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1.
Article in Chinese | WPRIM | ID: wpr-877668

ABSTRACT

OBJECTIVE@#To observe the effect of five-element acupuncture on the cognitive function repair of migraine patients with depression/anxiety disorder.@*METHODS@#The migraine patients with depression/anxiety disorder (19 cases, 5 cases dropped off) were taken as the observation group, and received five-element acupuncture twice a week for 8 weeks. Healthy subjects (19 cases) were selected by demographic data matching as the control group. The cognitive function was evaluated with the event related potential (ERP) technique, and the latency and amplitude of visual evoked potential P300 were adopted as the observation indexes. The headache days (every 4 weeks), headache intensity [visual analogue scale(VAS) score], and headache impact test-6 (HIT-6) score, Hamilton depression scale (HAMD) score and Hamilton anxiety scale (HAMA) score were used as the observation indexes for curative effect.@*RESULTS@#Before the treatment, latency of target stimulus at Fz [ (417.5±34.3) ms] in the observation group was extended compared with the healthy subjects of the control group [(388.6±42.1) ms, @*CONCLUSION@#There are some cognitive impairments in migraine patients with depression/anxiety disorder. Five-element acupuncture not only relieves headache, anxiety and depression effectively, but also improves the activation level of the frontal lobe. It significantly repairs the impaired cognitive function.


Subject(s)
Acupuncture Points , Acupuncture Therapy , Anxiety Disorders , Cognition , Depression/therapy , Evoked Potentials, Visual , Humans , Migraine Disorders/therapy , Treatment Outcome
2.
Article in Chinese | WPRIM | ID: wpr-877575

ABSTRACT

The current development situation and the hotspot of the relevant research on refractory facial paralysis are explored. The articles on refractory facial paralysis are retrieved from CNKI database. The bibliographic items co-occurrence matrix builder (BICOMB) 2.0 is adopted to extract and analyze statistically literature characteristics and generate the high-frequency keywords matrix. The graphical clustering toolkit (gCLUTO) 1.0 is used to cluster the high-frequency keywords. A total of 750 articles are included, mostly published in


Subject(s)
Acupuncture Points , Acupuncture Therapy , Bibliometrics , China , Facial Paralysis/therapy , Humans , Moxibustion
3.
Article in Chinese | WPRIM | ID: wpr-699676

ABSTRACT

Diabetic retinopathy (DR) is one of the severe microvascular complications caused by diabetes,and the precise pathogenesis of DR is still unsettled now.Recent studies have shown that inflammation and autoimmune responses play important roles in the development of DR.Nucleotide-binding domain and leucine-rich repeat receptor containing a pyrin domain 3 (NLRP3) inflammasome can trigger a variety of inflammatory responses and involves in various chronic inflammatory diseases.At present,a large number of studies have confirmed that NLRP3 inflammasome promotes inflammatory responses in DR through multiple pathways,which have suggested that inhibition of NLPR3 inflammasome or its involved pathways may have therapeutic effects on DR,and the role of NLRP3 inflammasome in DR will be reviewed in this article.

4.
Article in Chinese | WPRIM | ID: wpr-321319

ABSTRACT

Gindenosides are the active ingredients of Panax ginseng. 20 (S) -protopanaxadiolocotillol type epimers are the main metabolites of 20 (S) -protopanaxadiol. The previous studies showed that there are stereoselectivity difference in pharmacodynamics and pharmacokinetics between 24R-epimer and 24S-epimer. The purpose of this study was to explore the excretion of the epimers in bile, feces and urine of rat. Liquid chromatography tandem mass spectrometry method has been performed for determination of 24R-epimer and 24S-epimer in bile, feces and urine. 24R-epimer or 24S-epimer was intragastric administered to rats at a single dose of 10 mg x kg(-1). Results showed that after administration the recovery of 24R-epimer and 24S-epimer in feces was 17.69% and 17.09%, respectively, while both of the two epimers were hardly detected in urine. The 48 h cumulative biliary excretion rate of 24R-epimer was 8.01% after administration, while only 1.47% for 24S-epimer. It indicated that there are stereoselectivity in biliary excretion of the epimers with intragastric administration.


