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1.
Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 1602-1605, 2014.
Article in Chinese | WPRIM | ID: wpr-748988

ABSTRACT

OBJECTIVE@#To investigate the expression of peroxisome proliferator-activated receptor γ (PPAR-γ) in the sinus mucosa of chronic rhinosinusitis without nasal polyps (CRSsNP) and chronic rhinosinusitis with nasal polyps (CRSwNP).@*METHOD@#Using immunohistochemistry and RT-PCR, testing the content of PPAR-γ in sinus mucosa and nasal polyps of patients with chronic sinusitis without nasal polyps and normal inferior turbinate, and analyzing the differences.@*RESULT@#The PPAR-γ was found both in sinus mucosa of CRSsNP, nasal polyps of CRSwNP and in normal inferior turbinate; (2) The expression of PPAR-γ in sinus mucosa of CRSsNP and nasal polyps of CRSwNP was lower than that in normal inferior turbinate tissue, and the differences was prominent in statistics; (3) No differences in the expression of PPAR-γ were obtained in sinus mucosa of CRSsNP and nasal polyps of CRSwNP.@*CONCLUSION@#The PPAR-γ expressed in human nasal mucosa, meanwhile it was descending in sinus mucosa of CRSsNP and nasal polyps of CRSwNP. The long-term inflammations resulted from CRSsNP and nasal polyps of CRSwNP might relate to PPAR-γ, it suggested that PPAR-γ agonists may offer a new therapy for the treatment of Chronic Rhinosinusitis.


Subject(s)
Humans , Chronic Disease , Immunohistochemistry , Inflammation , Nasal Mucosa , Nasal Polyps , Metabolism , PPAR gamma , Rhinitis , Metabolism , Sinusitis , Metabolism , Turbinates
2.
Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 1789-1790, 2014.
Article in Chinese | WPRIM | ID: wpr-747629

ABSTRACT

OBJECTIVE@#To observe the clinical efficacy of nasal vestibule eczema by using beclomethasone dipropionate in combination with He-Ne laser therapy.@*METHOD@#The 200 cases of nasal vestibule eczema patients were randomly divided into treatment and control groups. The control group received the rub beclomethasone dipropionate cream treatment one time per day. The treatment group supplemented with He-Ne laser irradiation treatment on the basis of the control group on the same treatment, alsoone time per day. Then the results were analyzed.@*RESULT@#The total effective rate was 100.0% in treatment group, while 75.0% in the control group. The difference between the two groups was statistically significant (P < 0.05).@*CONCLUSION@#Beclomethasone dipropionate cream combined with He-Ne laser irradiation therapy on nasal vestibule eczema is significant, and easily to operate, with significant anti-inflammatory, anti-itch, analgesic effects.


Subject(s)
Humans , Male , Administration, Inhalation , Anti-Inflammatory Agents , Beclomethasone , Combined Modality Therapy , Double-Blind Method , Eczema , Therapeutics , Glucocorticoids , Laser Therapy
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