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Article in Chinese | WPRIM | ID: wpr-878944


By preparing 15 batches of lyophilized powder samples of substance benchmark in Houpo Wenzhong Decoction,the fingerprint,index component content and extract rate were determined,and the characteristic peaks,the range of similarity with the reference map,the content range and transfer rate range of magnolol,hesperidin,glycyrrhizic acid and pinocembrin,the extract rate range and the change range were clarified. The results showed that the similarity between the fingerprint of substance benchmark and the reference map R generated from the 15 batches of substance benchmark samples was higher than 0. 90. The assignment of the characteristic peaks in the full prescription's fingerprint of the herbs except Poria cocos was clarified. Nineteen characteristic peaks were assigned,and 12 characteristic peaks were assigned by the reference substance,of which 4 were from Magnolia ocinalis Cortex,5 from Exocarpium Citri Rubrum,2 from Radix aucklandiae,3 from Glycyrrhiza Radix et Rhizoma,4 from Semen Alpiniae Katsumadai,and one from Rhizoma Zingiberis and Zingiber officinale Roscoe. The index component content range and transfer rate range were 0. 80%-1. 14% and 20. 25%-39. 61% for hesperidin,0. 49%-0. 79% and 23. 09%-33. 87%for glycyrrhizic acid,0. 03%-0. 07% and 3. 55%-10. 09% for pinocembrin,0. 15%-0. 38% and 8. 08%-24. 35% for magnolol. The extract rate range and the change range were22. 60%-25. 57% and 12. 67%-23. 68% respectively. In this study,we introduced the concepts of index component content,fingerprint,extract rate,explored the transfer relation of quality value transmitting of substance benchmark in Houpo Wenzhong Decoction,and initially established the quality standard of Houpo Wenzhong Decoction,all of which would provide ideas for the development and research of similar prescriptions.

Benchmarking , Chromatography, High Pressure Liquid , Drugs, Chinese Herbal , Glycyrrhiza , Quality Control
Article in Chinese | WPRIM | ID: wpr-317375


A 13-year-old girl presented with a 1-month history of progressive exertional dyspnea (NYHA class IV) and exophthalmos for 6 months. She had a history of long-standing asthma and the presence of allergy. Hypereosinophilia and increased serum IgE levels (2472 IU/mL) were observed. Chest radiography and a high resolution CT scan documented a massive interstitial pulmonary infiltration. Echocardiography confirmed mild tricuspid regurgitation, apical obliteration of the right ventricle by fibrocalcific thickening of the endocardium and echogenic material suggestive of thrombosis. Churg-Strauss syndrome with cardiac involvement (endomyocardiopathy) was diagnosed. The patient received anticoagulation and corticosteroid therapy. In view of rapidly progressive severe endomyocardiopathy and stable hematology, the patient was referred for cardiac surgery. Histopathological examination of resected specimens confirmed laminated thrombus but without any trace of eosinophils embedded.

Adolescent , Churg-Strauss Syndrome , Endocardium , Pathology , Endomyocardial Fibrosis , Female , Humans
Article in Chinese | WPRIM | ID: wpr-292902


<p><b>OBJECTIVE</b>To observe the effect of acupuncture and moxibustion for preventing nosocomial infection in the patient with acute cerebrovascular disease.</p><p><b>METHODS</b>One hundred cases of acute cerebrovascular disease were randomly divided into a control group and an observation group, 50 cases in each group. The control group were treated by routine therapeutic method without any method for preventing nosocomial infection; the observation group were treated by the routine treatment, with acupuncture and moxibustion added at Guanyuan (GV 4) and Zusanli (ST 36), once daily, for 10 days. The nosocomial infection rate and the abnormal rates of body temperature, WBC and neutrophil were investigated in the two groups.</p><p><b>RESULTS</b>The nosocomial infection rate was 8.0% in the observation group and 26.0% in the control group with a significant difference between the two groups (P < 0.05), and the abnormal rates of body temperature, WBC and neutrophil in the observation group were significantly lower than those in the control group (all P < 0.05).</p><p><b>CONCLUSION</b>Acupuncture and moxibustion can effectively prevent nosocomial infection for the patient with acute cerebrovascular disease. The mechanism possibly is related with regulative action of acupuncture and moxibustion on immunity.</p>

Acupuncture Points , Acupuncture Therapy , Acute Disease , Aged , Cerebrovascular Disorders , Therapeutics , Cross Infection , Female , Humans , Male , Middle Aged , Moxibustion