Subject(s)
Animals , Bile , Chemistry , Metabolism , Drugs, Chinese Herbal , Chemistry , Pharmacokinetics , Feces , Chemistry , Ginsenosides , Chemistry , Pharmacokinetics , Male , Mass Spectrometry , Panax , Chemistry , Rats , Rats, Sprague-Dawley , Stereoisomerism , Urine , Chemistry
5.
Article in Chinese | WPRIM | ID: wpr-309339

ABSTRACT

Through document analysis, high trait anger as the hazard factor for the occurrence of many diseases was proposed. The high trait anger should be the main personality characteristics and important pathogenic condition for anger induced diseases. It is expected to find out more effective treatment and prevention pathways for anger induced diseases.


Subject(s)
Affective Symptoms , Psychology , Anger , Humans , Medicine, Chinese Traditional , Methods , Personality , Risk Factors
6.
Article in Chinese | WPRIM | ID: wpr-230516

ABSTRACT

<p><b>OBJECTIVE</b>To observe the influence of bone metabolism biochemical indices of senile osteoporosis treated with distant acupuncture and nearby tuina, and to probe the better therapy for senile osteoporosis.</p><p><b>METHODS</b>Sixty-four cases were randomly divided into an observation group and a control group. In control group (30 cases), Calcium Carbonate D, Tablet was orally taken for 12 weeks continuously. In observation group (34 cases), "distant acupuncture and nearby tuina" therapy were applied, that was puncture at Weizhong (BL 40) and Taixi (KI 3), and tuina therapy on lumber region, 30 times treatment was applied totally. The changes of blood calcium (Ca), phosphorus (P), ALP, BGP and urine DPD in bone metabolism biochemical indices were observed and compared before and after treatment in two groups.</p><p><b>RESULTS</b>There were significant differences in P, BGP, DPD in bone metabolism biochemical indices in both groups before and after treatment (P < 0.05, P < 0.01), the contents of blood P decreased, blood BGP increased and urine DPD decreased. But, there were no significant differences in above indices between two groups.</p><p><b>CONCLUSION</b>The calcium with oral administration and "distant acupuncture and nearby tuina" therapy can effectively improve the bone metabolism biochemical indices of senile osteoporosis, and they have positive significance in prevention of osteoporosis, however, it hasn't proved that which method is better for calcium protecting.</p>


Subject(s)
Acupuncture Therapy , Aged , Alkaline Phosphatase , Blood , Amobarbital , Bone and Bones , Metabolism , Calcium , Blood , Combined Modality Therapy , Drug Combinations , Female , Humans , Male , Middle Aged , Osteocalcin , Blood , Osteoporosis , Blood , Metabolism , Therapeutics , Phosphorus , Blood , Secobarbital
7.
Article in Chinese | WPRIM | ID: wpr-280830

ABSTRACT

<p><b>OBJECTIVE</b>To explore the mechanism on senile osteoporosis of kidney deficiency pattern in the prevention and treatment with acupuncture and Tuina therapy.</p><p><b>METHODS</b>Sixty-four cases were randomized into an acupuncture and Tuina therapy group (group A, 34 cases) and a calcium carbonate group (group B, 30 cases). In group A, the patients were treated with acupuncture at the distal acupoints and Tuina therapy in the local area. Acupuncture was applied to bilateral Weizhong (BL 40) and Taixi (KI 3). Tuina therapy was given in the lumbar region. Totally 30 treatments were required. In group B, the Calcium Carbonate D3 were prescribed for oral administration, continuously for 12 weeks. The changes in lumbar curvature, lumbar lordosis index, sacral inclination angle, lumbosacral angle, L5 vertebral index and L3 vertebral index of lumbar biomechanical indices were observed and compared before and after treatment in two groups.</p><p><b>RESULTS</b>In group A, the lumbar lordosis index and sacral inclination angle were increased after treatment, indicating the statistical significant differences before and after treatment (P < 0.05, P < 0.01). The improvement of lumbar lordosis index in group A was superior to that in group B [(19.59 +/- 19.16)mm vs (14.47 +/- 13.28)mm, P < 0.05]. After treatment, in group B, L5 vertebral index was improved as compared with that before treatment (P < 0.05). It was required to have a study on the reasons of its lumbar morphological change.</p><p><b>CONCLUSION</b>The acupuncture and Tuina therapy regulate the lumbar biomechanical structure through the positive stress stimulation and reconstruct the mechanical equilibrium of the lumbar vertebra. It plays the active significance in the prevention and treatment of osteoporosis.</p>


Subject(s)
Acupuncture Points , Acupuncture Therapy , Aged , Amobarbital , Biomechanical Phenomena , Combined Modality Therapy , Drug Combinations , Female , Humans , Kidney , Male , Middle Aged , Osteoporosis , Therapeutics , Secobarbital
8.
Article in Chinese | WPRIM | ID: wpr-280794

