluster sampling method was used to select navy soldiers from a navy warship troop. The subjects were surveyed by Pittsburgh sleep quality index (PSQI) scale and World Health Organization Quality of Life-Brief scale (WHOQOL-BREF). Results A total of 160 questionnaires were sent out and 154 valid questionnaires were returned (response rate 94.6%). Of 154 subjects, 31.8% (49/154) had good sleep quality, 53.2% (82/154) had moderate sleep quality, and 14.9% (23/154) had poor sleep quality. The soldiers with good sleep quality had significantly higher scores than those with poor sleep quality in physical, psychological, social and environmental domains of life quality (P0.05 or P0.01). Total PSQI score and most of scores of 7 parts of life quality, including subjective sleep quality, sleep latency, sleep time, sleep disturbances, hypnotic drugs, daytime dysfunction and sleep efficiency, were negatively correlated with the scores of 4 domains of sleep quality. There was significant difference in sleep latency of the subjects with the educational level of junior high school, senior high or polytechnic school, junior college, undergraduate college, or graduate degrees (F=5.368, P0.01), and the subjects with junior college degree had the highest score of sleep latency, while those with undergraduate college degree had the lowest score of sleep latency. Soldiers had a higher score of sleep latency than the officers (t=2.069, P=0.040). There was significant difference in the social domain scores of life quality between navy servicemen with military service time 8 years, 3-8 years and ≤2 years (F=3.401, P=0.036). Officers had a higher score of social domain than soldiers (t=-2.093, P=0.038). Conclusion The sleep quality of navy servicemen should be improved. Improving sleep quality can effectively ameliorate life quality. The sleep quality and life quality of navy servicemen are related to educational levels, work categories and military service time. The corresponding psychological and behavioral intervention should be carried out according to the characteristics of different personnels.

China Occupational Medicine ; (6): 301-304, 2016.
Article in Chinese | WPRIM | ID: wpr-876947


OBJECTIVE: To investigate the sentinel surveillance status of occupational hazards in Guangzhou manufacturing enterprises. METHODS: The stratified random sampling method was used to extract manufacturing enterprises with serious occupational hazard as sentinel enterprises in Guangzhou,2012-2014. The dynamic changes of samples were analyzed based on the sampling monitoring of occupational hazards. RESULTS: From 2012 to 2014,a total of 8 639 occupational hazard sample sites from 577 sentinel enterprises included in 11 kinds of industries were tested and the total over-standard rate was 7. 41%( 640 /8 639). The over-standard rate in these 3 years showed an increasing tendency each year( P <0. 01). The over-standard rates in different kinds of occupational hazard factors from high to low were physical factors,dust factor,inorganic chemistry factors and organic chemistry factors( P < 0. 01). The over-standard rates of occupational hazard factors in different industries from high to low were ship building,construction material,glass gem,wooden furniture,machinery manufacturing,other industries,storage battery,printing and packaging,the chemical,leather bags and shoes and electronic equipment manufacturing industry( P < 0. 01). The over-standard rates of occupational hazard factors in different scales from high to low were medium-sized,large-sized,small-sized and micro-sized enterprises( P <0. 01). CONCLUSION: Guangzhou City should carry on sentinel surveillance work on occupational hazards on factors of physical,dust and inorganic chemistry in key industries such as ship building,construction materials,glass gem,wood furniture and machinery manufacturing,especially in the large and medium-sized enterprises.

Article in Chinese | WPRIM | ID: wpr-324208


<p><b>OBJECTIVE</b>To explore the effects of noise exposure level and cumulative noise exposure (CNE) on the relationship between rs2070424 and rs10432782 SNPs in SOD1 and the susceptibility to noise-induced hearing loss (NIHL).</p><p><b>METHODS</b>A case-control study was performed for investigating the effects of environmental risk factors on the susceptibility to NIHL in 201 sensitive workers and 202 resistant workers.A questionnaire was utilized to investigate the occupational health and to identify the occupational risk factors. The noise exposure levels were detected according to the Chinese standard Measurement of noise in the workplace (GBZ/T 189.8-2007). The peripheral blood samples (5 ml blood for each sample) were from sensitive workers and resistant workers. Genomic DNA was extracted on the basis of the standard procedures of Takara kit. SNPs were detected using standard procedures of TaqMan probe allele identification method.</p><p><b>RESULTS</b>In group exposed to 85 - 92 dB noise (A), the risk of NIHL in the subjects with the AA genotype of rs2070424 was lower than that in the subjects with the GG genotype, OR = 0.37 (95%CI: 0.17∼ 0.80). In group exposed to > 82 dB CNE (A), the AA genotype of rs2070424 is a protective factor of NIHL, as compared with the GG genotype, OR = 0.25 (95%CI: 0.09 ∼ 0.70). In group exposed to 85 - 92 dB noise (A), the risk of NIHL in the subjects with the GG genotype of rs10432782 was compared with the risk of NIHL in the subjects with the TT genotype, OR = 3.17 (95%CI: 1.16 ∼ 6.89). The GT genotype was compared with TT genotype, OR = 2.39 (95%CI: 1.16 ∼ 4.97). In group exposed to 75 ∼ 82 dB CNE (A), the risk of NIHL in the subjects with the GG genotype was compared with the risk of NIHL in the subjects with the TT genotype, OR = 2.35 (95%CI: 0.96 ∼ 5.72), P = 0.06. The GG genotype may bea risk factor of NIHJ.</p><p><b>CONCLUSION</b>The noise exposure level and CNE may influence the relationship between rs2070424, rs10432782 SNPs in SOD1 and noise-induced hearing loss.</p>

Adult , Case-Control Studies , Female , Genetic Predisposition to Disease , Genotype , Hearing Loss, Noise-Induced , Genetics , Humans , Male , Noise, Occupational , Polymorphism, Single Nucleotide , Superoxide Dismutase , Genetics , Superoxide Dismutase-1 , Surveys and Questionnaires