ABSTRACT

<p><b>OBJECTIVE</b>To observe the impacts of different time of moxibustion on its regulating lipid effects and safety of hyperlipidemia.</p><p><b>METHODS</b>Seventy-six cases of hyperlipidemia patients were randomly divided into three groups: including moxibustion 10 min group (group A, 25 cases), moxibustion 20 min group (group B, 25 cases) and moxibustion 30 min group (group C, 26 cases). All of these three groups choose the same acupoints, Shenque (CV 8),Zusanli (ST 36), Fenglong (ST 40) and Sanyinjiao (SP 6) were selected. These three groups were treated with moxibustion for 10 min, 20 min and 30 min, respectively, three times a week, 12 times constituted one course, two courses were required for each group. All indices of blood lipid and fasting blood glucose were observed before and after treatment, and the preliminary evaluation was made on the safety of hepatic and renal function.</p><p><b>RESULTS</b>There were significant decrease in total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and blood sugar after moxibustion treatment (all P<0.001), there was no significant difference of high density lipoprotein cholesterol (HDL-C) before and after treatment (P>0.05). The group C played more prominent role than group A in regulating the TC (P<0.01) and LDL-C (P<0.05), there was no significant difference between group C and group B (P>0.05). The blood urea nitrogen(BUN) was significantly reduced after moxibustion treatment (P<0.05), and there were no significant differences of other safety indices before and after treatment (all P>0.05).</p><p><b>CONCLUSION</b>Moxibustion can effectively and safely reduce the blood lipid level of hyperlipidemia patients, the decreasing degree of lipid is different with different time of moxibustion after treatment, and the decreasing degree in moxibustion 30 min group is significantly better than that in moxibustion 10 min group.</p>


Subject(s)
Acupuncture Points , Aged , Blood Glucose , Metabolism , Cholesterol , Blood , Female , Humans , Hyperlipidemias , Blood , Therapeutics , Male , Middle Aged , Moxibustion , Triglycerides , Blood
9.
Chinese Medical Journal ; (24): 1995-1998, 2010.
Article in English | WPRIM | ID: wpr-352523

ABSTRACT

<p><b>BACKGROUND</b>Genital prolapse affects 30% of middle-aged and older women and is becoming a major public health concern. Sacrospinous ligament fixation is an effective and safe procedure for vaginal vault prolaps with a low recurrence and complication rate. This study aimed to investigate the efficacy and safety of unilateral sacrospinous ligament fixation (SSLF) for the management of pelvic organ prolapse (POP).</p><p><b>METHODS</b>Forty patients with severe prolapse of pelvic organ undergoing unilateral SSLF were retrospectively studied. In this study, all patients were staged by the value of POP-Q. All procedures were performed by a senior physician. The characteristics of these patients and their immediate and short-term post-operative outcome were recorded. All patients were seen six weeks and six months after the surgery. The evaluation included standardized questionnaire and site-specific vaginal examination by one physician.</p><p><b>RESULTS</b>The average operation time was 65-92 minutes. The average blood loss was 83-188 ml. The average hospitalization time was 6.1 days. The average cost was 5885 yuan. The average day of urethral catheter removal after the operation was 2.1 days. The incidence of postoperative morbidity was 17.1%. One (2.4%) patient had hematoma in the right pelvic. The mean length of postoperative follow-up for 35 patients was 13.1 months. The rate of follow-up was 87.5%. One (2.9%) patient showed recurrent vaginal vault prolapse six months after the surgery. The objective success rate of pelvic organ prolapse was 85% (34/40). There was significant difference between the POP-Q of Aa, Ba, Ap, Bp, and D before and after operation (P < 0.001). Five (14.3%) patients complained lower back pain, gluteal pain or right groin pain. Three (8.6%) patients developed de novo stress incontinence. Vaginal disabsorbable sutures were found in three (8.6%) patients. One (2.9%) patient had de novo urge incontinence.</p><p><b>CONCLUSIONS</b>Unilateral SSLF was both cost and treatment effective management for severe pelvic organ prolapse, especially for severe ovaginae anterior prolapse and uterus prolapse of POP I, II or III. Main complications from this procedure included lower back pain, gluteal and groin pain and new onset of stress incontinence.</p>


Subject(s)
Adult , Aged , Aged, 80 and over , Female , Gynecologic Surgical Procedures , Methods , Humans , Ligaments , General Surgery , Middle Aged , Sacrococcygeal Region , General Surgery , Treatment Outcome , Uterine Prolapse , General Surgery
10.
National Journal of Andrology ; (12): 371-376, 2008.
Article in Chinese | WPRIM | ID: wpr-319249

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the effects of Ginkgo biloba extract (EGB) on the testosterone synthesis in the Leydig cells of type 2 diabetic rats.</p><p><b>METHODS</b>Thirty male SD rats were equally randomised into a normal control, a type 2 diabetic and an EGB group. Morphological changes of Leydig cells were observed by light microscopy (LM) and transmission electron microscopy (TEM), concentrations of serum luteinizing hormone (LH) and testosterone (T) were determined by enzyme linked immunosorbent assay (ELISA), and the mRNA levels in the steroidogenic acute regulatory protein (StAR), cytochrome P450 side chain cleavage (P450scc), cytochrome P450 17a-hydroxylase (P450c17), 17beta-hydroxysteroid dehydrogenase 3 (17beta-HSD3) and 3beta-hydroxysteroid dehydrogenase (3beta-HSD1) from the Leydig cells were examined by RT-PCR.</p><p><b>RESULTS</b>Compared with the normal control, there was a significant decrease in the number and volume of Leydig cells, the levels of serum LH and T and the expression of mRNA in StAR, P450scc, 17beta-HSD3 and 3beta-HSD1 in the type 2 diabetes group. And the expression of the P450c17 gene showed a tendency of descending, but with no significance. Compared with the type 2 diabetes group, 12 weeks of EGB treatment caused very slight pathological changes in the Leydig cells, significantly increased the concentrations of blood LH and T, markedly elevated the levels of mRNA in StAR and P450scc and induced an ascending tendency of the expressions of P450c17, 17beta-HSD3 and 3beta-HSD1.</p><p><b>CONCLUSION</b>EGB enhances testosterone synthesis and secretion of Leydig cells by reducing the impairment of the testis in type 2 diabetic rats.</p>


Subject(s)
17-Hydroxysteroid Dehydrogenases , Genetics , Animals , Cholesterol Side-Chain Cleavage Enzyme , Genetics , Diabetes Mellitus, Type 2 , Blood , Genetics , Enzyme-Linked Immunosorbent Assay , Gene Expression , Ginkgo biloba , Chemistry , Hydroxysteroid Dehydrogenases , Genetics , Leydig Cells , Metabolism , Luteinizing Hormone , Blood , Male , Microscopy, Electron, Transmission , Phosphoproteins , Genetics , Plant Extracts , Pharmacology , RNA, Messenger , Genetics , Metabolism , Rats , Rats, Sprague-Dawley , Reverse Transcriptase Polymerase Chain Reaction , Testosterone , Blood
11.
Chinese Journal of Cardiology ; (12): 36-39, 2008.
Article in Chinese | WPRIM | ID: wpr-299503

ABSTRACT

<p><b>OBJECTIVE</b>Trimetazidine (TZM) has been shown to have anti-ischemia properties by optimizing ischemic myocardium metabolism. We evaluated the effect of TZM on myocardial metabolism with Positron Emission Computed Tomography (PET-CT) in patients with ischemic cardiomyopathy.</p><p><b>METHODS</b>TZM (60 mg/d, n = 15) or placebo (n = 15) was randomly applied to ischemic cardiomyopathy patients on top of conventional therapy for 12 months. Color Doppler Flow Imaging (CDFI), (18)F-FDP PET-CT imaging and (99m)Tc-MIBI gated single photon emission computerized tomography (SPECT) imaging were performed at study begin and after 12 months. LVEF with CDFI, summed rest scores (SRS) with SPECT and standard uptake value (SUV) with PET-CT of the segments which were perfusion-metabolism matched and decreased were determined respectively.</p><p><b>RESULTS</b>After 12 months, LVEF of the therapy group was increased from (37.9 +/- 5.0)% to (42.3 +/- 10.4)% (P < 0.05), while the control group increased from (37.9 +/- 4.6)% to (40.1 +/- 5.5)% (P > 0.05); SRSs of the matched segments of the therapy and the control were reduced from 3.9 +/- 1.0 to 2.4 +/- 2.3 (P < 0.01) and 4.0 +/- 0.7 to 2.8 +/- 1.8 (P < 0.05) respectively, while LVEF and SRSs were similar at study begin and after 12 months between these two groups. SUV of myocardial segments classified as myocardial perfusion-metabolism matched was increased from 5.3 +/- 1.5 to 9.8 +/- 4.7 in the therapy group (P < 0.05) and from 5.4 +/- 1.2 to 6.0 +/- 2.3 (P > 0.05) in the placebo group, SUV was significantly higher in the therapy group than that in placebo group after 12 months (P < 0.05).</p><p><b>CONCLUSION</b>SPECT and (18)F-FDG imaging combination could be used to detect the surviving myocardium and chronic trimetazidine treatment could increase the glucose metabolism of ischemic cardiomyocytes in patients with ischemic cardiomyopathy.</p>


Subject(s)
Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Myocardial Ischemia , Diagnostic Imaging , Drug Therapy , Myocardium , Metabolism , Positron-Emission Tomography , Tomography, Emission-Computed, Single-Photon , Trimetazidine , Therapeutic Uses
12.
Article in Chinese | WPRIM | ID: wpr-269122

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the etiology of Gan-qi inversion syndrome and Gan-qi stagnation syndrome, and to study the evocative mode of emotional diseases.</p><p><b>METHODS</b>One thousand and twenty-six subjects, engaged as workers, cadres, teachers and farmers, come from Qingdao City, Jinan City and Qingyun County were surveyed adopting the on-spot investigation.</p><p><b>RESULTS</b>The percentage of patients with Gan-qi inversion or stagnation syndrome caused by emotional internal injury was 53.9%; the emotional stimulations were primary the angry with compunction and the gloomy angry with grievance, secondly the unacquirable wishes, anxiety and grief.</p><p><b>CONCLUSION</b>Emotional stimulation is the main cause of Gan-qi inversion or stagnation syndromes, cross actions of several emotional factors directly impairing Gan is the main evocative mode of emotional diseases.</p>


Subject(s)
Adult , China , Epidemiology , Depression , Diagnosis , Epidemiology , Diagnosis, Differential , Female , Humans , Male , Medicine, Chinese Traditional , Middle Aged , Mood Disorders , Diagnosis , Epidemiology , Qi , Surveys and Questionnaires , Syndrome
13.
Chinese Journal of Cardiology ; (12): 45-48, 2005.
Article in Chinese | WPRIM | ID: wpr-243511

ABSTRACT

<p><b>OBJECTIVE</b>To study regulation of Ca(2+)-activated K(+) channels (KCa) of mesenteric artery smooth muscle cell (SMC) from 21 old patients with essential hypertension (EH) by endothelin-1 (ET-1) and prostagl E(1) (PGE(1)).</p><p><b>METHODS</b>Mesenteric artery branch from EH was digested by enzyme. Patch clamp technique was used to pull cell-attached and inside-out patches on mesenteric artery SMC from EH and the normotensive patients respectively. The signal channel open probability (Po), open dwell-time (To) and close dwell-time (Tc), open channel number per patch were recorded. After adding Ca(2+) (10(-8) approximately 10(-6) mol/L), ET-1(2 approximately 8 x 10(9) mol/L) and PGE(1) (10, 20, 40, 100, 200, 400 nmol/L) to cytoplasm respectively. The parameters above were observed again.</p><p><b>RESULTS</b>Compared to that of normotensive patients, the activities of KCa channels of patients with EH was higher. After adding Ca(2+) to cytoplasm,the Po of KCa channels in normotensive patients increased significantly. But it was few changes in EH group. KCa channels has dual reaction to ET-1 in normotensive patients. We have found no statistics difference when ET-1 present on KCa channels of EH cases. Whereas PGE(1) can affect KCa channels current and channels kinetic significantly in side-out patches. The Po of KCa channels increased. The To protracted and the Tc curtailed in EH.</p><p><b>CONCLUSIONS</b>The activities of KCa channels of patients with EH increased significantly. but the sensitive to Ca(2+) decreased. ET-1 were few effect to KCa channels. The PGE(1) can activated KCa channels of patients with EH.</p>


Subject(s)
Aged , Alprostadil , Pharmacology , Cells, Cultured , Endothelin-1 , Pharmacology , Female , Humans , Hypertension , Metabolism , In Vitro Techniques , Male , Mesenteric Arteries , Cell Biology , Middle Aged , Muscle, Smooth , Metabolism , Patch-Clamp Techniques , Potassium Channels, Calcium-Activated , Metabolism
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